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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: POLR2G (CAeditome ID:5436)

Gene summary for POLR2G

check button Gene summary
Gene informationGene symbol

POLR2G

Gene ID

5436

Gene nameRNA polymerase II subunit G
SynonymsRPB19|RPB7|hRPB19|hsRPB7
Cytomap

11q12.3

Type of geneprotein-coding
DescriptionDNA-directed RNA polymerase II subunit RPB7DNA directed RNA polymerase II 19 kda polypeptideDNA-directed RNA polymerase II 19 kDa polypeptideDNA-directed RNA polymerase II subunit GRNA polymerase II 19 kDa subunitRNA polymerase II seventh subunitRNA
Modification date20210518
UniProtAcc

P62487

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
POLR2G

GO:0006366

DNA-directed RNA polymerase II subunit RPB7

9852112

POLR2G

GO:0005634

DNA-directed RNA polymerase II subunit RPB7

9852112

POLR2G

GO:0005654

DNA-directed RNA polymerase II subunit RPB7

0000052

POLR2G

GO:0005665

DNA-directed RNA polymerase II subunit RPB7

9852112


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RNA A-to-I events for POLR2G

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000168002.10

check button RNA A-to-I editing events in Cancer.
CAediting_819462(62763176, +), CAediting_819463(62763232, +), CAediting_819464(62763261, +), CAediting_819465(62763271, +), CAediting_819466(62763272, +), CAediting_819467(62763273, +), CAediting_819468(62763421, +), CAediting_819469(62763424, +), CAediting_819470(62763501, +), CAediting_819471(62763556, +), CAediting_819472(62763807, +), CAediting_819473(62763842, +), CAediting_819474(62763846, +), CAediting_819475(62763903, +), CAediting_819476(62764214, +), CAediting_819477(62764236, +), CAediting_819478(62764259, +), CAediting_819479(62764260, +), CAediting_819480(62764285, +), CAediting_819481(62764301, +), CAediting_819482(62764302, +), CAediting_819483(62764303, +), CAediting_819484(62764305, +), CAediting_819485(62764314, +), CAediting_819486(62764330, +), CAediting_819487(62764340, +), CAediting_819488(62764373, +), CAediting_819489(62764376, +), CAediting_819490(62764382, +), CAediting_819491(62764395, +), CAediting_819492(62764402, +), CAediting_819493(62764443, +), CAediting_819494(62764449, +), CAediting_819495(62764533, +), CAediting_819496(62764539, +), CAediting_819497(62764540, +), CAediting_819498(62764563, +), CAediting_819499(62764570, +), CAediting_819500(62764594, +), CAediting_819501(62764629, +), CAediting_819502(62764634, +), CAediting_819503(62764635, +), CAediting_819504(62764643, +), CAediting_819505(62764644, +), CAediting_819506(62764645, +), CAediting_819507(62764646, +), CAediting_819508(62764649, +), CAediting_819509(62764657, +), CAediting_819510(62764684, +), CAediting_819511(62764685, +), CAediting_819512(62764692, +), CAediting_819513(62764705, +), CAediting_819514(62764735, +), CAediting_819515(62764737, +), CAediting_819516(62764753, +), CAediting_819517(62764759, +), CAediting_819518(62764767, +), CAediting_819519(62764776, +), CAediting_819520(62764778, +), CAediting_819521(62764807, +), CAediting_819522(62764909, +), CAediting_819523(62764914, +), CAediting_819524(62764960, +), CAediting_819525(62764963, +), CAediting_819526(62764988, +), CAediting_819527(62764998, +), CAediting_819528(62765042, +), CAediting_819529(62765068, +), CAediting_819530(62765081, +), CAediting_819531(62765100, +), CAediting_819532(62765119, +), CAediting_819533(62765131, +),

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RNA editing positional annotations for POLR2G using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_819462chr11_62763176_+ncRNA_intronic
CAediting_819463chr11_62763232_+ncRNA_intronic
CAediting_819464chr11_62763261_+ncRNA_intronic
CAediting_819465chr11_62763271_+ncRNA_intronic
CAediting_819466chr11_62763272_+ncRNA_intronic
CAediting_819467chr11_62763273_+ncRNA_intronic
CAediting_819468chr11_62763421_+ncRNA_intronic
CAediting_819469chr11_62763424_+ncRNA_intronic
CAediting_819470chr11_62763501_+ncRNA_intronic
CAediting_819471chr11_62763556_+ncRNA_intronic
CAediting_819472chr11_62763807_+ncRNA_intronic
CAediting_819473chr11_62763842_+ncRNA_intronic
CAediting_819474chr11_62763846_+ncRNA_intronic
CAediting_819475chr11_62763903_+ncRNA_intronic
CAediting_819476chr11_62764214_+ncRNA_intronic
CAediting_819477chr11_62764236_+ncRNA_intronic
CAediting_819478chr11_62764259_+ncRNA_intronic
CAediting_819479chr11_62764260_+ncRNA_intronic
CAediting_819480chr11_62764285_+ncRNA_intronic
CAediting_819481chr11_62764301_+ncRNA_intronic
CAediting_819482chr11_62764302_+ncRNA_intronic
CAediting_819483chr11_62764303_+ncRNA_intronic
CAediting_819484chr11_62764305_+ncRNA_intronic
CAediting_819485chr11_62764314_+ncRNA_intronic
CAediting_819486chr11_62764330_+ncRNA_intronic
CAediting_819487chr11_62764340_+ncRNA_intronic
CAediting_819488chr11_62764373_+ncRNA_intronic
CAediting_819489chr11_62764376_+ncRNA_intronic
CAediting_819490chr11_62764382_+ncRNA_intronic
CAediting_819491chr11_62764395_+ncRNA_intronic
CAediting_819492chr11_62764402_+ncRNA_intronic
CAediting_819493chr11_62764443_+ncRNA_intronic
CAediting_819494chr11_62764449_+ncRNA_intronic
CAediting_819495chr11_62764533_+ncRNA_intronic
CAediting_819496chr11_62764539_+ncRNA_intronic
CAediting_819497chr11_62764540_+ncRNA_intronic
CAediting_819498chr11_62764563_+ncRNA_intronic
CAediting_819499chr11_62764570_+ncRNA_intronic
CAediting_819500chr11_62764594_+ncRNA_intronic
CAediting_819501chr11_62764629_+ncRNA_intronic
CAediting_819502chr11_62764634_+ncRNA_intronic
CAediting_819503chr11_62764635_+ncRNA_intronic
CAediting_819504chr11_62764643_+ncRNA_intronic
CAediting_819505chr11_62764644_+ncRNA_intronic
CAediting_819506chr11_62764645_+ncRNA_intronic
CAediting_819507chr11_62764646_+ncRNA_intronic
CAediting_819508chr11_62764649_+ncRNA_intronic
CAediting_819509chr11_62764657_+ncRNA_intronic
CAediting_819510chr11_62764684_+ncRNA_intronic
CAediting_819511chr11_62764685_+ncRNA_intronic
CAediting_819512chr11_62764692_+ncRNA_intronic
CAediting_819513chr11_62764705_+ncRNA_intronic
CAediting_819514chr11_62764735_+ncRNA_intronic
CAediting_819515chr11_62764737_+ncRNA_intronic
CAediting_819516chr11_62764753_+ncRNA_intronic
CAediting_819517chr11_62764759_+ncRNA_intronic
CAediting_819518chr11_62764767_+ncRNA_intronic
CAediting_819519chr11_62764776_+ncRNA_intronic
CAediting_819520chr11_62764778_+ncRNA_intronic
CAediting_819521chr11_62764807_+ncRNA_intronic
CAediting_819522chr11_62764909_+ncRNA_intronic
CAediting_819523chr11_62764914_+ncRNA_intronic
CAediting_819524chr11_62764960_+ncRNA_intronic
CAediting_819525chr11_62764963_+ncRNA_intronic
CAediting_819526chr11_62764988_+ncRNA_intronic
CAediting_819527chr11_62764998_+ncRNA_intronic
CAediting_819528chr11_62765042_+ncRNA_intronic
CAediting_819529chr11_62765068_+ncRNA_intronic
CAediting_819530chr11_62765081_+ncRNA_intronic
CAediting_819531chr11_62765100_+ncRNA_intronic
CAediting_819532chr11_62765119_+ncRNA_intronic
CAediting_819533chr11_62765131_+ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_819462chr11_62763176_+SINEAluAluSc8
CAediting_819463chr11_62763232_+SINEAluAluSc8
CAediting_819464chr11_62763261_+SINEAluAluSc8
CAediting_819465chr11_62763271_+SINEAluAluSc8
CAediting_819466chr11_62763272_+SINEAluAluSc8
CAediting_819467chr11_62763273_+SINEAluAluSc8
CAediting_819468chr11_62763421_+SINEAluAluYm1
CAediting_819469chr11_62763424_+SINEAluAluYm1
CAediting_819470chr11_62763501_+SINEAluAluYm1
CAediting_819471chr11_62763556_+SINEAluAluYm1
CAediting_819472chr11_62763807_+SINEAluAluSx
CAediting_819473chr11_62763842_+SINEAluAluSx
CAediting_819474chr11_62763846_+SINEAluAluSx
CAediting_819475chr11_62763903_+SINEAluAluSx
CAediting_819476chr11_62764214_+SINEAluAluSx
CAediting_819477chr11_62764236_+SINEAluAluSx
CAediting_819478chr11_62764259_+SINEAluAluSx
CAediting_819479chr11_62764260_+SINEAluAluSx
CAediting_819480chr11_62764285_+SINEAluAluSx
CAediting_819481chr11_62764301_+SINEAluAluSx
CAediting_819482chr11_62764302_+SINEAluAluSx
CAediting_819483chr11_62764303_+SINEAluAluSx
CAediting_819484chr11_62764305_+SINEAluAluSx
CAediting_819485chr11_62764314_+SINEAluAluSx
CAediting_819486chr11_62764330_+SINEAluAluSx
CAediting_819487chr11_62764340_+SINEAluAluSx
CAediting_819488chr11_62764373_+SINEAluAluSx
CAediting_819489chr11_62764376_+SINEAluAluSx
CAediting_819490chr11_62764382_+SINEAluAluSx
CAediting_819491chr11_62764395_+SINEAluAluSx
CAediting_819492chr11_62764402_+SINEAluAluSx
CAediting_819493chr11_62764443_+SINEAluAluSx
CAediting_819494chr11_62764449_+SINEAluAluSx
CAediting_819495chr11_62764533_+SINEAluAluJr4
CAediting_819496chr11_62764539_+SINEAluAluJr4
CAediting_819497chr11_62764540_+SINEAluAluJr4
CAediting_819498chr11_62764563_+SINEAluAluJr4
CAediting_819499chr11_62764570_+SINEAluAluJr4
CAediting_819500chr11_62764594_+SINEAluAluJr4
CAediting_819501chr11_62764629_+SINEAluAluJr4
CAediting_819502chr11_62764634_+SINEAluAluJr4
CAediting_819503chr11_62764635_+SINEAluAluJr4
CAediting_819504chr11_62764643_+SINEAluAluJr4
CAediting_819505chr11_62764644_+SINEAluAluJr4
CAediting_819506chr11_62764645_+SINEAluAluJr4
CAediting_819507chr11_62764646_+SINEAluAluJr4
CAediting_819508chr11_62764649_+SINEAluAluJr4
CAediting_819509chr11_62764657_+SINEAluAluJr4
CAediting_819510chr11_62764684_+SINEAluAluJr4
CAediting_819511chr11_62764685_+SINEAluAluJr4
CAediting_819512chr11_62764692_+SINEAluAluJr4
CAediting_819513chr11_62764705_+SINEAluAluJr4
CAediting_819514chr11_62764735_+SINEAluAluJr4
CAediting_819515chr11_62764737_+SINEAluAluJr4
CAediting_819516chr11_62764753_+SINEAluAluJr4
CAediting_819517chr11_62764759_+SINEAluAluJr4
CAediting_819518chr11_62764767_+SINEAluAluJr4
CAediting_819519chr11_62764776_+SINEAluAluJr4
CAediting_819520chr11_62764778_+SINEAluAluJr4
CAediting_819521chr11_62764807_+SINEAluAluJr4
CAediting_819522chr11_62764909_+SINEAluAluSg
CAediting_819523chr11_62764914_+SINEAluAluSg
CAediting_819524chr11_62764960_+SINEAluAluSg
CAediting_819525chr11_62764963_+SINEAluAluSg
CAediting_819526chr11_62764988_+SINEAluAluSg
CAediting_819527chr11_62764998_+SINEAluAluSg
CAediting_819528chr11_62765042_+SINEAluAluSg
CAediting_819529chr11_62765068_+SINEAluAluSg
CAediting_819530chr11_62765081_+SINEAluAluSg
CAediting_819531chr11_62765100_+SINEAluAluSg
CAediting_819532chr11_62765119_+SINEAluAluSg
CAediting_819533chr11_62765131_+SINEAluAluSg

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RNA A-to-I editing events in the alternative splicing sites for POLR2G

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000168002.10.POLR2G.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000168002.10.POLR2G.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for POLR2G

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for POLR2G

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for POLR2G

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393chr1_1167164_+ENSG00000168002.10ENST00000525455hsa-miR-200b-3p62762671627626777mer-m86276265662762678168-20.61
CAediting_688080chr9_63819626_+ENSG00000168002.10ENST00000524819hsa-miR-4477b62762124627621318mer-1a6276211162762131154-14.51
CAediting_393chr1_1167164_+ENSG00000168002.10ENST00000531944hsa-miR-200b-3p62762671627626777mer-m86276265662762678168-20.61
CAediting_688080chr9_63819626_+ENSG00000168002.10ENST00000531944hsa-miR-4477b62762124627621318mer-1a6276211162762131154-14.51
CAediting_393chr1_1167164_+ENSG00000168002.10ENST00000531996hsa-miR-200b-3p62762671627626777mer-m86276265662762678168-20.61
CAediting_1229414chr17_67471546_+ENSG00000168002.10ENST00000525455hsa-miR-548aa62762678627626858mer-1a6276266162762685153-11.04
CAediting_86358chr1_109598906_+ENSG00000168002.10ENST00000524819hsa-miR-197-5p62761994627620007mer-1a6276197862762000142-36.16
CAediting_1229414chr17_67471546_+ENSG00000168002.10ENST00000531944hsa-miR-548aa62762678627626858mer-1a6276266162762685153-11.04
CAediting_1368054chr19_46709310_-ENSG00000168002.10ENST00000531944hsa-miR-320e62762452627624598mer-1a6276244262762459151-19.07
CAediting_86358chr1_109598906_+ENSG00000168002.10ENST00000531944hsa-miR-197-5p62761994627620007mer-1a6276197862762000142-36.16
CAediting_77128chr1_85133844_+ENSG00000168002.10ENST00000531944hsa-miR-4423-3p62762295627623017mer-m86276228262762302140-12.1
CAediting_396018chr5_1062918_-ENSG00000168002.10ENST00000531944hsa-miR-463562762623627626297mer-m86276260862762630153-18.81
CAediting_1229414chr17_67471546_+ENSG00000168002.10ENST00000531996hsa-miR-548aa62762678627626858mer-1a6276266162762685153-11.04
CAediting_468389chr6_31355314_-ENSG00000168002.10ENST00000525455hsa-miR-6891-5p62766659627666668mer-1a6276664862766666143-19.63
CAediting_468389chr6_31355314_-ENSG00000168002.10ENST00000301788hsa-miR-6891-5p62766659627666668mer-1a6276664862766666143-19.63
CAediting_468389chr6_31355314_-ENSG00000168002.10ENST00000524819hsa-miR-6891-5p62762015627620206mer6276200362762021141-21.45
CAediting_468389chr6_31355314_-ENSG00000168002.10ENST00000524819hsa-miR-6891-5p62766659627666668mer-1a6276664862766666143-19.63
CAediting_468389chr6_31355314_-ENSG00000168002.10ENST00000531944hsa-miR-6891-5p62762015627620206mer6276200362762021141-21.45
CAediting_468389chr6_31355314_-ENSG00000168002.10ENST00000531944hsa-miR-6891-5p62766659627666668mer-1a6276664862766666143-19.63

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1229414chr17_67471546_+ENSG00000168002.10ENST00000531944hsa-miR-548aa62762276627622827mer-m86276225662762283145-6.49
CAediting_1229415chr17_67471547_+ENSG00000168002.10ENST00000531944hsa-miR-548aa62762276627622827mer-m86276225662762283145-6.49
CAediting_468389chr6_31355314_-ENSG00000168002.10ENST00000531944hsa-miR-6891-5p62762523627625308mer-1a6276251262762530144-19.59
CAediting_468389chr6_31355314_-ENSG00000168002.10ENST00000531944hsa-miR-6891-5p62762855627628617mer-m86276284462762862152-23.44

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for POLR2G

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for POLR2G

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for POLR2G

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for POLR2G

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for POLR2G

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for POLR2G

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
POLR2GC0019193Hepatitis, Toxic1CTD_human
POLR2GC0860207Drug-Induced Liver Disease1CTD_human
POLR2GC1262760Hepatitis, Drug-Induced1CTD_human
POLR2GC3658290Drug-Induced Acute Liver Injury1CTD_human
POLR2GC4277682Chemical and Drug Induced Liver Injury1CTD_human
POLR2GC4279912Chemically-Induced Liver Toxicity1CTD_human