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Editing gene: TOMM7 (CAeditome ID:54543)

Gene summary for TOMM7

Gene summary

Gene information	Gene symbol	TOMM7
	Gene ID	54543
	Gene name	translocase of outer mitochondrial membrane 7
	Synonyms	TOM7
	Cytomap	7p15.3
	Type of gene	protein-coding
	Description	mitochondrial import receptor subunit TOM7 homologtranslocase of outer membrane 7 kDa subunit homologtranslocase of outer mitochondrial membrane 7 homolog
	Modification date	20210518
	UniProtAcc	Q9P0U1
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
TOMM7	GO:0005739	Mitochondrial import receptor subunit TOM7 homolog	12198123
TOMM7	GO:0005742	Mitochondrial import receptor subunit TOM7 homolog	12198123

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RNA A-to-I events for TOMM7

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000196683.9

RNA A-to-I editing events in Cancer.

CAediting_530923(22814088, -), CAediting_530924(22814092, -), CAediting_530925(22814100, -), CAediting_530926(22815516, -), CAediting_530927(22817462, -), CAediting_530928(22817505, -), CAediting_530929(22817518, -), CAediting_530930(22817526, -), CAediting_530931(22818304, -), CAediting_530932(22818341, -), CAediting_530933(22818389, -), CAediting_530934(22818402, -), CAediting_530935(22818416, -), CAediting_530936(22820079, -), CAediting_530937(22820117, -), CAediting_530938(22820146, -), CAediting_530939(22820166, -), CAediting_530940(22821999, -),

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RNA editing positional annotations for TOMM7 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_530927	chr7_22817462_-	nonsynonymous SNV	ENST00000372879.7	c.A239G	p.Q80R	D	.	N
CAediting_530928	chr7_22817505_-	nonsynonymous SNV	ENST00000372879.7	c.A196G	p.K66E	D	.	N
CAediting_530930	chr7_22817526_-	nonsynonymous SNV	ENST00000372879.7	c.A175G	p.I59V	D	.	N

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_530923	chr7_22814088_-	ncRNA_intronic
CAediting_530924	chr7_22814092_-	ncRNA_intronic
CAediting_530925	chr7_22814100_-	ncRNA_intronic
CAediting_530926	chr7_22815516_-	ncRNA_intronic
CAediting_530927	chr7_22817462_-	exonic
CAediting_530928	chr7_22817505_-	exonic
CAediting_530929	chr7_22817518_-	exonic
CAediting_530930	chr7_22817526_-	exonic
CAediting_530931	chr7_22818304_-	ncRNA_exonic
CAediting_530932	chr7_22818341_-	ncRNA_intronic
CAediting_530933	chr7_22818389_-	ncRNA_intronic
CAediting_530934	chr7_22818402_-	ncRNA_intronic
CAediting_530935	chr7_22818416_-	ncRNA_intronic
CAediting_530936	chr7_22820079_-	ncRNA_intronic
CAediting_530937	chr7_22820117_-	ncRNA_intronic
CAediting_530938	chr7_22820146_-	ncRNA_intronic
CAediting_530939	chr7_22820166_-	ncRNA_intronic
CAediting_530940	chr7_22821999_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_530923	chr7_22814088_-	SINE	Alu	AluSx
CAediting_530924	chr7_22814092_-	SINE	Alu	AluSx
CAediting_530925	chr7_22814100_-	SINE	Alu	AluSx
CAediting_530926	chr7_22815516_-	SINE	Alu	AluJo
CAediting_530927	chr7_22817462_-	SINE	Alu	FLAM_C
CAediting_530928	chr7_22817505_-	SINE	Alu	FLAM_C
CAediting_530929	chr7_22817518_-	SINE	Alu	FLAM_C
CAediting_530930	chr7_22817526_-	SINE	Alu	FLAM_C
CAediting_530931	chr7_22818304_-	SINE	Alu	AluSz
CAediting_530932	chr7_22818341_-	SINE	Alu	AluSz
CAediting_530933	chr7_22818389_-	SINE	Alu	AluSz
CAediting_530934	chr7_22818402_-	SINE	Alu	AluSz
CAediting_530935	chr7_22818416_-	SINE	Alu	AluSz
CAediting_530936	chr7_22820079_-	SINE	Alu	AluJr
CAediting_530937	chr7_22820117_-	SINE	Alu	AluJr
CAediting_530938	chr7_22820146_-	SINE	Alu	AluJr
CAediting_530939	chr7_22820166_-	SINE	Alu	AluJr
CAediting_530940	chr7_22821999_-	SINE	Alu	AluSc8

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RNA A-to-I editing events in the alternative splicing sites for TOMM7

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000196683.9.TOMM7.

Correlation between RNA A-to-I editing and PSI for ENSG00000196683.9.TOMM7.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TOMM7

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for TOMM7

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for TOMM7

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_524911	chr7_5495852_-	ENSG00000196683.9	ENST00000405021	hsa-miR-589-3p	22813107	22813113	7mer-m8	22813106	22813127	153	-18.24

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TOMM7

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000372879.7	protein_coding
ENST00000483581.1	retained_intron

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_530927	ENST00000372879.7	chr7_22817462_-	-152.70	-153.00	-156.00
CAediting_530928	ENST00000372879.7	chr7_22817505_-	-152.70	-153.00	-156.00
CAediting_530929	ENST00000372879.7	chr7_22817518_-	-152.60	-153.00	-156.00
CAediting_530930	ENST00000372879.7	chr7_22817526_-	-155.20	-153.00	-156.00
CAediting_530931	ENST00000483581.1	chr7_22818304_-	-153.10	-153.80	-153.10

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Relation with ADAR for TOMM7

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for TOMM7

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for TOMM7

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for TOMM7

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for TOMM7

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene