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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: TMEM63B (CAeditome ID:55362)

Gene summary for TMEM63B

check button Gene summary
Gene informationGene symbol

TMEM63B

Gene ID

55362

Gene nametransmembrane protein 63B
SynonymsC6orf110
Cytomap

6p21.1

Type of geneprotein-coding
DescriptionCSC1-like protein 2
Modification date20210518
UniProtAcc

Q5T3F8

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
TMEM63B

GO:0005886

CSC1-like protein 2

0000052

TMEM63B

GO:0015629

CSC1-like protein 2

0000052


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RNA A-to-I events for TMEM63B

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000137216.17

check button RNA A-to-I editing events in Cancer.
CAediting_485372(44129237, +), CAediting_485373(44129247, +), CAediting_485374(44129248, +), CAediting_485375(44129261, +), CAediting_485376(44129264, +), CAediting_485377(44129287, +), CAediting_485378(44129288, +), CAediting_485379(44129356, +), CAediting_485380(44130579, +), CAediting_485381(44130813, +), CAediting_485382(44130816, +), CAediting_485383(44131612, +), CAediting_485384(44131631, +), CAediting_485385(44131640, +), CAediting_485386(44137825, +), CAediting_485387(44141940, +), CAediting_485388(44141943, +), CAediting_485389(44141951, +), CAediting_485390(44141962, +), CAediting_485391(44142001, +), CAediting_485392(44142007, +), CAediting_485393(44142042, +), CAediting_485394(44142198, +), CAediting_485395(44142212, +), CAediting_485396(44142231, +), CAediting_485397(44142387, +), CAediting_485398(44142403, +), CAediting_485399(44142409, +), CAediting_485400(44142419, +), CAediting_485401(44142423, +), CAediting_485402(44142439, +), CAediting_485403(44142455, +), CAediting_485404(44142462, +), CAediting_485405(44142877, +), CAediting_485406(44142904, +), CAediting_485407(44144610, +), CAediting_485408(44144620, +), CAediting_485409(44144676, +), CAediting_485410(44144714, +), CAediting_485411(44144726, +), CAediting_485412(44144736, +), CAediting_485413(44144738, +), CAediting_485414(44144781, +), CAediting_485415(44144787, +), CAediting_485416(44144850, +), CAediting_485417(44144860, +), CAediting_485418(44145021, +), CAediting_485419(44145022, +), CAediting_485420(44145027, +), CAediting_485421(44145089, +), CAediting_485422(44145099, +), CAediting_485423(44145104, +), CAediting_485424(44145115, +), CAediting_485425(44145132, +), CAediting_485426(44145154, +), CAediting_485427(44145155, +), CAediting_485428(44145160, +), CAediting_485429(44145164, +), CAediting_485430(44145195, +), CAediting_485431(44145200, +), CAediting_485432(44145201, +), CAediting_485433(44145203, +), CAediting_485434(44145214, +), CAediting_485435(44145433, +), CAediting_485436(44145445, +), CAediting_485437(44145471, +), CAediting_485438(44145472, +), CAediting_485439(44145485, +), CAediting_485440(44145495, +), CAediting_485441(44145512, +), CAediting_485442(44145521, +), CAediting_485443(44145707, +), CAediting_485444(44152612, +),

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RNA editing positional annotations for TMEM63B using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
CAediting_485444chr6_44152612_+nonsynonymous SNVENST00000259746.12c.A1856Gp.Q619RDPD
CAediting_485444chr6_44152612_+nonsynonymous SNVENST00000323267.9c.A1856Gp.Q619RDPD

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_485372chr6_44129237_+ncRNA_intronic
CAediting_485373chr6_44129247_+ncRNA_intronic
CAediting_485374chr6_44129248_+ncRNA_intronic
CAediting_485375chr6_44129261_+ncRNA_intronic
CAediting_485376chr6_44129264_+ncRNA_intronic
CAediting_485377chr6_44129287_+ncRNA_intronic
CAediting_485378chr6_44129288_+ncRNA_intronic
CAediting_485379chr6_44129356_+ncRNA_intronic
CAediting_485380chr6_44130579_+ncRNA_intronic
CAediting_485381chr6_44130813_+ncRNA_intronic
CAediting_485382chr6_44130816_+ncRNA_intronic
CAediting_485383chr6_44131612_+ncRNA_intronic
CAediting_485384chr6_44131631_+ncRNA_intronic
CAediting_485385chr6_44131640_+ncRNA_intronic
CAediting_485386chr6_44137825_+ncRNA_intronic
CAediting_485387chr6_44141940_+ncRNA_intronic
CAediting_485388chr6_44141943_+ncRNA_intronic
CAediting_485389chr6_44141951_+ncRNA_intronic
CAediting_485390chr6_44141962_+ncRNA_intronic
CAediting_485391chr6_44142001_+ncRNA_intronic
CAediting_485392chr6_44142007_+ncRNA_intronic
CAediting_485393chr6_44142042_+ncRNA_intronic
CAediting_485394chr6_44142198_+ncRNA_intronic
CAediting_485395chr6_44142212_+ncRNA_intronic
CAediting_485396chr6_44142231_+ncRNA_intronic
CAediting_485397chr6_44142387_+ncRNA_intronic
CAediting_485398chr6_44142403_+ncRNA_intronic
CAediting_485399chr6_44142409_+ncRNA_intronic
CAediting_485400chr6_44142419_+ncRNA_intronic
CAediting_485401chr6_44142423_+ncRNA_intronic
CAediting_485402chr6_44142439_+ncRNA_intronic
CAediting_485403chr6_44142455_+ncRNA_intronic
CAediting_485404chr6_44142462_+ncRNA_intronic
CAediting_485405chr6_44142877_+ncRNA_intronic
CAediting_485406chr6_44142904_+ncRNA_intronic
CAediting_485407chr6_44144610_+ncRNA_intronic
CAediting_485408chr6_44144620_+ncRNA_intronic
CAediting_485409chr6_44144676_+ncRNA_intronic
CAediting_485410chr6_44144714_+ncRNA_intronic
CAediting_485411chr6_44144726_+ncRNA_intronic
CAediting_485412chr6_44144736_+ncRNA_intronic
CAediting_485413chr6_44144738_+ncRNA_intronic
CAediting_485414chr6_44144781_+ncRNA_intronic
CAediting_485415chr6_44144787_+ncRNA_intronic
CAediting_485416chr6_44144850_+ncRNA_intronic
CAediting_485417chr6_44144860_+ncRNA_intronic
CAediting_485418chr6_44145021_+ncRNA_intronic
CAediting_485419chr6_44145022_+ncRNA_intronic
CAediting_485420chr6_44145027_+ncRNA_intronic
CAediting_485421chr6_44145089_+ncRNA_intronic
CAediting_485422chr6_44145099_+ncRNA_intronic
CAediting_485423chr6_44145104_+ncRNA_intronic
CAediting_485424chr6_44145115_+ncRNA_intronic
CAediting_485425chr6_44145132_+ncRNA_intronic
CAediting_485426chr6_44145154_+ncRNA_intronic
CAediting_485427chr6_44145155_+ncRNA_intronic
CAediting_485428chr6_44145160_+ncRNA_intronic
CAediting_485429chr6_44145164_+ncRNA_intronic
CAediting_485430chr6_44145195_+ncRNA_intronic
CAediting_485431chr6_44145200_+ncRNA_intronic
CAediting_485432chr6_44145201_+ncRNA_intronic
CAediting_485433chr6_44145203_+ncRNA_intronic
CAediting_485434chr6_44145214_+ncRNA_intronic
CAediting_485435chr6_44145433_+ncRNA_intronic
CAediting_485436chr6_44145445_+ncRNA_intronic
CAediting_485437chr6_44145471_+ncRNA_intronic
CAediting_485438chr6_44145472_+ncRNA_intronic
CAediting_485439chr6_44145485_+ncRNA_intronic
CAediting_485440chr6_44145495_+ncRNA_intronic
CAediting_485441chr6_44145512_+ncRNA_intronic
CAediting_485442chr6_44145521_+ncRNA_intronic
CAediting_485443chr6_44145707_+ncRNA_intronic
CAediting_485444chr6_44152612_+exonic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_485372chr6_44129237_+SINEAluAluSz
CAediting_485373chr6_44129247_+SINEAluAluSz
CAediting_485374chr6_44129248_+SINEAluAluSz
CAediting_485375chr6_44129261_+SINEAluAluSz
CAediting_485376chr6_44129264_+SINEAluAluSz
CAediting_485377chr6_44129287_+SINEAluAluSz
CAediting_485378chr6_44129288_+SINEAluAluSz
CAediting_485379chr6_44129356_+SINEAluAluSz
CAediting_485380chr6_44130579_+SINEAluAluJo
CAediting_485381chr6_44130813_+SINEAluAluJr
CAediting_485382chr6_44130816_+SINEAluAluJr
CAediting_485383chr6_44131612_+SINEAluAluSc
CAediting_485384chr6_44131631_+SINEAluAluSc
CAediting_485385chr6_44131640_+SINEAluAluSc
CAediting_485386chr6_44137825_+SINEAluAluSx
CAediting_485387chr6_44141940_+SINEAluAluJo
CAediting_485388chr6_44141943_+SINEAluAluJo
CAediting_485389chr6_44141951_+SINEAluAluJo
CAediting_485390chr6_44141962_+SINEAluAluJo
CAediting_485391chr6_44142001_+SINEAluAluJo
CAediting_485392chr6_44142007_+SINEAluAluJo
CAediting_485393chr6_44142042_+SINEAluAluJo
CAediting_485394chr6_44142198_+SINEAluFLAM_C
CAediting_485395chr6_44142212_+SINEAluFLAM_C
CAediting_485396chr6_44142231_+SINEAluFLAM_C
CAediting_485397chr6_44142387_+SINEAluAluSx4
CAediting_485398chr6_44142403_+SINEAluAluSx4
CAediting_485399chr6_44142409_+SINEAluAluSx4
CAediting_485400chr6_44142419_+SINEAluAluSx4
CAediting_485401chr6_44142423_+SINEAluAluSx4
CAediting_485402chr6_44142439_+SINEAluAluSx4
CAediting_485403chr6_44142455_+SINEAluAluSx4
CAediting_485404chr6_44142462_+SINEAluAluSx4
CAediting_485405chr6_44142877_+SINEAluAluJb
CAediting_485406chr6_44142904_+SINEAluAluJb
CAediting_485407chr6_44144610_+SINEAluAluJr
CAediting_485408chr6_44144620_+SINEAluAluJr
CAediting_485409chr6_44144676_+SINEAluAluJr
CAediting_485410chr6_44144714_+SINEAluAluJr
CAediting_485411chr6_44144726_+SINEAluAluJr
CAediting_485412chr6_44144736_+SINEAluAluJr
CAediting_485413chr6_44144738_+SINEAluAluJr
CAediting_485414chr6_44144781_+SINEAluAluJr
CAediting_485415chr6_44144787_+SINEAluAluJr
CAediting_485416chr6_44144850_+SINEAluAluJr
CAediting_485417chr6_44144860_+SINEAluAluJr
CAediting_485418chr6_44145021_+SINEAluAluSg4
CAediting_485419chr6_44145022_+SINEAluAluSg4
CAediting_485420chr6_44145027_+SINEAluAluSg4
CAediting_485421chr6_44145089_+SINEAluAluSg4
CAediting_485422chr6_44145099_+SINEAluAluSg4
CAediting_485423chr6_44145104_+SINEAluAluSg4
CAediting_485424chr6_44145115_+SINEAluAluSg4
CAediting_485425chr6_44145132_+SINEAluAluSg4
CAediting_485426chr6_44145154_+SINEAluAluSg4
CAediting_485427chr6_44145155_+SINEAluAluSg4
CAediting_485428chr6_44145160_+SINEAluAluSg4
CAediting_485429chr6_44145164_+SINEAluAluSg4
CAediting_485430chr6_44145195_+SINEAluAluSg4
CAediting_485431chr6_44145200_+SINEAluAluSg4
CAediting_485432chr6_44145201_+SINEAluAluSg4
CAediting_485433chr6_44145203_+SINEAluAluSg4
CAediting_485434chr6_44145214_+SINEAluAluSg4
CAediting_485435chr6_44145433_+SINEAluAluSx
CAediting_485436chr6_44145445_+SINEAluAluSx
CAediting_485437chr6_44145471_+SINEAluAluSx
CAediting_485438chr6_44145472_+SINEAluAluSx
CAediting_485439chr6_44145485_+SINEAluAluSx
CAediting_485440chr6_44145495_+SINEAluAluSx
CAediting_485441chr6_44145512_+SINEAluAluSx
CAediting_485442chr6_44145521_+SINEAluAluSx
CAediting_485443chr6_44145707_+SINEAluFLAM_C

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RNA A-to-I editing events in the alternative splicing sites for TMEM63B

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000137216.17.TMEM63B.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000137216.17.TMEM63B.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TMEM63B

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
LGG.CAediting_485444.ENSG00000137216.TMEM63B.png
Soverview

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Protein coding region RNA A-to-I editings for TMEM63B

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.
all structure


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The effects of the RNA editing to the miRNA binding sites for TMEM63B

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_846604chr11_93733708_-ENSG00000137216.17ENST00000497371hsa-miR-1304-3p44148584441485907mer-m84414857044148591151-18.85
CAediting_86358chr1_109598906_+ENSG00000137216.17ENST00000259746hsa-miR-197-5p44155275441552817mer-m84415526044155282168-29.98
CAediting_86358chr1_109598906_+ENSG00000137216.17ENST00000371893hsa-miR-197-5p44155275441552817mer-m84415526044155282168-29.98
CAediting_442554chr5_154685830_+ENSG00000137216.17ENST00000497371hsa-miR-130344141055441410628mer-1a4414104144141062140-12.95
CAediting_442554chr5_154685830_+ENSG00000137216.17ENST00000497371hsa-miR-130344148601441486077mer-m84414858344148608163-26.2
CAediting_86358chr1_109598906_+ENSG00000137216.17ENST00000533121hsa-miR-197-5p44155275441552817mer-m84415526044155282168-29.98

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1229413chr17_67471544_+ENSG00000137216.17ENST00000259746hsa-miR-548aa44155460441554667mer-m84415544344155467147-10.27
CAediting_580943chr7_100356700_+ENSG00000137216.17ENST00000259746hsa-miR-6840-3p44155291441552988mer-1a4415527744155298152-28.82
CAediting_1229413chr17_67471544_+ENSG00000137216.17ENST00000371893hsa-miR-548aa44155460441554667mer-m84415544344155467147-10.27
CAediting_580943chr7_100356700_+ENSG00000137216.17ENST00000371893hsa-miR-6840-3p44155291441552988mer-1a4415527744155298152-28.82
CAediting_1229413chr17_67471544_+ENSG00000137216.17ENST00000533121hsa-miR-548aa44155460441554667mer-m84415544344155467147-10.27
CAediting_580943chr7_100356700_+ENSG00000137216.17ENST00000533121hsa-miR-6840-3p44154747441547548mer-1a4415473244154754147-19.17
CAediting_580943chr7_100356700_+ENSG00000137216.17ENST00000533121hsa-miR-6840-3p44155291441552988mer-1a4415527744155298152-28.82

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TMEM63B

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000259746.12protein_codingSoverviewSoverview
ENST00000323267.9protein_codingSoverviewSoverview
ENST00000371893.5protein_codingSoverviewSoverview
ENST00000533121.1nonsense_mediated_decaySoverviewSoverview

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
CAediting_485444ENST00000259746.12chr6_44152612_+-1262.60-1260.60-1262.60
CAediting_485444ENST00000323267.9chr6_44152612_+-1213.90-1211.90-1213.90
CAediting_485444ENST00000371893.5chr6_44152612_+-1090.10-1088.10-1090.10
CAediting_485444ENST00000533121.1chr6_44152612_+-913.00-911.00-913.00

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Relation with ADAR for TMEM63B

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
LGGCAediting_485444chr6_44152612_+..5.52543049220373e-060.574611262688336..

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Relation with cancer stages for TMEM63B

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for TMEM63B

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for TMEM63B

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMEM63B

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource