Home

Download

Statistics

Examples

Help

Contact

Editing gene: LSG1 (CAeditome ID:55341)

Gene summary for LSG1

Gene summary

Gene information	Gene symbol	LSG1
	Gene ID	55341
	Gene name	large 60S subunit nuclear export GTPase 1
	Synonyms	-
	Cytomap	3q29
	Type of gene	protein-coding
	Description	large subunit GTPase 1 homologhLsg1
	Modification date	20210522
	UniProtAcc	Q9H089
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
LSG1	GO:0003924	Large subunit GTPase 1 homolog	16209721
LSG1	GO:0005525	Large subunit GTPase 1 homolog	16209721
LSG1	GO:0051168	Large subunit GTPase 1 homolog	16209721
LSG1	GO:0005654	Large subunit GTPase 1 homolog	0000052
LSG1	GO:0005783	Large subunit GTPase 1 homolog	0000054
LSG1	GO:0005783	Large subunit GTPase 1 homolog	16209721
LSG1	GO:0005829	Large subunit GTPase 1 homolog	0000052
LSG1	GO:0015030	Large subunit GTPase 1 homolog	16209721
LSG1	GO:0016604	Large subunit GTPase 1 homolog	0000052

Top

RNA A-to-I events for LSG1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000041802.9

RNA A-to-I editing events in Cancer.

CAediting_335428(194646589, -), CAediting_335429(194646810, -), CAediting_335430(194649418, -), CAediting_335431(194649427, -), CAediting_335432(194649438, -), CAediting_335433(194649439, -), CAediting_335434(194649440, -), CAediting_335435(194649441, -), CAediting_335436(194649462, -), CAediting_335437(194649463, -), CAediting_335438(194649465, -), CAediting_335439(194649467, -), CAediting_335440(194649504, -), CAediting_335441(194649561, -), CAediting_335442(194649565, -), CAediting_335443(194649604, -), CAediting_335444(194649607, -), CAediting_335445(194649633, -), CAediting_335446(194649643, -), CAediting_335447(194649654, -), CAediting_335448(194649917, -), CAediting_335449(194649923, -), CAediting_335450(194649925, -), CAediting_335451(194649953, -), CAediting_335452(194649954, -), CAediting_335453(194649977, -), CAediting_335454(194649987, -), CAediting_335455(194649992, -), CAediting_335456(194650009, -), CAediting_335457(194650016, -), CAediting_335458(194650017, -), CAediting_335459(194650041, -), CAediting_335460(194650048, -), CAediting_335461(194650052, -), CAediting_335462(194650058, -), CAediting_335463(194650064, -), CAediting_335464(194650084, -), CAediting_335465(194650087, -), CAediting_335466(194650088, -), CAediting_335467(194650113, -), CAediting_335468(194650114, -), CAediting_335469(194650115, -), CAediting_335470(194650121, -), CAediting_335471(194650123, -), CAediting_335472(194650124, -), CAediting_335473(194650138, -), CAediting_335474(194650146, -), CAediting_335475(194650151, -), CAediting_335476(194650152, -), CAediting_335477(194650156, -), CAediting_335478(194650165, -), CAediting_335479(194650185, -), CAediting_335480(194650191, -), CAediting_335481(194650192, -), CAediting_335482(194650200, -), CAediting_335483(194650214, -), CAediting_335484(194664180, -), CAediting_335485(194664868, -),

Top

RNA editing positional annotations for LSG1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_335428	chr3_194646589_-	ncRNA_intronic
CAediting_335429	chr3_194646810_-	ncRNA_intronic
CAediting_335430	chr3_194649418_-	intronic
CAediting_335431	chr3_194649427_-	intronic
CAediting_335432	chr3_194649438_-	intronic
CAediting_335433	chr3_194649439_-	intronic
CAediting_335434	chr3_194649440_-	intronic
CAediting_335435	chr3_194649441_-	intronic
CAediting_335436	chr3_194649462_-	intronic
CAediting_335437	chr3_194649463_-	intronic
CAediting_335438	chr3_194649465_-	intronic
CAediting_335439	chr3_194649467_-	intronic
CAediting_335440	chr3_194649504_-	intronic
CAediting_335441	chr3_194649561_-	intronic
CAediting_335442	chr3_194649565_-	intronic
CAediting_335443	chr3_194649604_-	intronic
CAediting_335444	chr3_194649607_-	intronic
CAediting_335445	chr3_194649633_-	intronic
CAediting_335446	chr3_194649643_-	intronic
CAediting_335447	chr3_194649654_-	intronic
CAediting_335448	chr3_194649917_-	intronic
CAediting_335449	chr3_194649923_-	intronic
CAediting_335450	chr3_194649925_-	intronic
CAediting_335451	chr3_194649953_-	intronic
CAediting_335452	chr3_194649954_-	intronic
CAediting_335453	chr3_194649977_-	intronic
CAediting_335454	chr3_194649987_-	intronic
CAediting_335455	chr3_194649992_-	intronic
CAediting_335456	chr3_194650009_-	intronic
CAediting_335457	chr3_194650016_-	intronic
CAediting_335458	chr3_194650017_-	intronic
CAediting_335459	chr3_194650041_-	intronic
CAediting_335460	chr3_194650048_-	intronic
CAediting_335461	chr3_194650052_-	intronic
CAediting_335462	chr3_194650058_-	intronic
CAediting_335463	chr3_194650064_-	intronic
CAediting_335464	chr3_194650084_-	intronic
CAediting_335465	chr3_194650087_-	intronic
CAediting_335466	chr3_194650088_-	intronic
CAediting_335467	chr3_194650113_-	intronic
CAediting_335468	chr3_194650114_-	intronic
CAediting_335469	chr3_194650115_-	intronic
CAediting_335470	chr3_194650121_-	intronic
CAediting_335471	chr3_194650123_-	intronic
CAediting_335472	chr3_194650124_-	intronic
CAediting_335473	chr3_194650138_-	intronic
CAediting_335474	chr3_194650146_-	intronic
CAediting_335475	chr3_194650151_-	intronic
CAediting_335476	chr3_194650152_-	intronic
CAediting_335477	chr3_194650156_-	intronic
CAediting_335478	chr3_194650165_-	intronic
CAediting_335479	chr3_194650185_-	intronic
CAediting_335480	chr3_194650191_-	intronic
CAediting_335481	chr3_194650192_-	intronic
CAediting_335482	chr3_194650200_-	intronic
CAediting_335483	chr3_194650214_-	intronic
CAediting_335484	chr3_194664180_-	intronic
CAediting_335485	chr3_194664868_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_335428	chr3_194646589_-	SINE	Alu	AluSx
CAediting_335429	chr3_194646810_-	SINE	Alu	AluSx
CAediting_335430	chr3_194649418_-	SINE	Alu	AluSx
CAediting_335431	chr3_194649427_-	SINE	Alu	AluSx
CAediting_335432	chr3_194649438_-	SINE	Alu	AluSx
CAediting_335433	chr3_194649439_-	SINE	Alu	AluSx
CAediting_335434	chr3_194649440_-	SINE	Alu	AluSx
CAediting_335435	chr3_194649441_-	SINE	Alu	AluSx
CAediting_335436	chr3_194649462_-	SINE	Alu	AluSx
CAediting_335437	chr3_194649463_-	SINE	Alu	AluSx
CAediting_335438	chr3_194649465_-	SINE	Alu	AluSx
CAediting_335439	chr3_194649467_-	SINE	Alu	AluSx
CAediting_335440	chr3_194649504_-	SINE	Alu	AluSx
CAediting_335441	chr3_194649561_-	SINE	Alu	AluSx
CAediting_335442	chr3_194649565_-	SINE	Alu	AluSx
CAediting_335443	chr3_194649604_-	SINE	Alu	AluSx
CAediting_335444	chr3_194649607_-	SINE	Alu	AluSx
CAediting_335445	chr3_194649633_-	SINE	Alu	AluSx
CAediting_335446	chr3_194649643_-	SINE	Alu	AluSx
CAediting_335447	chr3_194649654_-	SINE	Alu	AluSx
CAediting_335448	chr3_194649917_-	SINE	Alu	AluSz6
CAediting_335449	chr3_194649923_-	SINE	Alu	AluSz6
CAediting_335450	chr3_194649925_-	SINE	Alu	AluSz6
CAediting_335451	chr3_194649953_-	SINE	Alu	AluSz6
CAediting_335452	chr3_194649954_-	SINE	Alu	AluSz6
CAediting_335453	chr3_194649977_-	SINE	Alu	AluSz6
CAediting_335454	chr3_194649987_-	SINE	Alu	AluSz6
CAediting_335455	chr3_194649992_-	SINE	Alu	AluSz6
CAediting_335456	chr3_194650009_-	SINE	Alu	AluSz6
CAediting_335457	chr3_194650016_-	SINE	Alu	AluSz6
CAediting_335458	chr3_194650017_-	SINE	Alu	AluSz6
CAediting_335459	chr3_194650041_-	SINE	Alu	AluSz6
CAediting_335460	chr3_194650048_-	SINE	Alu	AluSz6
CAediting_335461	chr3_194650052_-	SINE	Alu	AluSz6
CAediting_335462	chr3_194650058_-	SINE	Alu	AluSz6
CAediting_335463	chr3_194650064_-	SINE	Alu	AluSz6
CAediting_335464	chr3_194650084_-	SINE	Alu	AluSz6
CAediting_335465	chr3_194650087_-	SINE	Alu	AluSz6
CAediting_335466	chr3_194650088_-	SINE	Alu	AluSz6
CAediting_335467	chr3_194650113_-	SINE	Alu	AluSz6
CAediting_335468	chr3_194650114_-	SINE	Alu	AluSz6
CAediting_335469	chr3_194650115_-	SINE	Alu	AluSz6
CAediting_335470	chr3_194650121_-	SINE	Alu	AluSz6
CAediting_335471	chr3_194650123_-	SINE	Alu	AluSz6
CAediting_335472	chr3_194650124_-	SINE	Alu	AluSz6
CAediting_335473	chr3_194650138_-	SINE	Alu	AluSz6
CAediting_335474	chr3_194650146_-	SINE	Alu	AluSz6
CAediting_335475	chr3_194650151_-	SINE	Alu	AluSz6
CAediting_335476	chr3_194650152_-	SINE	Alu	AluSz6
CAediting_335477	chr3_194650156_-	SINE	Alu	AluSz6
CAediting_335478	chr3_194650165_-	SINE	Alu	AluSz6
CAediting_335479	chr3_194650185_-	SINE	Alu	AluSz6
CAediting_335480	chr3_194650191_-	SINE	Alu	AluSz6
CAediting_335481	chr3_194650192_-	SINE	Alu	AluSz6
CAediting_335482	chr3_194650200_-	SINE	Alu	AluSz6
CAediting_335483	chr3_194650214_-	SINE	Alu	AluSz6
CAediting_335484	chr3_194664180_-	SINE	Alu	AluSz
CAediting_335485	chr3_194664868_-	SINE	Alu	AluSp

Top

RNA A-to-I editing events in the alternative splicing sites for LSG1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000041802.9.LSG1.

Correlation between RNA A-to-I editing and PSI for ENSG00000041802.9.LSG1.

Top

Differntial gene expression between RNA A-to-I edited versus non-edited samples for LSG1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

Top

Protein coding region RNA A-to-I editings for LSG1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

Top

The effects of the RNA editing to the miRNA binding sites for LSG1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for LSG1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

Top

Relation with ADAR for LSG1

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
ESCA	CAediting_335431	chr3_194649427_-	.	.	0.0410108097058297	0.243172445529103	.	.
OV	CAediting_335431	chr3_194649427_-	0.0196716246195274	0.313740634299634	.	.	.	.
LUSC	CAediting_335432	chr3_194649438_-	0.0155078638509668	0.264914597818703	.	.	.	.
LUSC	CAediting_335461	chr3_194650052_-	0.00405314679005163	0.36285311344845	.	.	.	.
ESCA	CAediting_335481	chr3_194650192_-	0.0313323528936649	0.248841877531471	.	.	.	.

Top

Relation with cancer stages for LSG1

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
ESCA	clinical_stage	CAediting_335479	chr3_194650185_-	0.0372624930866577	-0.4273411267291
ESCA	pathologic_stage	CAediting_335432	chr3_194649438_-	0.0455108839488413	0.268376297480366
LUSC	pathologic_stage	CAediting_335479	chr3_194650185_-	0.0149901519572214	0.204513630329514

Top

Relation with survival for LSG1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

Top

RelatedDrugs for LSG1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for LSG1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene