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Center for Computational Systems Medicine
Soverview

Gene summary

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RNA A-to-I events

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Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

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Protein coding region RNA A-to-I editings

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The effects of the RNA editing to the miRNA binding sites

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The effects of the RNA editing to the stability of the RNA structures

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Relation with ADAR

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Relation with cancer stages

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Relation with survival state

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Related drugs with this gene

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Related diseases with this gene

Editing gene: PLCXD1 (CAeditome ID:55344)

Gene summary for PLCXD1

check button Gene summary
Gene informationGene symbol

PLCXD1

Gene ID

55344

Gene namephosphatidylinositol specific phospholipase C X domain containing 1
SynonymsLL0XNC01-136G2.1
Cytomap

X;Y

Type of geneprotein-coding
DescriptionPI-PLC X domain-containing protein 1
Modification date20210518
UniProtAcc

Q9NUJ7

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for PLCXD1

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000182378.11
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_1496982(301090, +), CAediting_1496983(301755, +), CAediting_1496984(301791, +), CAediting_1496985(301887, +), CAediting_1496986(301888, +), CAediting_1496987(302353, +), CAediting_1496988(302474, +), CAediting_1496989(302493, +), CAediting_1496990(302494, +), CAediting_1496991(302754, +), CAediting_1496992(302757, +), CAediting_1496993(302783, +), CAediting_1496994(302813, +), CAediting_1496995(302835, +), CAediting_1496996(302836, +),

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RNA editing positional annotations for PLCXD1 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1496982chrX_301090_+UTR3
CAediting_1496983chrX_301755_+UTR3
CAediting_1496984chrX_301791_+UTR3
CAediting_1496985chrX_301887_+UTR3
CAediting_1496986chrX_301888_+UTR3
CAediting_1496987chrX_302353_+UTR3
CAediting_1496988chrX_302474_+UTR3
CAediting_1496989chrX_302493_+UTR3
CAediting_1496990chrX_302494_+UTR3
CAediting_1496991chrX_302754_+UTR3
CAediting_1496992chrX_302757_+UTR3
CAediting_1496993chrX_302783_+UTR3
CAediting_1496994chrX_302813_+UTR3
CAediting_1496995chrX_302835_+splicing
CAediting_1496996chrX_302836_+splicing

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1496982chrX_301090_+SINEAluAluJb
CAediting_1496983chrX_301755_+SINEAluAluSx1
CAediting_1496984chrX_301791_+SINEAluAluSx1
CAediting_1496985chrX_301887_+SINEAluAluSx1
CAediting_1496986chrX_301888_+SINEAluAluSx1
CAediting_1496988chrX_302474_+SINEAluAluSp
CAediting_1496989chrX_302493_+SINEAluAluSp
CAediting_1496990chrX_302494_+SINEAluAluSp
CAediting_1496991chrX_302754_+SINEAluAluSq
CAediting_1496992chrX_302757_+SINEAluAluSq
CAediting_1496993chrX_302783_+SINEAluAluSq
CAediting_1496994chrX_302813_+SINEAluAluSq
CAediting_1496995chrX_302835_+SINEAluAluSq
CAediting_1496996chrX_302836_+SINEAluAluSq

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RNA A-to-I editing events in the alternative splicing sites for PLCXD1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
IRCAediting_1496995chrX_302835_+302816:3028383SS0+1iCACCCGCCTCGGCCTCCCAAAGT-1.95CACCCGCCTCGGCCTCCCAGAGT6.8
IRCAediting_1496996chrX_302836_+302816:3028383SS1+0iCACCCGCCTCGGCCTCCCAAAGT-1.95CACCCGCCTCGGCCTCCCAAGGT-1.24

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000182378.11.PLCXD1.
boxplot

check button Correlation between RNA A-to-I editing and PSI for ENSG00000182378.11.PLCXD1.
boxplot

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PLCXD1

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for PLCXD1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for PLCXD1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for PLCXD1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for PLCXD1

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
BLCACAediting_1496982chrX_301090_+0.006748207622198440.1781668436976....
STADCAediting_1496982chrX_301090_+0.03255990844496450.1186036034340170.03023090715060780.120233274603408..
SKCMCAediting_1496982chrX_301090_+..0.0160333496933820.144846069826151..
MESOCAediting_1496982chrX_301090_+..0.01746119225846830.32839413789042..
TGCTCAediting_1496982chrX_301090_+0.003538734936032250.248455445760772....
THYMCAediting_1496982chrX_301090_+....0.01035207521522520.320849575226312
CESCCAediting_1496983chrX_301755_+0.04417983048454520.200695218962973....
HNSCCAediting_1496983chrX_301755_+0.02955158104598740.293660616072425....
STADCAediting_1496983chrX_301755_+0.0002273203892323050.231606049156057....
OVCAediting_1496983chrX_301755_+0.004692285718785750.163373544686475....
TGCTCAediting_1496983chrX_301755_+0.003456024400644370.391072588334349....
BRCACAediting_1496984chrX_301791_+0.02262517156502270.218233203524677....
HNSCCAediting_1496984chrX_301791_+....0.0004798130751476970.459091947631603
TGCTCAediting_1496984chrX_301791_+0.03352018473255230.298253421678053....
BLCACAediting_1496985chrX_301887_+2.74455944818797e-060.336033286039227....
BRCACAediting_1496985chrX_301887_+3.89364566235954e-110.276387636667786....
LIHCCAediting_1496985chrX_301887_+1.54444451554574e-050.29970005177065....
CESCCAediting_1496985chrX_301887_+0.01192226086558820.175325539310968....
LUADCAediting_1496985chrX_301887_+1.86354049616022e-080.339372663407148....
LUSCCAediting_1496985chrX_301887_+0.03073629926366480.137233566512356....
HNSCCAediting_1496985chrX_301887_+0.006601262842426030.173112301041261....
STADCAediting_1496985chrX_301887_+0.0006255650501259650.212363398760417....
THCACAediting_1496985chrX_301887_+0.001395336531291750.420396034505966....
UCECCAediting_1496985chrX_301887_+0.002227824341118960.236480574267649....
OVCAediting_1496985chrX_301887_+0.02072253975373040.133723162886736....
SKCMCAediting_1496985chrX_301887_+0.02202555742096040.151278531596732....
SARCCAediting_1496985chrX_301887_+3.7926754549009e-050.341929269008467....
TGCTCAediting_1496985chrX_301887_+1.64141020132562e-070.457894301047638....
THYMCAediting_1496985chrX_301887_+0.0245846808341750.287648282368891....
BLCACAediting_1496986chrX_301888_+1.85404599038496e-120.422429169792516....
LGGCAediting_1496986chrX_301888_+0.001167380025828150.16952476742809....
BRCACAediting_1496986chrX_301888_+7.71288970974801e-130.268657510170861..0.02169501411135890.0875125922377138
LIHCCAediting_1496986chrX_301888_+9.76039529527785e-050.250383495901792....
CESCCAediting_1496986chrX_301888_+1.92352684925129e-060.290298477760612....
LUADCAediting_1496986chrX_301888_+6.02828570006655e-210.486447751864824....
LUSCCAediting_1496986chrX_301888_+0.01034051405280970.140772824065202....
HNSCCAediting_1496986chrX_301888_+0.0003148956479500750.193674554350181....
STADCAediting_1496986chrX_301888_+0.0001941724767780170.211140174911532....
THCACAediting_1496986chrX_301888_+....0.02636028948346210.235419702896857
UCECCAediting_1496986chrX_301888_+3.04126668520544e-090.387975899942187....
OVCAediting_1496986chrX_301888_+0.00162571791420870.171028644293936....
SKCMCAediting_1496986chrX_301888_+4.64287528182753e-050.225277782714332....
READCAediting_1496986chrX_301888_+0.03326739027678570.247817440180172....
SARCCAediting_1496986chrX_301888_+0.01407844687323040.190258465424896....
TGCTCAediting_1496986chrX_301888_+7.38711991421027e-060.37248202094288....
THYMCAediting_1496986chrX_301888_+....0.04745358246523990.215658909724804
LIHCCAediting_1496992chrX_302757_+....0.008504976365668940.290550420544668

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Relation with cancer stages for PLCXD1

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
COADpathologic_stageCAediting_1496985chrX_301887_+0.021952068771089-0.185146135342997
ESCApathologic_stageCAediting_1496983chrX_301755_+0.03447845616652870.192418233936812
OVclinical_stageCAediting_1496987chrX_302353_+0.01975094785681410.290784768609467
READpathologic_stageCAediting_1496985chrX_301887_+0.0388218220490343-0.299228390082856

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Relation with survival for PLCXD1

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for PLCXD1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PLCXD1

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource