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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: TTC38 (CAeditome ID:55020)

Gene summary for TTC38

check button Gene summary
Gene informationGene symbol

TTC38

Gene ID

55020

Gene nametetratricopeptide repeat domain 38
SynonymsLL22NC03-5H6.5
Cytomap

22q13.31

Type of geneprotein-coding
Descriptiontetratricopeptide repeat protein 38TPR repeat protein 38
Modification date20210518
UniProtAcc

Q5R3I4

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for TTC38

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000075234.15
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_1494166(46268759, +), CAediting_1494167(46268862, +), CAediting_1494168(46269918, +), CAediting_1494169(46269950, +), CAediting_1494170(46269954, +), CAediting_1494171(46269974, +), CAediting_1494172(46269981, +), CAediting_1494173(46270054, +), CAediting_1494174(46270268, +), CAediting_1494175(46270285, +), CAediting_1494176(46270646, +), CAediting_1494177(46270647, +), CAediting_1494178(46270714, +), CAediting_1494179(46270715, +), CAediting_1494180(46270731, +), CAediting_1494181(46270755, +), CAediting_1494182(46270788, +), CAediting_1494183(46270855, +), CAediting_1494184(46270875, +), CAediting_1494185(46270895, +), CAediting_1494186(46270944, +), CAediting_1494187(46271272, +), CAediting_1494188(46271352, +), CAediting_1494189(46271354, +), CAediting_1494190(46271397, +), CAediting_1494191(46271420, +), CAediting_1494192(46271474, +), CAediting_1494193(46271475, +), CAediting_1494194(46271582, +), CAediting_1494195(46271589, +), CAediting_1494196(46271595, +), CAediting_1494197(46271628, +), CAediting_1494198(46271637, +), CAediting_1494199(46271644, +), CAediting_1494200(46271694, +), CAediting_1494201(46271700, +), CAediting_1494202(46271702, +), CAediting_1494203(46271746, +), CAediting_1494204(46272013, +), CAediting_1494205(46272055, +), CAediting_1494206(46272056, +), CAediting_1494207(46272077, +), CAediting_1494208(46272116, +), CAediting_1494209(46272132, +), CAediting_1494210(46272136, +), CAediting_1494211(46272171, +), CAediting_1494212(46272174, +), CAediting_1494213(46282973, +), CAediting_1494214(46283003, +), CAediting_1494215(46283008, +), CAediting_1494216(46283015, +), CAediting_1494217(46283068, +), CAediting_1494218(46283731, +), CAediting_1494219(46283732, +), CAediting_1494220(46283745, +), CAediting_1494221(46283758, +), CAediting_1494222(46283772, +), CAediting_1494223(46283773, +), CAediting_1494224(46283793, +), CAediting_1494225(46283815, +), CAediting_1494226(46284650, +), CAediting_1494227(46284758, +), CAediting_1494228(46284771, +), CAediting_1494229(46285894, +), CAediting_1494230(46285949, +), CAediting_1494231(46285954, +), CAediting_1494232(46286520, +), CAediting_1494233(46286534, +), CAediting_1494234(46286586, +), CAediting_1494235(46291835, +), CAediting_1494236(46291836, +), CAediting_1494237(46291876, +), CAediting_1494238(46291906, +), CAediting_1494239(46292201, +), CAediting_1494240(46292215, +), CAediting_1494241(46292223, +), CAediting_1494242(46292235, +), CAediting_1494243(46292239, +), CAediting_1494244(46292248, +), CAediting_1494245(46292251, +), CAediting_1494246(46292253, +), CAediting_1494247(46292264, +), CAediting_1494248(46292283, +), CAediting_1494249(46292284, +), CAediting_1494250(46292287, +), CAediting_1494251(46292323, +),

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RNA editing positional annotations for TTC38 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1494166chr22_46268759_+ncRNA_exonic
CAediting_1494167chr22_46268862_+ncRNA_exonic
CAediting_1494168chr22_46269918_+intronic
CAediting_1494169chr22_46269950_+intronic
CAediting_1494170chr22_46269954_+intronic
CAediting_1494171chr22_46269974_+intronic
CAediting_1494172chr22_46269981_+intronic
CAediting_1494173chr22_46270054_+intronic
CAediting_1494174chr22_46270268_+intronic
CAediting_1494175chr22_46270285_+intronic
CAediting_1494176chr22_46270646_+intronic
CAediting_1494177chr22_46270647_+intronic
CAediting_1494178chr22_46270714_+intronic
CAediting_1494179chr22_46270715_+intronic
CAediting_1494180chr22_46270731_+intronic
CAediting_1494181chr22_46270755_+intronic
CAediting_1494182chr22_46270788_+intronic
CAediting_1494183chr22_46270855_+intronic
CAediting_1494184chr22_46270875_+intronic
CAediting_1494185chr22_46270895_+intronic
CAediting_1494186chr22_46270944_+intronic
CAediting_1494187chr22_46271272_+intronic
CAediting_1494188chr22_46271352_+intronic
CAediting_1494189chr22_46271354_+intronic
CAediting_1494190chr22_46271397_+intronic
CAediting_1494191chr22_46271420_+intronic
CAediting_1494192chr22_46271474_+intronic
CAediting_1494193chr22_46271475_+intronic
CAediting_1494194chr22_46271582_+intronic
CAediting_1494195chr22_46271589_+intronic
CAediting_1494196chr22_46271595_+intronic
CAediting_1494197chr22_46271628_+intronic
CAediting_1494198chr22_46271637_+intronic
CAediting_1494199chr22_46271644_+intronic
CAediting_1494200chr22_46271694_+intronic
CAediting_1494201chr22_46271700_+intronic
CAediting_1494202chr22_46271702_+intronic
CAediting_1494203chr22_46271746_+intronic
CAediting_1494204chr22_46272013_+intronic
CAediting_1494205chr22_46272055_+intronic
CAediting_1494206chr22_46272056_+intronic
CAediting_1494207chr22_46272077_+intronic
CAediting_1494208chr22_46272116_+intronic
CAediting_1494209chr22_46272132_+intronic
CAediting_1494210chr22_46272136_+intronic
CAediting_1494211chr22_46272171_+intronic
CAediting_1494212chr22_46272174_+intronic
CAediting_1494213chr22_46282973_+intronic
CAediting_1494214chr22_46283003_+intronic
CAediting_1494215chr22_46283008_+intronic
CAediting_1494216chr22_46283015_+intronic
CAediting_1494217chr22_46283068_+intronic
CAediting_1494218chr22_46283731_+intronic
CAediting_1494219chr22_46283732_+intronic
CAediting_1494220chr22_46283745_+intronic
CAediting_1494221chr22_46283758_+intronic
CAediting_1494222chr22_46283772_+intronic
CAediting_1494223chr22_46283773_+intronic
CAediting_1494224chr22_46283793_+intronic
CAediting_1494225chr22_46283815_+intronic
CAediting_1494226chr22_46284650_+intronic
CAediting_1494227chr22_46284758_+intronic
CAediting_1494228chr22_46284771_+intronic
CAediting_1494229chr22_46285894_+intronic
CAediting_1494230chr22_46285949_+intronic
CAediting_1494231chr22_46285954_+intronic
CAediting_1494232chr22_46286520_+intronic
CAediting_1494233chr22_46286534_+intronic
CAediting_1494234chr22_46286586_+intronic
CAediting_1494235chr22_46291835_+intronic
CAediting_1494236chr22_46291836_+intronic
CAediting_1494237chr22_46291876_+intronic
CAediting_1494238chr22_46291906_+intronic
CAediting_1494239chr22_46292201_+splicing
CAediting_1494240chr22_46292215_+exonic
CAediting_1494241chr22_46292223_+exonic
CAediting_1494242chr22_46292235_+exonic
CAediting_1494243chr22_46292239_+exonic
CAediting_1494244chr22_46292248_+exonic
CAediting_1494245chr22_46292251_+UTR3
CAediting_1494246chr22_46292253_+UTR3
CAediting_1494247chr22_46292264_+UTR3
CAediting_1494248chr22_46292283_+UTR3
CAediting_1494249chr22_46292284_+UTR3
CAediting_1494250chr22_46292287_+UTR3
CAediting_1494251chr22_46292323_+UTR3

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1494166chr22_46268759_+SINEAluAluYk3
CAediting_1494167chr22_46268862_+SINEAluAluYk3
CAediting_1494168chr22_46269918_+SINEAluAluSx3
CAediting_1494169chr22_46269950_+SINEAluAluSx3
CAediting_1494170chr22_46269954_+SINEAluAluSx3
CAediting_1494171chr22_46269974_+SINEAluAluSx3
CAediting_1494172chr22_46269981_+SINEAluAluSx3
CAediting_1494173chr22_46270054_+SINEAluAluSx3
CAediting_1494174chr22_46270268_+SINEAluAluJb
CAediting_1494175chr22_46270285_+SINEAluAluJb
CAediting_1494176chr22_46270646_+SINEAluAluSx
CAediting_1494177chr22_46270647_+SINEAluAluSx
CAediting_1494178chr22_46270714_+SINEAluAluSx
CAediting_1494179chr22_46270715_+SINEAluAluSx
CAediting_1494180chr22_46270731_+SINEAluAluSx
CAediting_1494181chr22_46270755_+SINEAluAluSx
CAediting_1494182chr22_46270788_+SINEAluAluSx
CAediting_1494183chr22_46270855_+SINEAluAluSx
CAediting_1494184chr22_46270875_+SINEAluAluSx
CAediting_1494185chr22_46270895_+SINEAluAluSx
CAediting_1494186chr22_46270944_+SINEAluAluSx
CAediting_1494187chr22_46271272_+SINEAluAluY
CAediting_1494188chr22_46271352_+SINEAluAluY
CAediting_1494189chr22_46271354_+SINEAluAluY
CAediting_1494190chr22_46271397_+SINEAluAluY
CAediting_1494191chr22_46271420_+SINEAluAluY
CAediting_1494192chr22_46271474_+SINEAluAluY
CAediting_1494193chr22_46271475_+SINEAluAluY
CAediting_1494194chr22_46271582_+SINEAluAluSz6
CAediting_1494195chr22_46271589_+SINEAluAluSz6
CAediting_1494196chr22_46271595_+SINEAluAluSz6
CAediting_1494197chr22_46271628_+SINEAluAluSz6
CAediting_1494198chr22_46271637_+SINEAluAluSz6
CAediting_1494199chr22_46271644_+SINEAluAluSz6
CAediting_1494200chr22_46271694_+SINEAluAluSz6
CAediting_1494201chr22_46271700_+SINEAluAluSz6
CAediting_1494202chr22_46271702_+SINEAluAluSz6
CAediting_1494203chr22_46271746_+SINEAluAluSz6
CAediting_1494204chr22_46272013_+SINEAluAluSx
CAediting_1494205chr22_46272055_+SINEAluAluSx
CAediting_1494206chr22_46272056_+SINEAluAluSx
CAediting_1494207chr22_46272077_+SINEAluAluSx
CAediting_1494208chr22_46272116_+SINEAluAluSx
CAediting_1494209chr22_46272132_+SINEAluAluSx
CAediting_1494210chr22_46272136_+SINEAluAluSx
CAediting_1494211chr22_46272171_+SINEAluAluSx
CAediting_1494212chr22_46272174_+SINEAluAluSx
CAediting_1494213chr22_46282973_+SINEAluAluJb
CAediting_1494214chr22_46283003_+SINEAluAluJb
CAediting_1494215chr22_46283008_+SINEAluAluJb
CAediting_1494216chr22_46283015_+SINEAluAluJb
CAediting_1494217chr22_46283068_+SINEAluAluJb
CAediting_1494218chr22_46283731_+SINEAluAluSx
CAediting_1494219chr22_46283732_+SINEAluAluSx
CAediting_1494220chr22_46283745_+SINEAluAluSx
CAediting_1494221chr22_46283758_+SINEAluAluSx
CAediting_1494222chr22_46283772_+SINEAluAluSx
CAediting_1494223chr22_46283773_+SINEAluAluSx
CAediting_1494224chr22_46283793_+SINEAluAluSx
CAediting_1494225chr22_46283815_+SINEAluAluSx
CAediting_1494226chr22_46284650_+SINEAluAluSz
CAediting_1494227chr22_46284758_+SINEAluAluSz
CAediting_1494228chr22_46284771_+SINEAluAluSz
CAediting_1494229chr22_46285894_+SINEAluAluSx1
CAediting_1494230chr22_46285949_+SINEAluAluSx1
CAediting_1494231chr22_46285954_+SINEAluAluSx1
CAediting_1494232chr22_46286520_+SINEAluAluSx1
CAediting_1494233chr22_46286534_+SINEAluAluSx1
CAediting_1494234chr22_46286586_+SINEAluAluSx1
CAediting_1494235chr22_46291835_+SINEAluAluSx1
CAediting_1494236chr22_46291836_+SINEAluAluSx1
CAediting_1494237chr22_46291876_+SINEAluAluSx1
CAediting_1494238chr22_46291906_+SINEAluAluSx1
CAediting_1494239chr22_46292201_+SINEAluAluJr4
CAediting_1494240chr22_46292215_+SINEAluAluJr4
CAediting_1494241chr22_46292223_+SINEAluAluJr4
CAediting_1494242chr22_46292235_+SINEAluAluJr4
CAediting_1494243chr22_46292239_+SINEAluAluJr4
CAediting_1494244chr22_46292248_+SINEAluAluJr4
CAediting_1494245chr22_46292251_+SINEAluAluJr4
CAediting_1494246chr22_46292253_+SINEAluAluJr4
CAediting_1494247chr22_46292264_+SINEAluAluJr4
CAediting_1494248chr22_46292283_+SINEAluAluJr4
CAediting_1494249chr22_46292284_+SINEAluAluJr4
CAediting_1494250chr22_46292287_+SINEAluAluJr4
CAediting_1494251chr22_46292323_+SINEAluAluJr4

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RNA A-to-I editing events in the alternative splicing sites for TTC38

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESCAediting_1494239chr22_46292201_+46292182:462922043SS0+1iTAAATTTTTTTATATTTTTAGAG-7.82TAAATTTTTTTATATTTTTGGAG0.93
ESCAediting_1494239chr22_46292201_+46292184:462922063SS0+3iAATTTTTTTATATTTTTAGAGGC-8.52AATTTTTTTATATTTTTGGAGGC-20.07
MEX_2CAediting_1494239chr22_46292201_+46292182:462922043SS0+1iTAAATTTTTTTATATTTTTAGAG-7.82TAAATTTTTTTATATTTTTGGAG0.93

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000075234.15.TTC38.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000075234.15.TTC38.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TTC38

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for TTC38

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for TTC38

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1494250chr22_46292287_+ENSG00000075234.15ENST00000451998hsa-miR-188-5p46292282462922887mer-m84629226946292289151.00-19.52
CAediting_1494250chr22_46292287_+ENSG00000075234.15ENST00000451998hsa-miR-478046292280462922878mer-1a4629226646292287157.00-21.50
CAediting_1494250chr22_46292287_+ENSG00000075234.15ENST00000451998hsa-miR-62346292281462922877mer-m84629226446292288148.00-27.72
CAediting_1494250chr22_46292287_+ENSG00000075234.15ENST00000451998hsa-miR-6866-3p46292282462922887mer-m84629226846292289145.00-19.09
CAediting_1494247chr22_46292264_+ENSG00000075234.15ENST00000451998hsa-miR-627-5p46292262462922698mer-1a4629224846292269147.00-13.21
CAediting_1494249chr22_46292284_+ENSG00000075234.15ENST00000451998hsa-miR-1199-5p46292277462922837mer-m84629226546292284156.00-28.57
CAediting_1494249chr22_46292284_+ENSG00000075234.15ENST00000451998hsa-miR-125a-5p46292279462922868mer-1a4629226346292286147.00-22.49
CAediting_1494249chr22_46292284_+ENSG00000075234.15ENST00000451998hsa-miR-125b-5p46292279462922868mer-1a4629226546292286150.00-23.05
CAediting_1494249chr22_46292284_+ENSG00000075234.15ENST00000451998hsa-miR-125b-5p46292279462922868mer-1a4629226546292286150.00-23.05
CAediting_1494249chr22_46292284_+ENSG00000075234.15ENST00000451998hsa-miR-393846292282462922887mer-m84629226846292289140.00-17.43
CAediting_1494249chr22_46292284_+ENSG00000075234.15ENST00000451998hsa-miR-431946292279462922868mer-1a4629227046292286149.00-22.07
CAediting_1494249chr22_46292284_+ENSG00000075234.15ENST00000451998hsa-miR-670-5p46292280462922878mer-1a4629226846292287153.00-20.27
CAediting_1494249chr22_46292284_+ENSG00000075234.15ENST00000451998hsa-miR-6751-3p46292277462922837mer-m84629226446292284141.00-13.15
CAediting_1494248chr22_46292283_+ENSG00000075234.15ENST00000451998hsa-miR-1238-3p46292281462922877mer-m84629226946292288140.00-16.22

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1494250chr22_46292287_+ENSG00000075234.15ENST00000451998hsa-miR-145-3p46292283462922897mer-m84629226946292290147-11.29

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1054808chr15_66496985_-ENSG00000075234.15ENST00000381031hsa-miR-451246293421462934277mer-m84629340546293428154-24.06
CAediting_86358chr1_109598906_+ENSG00000075234.15ENST00000381031hsa-miR-197-5p46292899462929057mer-m84629288446292906157-28.14
CAediting_524911chr7_5495852_-ENSG00000075234.15ENST00000381031hsa-miR-589-3p46293667462936737mer-m84629365146293674147-16.87
CAediting_86358chr1_109598906_+ENSG00000075234.15ENST00000451998hsa-miR-197-5p46292899462929057mer-m84629288146292906157-28.14

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TTC38

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for TTC38

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
BLCACAediting_1494242chr22_46292235_+0.01839060494166890.252312657923501....
BRCACAediting_1494242chr22_46292235_+0.001123052804771250.183019283519538....
LIHCCAediting_1494242chr22_46292235_+9.81996274927662e-090.311315790978841....
LUADCAediting_1494242chr22_46292235_+0.001561092106081040.223916611063537....
LUSCCAediting_1494242chr22_46292235_+0.005748684091868090.225236061985442....
PRADCAediting_1494242chr22_46292235_+0.00342321248235740.167649250887891....
STADCAediting_1494242chr22_46292235_+0.0148987383921790.155088641007845..0.02623766425535940.14171844015956
KIRCCAediting_1494242chr22_46292235_+0.0004186919324693130.180802613174913....
KIRPCAediting_1494242chr22_46292235_+0.04849513622880520.178292115763067....
SKCMCAediting_1494242chr22_46292235_+6.35563367339167e-100.376117432280747....
SARCCAediting_1494242chr22_46292235_+0.003023945528502910.317948413344891....

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Relation with cancer stages for TTC38

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for TTC38

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR
ESCACAediting_1494242chr22_46292235_+0.03258145818348980.03552425.3397

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RelatedDrugs for TTC38

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TTC38

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource