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Editing gene: MIOS (CAeditome ID:54468)

Gene summary for MIOS

Gene summary

Gene information	Gene symbol	MIOS
	Gene ID	54468
	Gene name	meiosis regulator for oocyte development
	Synonyms	MIO\|Sea4\|Yulink
	Cytomap	7p21.3
	Type of gene	protein-coding
	Description	GATOR complex protein MIOSH_DJ1159O04.1WD repeat-containing protein mioWUGSC:H_DJ1159O04.1missing oocyte, meiosis regulator, homolog
	Modification date	20210518
	UniProtAcc	Q9NXC5
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
MIOS	GO:0005654	GATOR complex protein MIOS	0000052
MIOS	GO:0005765	GATOR complex protein MIOS	28199306
MIOS	GO:0005829	GATOR complex protein MIOS	0000052
MIOS	GO:0030054	GATOR complex protein MIOS	0000052
MIOS	GO:0061700	GATOR complex protein MIOS	23723238

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RNA A-to-I events for MIOS

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000164654.14

RNA A-to-I editing events in Cancer.

CAediting_528162(7578939, +), CAediting_528163(7580728, +), CAediting_528164(7580787, +), CAediting_528165(7580921, +), CAediting_528166(7581170, +), CAediting_528167(7581171, +), CAediting_528168(7581175, +), CAediting_528169(7581290, +), CAediting_528170(7591466, +), CAediting_528171(7591515, +), CAediting_528172(7591548, +), CAediting_528173(7591999, +), CAediting_528174(7592045, +), CAediting_528175(7592134, +), CAediting_528176(7592146, +), CAediting_528177(7592173, +), CAediting_528178(7593620, +), CAediting_528179(7593630, +), CAediting_528180(7593638, +), CAediting_528181(7593639, +), CAediting_528182(7593644, +), CAediting_528183(7593669, +), CAediting_528184(7593738, +), CAediting_528185(7593747, +), CAediting_528186(7593773, +), CAediting_528187(7593777, +), CAediting_528188(7593799, +), CAediting_528189(7593807, +), CAediting_528190(7593811, +), CAediting_528191(7593813, +), CAediting_528192(7593820, +), CAediting_528193(7593824, +), CAediting_528194(7593829, +), CAediting_528195(7593831, +), CAediting_528196(7593839, +), CAediting_528197(7593906, +), CAediting_528198(7594326, +), CAediting_528199(7594327, +), CAediting_528200(7594368, +), CAediting_528201(7594370, +), CAediting_528202(7594376, +), CAediting_528203(7594381, +), CAediting_528204(7594421, +), CAediting_528205(7594424, +), CAediting_528206(7594425, +), CAediting_528207(7594428, +), CAediting_528208(7594478, +), CAediting_528209(7594504, +), CAediting_528210(7594529, +), CAediting_528211(7594530, +), CAediting_528212(7594555, +), CAediting_528213(7594556, +), CAediting_528214(7594557, +), CAediting_528215(7594569, +), CAediting_528216(7596961, +), CAediting_528217(7597071, +), CAediting_528218(7597072, +), CAediting_528219(7597077, +), CAediting_528220(7597102, +), CAediting_528221(7597107, +), CAediting_528222(7597117, +), CAediting_528223(7597118, +), CAediting_528224(7597123, +), CAediting_528225(7597124, +), CAediting_528226(7597730, +), CAediting_528227(7597738, +), CAediting_528228(7597747, +), CAediting_528229(7597754, +), CAediting_528230(7597760, +), CAediting_528231(7597812, +), CAediting_528232(7597825, +), CAediting_528233(7597830, +), CAediting_528234(7597900, +), CAediting_528235(7597908, +), CAediting_528236(7597917, +), CAediting_528237(7597926, +), CAediting_528238(7597939, +),

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RNA editing positional annotations for MIOS using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_528162	chr7_7578939_+	intronic
CAediting_528163	chr7_7580728_+	intronic
CAediting_528164	chr7_7580787_+	intronic
CAediting_528165	chr7_7580921_+	intronic
CAediting_528166	chr7_7581170_+	intronic
CAediting_528167	chr7_7581171_+	intronic
CAediting_528168	chr7_7581175_+	intronic
CAediting_528169	chr7_7581290_+	intronic
CAediting_528170	chr7_7591466_+	ncRNA_intronic
CAediting_528171	chr7_7591515_+	ncRNA_intronic
CAediting_528172	chr7_7591548_+	ncRNA_intronic
CAediting_528173	chr7_7591999_+	ncRNA_intronic
CAediting_528174	chr7_7592045_+	ncRNA_intronic
CAediting_528175	chr7_7592134_+	ncRNA_intronic
CAediting_528176	chr7_7592146_+	ncRNA_intronic
CAediting_528177	chr7_7592173_+	ncRNA_intronic
CAediting_528178	chr7_7593620_+	ncRNA_intronic
CAediting_528179	chr7_7593630_+	ncRNA_intronic
CAediting_528180	chr7_7593638_+	ncRNA_intronic
CAediting_528181	chr7_7593639_+	ncRNA_intronic
CAediting_528182	chr7_7593644_+	ncRNA_intronic
CAediting_528183	chr7_7593669_+	ncRNA_intronic
CAediting_528184	chr7_7593738_+	ncRNA_intronic
CAediting_528185	chr7_7593747_+	ncRNA_intronic
CAediting_528186	chr7_7593773_+	ncRNA_intronic
CAediting_528187	chr7_7593777_+	ncRNA_intronic
CAediting_528188	chr7_7593799_+	ncRNA_intronic
CAediting_528189	chr7_7593807_+	ncRNA_intronic
CAediting_528190	chr7_7593811_+	ncRNA_intronic
CAediting_528191	chr7_7593813_+	ncRNA_intronic
CAediting_528192	chr7_7593820_+	ncRNA_intronic
CAediting_528193	chr7_7593824_+	ncRNA_intronic
CAediting_528194	chr7_7593829_+	ncRNA_intronic
CAediting_528195	chr7_7593831_+	ncRNA_intronic
CAediting_528196	chr7_7593839_+	ncRNA_intronic
CAediting_528197	chr7_7593906_+	ncRNA_intronic
CAediting_528198	chr7_7594326_+	ncRNA_intronic
CAediting_528199	chr7_7594327_+	ncRNA_intronic
CAediting_528200	chr7_7594368_+	ncRNA_intronic
CAediting_528201	chr7_7594370_+	ncRNA_intronic
CAediting_528202	chr7_7594376_+	ncRNA_intronic
CAediting_528203	chr7_7594381_+	ncRNA_intronic
CAediting_528204	chr7_7594421_+	ncRNA_intronic
CAediting_528205	chr7_7594424_+	ncRNA_intronic
CAediting_528206	chr7_7594425_+	ncRNA_intronic
CAediting_528207	chr7_7594428_+	ncRNA_intronic
CAediting_528208	chr7_7594478_+	ncRNA_intronic
CAediting_528209	chr7_7594504_+	ncRNA_intronic
CAediting_528210	chr7_7594529_+	ncRNA_intronic
CAediting_528211	chr7_7594530_+	ncRNA_intronic
CAediting_528212	chr7_7594555_+	ncRNA_intronic
CAediting_528213	chr7_7594556_+	ncRNA_intronic
CAediting_528214	chr7_7594557_+	ncRNA_intronic
CAediting_528215	chr7_7594569_+	ncRNA_intronic
CAediting_528216	chr7_7596961_+	ncRNA_intronic
CAediting_528217	chr7_7597071_+	ncRNA_intronic
CAediting_528218	chr7_7597072_+	ncRNA_intronic
CAediting_528219	chr7_7597077_+	ncRNA_intronic
CAediting_528220	chr7_7597102_+	ncRNA_intronic
CAediting_528221	chr7_7597107_+	ncRNA_intronic
CAediting_528222	chr7_7597117_+	ncRNA_intronic
CAediting_528223	chr7_7597118_+	ncRNA_intronic
CAediting_528224	chr7_7597123_+	ncRNA_intronic
CAediting_528225	chr7_7597124_+	ncRNA_intronic
CAediting_528226	chr7_7597730_+	ncRNA_intronic
CAediting_528227	chr7_7597738_+	ncRNA_intronic
CAediting_528228	chr7_7597747_+	ncRNA_intronic
CAediting_528229	chr7_7597754_+	ncRNA_intronic
CAediting_528230	chr7_7597760_+	ncRNA_intronic
CAediting_528231	chr7_7597812_+	ncRNA_intronic
CAediting_528232	chr7_7597825_+	ncRNA_intronic
CAediting_528233	chr7_7597830_+	ncRNA_intronic
CAediting_528234	chr7_7597900_+	ncRNA_intronic
CAediting_528235	chr7_7597908_+	ncRNA_intronic
CAediting_528236	chr7_7597917_+	ncRNA_intronic
CAediting_528237	chr7_7597926_+	ncRNA_intronic
CAediting_528238	chr7_7597939_+	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_528162	chr7_7578939_+	SINE	Alu	AluSz6
CAediting_528163	chr7_7580728_+	SINE	Alu	AluSx
CAediting_528164	chr7_7580787_+	SINE	Alu	AluSx
CAediting_528165	chr7_7580921_+	SINE	Alu	AluSx
CAediting_528166	chr7_7581170_+	SINE	Alu	AluSx
CAediting_528167	chr7_7581171_+	SINE	Alu	AluSx
CAediting_528168	chr7_7581175_+	SINE	Alu	AluSx
CAediting_528169	chr7_7581290_+	SINE	Alu	AluSx
CAediting_528170	chr7_7591466_+	SINE	Alu	AluJb
CAediting_528171	chr7_7591515_+	SINE	Alu	AluJb
CAediting_528172	chr7_7591548_+	SINE	Alu	AluJb
CAediting_528173	chr7_7591999_+	SINE	Alu	AluSz
CAediting_528174	chr7_7592045_+	SINE	Alu	AluSz
CAediting_528175	chr7_7592134_+	SINE	Alu	AluSz
CAediting_528176	chr7_7592146_+	SINE	Alu	AluSz
CAediting_528177	chr7_7592173_+	SINE	Alu	AluSz
CAediting_528178	chr7_7593620_+	SINE	Alu	AluSx
CAediting_528179	chr7_7593630_+	SINE	Alu	AluSx
CAediting_528180	chr7_7593638_+	SINE	Alu	AluSx
CAediting_528181	chr7_7593639_+	SINE	Alu	AluSx
CAediting_528182	chr7_7593644_+	SINE	Alu	AluSx
CAediting_528183	chr7_7593669_+	SINE	Alu	AluSx
CAediting_528184	chr7_7593738_+	SINE	Alu	AluSx
CAediting_528185	chr7_7593747_+	SINE	Alu	AluSx
CAediting_528186	chr7_7593773_+	SINE	Alu	AluSx
CAediting_528187	chr7_7593777_+	SINE	Alu	AluSx
CAediting_528188	chr7_7593799_+	SINE	Alu	AluSx
CAediting_528189	chr7_7593807_+	SINE	Alu	AluSx
CAediting_528190	chr7_7593811_+	SINE	Alu	AluSx
CAediting_528191	chr7_7593813_+	SINE	Alu	AluSx
CAediting_528192	chr7_7593820_+	SINE	Alu	AluSx
CAediting_528193	chr7_7593824_+	SINE	Alu	AluSx
CAediting_528194	chr7_7593829_+	SINE	Alu	AluSx
CAediting_528195	chr7_7593831_+	SINE	Alu	AluSx
CAediting_528196	chr7_7593839_+	SINE	Alu	AluSx
CAediting_528197	chr7_7593906_+	SINE	Alu	AluSx
CAediting_528198	chr7_7594326_+	SINE	Alu	AluSx1
CAediting_528199	chr7_7594327_+	SINE	Alu	AluSx1
CAediting_528200	chr7_7594368_+	SINE	Alu	AluSx1
CAediting_528201	chr7_7594370_+	SINE	Alu	AluSx1
CAediting_528202	chr7_7594376_+	SINE	Alu	AluSx1
CAediting_528203	chr7_7594381_+	SINE	Alu	AluSx1
CAediting_528204	chr7_7594421_+	SINE	Alu	AluSx1
CAediting_528205	chr7_7594424_+	SINE	Alu	AluSx1
CAediting_528206	chr7_7594425_+	SINE	Alu	AluSx1
CAediting_528207	chr7_7594428_+	SINE	Alu	AluSx1
CAediting_528208	chr7_7594478_+	SINE	Alu	AluSx1
CAediting_528209	chr7_7594504_+	SINE	Alu	AluSx1
CAediting_528210	chr7_7594529_+	SINE	Alu	AluSx1
CAediting_528211	chr7_7594530_+	SINE	Alu	AluSx1
CAediting_528212	chr7_7594555_+	SINE	Alu	AluSx1
CAediting_528213	chr7_7594556_+	SINE	Alu	AluSx1
CAediting_528214	chr7_7594557_+	SINE	Alu	AluSx1
CAediting_528215	chr7_7594569_+	SINE	Alu	AluSx1
CAediting_528216	chr7_7596961_+	SINE	Alu	AluJo
CAediting_528217	chr7_7597071_+	SINE	Alu	AluSc8
CAediting_528218	chr7_7597072_+	SINE	Alu	AluSc8
CAediting_528219	chr7_7597077_+	SINE	Alu	AluSc8
CAediting_528220	chr7_7597102_+	SINE	Alu	AluSc8
CAediting_528221	chr7_7597107_+	SINE	Alu	AluSc8
CAediting_528222	chr7_7597117_+	SINE	Alu	AluSc8
CAediting_528223	chr7_7597118_+	SINE	Alu	AluSc8
CAediting_528224	chr7_7597123_+	SINE	Alu	AluSc8
CAediting_528225	chr7_7597124_+	SINE	Alu	AluSc8
CAediting_528226	chr7_7597730_+	SINE	Alu	AluJb
CAediting_528227	chr7_7597738_+	SINE	Alu	AluJb
CAediting_528228	chr7_7597747_+	SINE	Alu	AluJb
CAediting_528229	chr7_7597754_+	SINE	Alu	AluJb
CAediting_528230	chr7_7597760_+	SINE	Alu	AluJb
CAediting_528231	chr7_7597812_+	SINE	Alu	AluJb
CAediting_528232	chr7_7597825_+	SINE	Alu	AluJb
CAediting_528233	chr7_7597830_+	SINE	Alu	AluJb
CAediting_528234	chr7_7597900_+	SINE	Alu	AluJb
CAediting_528235	chr7_7597908_+	SINE	Alu	AluJb
CAediting_528236	chr7_7597917_+	SINE	Alu	AluJb
CAediting_528237	chr7_7597926_+	SINE	Alu	AluJb
CAediting_528238	chr7_7597939_+	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for MIOS

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000164654.14.MIOS.

Correlation between RNA A-to-I editing and PSI for ENSG00000164654.14.MIOS.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for MIOS

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for MIOS

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for MIOS

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for MIOS

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for MIOS

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for MIOS

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
ESCA	pathologic_stage	CAediting_528190	chr7_7593811_+	0.00210868458450494	0.399006674207477

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Relation with survival for MIOS

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for MIOS

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for MIOS

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene