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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: DDIT4 (CAeditome ID:54541) |
Gene summary for DDIT4 |
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Gene information | Gene symbol | DDIT4 | Gene ID | 54541 |
Gene name | DNA damage inducible transcript 4 | |
Synonyms | Dig2|REDD-1|REDD1 | |
Cytomap | 10q22.1 | |
Type of gene | protein-coding | |
Description | DNA damage-inducible transcript 4 proteinHIF-1 responsive protein RTP801protein regulated in development and DNA damage response 1 | |
Modification date | 20210524 | |
UniProtAcc | Q9NX09 | |
Context |
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Gene | GO ID | GO term | PubMed ID |
DDIT4 | GO:0001666 | DNA damage-inducible transcript 4 protein | 20166753 |
DDIT4 | GO:0051607 | DNA damage-inducible transcript 4 protein | 21478870 |
DDIT4 | GO:0005737 | DNA damage-inducible transcript 4 protein | 12453409 |
DDIT4 | GO:0005829 | DNA damage-inducible transcript 4 protein | 0000052 |
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RNA A-to-I events for DDIT4 |
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CAediting_758198(72274758, +), |
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RNA editing positional annotations for DDIT4 using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
CAediting_758198 | chr10_72274758_+ | nonsynonymous SNV | ENST00000307365.3 | c.A269G | p.E90G | D | D | D |
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CAeditome ID | Position | Variant type |
CAediting_758198 | chr10_72274758_+ | exonic |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
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RNA A-to-I editing events in the alternative splicing sites for DDIT4 |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for DDIT4 |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for DDIT4 |
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The effects of the RNA editing to the miRNA binding sites for DDIT4 |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_748296 | chr10_51299626_+ | ENSG00000168209.4 | ENST00000307365 | hsa-miR-605-3p | 72275212 | 72275218 | 7mer-m8 | 72275198 | 72275219 | 152 | -18.77 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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The effects of the RNA editing to the stability of the RNA structures for DDIT4 |
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ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for DDIT4 |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for DDIT4 |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for DDIT4 |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for DDIT4 |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DDIT4 |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
DDIT4 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
DDIT4 | C0023418 | leukemia | 1 | CTD_human |
DDIT4 | C0026636 | Mouth Diseases | 1 | CTD_human |
DDIT4 | C0027746 | Nerve Degeneration | 1 | CTD_human |
DDIT4 | C0030567 | Parkinson Disease | 1 | CTD_human |
DDIT4 | C0041696 | Unipolar Depression | 1 | PSYGENET |
DDIT4 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |