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Editing gene: P4HTM (CAeditome ID:54681)

Gene summary for P4HTM

Gene summary

Gene information	Gene symbol	P4HTM
	Gene ID	54681
	Gene name	prolyl 4-hydroxylase, transmembrane
	Synonyms	EGLN4\|HIDEA\|HIFPH4\|P4H-TM\|PH-4\|PH4\|PHD4
	Cytomap	3p21.31\|3p21.3
	Type of gene	protein-coding
	Description	transmembrane prolyl 4-hydroxylaseHIF-PH4HIF-prolyl hydroxylase 4HPH-4P4H with transmembrane domainProlyl hydroxlase domain-containing 4hypoxia-inducible factor prolyl 4-hydroxylasehypoxia-inducible factor prolyl hydroxylase 4proline 4-hydroxylase
	Modification date	20210518
	UniProtAcc	Q9NXG6
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
P4HTM	GO:0016706	Transmembrane prolyl 4-hydroxylase	22955912

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RNA A-to-I events for P4HTM

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000178467.16

RNA A-to-I editing events in Cancer.

CAediting_277496(48990849, +), CAediting_277497(48992356, +), CAediting_277498(48992521, +), CAediting_277499(48992526, +), CAediting_277500(48992527, +), CAediting_277501(48992531, +), CAediting_277502(48992538, +), CAediting_277503(48992919, +), CAediting_277504(48993040, +), CAediting_277505(48993142, +), CAediting_277506(48993145, +), CAediting_277507(48993147, +), CAediting_277508(48993155, +), CAediting_277509(48993208, +), CAediting_277510(48993251, +), CAediting_277511(48993252, +), CAediting_277512(48993662, +), CAediting_277513(48993663, +), CAediting_277514(48993741, +), CAediting_277515(48993742, +), CAediting_277516(48993747, +), CAediting_277517(48993751, +), CAediting_277518(48993768, +), CAediting_277519(48993774, +), CAediting_277520(48993794, +), CAediting_277521(48993807, +), CAediting_277522(48993811, +), CAediting_277523(48993812, +), CAediting_277524(48995725, +), CAediting_277525(48995860, +), CAediting_277526(48996292, +), CAediting_277527(48996294, +), CAediting_277528(48996348, +), CAediting_277529(48996354, +), CAediting_277530(48996377, +), CAediting_277531(48996391, +), CAediting_277532(48996399, +), CAediting_277533(48996403, +), CAediting_277534(48996413, +), CAediting_277535(48996497, +), CAediting_277536(49000295, +), CAediting_277537(49000296, +), CAediting_277538(49000368, +), CAediting_277539(49001512, +), CAediting_277540(49006773, +), CAediting_277541(49007043, +), CAediting_277542(49007061, +), CAediting_277543(49007093, +), CAediting_277544(49007100, +), CAediting_277545(49007101, +), CAediting_277546(49007108, +),

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RNA editing positional annotations for P4HTM using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_277539	chr3_49001512_+	nonsynonymous SNV	ENST00000343546.7	c.A511G	p.S171G	T	D	N
CAediting_277539	chr3_49001512_+	nonsynonymous SNV	ENST00000383729.7	c.A511G	p.S171G	T	D	N
CAediting_277540	chr3_49006773_+	nonsynonymous SNV	ENST00000343546.7	c.A1558G	p.N520D	D	D	D
CAediting_277540	chr3_49006773_+	nonsynonymous SNV	ENST00000383729.7	c.A1375G	p.N459D	D	D	D

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_277496	chr3_48990849_+	exonic
CAediting_277497	chr3_48992356_+	ncRNA_intronic
CAediting_277498	chr3_48992521_+	ncRNA_intronic
CAediting_277499	chr3_48992526_+	ncRNA_intronic
CAediting_277500	chr3_48992527_+	ncRNA_intronic
CAediting_277501	chr3_48992531_+	ncRNA_intronic
CAediting_277502	chr3_48992538_+	ncRNA_intronic
CAediting_277503	chr3_48992919_+	ncRNA_intronic
CAediting_277504	chr3_48993040_+	ncRNA_intronic
CAediting_277505	chr3_48993142_+	ncRNA_intronic
CAediting_277506	chr3_48993145_+	ncRNA_intronic
CAediting_277507	chr3_48993147_+	ncRNA_intronic
CAediting_277508	chr3_48993155_+	ncRNA_intronic
CAediting_277509	chr3_48993208_+	ncRNA_intronic
CAediting_277510	chr3_48993251_+	ncRNA_intronic
CAediting_277511	chr3_48993252_+	ncRNA_intronic
CAediting_277512	chr3_48993662_+	ncRNA_intronic
CAediting_277513	chr3_48993663_+	ncRNA_intronic
CAediting_277514	chr3_48993741_+	ncRNA_intronic
CAediting_277515	chr3_48993742_+	ncRNA_intronic
CAediting_277516	chr3_48993747_+	ncRNA_intronic
CAediting_277517	chr3_48993751_+	ncRNA_intronic
CAediting_277518	chr3_48993768_+	ncRNA_intronic
CAediting_277519	chr3_48993774_+	ncRNA_intronic
CAediting_277520	chr3_48993794_+	ncRNA_intronic
CAediting_277521	chr3_48993807_+	ncRNA_intronic
CAediting_277522	chr3_48993811_+	ncRNA_intronic
CAediting_277523	chr3_48993812_+	ncRNA_intronic
CAediting_277524	chr3_48995725_+	ncRNA_intronic
CAediting_277525	chr3_48995860_+	ncRNA_intronic
CAediting_277526	chr3_48996292_+	ncRNA_exonic
CAediting_277527	chr3_48996294_+	ncRNA_exonic
CAediting_277528	chr3_48996348_+	ncRNA_exonic
CAediting_277529	chr3_48996354_+	ncRNA_exonic
CAediting_277530	chr3_48996377_+	ncRNA_exonic
CAediting_277531	chr3_48996391_+	ncRNA_exonic
CAediting_277532	chr3_48996399_+	ncRNA_exonic
CAediting_277533	chr3_48996403_+	ncRNA_exonic
CAediting_277534	chr3_48996413_+	ncRNA_exonic
CAediting_277535	chr3_48996497_+	ncRNA_intronic
CAediting_277536	chr3_49000295_+	ncRNA_intronic
CAediting_277537	chr3_49000296_+	ncRNA_intronic
CAediting_277538	chr3_49000368_+	ncRNA_intronic
CAediting_277539	chr3_49001512_+	exonic
CAediting_277540	chr3_49006773_+	exonic
CAediting_277541	chr3_49007043_+	ncRNA_exonic
CAediting_277542	chr3_49007061_+	ncRNA_exonic
CAediting_277543	chr3_49007093_+	ncRNA_exonic
CAediting_277544	chr3_49007100_+	ncRNA_exonic
CAediting_277545	chr3_49007101_+	ncRNA_exonic
CAediting_277546	chr3_49007108_+	ncRNA_exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_277497	chr3_48992356_+	SINE	Alu	AluSz
CAediting_277498	chr3_48992521_+	SINE	Alu	AluSz
CAediting_277499	chr3_48992526_+	SINE	Alu	AluSz
CAediting_277500	chr3_48992527_+	SINE	Alu	AluSz
CAediting_277501	chr3_48992531_+	SINE	Alu	AluSz
CAediting_277502	chr3_48992538_+	SINE	Alu	AluSz
CAediting_277503	chr3_48992919_+	SINE	Alu	AluSq2
CAediting_277504	chr3_48993040_+	SINE	Alu	AluSp
CAediting_277505	chr3_48993142_+	SINE	Alu	AluSp
CAediting_277506	chr3_48993145_+	SINE	Alu	AluSp
CAediting_277507	chr3_48993147_+	SINE	Alu	AluSp
CAediting_277508	chr3_48993155_+	SINE	Alu	AluSp
CAediting_277509	chr3_48993208_+	SINE	Alu	AluSp
CAediting_277510	chr3_48993251_+	SINE	Alu	AluSp
CAediting_277511	chr3_48993252_+	SINE	Alu	AluSp
CAediting_277512	chr3_48993662_+	SINE	Alu	AluSx1
CAediting_277513	chr3_48993663_+	SINE	Alu	AluSx1
CAediting_277514	chr3_48993741_+	SINE	Alu	AluSx1
CAediting_277515	chr3_48993742_+	SINE	Alu	AluSx1
CAediting_277516	chr3_48993747_+	SINE	Alu	AluSx1
CAediting_277517	chr3_48993751_+	SINE	Alu	AluSx1
CAediting_277518	chr3_48993768_+	SINE	Alu	AluSx1
CAediting_277519	chr3_48993774_+	SINE	Alu	AluSx1
CAediting_277520	chr3_48993794_+	SINE	Alu	AluSx1
CAediting_277521	chr3_48993807_+	SINE	Alu	AluSx1
CAediting_277522	chr3_48993811_+	SINE	Alu	AluSx1
CAediting_277523	chr3_48993812_+	SINE	Alu	AluSx1
CAediting_277524	chr3_48995725_+	SINE	Alu	AluSx1
CAediting_277525	chr3_48995860_+	SINE	Alu	AluSx1
CAediting_277526	chr3_48996292_+	SINE	Alu	AluSc
CAediting_277527	chr3_48996294_+	SINE	Alu	AluSc
CAediting_277528	chr3_48996348_+	SINE	Alu	AluSc
CAediting_277529	chr3_48996354_+	SINE	Alu	AluSc
CAediting_277530	chr3_48996377_+	SINE	Alu	AluSc
CAediting_277531	chr3_48996391_+	SINE	Alu	AluSc
CAediting_277532	chr3_48996399_+	SINE	Alu	AluSc
CAediting_277533	chr3_48996403_+	SINE	Alu	AluSc
CAediting_277534	chr3_48996413_+	SINE	Alu	AluSc
CAediting_277535	chr3_48996497_+	SINE	Alu	AluSc
CAediting_277536	chr3_49000295_+	SINE	Alu	AluJo
CAediting_277537	chr3_49000296_+	SINE	Alu	AluJo
CAediting_277538	chr3_49000368_+	SINE	Alu	AluJo

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RNA A-to-I editing events in the alternative splicing sites for P4HTM

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
ES	CAediting_277526	chr3_48996292_+	48996273:48996295	3SS	0+1i	TGTTTTGTTTTGTTTTTTGAGAC	-3.91	TGTTTTGTTTTGTTTTTTGGGAC	4.84
MEX_2	CAediting_277526	chr3_48996292_+	48996273:48996295	3SS	0+1i	TGTTTTGTTTTGTTTTTTGAGAC	-3.91	TGTTTTGTTTTGTTTTTTGGGAC	4.84
MEX_1	CAediting_277526	chr3_48996292_+	48996273:48996295	3SS	0+1i	TGTTTTGTTTTGTTTTTTGAGAC	-3.91	TGTTTTGTTTTGTTTTTTGGGAC	4.84
ES	CAediting_277527	chr3_48996294_+	48996273:48996295	3SS	2+0i	TGTTTTGTTTTGTTTTTTGAGAC	-3.91	TGTTTTGTTTTGTTTTTTGAGGC	-4.15
MEX_2	CAediting_277527	chr3_48996294_+	48996273:48996295	3SS	2+0i	TGTTTTGTTTTGTTTTTTGAGAC	-3.91	TGTTTTGTTTTGTTTTTTGAGGC	-4.15
MEX_1	CAediting_277527	chr3_48996294_+	48996273:48996295	3SS	2+0i	TGTTTTGTTTTGTTTTTTGAGAC	-3.91	TGTTTTGTTTTGTTTTTTGAGGC	-4.15

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000178467.16.P4HTM.

Correlation between RNA A-to-I editing and PSI for ENSG00000178467.16.P4HTM.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for P4HTM

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for P4HTM

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for P4HTM

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_277546	chr3_49007108_+	ENSG00000178467.16	ENST00000343546	hsa-miR-10a-5p	49007104	49007110	7mer-m8	49007089	49007111	157.00	-14.70
CAediting_277546	chr3_49007108_+	ENSG00000178467.16	ENST00000343546	hsa-miR-10b-5p	49007104	49007110	7mer-m8	49007089	49007111	149.00	-14.70
CAediting_277546	chr3_49007108_+	ENSG00000178467.16	ENST00000343546	hsa-miR-146b-3p	49007103	49007109	7mer-m8	49007089	49007110	145.00	-18.75
CAediting_277546	chr3_49007108_+	ENSG00000178467.16	ENST00000343546	hsa-miR-6732-3p	49007105	49007111	7mer-m8	49007090	49007112	146.00	-11.76
CAediting_277546	chr3_49007108_+	ENSG00000178467.16	ENST00000491739	hsa-miR-10a-5p	49007104	49007110	7mer-m8	49007089	49007111	157.00	-14.70
CAediting_277546	chr3_49007108_+	ENSG00000178467.16	ENST00000491739	hsa-miR-10b-5p	49007104	49007110	7mer-m8	49007089	49007111	149.00	-14.70
CAediting_277546	chr3_49007108_+	ENSG00000178467.16	ENST00000491739	hsa-miR-146b-3p	49007103	49007109	7mer-m8	49007089	49007110	145.00	-18.75
CAediting_277546	chr3_49007108_+	ENSG00000178467.16	ENST00000491739	hsa-miR-6732-3p	49007105	49007111	7mer-m8	49007090	49007112	146.00	-11.76
CAediting_277542	chr3_49007061_+	ENSG00000178467.16	ENST00000343546	hsa-miR-196a-1-3p	49007056	49007062	7mer-m8	49007043	49007063	152.00	-7.05
CAediting_277542	chr3_49007061_+	ENSG00000178467.16	ENST00000491739	hsa-miR-196a-1-3p	49007056	49007062	7mer-m8	49007043	49007063	152.00	-7.05

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1054808	chr15_66496985_-	ENSG00000178467.16	ENST00000475629	hsa-miR-4512	48999660	48999667	8mer-1a	48999646	48999667	158	-24.07

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for P4HTM

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000343546.7	protein_coding
ENST00000383729.7	protein_coding
ENST00000444213.4	protein_coding
ENST00000468374.4	processed_transcript
ENST00000472301.4	retained_intron
ENST00000475629.4	protein_coding
ENST00000484115.4	retained_intron
ENST00000609406.1	processed_transcript
ENST00000486817.1	processed_transcript
ENST00000485210.1	retained_intron
ENST00000491739.4	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_277496	ENST00000343546.7	chr3_48990849_+	-1008.40	-1008.00	-1021.10
CAediting_277539	ENST00000343546.7	chr3_49001512_+	-1009.10	-1008.00	-1021.10
CAediting_277540	ENST00000343546.7	chr3_49006773_+	-1011.80	-1008.00	-1021.10
CAediting_277541	ENST00000343546.7	chr3_49007043_+	-1012.20	-1008.00	-1021.10
CAediting_277542	ENST00000343546.7	chr3_49007061_+	-1010.80	-1008.00	-1021.10
CAediting_277543	ENST00000343546.7	chr3_49007093_+	-1008.50	-1008.00	-1021.10
CAediting_277544	ENST00000343546.7	chr3_49007100_+	-1011.60	-1008.00	-1021.10
CAediting_277545	ENST00000343546.7	chr3_49007101_+	-1008.40	-1008.00	-1021.10
CAediting_277546	ENST00000343546.7	chr3_49007108_+	-1008.20	-1008.00	-1021.10
CAediting_277496	ENST00000383729.7	chr3_48990849_+	-943.10	-942.20	-954.20
CAediting_277539	ENST00000383729.7	chr3_49001512_+	-943.60	-942.20	-954.20
CAediting_277540	ENST00000383729.7	chr3_49006773_+	-946.40	-942.20	-954.20
CAediting_277541	ENST00000383729.7	chr3_49007043_+	-943.80	-942.20	-954.20
CAediting_277542	ENST00000383729.7	chr3_49007061_+	-942.20	-942.20	-954.20
CAediting_277543	ENST00000383729.7	chr3_49007093_+	-941.90	-942.20	-954.20
CAediting_277544	ENST00000383729.7	chr3_49007100_+	-944.70	-942.20	-954.20
CAediting_277545	ENST00000383729.7	chr3_49007101_+	-943.60	-942.20	-954.20
CAediting_277546	ENST00000383729.7	chr3_49007108_+	-941.90	-942.20	-954.20
CAediting_277496	ENST00000444213.4	chr3_48990849_+	-268.30	-264.70	-271.80
CAediting_277539	ENST00000444213.4	chr3_49001512_+	-268.20	-264.70	-271.80
CAediting_277496	ENST00000468374.4	chr3_48990849_+	-294.40	-294.30	-296.30
CAediting_277539	ENST00000468374.4	chr3_49001512_+	-295.40	-294.30	-296.30
CAediting_277496	ENST00000472301.4	chr3_48990849_+	-1208.40	-1207.50	-1220.00
CAediting_277539	ENST00000472301.4	chr3_49001512_+	-1208.90	-1207.50	-1220.00
CAediting_277540	ENST00000472301.4	chr3_49006773_+	-1209.30	-1207.50	-1220.00
CAediting_277541	ENST00000472301.4	chr3_49007043_+	-1210.50	-1207.50	-1220.00
CAediting_277542	ENST00000472301.4	chr3_49007061_+	-1208.80	-1207.50	-1220.00
CAediting_277543	ENST00000472301.4	chr3_49007093_+	-1207.80	-1207.50	-1220.00
CAediting_277544	ENST00000472301.4	chr3_49007100_+	-1211.10	-1207.50	-1220.00
CAediting_277545	ENST00000472301.4	chr3_49007101_+	-1207.90	-1207.50	-1220.00
CAediting_277546	ENST00000472301.4	chr3_49007108_+	-1208.40	-1207.50	-1220.00
CAediting_277496	ENST00000475629.4	chr3_48990849_+	-283.90	-280.30	-283.90
CAediting_277496	ENST00000484115.4	chr3_48990849_+	-2274.80	-2274.60	-2282.50
CAediting_277539	ENST00000484115.4	chr3_49001512_+	-2274.20	-2274.60	-2282.50
CAediting_277540	ENST00000484115.4	chr3_49006773_+	-2275.80	-2274.60	-2282.50
CAediting_277541	ENST00000484115.4	chr3_49007043_+	-2275.00	-2274.60	-2282.50
CAediting_277542	ENST00000484115.4	chr3_49007061_+	-2275.60	-2274.60	-2282.50
CAediting_277543	ENST00000484115.4	chr3_49007093_+	-2274.50	-2274.60	-2282.50
CAediting_277544	ENST00000484115.4	chr3_49007100_+	-2276.30	-2274.60	-2282.50
CAediting_277545	ENST00000484115.4	chr3_49007101_+	-2276.00	-2274.60	-2282.50
CAediting_277546	ENST00000484115.4	chr3_49007108_+	-2278.20	-2274.60	-2282.50
CAediting_277496	ENST00000609406.1	chr3_48990849_+	-806.80	-804.80	-806.80
CAediting_277526	ENST00000486817.1	chr3_48996292_+	-192.90	-193.40	-212.60
CAediting_277527	ENST00000486817.1	chr3_48996294_+	-199.70	-193.40	-212.60
CAediting_277528	ENST00000486817.1	chr3_48996348_+	-195.40	-193.40	-212.60
CAediting_277529	ENST00000486817.1	chr3_48996354_+	-193.40	-193.40	-212.60
CAediting_277530	ENST00000486817.1	chr3_48996377_+	-197.10	-193.40	-212.60
CAediting_277531	ENST00000486817.1	chr3_48996391_+	-195.90	-193.40	-212.60
CAediting_277532	ENST00000486817.1	chr3_48996399_+	-196.00	-193.40	-212.60
CAediting_277533	ENST00000486817.1	chr3_48996403_+	-196.00	-193.40	-212.60
CAediting_277534	ENST00000486817.1	chr3_48996413_+	-198.00	-193.40	-212.60
CAediting_277539	ENST00000486817.1	chr3_49001512_+	-196.40	-193.40	-212.60
CAediting_277539	ENST00000485210.1	chr3_49001512_+	-404.50	-405.20	-404.50
CAediting_277539	ENST00000491739.4	chr3_49001512_+	-271.50	-267.90	-278.00
CAediting_277540	ENST00000491739.4	chr3_49006773_+	-269.10	-267.90	-278.00
CAediting_277541	ENST00000491739.4	chr3_49007043_+	-270.80	-267.90	-278.00
CAediting_277542	ENST00000491739.4	chr3_49007061_+	-268.00	-267.90	-278.00
CAediting_277543	ENST00000491739.4	chr3_49007093_+	-268.40	-267.90	-278.00
CAediting_277544	ENST00000491739.4	chr3_49007100_+	-271.50	-267.90	-278.00
CAediting_277545	ENST00000491739.4	chr3_49007101_+	-268.30	-267.90	-278.00
CAediting_277546	ENST00000491739.4	chr3_49007108_+	-267.80	-267.90	-278.00

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Relation with ADAR for P4HTM

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for P4HTM

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for P4HTM

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for P4HTM

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P4HTM	Q9NXG6	DB00126	Ascorbic acid	Transmembrane prolyl 4-hydroxylase	SmallMoleculeDrug	approved\|nutraceutical

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RelatedDiseases for P4HTM

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
P4HTM	C0036572	Seizures	2	GENOMICS_ENGLAND
P4HTM	C0557874	Global developmental delay	2	GENOMICS_ENGLAND
P4HTM	C3714756	Intellectual Disability	2	GENOMICS_ENGLAND
P4HTM	C0013363	Dysautonomia	1	GENOMICS_ENGLAND
P4HTM	C0026827	Muscle hypotonia	1	GENOMICS_ENGLAND
P4HTM	C0037315	Sleep Apnea Syndromes	1	GENOMICS_ENGLAND
P4HTM	C1842364	Central hypotonia	1	GENOMICS_ENGLAND
P4HTM	C3203358	Hypoventilation	1	GENOMICS_ENGLAND
P4HTM	C4316870	Abnormality of the eye	1	GENOMICS_ENGLAND

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene