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Editing gene: CLIC6 (CAeditome ID:54102)

Gene summary for CLIC6

Gene summary

Gene information	Gene symbol	CLIC6
	Gene ID	54102
	Gene name	chloride intracellular channel 6
	Synonyms	CLIC1L
	Cytomap	21q22.12
	Type of gene	protein-coding
	Description	chloride intracellular channel protein 6chloride channel form Aparchorin
	Modification date	20210518
	UniProtAcc	Q96NY7
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for CLIC6

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000159212.11

RNA A-to-I editing events in Cancer.

CAediting_1449981(34673478, +), CAediting_1449982(34681108, +), CAediting_1449983(34681248, +), CAediting_1449984(34681255, +), CAediting_1449985(34681264, +), CAediting_1449986(34681265, +), CAediting_1449987(34681284, +), CAediting_1449988(34681285, +), CAediting_1449989(34681288, +), CAediting_1449990(34681290, +), CAediting_1449991(34681300, +), CAediting_1449992(34681301, +), CAediting_1449993(34681302, +), CAediting_1449994(34681368, +), CAediting_1449995(34683588, +), CAediting_1449996(34683654, +), CAediting_1449997(34683657, +), CAediting_1449998(34683659, +), CAediting_1449999(34683667, +), CAediting_1450000(34683734, +), CAediting_1450001(34683774, +), CAediting_1450002(34683775, +), CAediting_1450003(34683784, +), CAediting_1450004(34699271, +), CAediting_1450005(34699273, +), CAediting_1450006(34699275, +), CAediting_1450007(34699321, +), CAediting_1450008(34699352, +), CAediting_1450009(34699391, +), CAediting_1450010(34699393, +), CAediting_1450011(34699453, +), CAediting_1450012(34700300, +), CAediting_1450013(34700353, +), CAediting_1450014(34700367, +), CAediting_1450015(34700368, +), CAediting_1450016(34706044, +), CAediting_1450017(34706092, +), CAediting_1450018(34711389, +),

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RNA editing positional annotations for CLIC6 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1449981	chr21_34673478_+	intronic
CAediting_1449982	chr21_34681108_+	intronic
CAediting_1449983	chr21_34681248_+	intronic
CAediting_1449984	chr21_34681255_+	intronic
CAediting_1449985	chr21_34681264_+	intronic
CAediting_1449986	chr21_34681265_+	intronic
CAediting_1449987	chr21_34681284_+	intronic
CAediting_1449988	chr21_34681285_+	intronic
CAediting_1449989	chr21_34681288_+	intronic
CAediting_1449990	chr21_34681290_+	intronic
CAediting_1449991	chr21_34681300_+	intronic
CAediting_1449992	chr21_34681301_+	intronic
CAediting_1449993	chr21_34681302_+	intronic
CAediting_1449994	chr21_34681368_+	intronic
CAediting_1449995	chr21_34683588_+	intronic
CAediting_1449996	chr21_34683654_+	intronic
CAediting_1449997	chr21_34683657_+	intronic
CAediting_1449998	chr21_34683659_+	intronic
CAediting_1449999	chr21_34683667_+	intronic
CAediting_1450000	chr21_34683734_+	intronic
CAediting_1450001	chr21_34683774_+	intronic
CAediting_1450002	chr21_34683775_+	intronic
CAediting_1450003	chr21_34683784_+	intronic
CAediting_1450004	chr21_34699271_+	intronic
CAediting_1450005	chr21_34699273_+	intronic
CAediting_1450006	chr21_34699275_+	intronic
CAediting_1450007	chr21_34699321_+	intronic
CAediting_1450008	chr21_34699352_+	intronic
CAediting_1450009	chr21_34699391_+	intronic
CAediting_1450010	chr21_34699393_+	intronic
CAediting_1450011	chr21_34699453_+	intronic
CAediting_1450012	chr21_34700300_+	intronic
CAediting_1450013	chr21_34700353_+	intronic
CAediting_1450014	chr21_34700367_+	intronic
CAediting_1450015	chr21_34700368_+	intronic
CAediting_1450016	chr21_34706044_+	exonic
CAediting_1450017	chr21_34706092_+	intronic
CAediting_1450018	chr21_34711389_+	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1449981	chr21_34673478_+	SINE	Alu	AluSz6
CAediting_1449982	chr21_34681108_+	LTR	ERVL-MaLR	THE1C
CAediting_1449983	chr21_34681248_+	LTR	ERVL-MaLR	THE1C
CAediting_1449984	chr21_34681255_+	LTR	ERVL-MaLR	THE1C
CAediting_1449985	chr21_34681264_+	LTR	ERVL-MaLR	THE1C
CAediting_1449986	chr21_34681265_+	LTR	ERVL-MaLR	THE1C
CAediting_1449987	chr21_34681284_+	LTR	ERVL-MaLR	THE1C
CAediting_1449988	chr21_34681285_+	LTR	ERVL-MaLR	THE1C
CAediting_1449989	chr21_34681288_+	LTR	ERVL-MaLR	THE1C
CAediting_1449990	chr21_34681290_+	LTR	ERVL-MaLR	THE1C
CAediting_1449991	chr21_34681300_+	LTR	ERVL-MaLR	THE1C
CAediting_1449992	chr21_34681301_+	LTR	ERVL-MaLR	THE1C
CAediting_1449993	chr21_34681302_+	LTR	ERVL-MaLR	THE1C
CAediting_1449994	chr21_34681368_+	LTR	ERVL-MaLR	THE1C
CAediting_1449995	chr21_34683588_+	LTR	ERVL-MaLR	THE1D
CAediting_1449996	chr21_34683654_+	LTR	ERVL-MaLR	THE1D
CAediting_1449997	chr21_34683657_+	LTR	ERVL-MaLR	THE1D
CAediting_1449998	chr21_34683659_+	LTR	ERVL-MaLR	THE1D
CAediting_1449999	chr21_34683667_+	LTR	ERVL-MaLR	THE1D
CAediting_1450000	chr21_34683734_+	LTR	ERVL-MaLR	THE1D
CAediting_1450001	chr21_34683774_+	LTR	ERVL-MaLR	THE1D
CAediting_1450002	chr21_34683775_+	LTR	ERVL-MaLR	THE1D
CAediting_1450003	chr21_34683784_+	LTR	ERVL-MaLR	THE1D
CAediting_1450004	chr21_34699271_+	SINE	Alu	AluJb
CAediting_1450005	chr21_34699273_+	SINE	Alu	AluJb
CAediting_1450006	chr21_34699275_+	SINE	Alu	AluJb
CAediting_1450007	chr21_34699321_+	SINE	Alu	AluJb
CAediting_1450008	chr21_34699352_+	SINE	Alu	AluJb
CAediting_1450009	chr21_34699391_+	SINE	Alu	AluJb
CAediting_1450010	chr21_34699393_+	SINE	Alu	AluJb
CAediting_1450011	chr21_34699453_+	SINE	Alu	AluJb
CAediting_1450012	chr21_34700300_+	SINE	Alu	AluY
CAediting_1450013	chr21_34700353_+	SINE	Alu	AluY
CAediting_1450014	chr21_34700367_+	SINE	Alu	AluY
CAediting_1450015	chr21_34700368_+	SINE	Alu	AluY
CAediting_1450016	chr21_34706044_+	LTR	ERVL-MaLR	MSTA
CAediting_1450017	chr21_34706092_+	LTR	ERVL-MaLR	MSTA
CAediting_1450018	chr21_34711389_+	SINE	Alu	AluSz6

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RNA A-to-I editing events in the alternative splicing sites for CLIC6

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000159212.11.CLIC6.

Correlation between RNA A-to-I editing and PSI for ENSG00000159212.11.CLIC6.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CLIC6

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CLIC6

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for CLIC6

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_688081	chr9_63819627_+	ENSG00000159212.11	ENST00000360731	hsa-miR-4477b	34717581	34717587	7mer-m8	34717567	34717588	140	-10.19
CAediting_1229415	chr17_67471547_+	ENSG00000159212.11	ENST00000360731	hsa-miR-548aa	34717564	34717570	7mer-m8	34717546	34717571	158	-14
CAediting_1351755	chr19_40282625_-	ENSG00000159212.11	ENST00000360731	hsa-miR-641	34717202	34717207	6mer	34717188	34717208	152	-26.78
CAediting_228905	chr2_188297554_+	ENSG00000159212.11	ENST00000360731	hsa-miR-561-3p	34718171	34718177	7mer-m8	34718154	34718178	152	-9.15

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_604450	chr7_133034877_-	ENSG00000159212.11	ENST00000360731	hsa-miR-3654	34717508	34717514	7mer-m8	34717497	34717515	140	-13.45
CAediting_580943	chr7_100356700_+	ENSG00000159212.11	ENST00000360731	hsa-miR-6840-3p	34717870	34717877	8mer-1a	34717854	34717877	146	-19.82

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CLIC6

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for CLIC6

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for CLIC6

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for CLIC6

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for CLIC6

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CLIC6

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene