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Editing gene: FANCI (CAeditome ID:55215)

Gene summary for FANCI

Gene summary

Gene information	Gene symbol	FANCI
	Gene ID	55215
	Gene name	FA complementation group I
	Synonyms	KIAA1794
	Cytomap	15q26.1
	Type of gene	protein-coding
	Description	Fanconi anemia group I proteinFanconi anemia complementation group I
	Modification date	20210518
	UniProtAcc	Q9NVI1
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
FANCI	GO:0031398	Fanconi anemia group I protein	18029348
FANCI	GO:0005654	Fanconi anemia group I protein	0000052
FANCI	GO:0005737	Fanconi anemia group I protein	18445686
FANCI	GO:0005829	Fanconi anemia group I protein	0000052

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RNA A-to-I events for FANCI

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000140525.16

RNA A-to-I editing events in Cancer.

CAediting_1068543(89248926, +), CAediting_1068544(89248993, +), CAediting_1068545(89249447, +), CAediting_1068546(89249490, +), CAediting_1068547(89249583, +), CAediting_1068548(89252150, +), CAediting_1068549(89266074, +), CAediting_1068550(89267183, +), CAediting_1068551(89267199, +), CAediting_1068552(89267206, +), CAediting_1068553(89267235, +), CAediting_1068554(89267240, +), CAediting_1068555(89268144, +), CAediting_1068556(89271632, +), CAediting_1068557(89273118, +), CAediting_1068558(89279297, +), CAediting_1068559(89295219, +), CAediting_1068560(89295229, +), CAediting_1068561(89295236, +), CAediting_1068562(89295246, +), CAediting_1068563(89295247, +), CAediting_1068564(89295260, +), CAediting_1068565(89295264, +), CAediting_1068566(89295273, +), CAediting_1068567(89295278, +), CAediting_1068568(89295282, +), CAediting_1068569(89295288, +), CAediting_1068570(89295291, +), CAediting_1068571(89295307, +), CAediting_1068572(89295311, +), CAediting_1068573(89295323, +), CAediting_1068574(89295348, +), CAediting_1068575(89295353, +), CAediting_1068576(89295397, +), CAediting_1068577(89295402, +), CAediting_1068578(89295410, +), CAediting_1068579(89295411, +), CAediting_1068580(89295451, +), CAediting_1068581(89295465, +), CAediting_1068582(89295467, +), CAediting_1068583(89295470, +), CAediting_1068584(89295476, +), CAediting_1068585(89295480, +), CAediting_1068586(89295482, +), CAediting_1068587(89295489, +), CAediting_1068588(89295490, +), CAediting_1068589(89295501, +), CAediting_1068590(89295504, +), CAediting_1068591(89295505, +), CAediting_1068592(89295507, +), CAediting_1068593(89295508, +), CAediting_1068594(89295510, +), CAediting_1068595(89295513, +), CAediting_1068596(89295514, +), CAediting_1068597(89295515, +), CAediting_1068598(89295516, +), CAediting_1068599(89295519, +), CAediting_1068600(89295548, +), CAediting_1068601(89295555, +), CAediting_1068602(89295572, +), CAediting_1068603(89295577, +), CAediting_1068604(89295587, +), CAediting_1068605(89295616, +), CAediting_1068606(89295825, +), CAediting_1068607(89295853, +), CAediting_1068608(89295854, +), CAediting_1068609(89295873, +), CAediting_1068610(89295877, +), CAediting_1068611(89295886, +), CAediting_1068612(89296047, +), CAediting_1068613(89296067, +), CAediting_1068614(89296068, +), CAediting_1068615(89296085, +), CAediting_1068616(89296154, +), CAediting_1068617(89296224, +), CAediting_1068618(89296226, +), CAediting_1068619(89296310, +), CAediting_1068620(89298901, +),

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RNA editing positional annotations for FANCI using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1068543	chr15_89248926_+	ncRNA_intronic
CAediting_1068544	chr15_89248993_+	ncRNA_intronic
CAediting_1068545	chr15_89249447_+	ncRNA_intronic
CAediting_1068546	chr15_89249490_+	ncRNA_intronic
CAediting_1068547	chr15_89249583_+	ncRNA_intronic
CAediting_1068548	chr15_89252150_+	ncRNA_intronic
CAediting_1068549	chr15_89266074_+	ncRNA_intronic
CAediting_1068550	chr15_89267183_+	ncRNA_intronic
CAediting_1068551	chr15_89267199_+	ncRNA_intronic
CAediting_1068552	chr15_89267206_+	ncRNA_intronic
CAediting_1068553	chr15_89267235_+	ncRNA_intronic
CAediting_1068554	chr15_89267240_+	ncRNA_intronic
CAediting_1068555	chr15_89268144_+	ncRNA_intronic
CAediting_1068556	chr15_89271632_+	ncRNA_intronic
CAediting_1068557	chr15_89273118_+	ncRNA_intronic
CAediting_1068558	chr15_89279297_+	ncRNA_intronic
CAediting_1068559	chr15_89295219_+	ncRNA_intronic
CAediting_1068560	chr15_89295229_+	ncRNA_intronic
CAediting_1068561	chr15_89295236_+	ncRNA_intronic
CAediting_1068562	chr15_89295246_+	ncRNA_intronic
CAediting_1068563	chr15_89295247_+	ncRNA_intronic
CAediting_1068564	chr15_89295260_+	ncRNA_intronic
CAediting_1068565	chr15_89295264_+	ncRNA_intronic
CAediting_1068566	chr15_89295273_+	ncRNA_intronic
CAediting_1068567	chr15_89295278_+	ncRNA_intronic
CAediting_1068568	chr15_89295282_+	ncRNA_intronic
CAediting_1068569	chr15_89295288_+	ncRNA_intronic
CAediting_1068570	chr15_89295291_+	ncRNA_intronic
CAediting_1068571	chr15_89295307_+	ncRNA_intronic
CAediting_1068572	chr15_89295311_+	ncRNA_intronic
CAediting_1068573	chr15_89295323_+	ncRNA_intronic
CAediting_1068574	chr15_89295348_+	ncRNA_intronic
CAediting_1068575	chr15_89295353_+	ncRNA_intronic
CAediting_1068576	chr15_89295397_+	ncRNA_intronic
CAediting_1068577	chr15_89295402_+	ncRNA_intronic
CAediting_1068578	chr15_89295410_+	ncRNA_intronic
CAediting_1068579	chr15_89295411_+	ncRNA_intronic
CAediting_1068580	chr15_89295451_+	ncRNA_intronic
CAediting_1068581	chr15_89295465_+	ncRNA_intronic
CAediting_1068582	chr15_89295467_+	ncRNA_intronic
CAediting_1068583	chr15_89295470_+	ncRNA_intronic
CAediting_1068584	chr15_89295476_+	ncRNA_intronic
CAediting_1068585	chr15_89295480_+	ncRNA_intronic
CAediting_1068586	chr15_89295482_+	ncRNA_intronic
CAediting_1068587	chr15_89295489_+	ncRNA_intronic
CAediting_1068588	chr15_89295490_+	ncRNA_intronic
CAediting_1068589	chr15_89295501_+	ncRNA_intronic
CAediting_1068590	chr15_89295504_+	ncRNA_intronic
CAediting_1068591	chr15_89295505_+	ncRNA_intronic
CAediting_1068592	chr15_89295507_+	ncRNA_intronic
CAediting_1068593	chr15_89295508_+	ncRNA_intronic
CAediting_1068594	chr15_89295510_+	ncRNA_intronic
CAediting_1068595	chr15_89295513_+	ncRNA_intronic
CAediting_1068596	chr15_89295514_+	ncRNA_intronic
CAediting_1068597	chr15_89295515_+	ncRNA_intronic
CAediting_1068598	chr15_89295516_+	ncRNA_intronic
CAediting_1068599	chr15_89295519_+	ncRNA_intronic
CAediting_1068600	chr15_89295548_+	ncRNA_intronic
CAediting_1068601	chr15_89295555_+	ncRNA_intronic
CAediting_1068602	chr15_89295572_+	ncRNA_intronic
CAediting_1068603	chr15_89295577_+	ncRNA_intronic
CAediting_1068604	chr15_89295587_+	ncRNA_intronic
CAediting_1068605	chr15_89295616_+	ncRNA_intronic
CAediting_1068606	chr15_89295825_+	ncRNA_intronic
CAediting_1068607	chr15_89295853_+	ncRNA_intronic
CAediting_1068608	chr15_89295854_+	ncRNA_intronic
CAediting_1068609	chr15_89295873_+	ncRNA_intronic
CAediting_1068610	chr15_89295877_+	ncRNA_intronic
CAediting_1068611	chr15_89295886_+	ncRNA_intronic
CAediting_1068612	chr15_89296047_+	ncRNA_intronic
CAediting_1068613	chr15_89296067_+	ncRNA_intronic
CAediting_1068614	chr15_89296068_+	ncRNA_intronic
CAediting_1068615	chr15_89296085_+	ncRNA_intronic
CAediting_1068616	chr15_89296154_+	ncRNA_intronic
CAediting_1068617	chr15_89296224_+	ncRNA_intronic
CAediting_1068618	chr15_89296226_+	ncRNA_intronic
CAediting_1068619	chr15_89296310_+	ncRNA_intronic
CAediting_1068620	chr15_89298901_+	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1068543	chr15_89248926_+	SINE	Alu	AluJr
CAediting_1068544	chr15_89248993_+	SINE	Alu	AluJr
CAediting_1068545	chr15_89249447_+	SINE	Alu	AluJb
CAediting_1068546	chr15_89249490_+	SINE	Alu	AluJb
CAediting_1068547	chr15_89249583_+	SINE	Alu	AluJb
CAediting_1068548	chr15_89252150_+	SINE	Alu	AluSz
CAediting_1068549	chr15_89266074_+	SINE	Alu	AluJr
CAediting_1068550	chr15_89267183_+	SINE	Alu	AluSq2
CAediting_1068551	chr15_89267199_+	SINE	Alu	AluSq2
CAediting_1068552	chr15_89267206_+	SINE	Alu	AluSq2
CAediting_1068553	chr15_89267235_+	SINE	Alu	AluSq2
CAediting_1068554	chr15_89267240_+	SINE	Alu	AluSq2
CAediting_1068555	chr15_89268144_+	SINE	Alu	AluJb
CAediting_1068556	chr15_89271632_+	SINE	Alu	AluJr
CAediting_1068557	chr15_89273118_+	SINE	Alu	AluJr
CAediting_1068558	chr15_89279297_+	SINE	Alu	AluSz6
CAediting_1068559	chr15_89295219_+	SINE	Alu	AluSx1
CAediting_1068560	chr15_89295229_+	SINE	Alu	AluSx1
CAediting_1068561	chr15_89295236_+	SINE	Alu	AluSx1
CAediting_1068562	chr15_89295246_+	SINE	Alu	AluSx1
CAediting_1068563	chr15_89295247_+	SINE	Alu	AluSx1
CAediting_1068564	chr15_89295260_+	SINE	Alu	AluSx1
CAediting_1068565	chr15_89295264_+	SINE	Alu	AluSx1
CAediting_1068566	chr15_89295273_+	SINE	Alu	AluSx1
CAediting_1068567	chr15_89295278_+	SINE	Alu	AluSx1
CAediting_1068568	chr15_89295282_+	SINE	Alu	AluSx1
CAediting_1068569	chr15_89295288_+	SINE	Alu	AluSx1
CAediting_1068570	chr15_89295291_+	SINE	Alu	AluSx1
CAediting_1068571	chr15_89295307_+	SINE	Alu	AluSx1
CAediting_1068572	chr15_89295311_+	SINE	Alu	AluSx1
CAediting_1068573	chr15_89295323_+	SINE	Alu	AluSx1
CAediting_1068574	chr15_89295348_+	SINE	Alu	AluSx1
CAediting_1068575	chr15_89295353_+	SINE	Alu	AluSx1
CAediting_1068576	chr15_89295397_+	SINE	Alu	AluSp
CAediting_1068577	chr15_89295402_+	SINE	Alu	AluSp
CAediting_1068578	chr15_89295410_+	SINE	Alu	AluSp
CAediting_1068579	chr15_89295411_+	SINE	Alu	AluSp
CAediting_1068580	chr15_89295451_+	SINE	Alu	AluSp
CAediting_1068581	chr15_89295465_+	SINE	Alu	AluSp
CAediting_1068582	chr15_89295467_+	SINE	Alu	AluSp
CAediting_1068583	chr15_89295470_+	SINE	Alu	AluSp
CAediting_1068584	chr15_89295476_+	SINE	Alu	AluSp
CAediting_1068585	chr15_89295480_+	SINE	Alu	AluSp
CAediting_1068586	chr15_89295482_+	SINE	Alu	AluSp
CAediting_1068587	chr15_89295489_+	SINE	Alu	AluSp
CAediting_1068588	chr15_89295490_+	SINE	Alu	AluSp
CAediting_1068589	chr15_89295501_+	SINE	Alu	AluSp
CAediting_1068590	chr15_89295504_+	SINE	Alu	AluSp
CAediting_1068591	chr15_89295505_+	SINE	Alu	AluSp
CAediting_1068592	chr15_89295507_+	SINE	Alu	AluSp
CAediting_1068593	chr15_89295508_+	SINE	Alu	AluSp
CAediting_1068594	chr15_89295510_+	SINE	Alu	AluSp
CAediting_1068595	chr15_89295513_+	SINE	Alu	AluSp
CAediting_1068596	chr15_89295514_+	SINE	Alu	AluSp
CAediting_1068597	chr15_89295515_+	SINE	Alu	AluSp
CAediting_1068598	chr15_89295516_+	SINE	Alu	AluSp
CAediting_1068599	chr15_89295519_+	SINE	Alu	AluSp
CAediting_1068600	chr15_89295548_+	SINE	Alu	AluSp
CAediting_1068601	chr15_89295555_+	SINE	Alu	AluSp
CAediting_1068602	chr15_89295572_+	SINE	Alu	AluSp
CAediting_1068603	chr15_89295577_+	SINE	Alu	AluSp
CAediting_1068604	chr15_89295587_+	SINE	Alu	AluSp
CAediting_1068605	chr15_89295616_+	SINE	Alu	AluSp
CAediting_1068606	chr15_89295825_+	SINE	Alu	AluJb
CAediting_1068607	chr15_89295853_+	SINE	Alu	AluJb
CAediting_1068608	chr15_89295854_+	SINE	Alu	AluJb
CAediting_1068609	chr15_89295873_+	SINE	Alu	AluJb
CAediting_1068610	chr15_89295877_+	SINE	Alu	AluJb
CAediting_1068611	chr15_89295886_+	SINE	Alu	AluJb
CAediting_1068612	chr15_89296047_+	SINE	Alu	AluSx
CAediting_1068613	chr15_89296067_+	SINE	Alu	AluSx
CAediting_1068614	chr15_89296068_+	SINE	Alu	AluSx
CAediting_1068615	chr15_89296085_+	SINE	Alu	AluSx
CAediting_1068616	chr15_89296154_+	SINE	Alu	AluSx
CAediting_1068617	chr15_89296224_+	SINE	Alu	AluSx
CAediting_1068618	chr15_89296226_+	SINE	Alu	AluSx
CAediting_1068619	chr15_89296310_+	SINE	Alu	AluJb
CAediting_1068620	chr15_89298901_+	SINE	Alu	AluSx

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RNA A-to-I editing events in the alternative splicing sites for FANCI

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000140525.16.FANCI.

Correlation between RNA A-to-I editing and PSI for ENSG00000140525.16.FANCI.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for FANCI

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for FANCI

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for FANCI

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_688081	chr9_63819627_+	ENSG00000140525.16	ENST00000447611	hsa-miR-4477b	89314639	89314645	7mer-m8	89314629	89314646	146	-11.36
CAediting_396018	chr5_1062918_-	ENSG00000140525.16	ENST00000300027	hsa-miR-4635	89316859	89316866	8mer-1a	89316846	89316866	148	-18.22
CAediting_1524209	chrX_134546392_-	ENSG00000140525.16	ENST00000447611	hsa-miR-503-5p	89312951	89312956	6mer	89312939	89312963	152	-26.6

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for FANCI

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for FANCI

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for FANCI

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for FANCI

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for FANCI

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for FANCI

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
FANCI	C1836861	FANCONI ANEMIA, COMPLEMENTATION GROUP I	5	CTD_human;GENOMICS_ENGLAND;UNIPROT
FANCI	C0015625	Fanconi Anemia	4	GENOMICS_ENGLAND
FANCI	C0023465	Acute monocytic leukemia	1	GENOMICS_ENGLAND
FANCI	C0023467	Leukemia, Myelocytic, Acute	1	GENOMICS_ENGLAND
FANCI	C0030312	Pancytopenia	1	GENOMICS_ENGLAND
FANCI	C0265219	Miller Dieker syndrome	1	GENOMICS_ENGLAND
FANCI	C1855710	Bone marrow hypocellularity	1	GENOMICS_ENGLAND
FANCI	C2239176	Liver carcinoma	1	CTD_human
FANCI	C3463824	MYELODYSPLASTIC SYNDROME	1	GENOMICS_ENGLAND
FANCI	C4228778	Abnormality of radial ray	1	GENOMICS_ENGLAND

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene