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Editing gene: TMEM127 (CAeditome ID:55654)

Gene summary for TMEM127

Gene summary

Gene information	Gene symbol	TMEM127
	Gene ID	55654
	Gene name	transmembrane protein 127
	Synonyms	-
	Cytomap	2q11.2
	Type of gene	protein-coding
	Description	transmembrane protein 127
	Modification date	20210518
	UniProtAcc	O75204
	Context	- 33051659(Genotype-Phenotype Features of Germline Variants of the TMEM127 Pheochromocytoma Susceptibility Gene: A 10-Year Update)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
TMEM127	GO:0031267	Transmembrane protein 127	24334765
TMEM127	GO:0005737	Transmembrane protein 127	20154675
TMEM127	GO:0005769	Transmembrane protein 127	24334765
TMEM127	GO:0005886	Transmembrane protein 127	20154675

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RNA A-to-I events for TMEM127

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000135956.7

RNA A-to-I editing events in Cancer.

CAediting_199762(96249124, -), CAediting_199763(96249135, -), CAediting_199764(96249137, -), CAediting_199765(96249139, -), CAediting_199766(96249163, -), CAediting_199767(96249165, -), CAediting_199768(96249170, -), CAediting_199769(96249174, -), CAediting_199770(96249181, -), CAediting_199771(96249183, -), CAediting_199772(96249187, -), CAediting_199773(96249195, -), CAediting_199774(96249200, -), CAediting_199775(96249203, -), CAediting_199776(96249204, -), CAediting_199777(96249206, -), CAediting_199778(96249209, -), CAediting_199779(96249213, -), CAediting_199780(96249219, -), CAediting_199781(96249226, -), CAediting_199782(96249230, -), CAediting_199783(96249236, -), CAediting_199784(96249246, -), CAediting_199785(96249261, -), CAediting_199786(96249262, -), CAediting_199787(96249266, -), CAediting_199788(96249271, -), CAediting_199789(96249273, -), CAediting_199790(96249274, -), CAediting_199791(96249276, -), CAediting_199792(96249277, -), CAediting_199793(96249291, -), CAediting_199794(96249292, -), CAediting_199795(96249293, -), CAediting_199796(96249301, -), CAediting_199797(96249302, -), CAediting_199798(96249311, -), CAediting_199799(96249314, -), CAediting_199800(96249316, -), CAediting_199801(96249322, -), CAediting_199802(96249325, -), CAediting_199803(96249330, -), CAediting_199804(96249331, -), CAediting_199805(96249333, -), CAediting_199806(96249352, -), CAediting_199807(96249360, -), CAediting_199808(96249363, -), CAediting_199809(96249368, -), CAediting_199810(96249377, -), CAediting_199811(96249480, -), CAediting_199812(96249484, -), CAediting_199813(96249500, -), CAediting_199814(96249502, -), CAediting_199815(96249514, -), CAediting_199816(96249516, -), CAediting_199817(96249537, -), CAediting_199818(96249541, -), CAediting_199819(96249550, -), CAediting_199820(96249553, -), CAediting_199821(96249554, -), CAediting_199822(96249555, -), CAediting_199823(96249566, -), CAediting_199824(96249575, -), CAediting_199825(96249578, -), CAediting_199826(96249584, -), CAediting_199827(96249588, -), CAediting_199828(96249590, -), CAediting_199829(96251251, -), CAediting_199830(96251255, -), CAediting_199831(96251261, -), CAediting_199832(96251273, -), CAediting_199833(96251288, -), CAediting_199834(96251326, -), CAediting_199835(96251346, -), CAediting_199836(96251352, -), CAediting_199837(96251355, -), CAediting_199838(96251371, -), CAediting_199839(96251374, -), CAediting_199840(96251376, -), CAediting_199841(96251398, -), CAediting_199842(96251408, -), CAediting_199843(96251420, -), CAediting_199844(96251433, -), CAediting_199845(96251437, -), CAediting_199846(96251438, -), CAediting_199847(96251457, -), CAediting_199848(96251458, -), CAediting_199849(96251463, -), CAediting_199850(96251468, -), CAediting_199851(96251473, -), CAediting_199852(96251476, -), CAediting_199853(96251516, -), CAediting_199854(96251517, -), CAediting_199855(96251521, -), CAediting_199856(96252015, -), CAediting_199857(96256188, -), CAediting_199858(96261373, -), CAediting_199859(96261378, -), CAediting_199860(96262088, -), CAediting_199861(96262095, -), CAediting_199862(96262140, -), CAediting_199863(96262159, -), CAediting_199864(96262173, -), CAediting_199865(96262176, -), CAediting_199866(96262177, -), CAediting_199867(96263112, -), CAediting_199868(96263228, -), CAediting_199869(96263237, -), CAediting_199870(96263285, -), CAediting_199871(96263286, -), CAediting_199872(96263401, -), CAediting_199873(96263495, -), CAediting_199874(96263500, -), CAediting_199875(96263501, -), CAediting_199876(96263511, -), CAediting_199877(96263536, -),

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RNA editing positional annotations for TMEM127 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_199762	chr2_96249124_-	UTR3
CAediting_199763	chr2_96249135_-	UTR3
CAediting_199764	chr2_96249137_-	UTR3
CAediting_199765	chr2_96249139_-	UTR3
CAediting_199766	chr2_96249163_-	UTR3
CAediting_199767	chr2_96249165_-	UTR3
CAediting_199768	chr2_96249170_-	UTR3
CAediting_199769	chr2_96249174_-	UTR3
CAediting_199770	chr2_96249181_-	UTR3
CAediting_199771	chr2_96249183_-	UTR3
CAediting_199772	chr2_96249187_-	UTR3
CAediting_199773	chr2_96249195_-	UTR3
CAediting_199774	chr2_96249200_-	UTR3
CAediting_199775	chr2_96249203_-	UTR3
CAediting_199776	chr2_96249204_-	UTR3
CAediting_199777	chr2_96249206_-	UTR3
CAediting_199778	chr2_96249209_-	UTR3
CAediting_199779	chr2_96249213_-	UTR3
CAediting_199780	chr2_96249219_-	UTR3
CAediting_199781	chr2_96249226_-	UTR3
CAediting_199782	chr2_96249230_-	UTR3
CAediting_199783	chr2_96249236_-	UTR3
CAediting_199784	chr2_96249246_-	UTR3
CAediting_199785	chr2_96249261_-	UTR3
CAediting_199786	chr2_96249262_-	UTR3
CAediting_199787	chr2_96249266_-	UTR3
CAediting_199788	chr2_96249271_-	UTR3
CAediting_199789	chr2_96249273_-	UTR3
CAediting_199790	chr2_96249274_-	UTR3
CAediting_199791	chr2_96249276_-	UTR3
CAediting_199792	chr2_96249277_-	UTR3
CAediting_199793	chr2_96249291_-	UTR3
CAediting_199794	chr2_96249292_-	UTR3
CAediting_199795	chr2_96249293_-	UTR3
CAediting_199796	chr2_96249301_-	UTR3
CAediting_199797	chr2_96249302_-	UTR3
CAediting_199798	chr2_96249311_-	UTR3
CAediting_199799	chr2_96249314_-	UTR3
CAediting_199800	chr2_96249316_-	UTR3
CAediting_199801	chr2_96249322_-	UTR3
CAediting_199802	chr2_96249325_-	UTR3
CAediting_199803	chr2_96249330_-	UTR3
CAediting_199804	chr2_96249331_-	UTR3
CAediting_199805	chr2_96249333_-	UTR3
CAediting_199806	chr2_96249352_-	UTR3
CAediting_199807	chr2_96249360_-	UTR3
CAediting_199808	chr2_96249363_-	UTR3
CAediting_199809	chr2_96249368_-	UTR3
CAediting_199810	chr2_96249377_-	UTR3
CAediting_199811	chr2_96249480_-	UTR3
CAediting_199812	chr2_96249484_-	UTR3
CAediting_199813	chr2_96249500_-	UTR3
CAediting_199814	chr2_96249502_-	UTR3
CAediting_199815	chr2_96249514_-	UTR3
CAediting_199816	chr2_96249516_-	UTR3
CAediting_199817	chr2_96249537_-	UTR3
CAediting_199818	chr2_96249541_-	UTR3
CAediting_199819	chr2_96249550_-	UTR3
CAediting_199820	chr2_96249553_-	UTR3
CAediting_199821	chr2_96249554_-	UTR3
CAediting_199822	chr2_96249555_-	UTR3
CAediting_199823	chr2_96249566_-	UTR3
CAediting_199824	chr2_96249575_-	UTR3
CAediting_199825	chr2_96249578_-	UTR3
CAediting_199826	chr2_96249584_-	UTR3
CAediting_199827	chr2_96249588_-	UTR3
CAediting_199828	chr2_96249590_-	UTR3
CAediting_199829	chr2_96251251_-	UTR3
CAediting_199830	chr2_96251255_-	UTR3
CAediting_199831	chr2_96251261_-	UTR3
CAediting_199832	chr2_96251273_-	UTR3
CAediting_199833	chr2_96251288_-	UTR3
CAediting_199834	chr2_96251326_-	UTR3
CAediting_199835	chr2_96251346_-	UTR3
CAediting_199836	chr2_96251352_-	UTR3
CAediting_199837	chr2_96251355_-	UTR3
CAediting_199838	chr2_96251371_-	UTR3
CAediting_199839	chr2_96251374_-	UTR3
CAediting_199840	chr2_96251376_-	UTR3
CAediting_199841	chr2_96251398_-	UTR3
CAediting_199842	chr2_96251408_-	UTR3
CAediting_199843	chr2_96251420_-	UTR3
CAediting_199844	chr2_96251433_-	UTR3
CAediting_199845	chr2_96251437_-	UTR3
CAediting_199846	chr2_96251438_-	UTR3
CAediting_199847	chr2_96251457_-	UTR3
CAediting_199848	chr2_96251458_-	UTR3
CAediting_199849	chr2_96251463_-	UTR3
CAediting_199850	chr2_96251468_-	UTR3
CAediting_199851	chr2_96251473_-	UTR3
CAediting_199852	chr2_96251476_-	UTR3
CAediting_199853	chr2_96251516_-	UTR3
CAediting_199854	chr2_96251517_-	UTR3
CAediting_199855	chr2_96251521_-	UTR3
CAediting_199856	chr2_96252015_-	UTR3
CAediting_199857	chr2_96256188_-	intronic
CAediting_199858	chr2_96261373_-	intronic
CAediting_199859	chr2_96261378_-	intronic
CAediting_199860	chr2_96262088_-	intronic
CAediting_199861	chr2_96262095_-	intronic
CAediting_199862	chr2_96262140_-	intronic
CAediting_199863	chr2_96262159_-	intronic
CAediting_199864	chr2_96262173_-	intronic
CAediting_199865	chr2_96262176_-	intronic
CAediting_199866	chr2_96262177_-	intronic
CAediting_199867	chr2_96263112_-	intronic
CAediting_199868	chr2_96263228_-	intronic
CAediting_199869	chr2_96263237_-	intronic
CAediting_199870	chr2_96263285_-	intronic
CAediting_199871	chr2_96263286_-	intronic
CAediting_199872	chr2_96263401_-	intronic
CAediting_199873	chr2_96263495_-	intronic
CAediting_199874	chr2_96263500_-	intronic
CAediting_199875	chr2_96263501_-	intronic
CAediting_199876	chr2_96263511_-	intronic
CAediting_199877	chr2_96263536_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_199762	chr2_96249124_-	SINE	Alu	AluSc
CAediting_199763	chr2_96249135_-	SINE	Alu	AluSc
CAediting_199764	chr2_96249137_-	SINE	Alu	AluSc
CAediting_199765	chr2_96249139_-	SINE	Alu	AluSc
CAediting_199766	chr2_96249163_-	SINE	Alu	AluSc
CAediting_199767	chr2_96249165_-	SINE	Alu	AluSc
CAediting_199768	chr2_96249170_-	SINE	Alu	AluSc
CAediting_199769	chr2_96249174_-	SINE	Alu	AluSc
CAediting_199770	chr2_96249181_-	SINE	Alu	AluSc
CAediting_199771	chr2_96249183_-	SINE	Alu	AluSc
CAediting_199772	chr2_96249187_-	SINE	Alu	AluSc
CAediting_199773	chr2_96249195_-	SINE	Alu	AluSc
CAediting_199774	chr2_96249200_-	SINE	Alu	AluSc
CAediting_199775	chr2_96249203_-	SINE	Alu	AluSc
CAediting_199776	chr2_96249204_-	SINE	Alu	AluSc
CAediting_199777	chr2_96249206_-	SINE	Alu	AluSc
CAediting_199778	chr2_96249209_-	SINE	Alu	AluSc
CAediting_199779	chr2_96249213_-	SINE	Alu	AluSc
CAediting_199780	chr2_96249219_-	SINE	Alu	AluSc
CAediting_199781	chr2_96249226_-	SINE	Alu	AluSc
CAediting_199782	chr2_96249230_-	SINE	Alu	AluSc
CAediting_199783	chr2_96249236_-	SINE	Alu	AluSc
CAediting_199784	chr2_96249246_-	SINE	Alu	AluSc
CAediting_199785	chr2_96249261_-	SINE	Alu	AluSc
CAediting_199786	chr2_96249262_-	SINE	Alu	AluSc
CAediting_199787	chr2_96249266_-	SINE	Alu	AluSc
CAediting_199788	chr2_96249271_-	SINE	Alu	AluSc
CAediting_199789	chr2_96249273_-	SINE	Alu	AluSc
CAediting_199790	chr2_96249274_-	SINE	Alu	AluSc
CAediting_199791	chr2_96249276_-	SINE	Alu	AluSc
CAediting_199792	chr2_96249277_-	SINE	Alu	AluSc
CAediting_199793	chr2_96249291_-	SINE	Alu	AluSc
CAediting_199794	chr2_96249292_-	SINE	Alu	AluSc
CAediting_199795	chr2_96249293_-	SINE	Alu	AluSc
CAediting_199796	chr2_96249301_-	SINE	Alu	AluSc
CAediting_199797	chr2_96249302_-	SINE	Alu	AluSc
CAediting_199798	chr2_96249311_-	SINE	Alu	AluSc
CAediting_199799	chr2_96249314_-	SINE	Alu	AluSc
CAediting_199800	chr2_96249316_-	SINE	Alu	AluSc
CAediting_199801	chr2_96249322_-	SINE	Alu	AluSc
CAediting_199802	chr2_96249325_-	SINE	Alu	AluSc
CAediting_199803	chr2_96249330_-	SINE	Alu	AluSc
CAediting_199804	chr2_96249331_-	SINE	Alu	AluSc
CAediting_199805	chr2_96249333_-	SINE	Alu	AluSc
CAediting_199806	chr2_96249352_-	SINE	Alu	AluSc
CAediting_199807	chr2_96249360_-	SINE	Alu	AluSc
CAediting_199808	chr2_96249363_-	SINE	Alu	AluSc
CAediting_199809	chr2_96249368_-	SINE	Alu	AluSc
CAediting_199810	chr2_96249377_-	SINE	Alu	AluSc
CAediting_199811	chr2_96249480_-	SINE	Alu	AluJr
CAediting_199812	chr2_96249484_-	SINE	Alu	AluJr
CAediting_199813	chr2_96249500_-	SINE	Alu	AluJr
CAediting_199814	chr2_96249502_-	SINE	Alu	AluJr
CAediting_199815	chr2_96249514_-	SINE	Alu	AluJr
CAediting_199816	chr2_96249516_-	SINE	Alu	AluJr
CAediting_199817	chr2_96249537_-	SINE	Alu	AluJr
CAediting_199818	chr2_96249541_-	SINE	Alu	AluJr
CAediting_199819	chr2_96249550_-	SINE	Alu	AluJr
CAediting_199820	chr2_96249553_-	SINE	Alu	AluJr
CAediting_199821	chr2_96249554_-	SINE	Alu	AluJr
CAediting_199822	chr2_96249555_-	SINE	Alu	AluJr
CAediting_199823	chr2_96249566_-	SINE	Alu	AluJr
CAediting_199824	chr2_96249575_-	SINE	Alu	AluJr
CAediting_199825	chr2_96249578_-	SINE	Alu	AluJr
CAediting_199826	chr2_96249584_-	SINE	Alu	AluJr
CAediting_199827	chr2_96249588_-	SINE	Alu	AluJr
CAediting_199828	chr2_96249590_-	SINE	Alu	AluJr
CAediting_199829	chr2_96251251_-	SINE	Alu	AluSx
CAediting_199830	chr2_96251255_-	SINE	Alu	AluSx
CAediting_199831	chr2_96251261_-	SINE	Alu	AluSx
CAediting_199832	chr2_96251273_-	SINE	Alu	AluSx
CAediting_199833	chr2_96251288_-	SINE	Alu	AluSx
CAediting_199834	chr2_96251326_-	SINE	Alu	AluSx
CAediting_199835	chr2_96251346_-	SINE	Alu	AluSx
CAediting_199836	chr2_96251352_-	SINE	Alu	AluSx
CAediting_199837	chr2_96251355_-	SINE	Alu	AluSx
CAediting_199838	chr2_96251371_-	SINE	Alu	AluSx
CAediting_199839	chr2_96251374_-	SINE	Alu	AluSx
CAediting_199840	chr2_96251376_-	SINE	Alu	AluSx
CAediting_199841	chr2_96251398_-	SINE	Alu	AluSx
CAediting_199842	chr2_96251408_-	SINE	Alu	AluSx
CAediting_199843	chr2_96251420_-	SINE	Alu	AluSx
CAediting_199844	chr2_96251433_-	SINE	Alu	AluSx
CAediting_199845	chr2_96251437_-	SINE	Alu	AluSx
CAediting_199846	chr2_96251438_-	SINE	Alu	AluSx
CAediting_199847	chr2_96251457_-	SINE	Alu	AluSx
CAediting_199848	chr2_96251458_-	SINE	Alu	AluSx
CAediting_199849	chr2_96251463_-	SINE	Alu	AluSx
CAediting_199850	chr2_96251468_-	SINE	Alu	AluSx
CAediting_199851	chr2_96251473_-	SINE	Alu	AluSx
CAediting_199852	chr2_96251476_-	SINE	Alu	AluSx
CAediting_199853	chr2_96251516_-	SINE	Alu	AluSx
CAediting_199854	chr2_96251517_-	SINE	Alu	AluSx
CAediting_199855	chr2_96251521_-	SINE	Alu	AluSx
CAediting_199857	chr2_96256188_-	SINE	Alu	AluSc
CAediting_199858	chr2_96261373_-	SINE	Alu	AluJo
CAediting_199859	chr2_96261378_-	SINE	Alu	AluJo
CAediting_199860	chr2_96262088_-	SINE	Alu	AluSx1
CAediting_199861	chr2_96262095_-	SINE	Alu	AluSx1
CAediting_199862	chr2_96262140_-	SINE	Alu	AluSx1
CAediting_199863	chr2_96262159_-	SINE	Alu	AluSx1
CAediting_199864	chr2_96262173_-	SINE	Alu	AluSx1
CAediting_199865	chr2_96262176_-	SINE	Alu	AluSx1
CAediting_199866	chr2_96262177_-	SINE	Alu	AluSx1
CAediting_199867	chr2_96263112_-	SINE	Alu	AluSx
CAediting_199868	chr2_96263228_-	SINE	Alu	AluSx
CAediting_199869	chr2_96263237_-	SINE	Alu	AluSx
CAediting_199870	chr2_96263285_-	SINE	Alu	AluSx
CAediting_199871	chr2_96263286_-	SINE	Alu	AluSx
CAediting_199872	chr2_96263401_-	SINE	Alu	AluSq2
CAediting_199873	chr2_96263495_-	SINE	Alu	AluSq2
CAediting_199874	chr2_96263500_-	SINE	Alu	AluSq2
CAediting_199875	chr2_96263501_-	SINE	Alu	AluSq2
CAediting_199876	chr2_96263511_-	SINE	Alu	AluSq2
CAediting_199877	chr2_96263536_-	SINE	Alu	AluSq2

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RNA A-to-I editing events in the alternative splicing sites for TMEM127

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
IR	CAediting_199770	chr2_96249181_-	96249177:96249199	3SS	0+2i	CTTGAACCCGGGAGGCAGAGGTT	-18.94	CTTGAACCCGGGAGGCAGGGGTT	-26.9
IR	CAediting_199771	chr2_96249183_-	96249177:96249199	3SS	0+4i	CTTGAACCCGGGAGGCAGAGGTT	-18.94	CTTGAACCCGGGAGGCGGAGGTT	-18.74
IR	CAediting_199771	chr2_96249183_-	96249183:96249205	3SS	3+0i	GAATCACTTGAACCCGGGAGGCA	-10.76	GAATCACTTGAACCCGGGAGGCG	-8.94
IR	CAediting_199772	chr2_96249187_-	96249177:96249199	3SS	0+8i	CTTGAACCCGGGAGGCAGAGGTT	-18.94	CTTGAACCCGGGGGGCAGAGGTT	-11.41
IR	CAediting_199772	chr2_96249187_-	96249183:96249205	3SS	0+2i	GAATCACTTGAACCCGGGAGGCA	-10.76	GAATCACTTGAACCCGGGGGGCA	-18.71
IR	CAediting_199773	chr2_96249195_-	96249177:96249199	3SS	0+16i	CTTGAACCCGGGAGGCAGAGGTT	-18.94	CTTGGACCCGGGAGGCAGAGGTT	-18.07
IR	CAediting_199773	chr2_96249195_-	96249183:96249205	3SS	0+10i	GAATCACTTGAACCCGGGAGGCA	-10.76	GAATCACTTGGACCCGGGAGGCA	-10.32
IR	CAediting_199774	chr2_96249200_-	96249183:96249205	3SS	0+15i	GAATCACTTGAACCCGGGAGGCA	-10.76	GAATCGCTTGAACCCGGGAGGCA	-11.23
IR	CAediting_199775	chr2_96249203_-	96249183:96249205	3SS	0+18i	GAATCACTTGAACCCGGGAGGCA	-10.76	GAGTCACTTGAACCCGGGAGGCA	-11.09
IR	CAediting_199776	chr2_96249204_-	96249183:96249205	3SS	0+19i	GAATCACTTGAACCCGGGAGGCA	-10.76	GGATCACTTGAACCCGGGAGGCA	-11.13
IR	CAediting_199851	chr2_96251473_-	96251472:96251480	5SS	0+5i	TGGCATGAT	-23.82	TGGCATGGT	-16.11
IR	CAediting_199852	chr2_96251476_-	96251475:96251483	5SS	0+5i	ACGTGGCAT	-12.69	ACGTGGCGT	-5.9
IR	CAediting_199852	chr2_96251476_-	96251472:96251480	5SS	0+2i	TGGCATGAT	-23.82	TGGCGTGAT	-23.28

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000135956.7.TMEM127.

Correlation between RNA A-to-I editing and PSI for ENSG00000135956.7.TMEM127.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TMEM127

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for TMEM127

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for TMEM127

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_199856	chr2_96252015_-	ENSG00000135956.7	ENST00000432959	hsa-miR-5008-3p	96252014	96252021	8mer-1a	96252014	96252031	151.00	-21.57
CAediting_199856	chr2_96252015_-	ENSG00000135956.7	ENST00000432959	hsa-miR-6737-3p	96252014	96252021	8mer-1a	96252014	96252035	143.00	-16.38
CAediting_199856	chr2_96252015_-	ENSG00000135956.7	ENST00000432959	hsa-miR-7157-3p	96252014	96252021	8mer-1a	96252014	96252035	146.00	-17.15
CAediting_199856	chr2_96252015_-	ENSG00000135956.7	ENST00000432959	hsa-miR-760	96252010	96252017	8mer-1a	96252010	96252028	147.00	-18.53
CAediting_199856	chr2_96252015_-	ENSG00000135956.7	ENST00000432959	hsa-miR-8057	96252009	96252016	8mer-1a	96252009	96252029	156.00	-18.71

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_199856	chr2_96252015_-	ENSG00000135956.7	ENST00000432959	hsa-miR-2113	96252014	96252020	7mer-m8	96252013	96252035	153	-19.76

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_748296	chr10_51299626_+	ENSG00000135956.7	ENST00000432959	hsa-miR-605-3p	96252554	96252560	7mer-m8	96252553	96252574	147	-19.06
CAediting_980496	chr14_31014685_-	ENSG00000135956.7	ENST00000432959	hsa-miR-624-3p	96251840	96251846	7mer-m8	96251839	96251860	150	-18.79
CAediting_1229414	chr17_67471546_+	ENSG00000135956.7	ENST00000432959	hsa-miR-548aa	96252528	96252534	7mer-m8	96252527	96252550	154	-9.19
CAediting_1368054	chr19_46709310_-	ENSG00000135956.7	ENST00000432959	hsa-miR-320e	96251942	96251948	7mer-m8	96251941	96251959	143	-16.47
CAediting_442554	chr5_154685830_+	ENSG00000135956.7	ENST00000432959	hsa-miR-1303	96253687	96253694	8mer-1a	96253687	96253709	155	-21.21
CAediting_524911	chr7_5495852_-	ENSG00000135956.7	ENST00000432959	hsa-miR-589-3p	96252469	96252475	7mer-m8	96252468	96252490	164	-26.97
CAediting_573001	chr7_92204086_-	ENSG00000135956.7	ENST00000432959	hsa-miR-1285-5p	96253144	96253150	7mer-m8	96253143	96253163	153	-18.31

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1368054	chr19_46709310_-	ENSG00000135956.7	ENST00000432959	hsa-miR-320e	96252567	96252573	7mer-m8	96252566	96252584	146	-17.64
CAediting_1229414	chr17_67471546_+	ENSG00000135956.7	ENST00000432959	hsa-miR-548aa	96253612	96253618	7mer-m8	96253611	96253634	142	-12.46
CAediting_1229414	chr17_67471546_+	ENSG00000135956.7	ENST00000432959	hsa-miR-548aa	96253250	96253257	8mer-1a	96253250	96253274	140	-8.62
CAediting_1229414	chr17_67471546_+	ENSG00000135956.7	ENST00000432959	hsa-miR-548aa	96253060	96253067	8mer-1a	96253060	96253082	155	-9.49
CAediting_980496	chr14_31014685_-	ENSG00000135956.7	ENST00000432959	hsa-miR-624-3p	96252477	96252483	7mer-m8	96252476	96252497	145	-10.53

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TMEM127

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000258439.6	protein_coding
ENST00000432959.1	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_199762	ENST00000258439.6	chr2_96249124_-	-2624.90	-2621.70	-2651.90
CAediting_199763	ENST00000258439.6	chr2_96249135_-	-2620.80	-2621.70	-2651.90
CAediting_199764	ENST00000258439.6	chr2_96249137_-	-2621.00	-2621.70	-2651.90
CAediting_199765	ENST00000258439.6	chr2_96249139_-	-2622.30	-2621.70	-2651.90
CAediting_199766	ENST00000258439.6	chr2_96249163_-	-2621.10	-2621.70	-2651.90
CAediting_199767	ENST00000258439.6	chr2_96249165_-	-2620.80	-2621.70	-2651.90
CAediting_199768	ENST00000258439.6	chr2_96249170_-	-2620.80	-2621.70	-2651.90
CAediting_199769	ENST00000258439.6	chr2_96249174_-	-2621.00	-2621.70	-2651.90
CAediting_199770	ENST00000258439.6	chr2_96249181_-	-2620.80	-2621.70	-2651.90
CAediting_199771	ENST00000258439.6	chr2_96249183_-	-2621.00	-2621.70	-2651.90
CAediting_199772	ENST00000258439.6	chr2_96249187_-	-2620.80	-2621.70	-2651.90
CAediting_199773	ENST00000258439.6	chr2_96249195_-	-2621.20	-2621.70	-2651.90
CAediting_199774	ENST00000258439.6	chr2_96249200_-	-2627.10	-2621.70	-2651.90
CAediting_199775	ENST00000258439.6	chr2_96249203_-	-2621.70	-2621.70	-2651.90
CAediting_199776	ENST00000258439.6	chr2_96249204_-	-2622.10	-2621.70	-2651.90
CAediting_199777	ENST00000258439.6	chr2_96249206_-	-2620.80	-2621.70	-2651.90
CAediting_199778	ENST00000258439.6	chr2_96249209_-	-2621.00	-2621.70	-2651.90
CAediting_199779	ENST00000258439.6	chr2_96249213_-	-2620.80	-2621.70	-2651.90
CAediting_199780	ENST00000258439.6	chr2_96249219_-	-2620.80	-2621.70	-2651.90
CAediting_199781	ENST00000258439.6	chr2_96249226_-	-2621.70	-2621.70	-2651.90
CAediting_199782	ENST00000258439.6	chr2_96249230_-	-2621.00	-2621.70	-2651.90
CAediting_199783	ENST00000258439.6	chr2_96249236_-	-2621.30	-2621.70	-2651.90
CAediting_199784	ENST00000258439.6	chr2_96249246_-	-2626.60	-2621.70	-2651.90
CAediting_199785	ENST00000258439.6	chr2_96249261_-	-2622.00	-2621.70	-2651.90
CAediting_199786	ENST00000258439.6	chr2_96249262_-	-2621.10	-2621.70	-2651.90
CAediting_199787	ENST00000258439.6	chr2_96249266_-	-2622.10	-2621.70	-2651.90
CAediting_199788	ENST00000258439.6	chr2_96249271_-	-2621.70	-2621.70	-2651.90
CAediting_199789	ENST00000258439.6	chr2_96249273_-	-2621.70	-2621.70	-2651.90
CAediting_199790	ENST00000258439.6	chr2_96249274_-	-2621.80	-2621.70	-2651.90
CAediting_199791	ENST00000258439.6	chr2_96249276_-	-2621.80	-2621.70	-2651.90
CAediting_199792	ENST00000258439.6	chr2_96249277_-	-2621.80	-2621.70	-2651.90
CAediting_199793	ENST00000258439.6	chr2_96249291_-	-2621.70	-2621.70	-2651.90
CAediting_199794	ENST00000258439.6	chr2_96249292_-	-2621.80	-2621.70	-2651.90
CAediting_199795	ENST00000258439.6	chr2_96249293_-	-2621.20	-2621.70	-2651.90
CAediting_199796	ENST00000258439.6	chr2_96249301_-	-2621.70	-2621.70	-2651.90
CAediting_199797	ENST00000258439.6	chr2_96249302_-	-2621.40	-2621.70	-2651.90
CAediting_199798	ENST00000258439.6	chr2_96249311_-	-2621.00	-2621.70	-2651.90
CAediting_199799	ENST00000258439.6	chr2_96249314_-	-2621.10	-2621.70	-2651.90
CAediting_199800	ENST00000258439.6	chr2_96249316_-	-2621.70	-2621.70	-2651.90
CAediting_199801	ENST00000258439.6	chr2_96249322_-	-2620.80	-2621.70	-2651.90
CAediting_199802	ENST00000258439.6	chr2_96249325_-	-2621.70	-2621.70	-2651.90
CAediting_199803	ENST00000258439.6	chr2_96249330_-	-2621.70	-2621.70	-2651.90
CAediting_199804	ENST00000258439.6	chr2_96249331_-	-2624.30	-2621.70	-2651.90
CAediting_199805	ENST00000258439.6	chr2_96249333_-	-2622.00	-2621.70	-2651.90
CAediting_199806	ENST00000258439.6	chr2_96249352_-	-2620.80	-2621.70	-2651.90
CAediting_199807	ENST00000258439.6	chr2_96249360_-	-2621.30	-2621.70	-2651.90
CAediting_199808	ENST00000258439.6	chr2_96249363_-	-2621.00	-2621.70	-2651.90
CAediting_199809	ENST00000258439.6	chr2_96249368_-	-2621.80	-2621.70	-2651.90
CAediting_199810	ENST00000258439.6	chr2_96249377_-	-2621.70	-2621.70	-2651.90
CAediting_199811	ENST00000258439.6	chr2_96249480_-	-2621.40	-2621.70	-2651.90
CAediting_199812	ENST00000258439.6	chr2_96249484_-	-2624.00	-2621.70	-2651.90
CAediting_199813	ENST00000258439.6	chr2_96249500_-	-2621.00	-2621.70	-2651.90
CAediting_199814	ENST00000258439.6	chr2_96249502_-	-2621.90	-2621.70	-2651.90
CAediting_199815	ENST00000258439.6	chr2_96249514_-	-2622.50	-2621.70	-2651.90
CAediting_199816	ENST00000258439.6	chr2_96249516_-	-2621.40	-2621.70	-2651.90
CAediting_199817	ENST00000258439.6	chr2_96249537_-	-2621.40	-2621.70	-2651.90
CAediting_199818	ENST00000258439.6	chr2_96249541_-	-2626.30	-2621.70	-2651.90
CAediting_199819	ENST00000258439.6	chr2_96249550_-	-2622.00	-2621.70	-2651.90
CAediting_199820	ENST00000258439.6	chr2_96249553_-	-2621.70	-2621.70	-2651.90
CAediting_199821	ENST00000258439.6	chr2_96249554_-	-2621.70	-2621.70	-2651.90
CAediting_199822	ENST00000258439.6	chr2_96249555_-	-2621.70	-2621.70	-2651.90
CAediting_199823	ENST00000258439.6	chr2_96249566_-	-2621.60	-2621.70	-2651.90
CAediting_199824	ENST00000258439.6	chr2_96249575_-	-2621.70	-2621.70	-2651.90
CAediting_199825	ENST00000258439.6	chr2_96249578_-	-2622.20	-2621.70	-2651.90
CAediting_199826	ENST00000258439.6	chr2_96249584_-	-2621.00	-2621.70	-2651.90
CAediting_199827	ENST00000258439.6	chr2_96249588_-	-2621.70	-2621.70	-2651.90
CAediting_199828	ENST00000258439.6	chr2_96249590_-	-2621.70	-2621.70	-2651.90
CAediting_199829	ENST00000258439.6	chr2_96251251_-	-2628.40	-2621.70	-2651.90
CAediting_199830	ENST00000258439.6	chr2_96251255_-	-2627.50	-2621.70	-2651.90
CAediting_199831	ENST00000258439.6	chr2_96251261_-	-2621.80	-2621.70	-2651.90
CAediting_199832	ENST00000258439.6	chr2_96251273_-	-2621.40	-2621.70	-2651.90
CAediting_199833	ENST00000258439.6	chr2_96251288_-	-2621.30	-2621.70	-2651.90
CAediting_199834	ENST00000258439.6	chr2_96251326_-	-2621.00	-2621.70	-2651.90
CAediting_199835	ENST00000258439.6	chr2_96251346_-	-2627.90	-2621.70	-2651.90
CAediting_199836	ENST00000258439.6	chr2_96251352_-	-2621.40	-2621.70	-2651.90
CAediting_199837	ENST00000258439.6	chr2_96251355_-	-2621.40	-2621.70	-2651.90
CAediting_199838	ENST00000258439.6	chr2_96251371_-	-2621.70	-2621.70	-2651.90
CAediting_199839	ENST00000258439.6	chr2_96251374_-	-2625.10	-2621.70	-2651.90
CAediting_199840	ENST00000258439.6	chr2_96251376_-	-2625.60	-2621.70	-2651.90
CAediting_199841	ENST00000258439.6	chr2_96251398_-	-2621.70	-2621.70	-2651.90
CAediting_199842	ENST00000258439.6	chr2_96251408_-	-2621.40	-2621.70	-2651.90
CAediting_199843	ENST00000258439.6	chr2_96251420_-	-2621.00	-2621.70	-2651.90
CAediting_199844	ENST00000258439.6	chr2_96251433_-	-2621.10	-2621.70	-2651.90
CAediting_199845	ENST00000258439.6	chr2_96251437_-	-2621.40	-2621.70	-2651.90
CAediting_199846	ENST00000258439.6	chr2_96251438_-	-2621.40	-2621.70	-2651.90
CAediting_199847	ENST00000258439.6	chr2_96251457_-	-2621.70	-2621.70	-2651.90
CAediting_199848	ENST00000258439.6	chr2_96251458_-	-2621.40	-2621.70	-2651.90
CAediting_199849	ENST00000258439.6	chr2_96251463_-	-2621.30	-2621.70	-2651.90
CAediting_199850	ENST00000258439.6	chr2_96251468_-	-2627.90	-2621.70	-2651.90
CAediting_199851	ENST00000258439.6	chr2_96251473_-	-2621.10	-2621.70	-2651.90
CAediting_199852	ENST00000258439.6	chr2_96251476_-	-2621.30	-2621.70	-2651.90
CAediting_199853	ENST00000258439.6	chr2_96251516_-	-2625.30	-2621.70	-2651.90
CAediting_199854	ENST00000258439.6	chr2_96251517_-	-2623.30	-2621.70	-2651.90
CAediting_199855	ENST00000258439.6	chr2_96251521_-	-2620.80	-2621.70	-2651.90
CAediting_199856	ENST00000258439.6	chr2_96252015_-	-2628.10	-2621.70	-2651.90
CAediting_199856	ENST00000432959.1	chr2_96252015_-	-1197.20	-1192.60	-1197.20

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Relation with ADAR for TMEM127

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
BRCA	CAediting_199771	chr2_96249183_-	0.0169204712682105	0.280707407769446	.	.	.	.
UCEC	CAediting_199771	chr2_96249183_-	.	.	.	.	0.0279294125714503	0.286296972578316
BRCA	CAediting_199783	chr2_96249236_-	.	.	0.0487297366714848	0.125042333836839	.	.
LUSC	CAediting_199783	chr2_96249236_-	0.0358193798807774	0.230772257242953	.	.	.	.
KIRP	CAediting_199783	chr2_96249236_-	0.0269901638993421	0.298247431404352	.	.	.	.
BRCA	CAediting_199802	chr2_96249325_-	0.0373352242647313	0.180078222539735	.	.	.	.
BLCA	CAediting_199809	chr2_96249368_-	0.0166184377264461	0.246503166126508	.	.	.	.
BRCA	CAediting_199809	chr2_96249368_-	1.72719878050283e-14	0.366618475044157	.	.	.	.
CESC	CAediting_199809	chr2_96249368_-	0.00528168664791	0.3711043941817	.	.	.	.
LUAD	CAediting_199809	chr2_96249368_-	6.61803348487401e-06	0.477327489461154	.	.	.	.
LUSC	CAediting_199809	chr2_96249368_-	0.00693690266049789	0.273851760071824	.	.	.	.
PRAD	CAediting_199809	chr2_96249368_-	0.0379518234997934	0.288661724811965	.	.	.	.
HNSC	CAediting_199809	chr2_96249368_-	0.000553639373820216	0.32262070618131	.	.	.	.
OV	CAediting_199809	chr2_96249368_-	0.0299309346530936	0.140469958261656	.	.	.	.
BLCA	CAediting_199813	chr2_96249500_-	5.84085572796246e-08	0.3728630628977	.	.	.	.
LGG	CAediting_199813	chr2_96249500_-	.	.	6.06958039203756e-05	0.265201689318963	0.00223117405938458	0.203745001806029
BRCA	CAediting_199813	chr2_96249500_-	1.58136576747696e-77	0.574693919608855	.	.	.	.
LIHC	CAediting_199813	chr2_96249500_-	7.0970004645883e-10	0.364508656208787	.	.	.	.
CESC	CAediting_199813	chr2_96249500_-	3.84634504760498e-09	0.427980963553668	.	.	.	.
LUAD	CAediting_199813	chr2_96249500_-	5.57028331831945e-13	0.385863462571245	.	.	.	.
COAD	CAediting_199813	chr2_96249500_-	0.0445840595927426	0.191046729528792	.	.	.	.
LUSC	CAediting_199813	chr2_96249500_-	1.38215120985258e-06	0.278573941511935	.	.	.	.
GBM	CAediting_199813	chr2_96249500_-	5.22146109474852e-05	0.406713294745807	.	.	.	.
PRAD	CAediting_199813	chr2_96249500_-	0.000564713774699246	0.248508944773842	.	.	.	.
HNSC	CAediting_199813	chr2_96249500_-	3.24722077231082e-06	0.257609018520851	.	.	.	.
STAD	CAediting_199813	chr2_96249500_-	0.00209706203302124	0.205869335904894	.	.	.	.
KIRC	CAediting_199813	chr2_96249500_-	0.00491697156341433	0.136347478559165	.	.	.	.
UCEC	CAediting_199813	chr2_96249500_-	0.00229855939073991	0.238647029715721	.	.	.	.
KIRP	CAediting_199813	chr2_96249500_-	0.0436847214640435	0.222001592201327	.	.	.	.
ESCA	CAediting_199813	chr2_96249500_-	0.000954689406349024	0.297815256949793	.	.	.	.
OV	CAediting_199813	chr2_96249500_-	8.38563491347978e-10	0.344856548153314	.	.	.	.
PAAD	CAediting_199813	chr2_96249500_-	0.0187728054369092	0.212511565326379	.	.	.	.
PCPG	CAediting_199813	chr2_96249500_-	0.000198441172151859	0.317268882130014	.	.	.	.
SKCM	CAediting_199813	chr2_96249500_-	1.16156223115147e-08	0.371237073583089	.	.	.	.
MESO	CAediting_199813	chr2_96249500_-	0.0442546447541899	0.280164763006756	.	.	.	.
SARC	CAediting_199813	chr2_96249500_-	0.00168874859693106	0.284872987560935	0.00534718165380852	0.253815411219168	.	.
THYM	CAediting_199813	chr2_96249500_-	0.00143410733006856	0.434720441123212	.	.	.	.
LGG	CAediting_199815	chr2_96249514_-	.	.	.	.	0.000227601215509469	0.455233414492061
BRCA	CAediting_199815	chr2_96249514_-	9.79232011442201e-09	0.258486534240675	.	.	.	.
LIHC	CAediting_199815	chr2_96249514_-	0.0114156387070453	0.180823114750161	.	.	.	.
CESC	CAediting_199815	chr2_96249514_-	0.0088932540398405	0.247243245736106	.	.	0.00889685113589741	0.247230604021433
LUAD	CAediting_199815	chr2_96249514_-	2.34066603814538e-09	0.422376694196911	.	.	.	.
LUSC	CAediting_199815	chr2_96249514_-	0.0222809855808793	0.182331450567188	.	.	.	.
BRCA	CAediting_199824	chr2_96249575_-	.	.	0.0457742207753554	0.159667101868559	.	.

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Relation with cancer stages for TMEM127

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
BRCA	pathologic_stage	CAediting_199809	chr2_96249368_-	0.0174731045956857	0.118780675556499
COAD	pathologic_stage	CAediting_199813	chr2_96249500_-	0.0495652224785518	-0.191234426473004
COAD	pathologic_stage	CAediting_199815	chr2_96249514_-	0.0114976810935962	0.344647938724434
HNSC	clinical_stage	CAediting_199809	chr2_96249368_-	0.0410905357966801	0.196913256055498
HNSC	pathologic_stage	CAediting_199809	chr2_96249368_-	0.0217159530245905	0.229344903771934
LUAD	pathologic_stage	CAediting_199815	chr2_96249514_-	0.011969806854475	0.185932235893173
LUSC	pathologic_stage	CAediting_199813	chr2_96249500_-	0.0325523778047172	0.125784217041352

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Relation with survival for TMEM127

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
BRCA	CAediting_199814	chr2_96249502_-	0.0297238241742697	0.0073905	2003240

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RelatedDrugs for TMEM127

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for TMEM127

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
TMEM127	C1708353	Hereditary Paraganglioma-Pheochromocytoma Syndrome	8	CLINGEN
TMEM127	C0031511	Pheochromocytoma	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
TMEM127	C0279702	Conventional (Clear Cell) Renal Cell Carcinoma	1	ORPHANET
TMEM127	C1257877	Pheochromocytoma, Extra-Adrenal	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene