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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: PIK3R1 (CAeditome ID:5295) |
Gene summary for PIK3R1 |
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Gene information | Gene symbol | PIK3R1 | Gene ID | 5295 |
Gene name | phosphoinositide-3-kinase regulatory subunit 1 | |
Synonyms | AGM7|GRB1|IMD36|p85|p85-ALPHA | |
Cytomap | 5q13.1 | |
Type of gene | protein-coding | |
Description | phosphatidylinositol 3-kinase regulatory subunit alphaPI3-kinase subunit p85-alphaPI3K regulatory subunit alphaphosphatidylinositol 3-kinase 85 kDa regulatory subunit alphaphosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)ph | |
Modification date | 20210531 | |
UniProtAcc | P27986 | |
Context | - 34098850(Oral squamous cell carcinoma (OSCC)-derived exosomal MiR-221 targets and regulates phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) to promote human umbilical vein endothelial cells migration and tube formation) |
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Gene | GO ID | GO term | PubMed ID |
PIK3R1 | GO:0043125 | Phosphatidylinositol 3-kinase regulatory subunit alpha | 10572067 |
PIK3R1 | GO:0043559 | Phosphatidylinositol 3-kinase regulatory subunit alpha | 8440175 |
PIK3R1 | GO:0014065 | Phosphatidylinositol 3-kinase regulatory subunit alpha | 7782332 |
PIK3R1 | GO:0034976 | Phosphatidylinositol 3-kinase regulatory subunit alpha | 20348923 |
PIK3R1 | GO:0042307 | Phosphatidylinositol 3-kinase regulatory subunit alpha | 20348923 |
PIK3R1 | GO:0048009 | Phosphatidylinositol 3-kinase regulatory subunit alpha | 7782332 |
PIK3R1 | GO:0050821 | Phosphatidylinositol 3-kinase regulatory subunit alpha | 20348923 |
PIK3R1 | GO:0060396 | Phosphatidylinositol 3-kinase regulatory subunit alpha | 7782332 |
PIK3R1 | GO:0005737 | Phosphatidylinositol 3-kinase regulatory subunit alpha | 20348923 |
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RNA A-to-I events for PIK3R1 |
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CAediting_412048(68235204, +), CAediting_412049(68236434, +), CAediting_412050(68236456, +), CAediting_412051(68236529, +), CAediting_412052(68248265, +), CAediting_412053(68272055, +), CAediting_412054(68272146, +), CAediting_412055(68272202, +), CAediting_412056(68298465, +), CAediting_412057(68300995, +), CAediting_412058(68301325, +), CAediting_412059(68301348, +), CAediting_412060(68301350, +), CAediting_412061(68301356, +), |
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RNA editing positional annotations for PIK3R1 using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
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CAeditome ID | Position | Variant type |
CAediting_412048 | chr5_68235204_+ | ncRNA_intronic |
CAediting_412049 | chr5_68236434_+ | ncRNA_intronic |
CAediting_412050 | chr5_68236456_+ | ncRNA_intronic |
CAediting_412051 | chr5_68236529_+ | ncRNA_intronic |
CAediting_412052 | chr5_68248265_+ | ncRNA_intronic |
CAediting_412053 | chr5_68272055_+ | ncRNA_intronic |
CAediting_412054 | chr5_68272146_+ | ncRNA_intronic |
CAediting_412055 | chr5_68272202_+ | ncRNA_intronic |
CAediting_412056 | chr5_68298465_+ | ncRNA_exonic |
CAediting_412057 | chr5_68300995_+ | UTR3 |
CAediting_412058 | chr5_68301325_+ | UTR3 |
CAediting_412059 | chr5_68301348_+ | UTR3 |
CAediting_412060 | chr5_68301350_+ | UTR3 |
CAediting_412061 | chr5_68301356_+ | UTR3 |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
CAediting_412048 | chr5_68235204_+ | SINE | Alu | AluSz |
CAediting_412049 | chr5_68236434_+ | SINE | Alu | AluY |
CAediting_412050 | chr5_68236456_+ | SINE | Alu | AluY |
CAediting_412051 | chr5_68236529_+ | SINE | Alu | AluY |
CAediting_412052 | chr5_68248265_+ | SINE | Alu | AluSz6 |
CAediting_412053 | chr5_68272055_+ | SINE | Alu | AluJr |
CAediting_412054 | chr5_68272146_+ | SINE | Alu | AluJr |
CAediting_412055 | chr5_68272202_+ | SINE | Alu | AluJr |
CAediting_412059 | chr5_68301348_+ | Simple_repeat | Simple_repeat | (TA)n |
CAediting_412060 | chr5_68301350_+ | Simple_repeat | Simple_repeat | (TA)n |
CAediting_412061 | chr5_68301356_+ | Simple_repeat | Simple_repeat | (TA)n |
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RNA A-to-I editing events in the alternative splicing sites for PIK3R1 |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PIK3R1 |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for PIK3R1 |
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The effects of the RNA editing to the miRNA binding sites for PIK3R1 |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_412056 | chr5_68298465_+ | ENSG00000145675.13 | ENST00000521381 | hsa-miR-26a-1-3p | 68298458 | 68298464 | 7mer-m8 | 68298443 | 68298465 | 148.00 | -14.79 |
CAediting_412056 | chr5_68298465_+ | ENSG00000145675.13 | ENST00000521381 | hsa-miR-26a-2-3p | 68298458 | 68298464 | 7mer-m8 | 68298443 | 68298465 | 150.00 | -12.87 |
CAediting_412056 | chr5_68298465_+ | ENSG00000145675.13 | ENST00000521657 | hsa-miR-26a-1-3p | 68298458 | 68298464 | 7mer-m8 | 68298443 | 68298465 | 148.00 | -14.79 |
CAediting_412056 | chr5_68298465_+ | ENSG00000145675.13 | ENST00000521657 | hsa-miR-26a-2-3p | 68298458 | 68298464 | 7mer-m8 | 68298443 | 68298465 | 150.00 | -12.87 |
CAediting_412056 | chr5_68298465_+ | ENSG00000145675.13 | ENST00000320694 | hsa-miR-26a-1-3p | 68298458 | 68298464 | 7mer-m8 | 68298443 | 68298465 | 148.00 | -14.79 |
CAediting_412056 | chr5_68298465_+ | ENSG00000145675.13 | ENST00000320694 | hsa-miR-26a-2-3p | 68298458 | 68298464 | 7mer-m8 | 68298443 | 68298465 | 150.00 | -12.87 |
CAediting_412056 | chr5_68298465_+ | ENSG00000145675.13 | ENST00000336483 | hsa-miR-26a-1-3p | 68298458 | 68298464 | 7mer-m8 | 68298443 | 68298465 | 148.00 | -14.79 |
CAediting_412056 | chr5_68298465_+ | ENSG00000145675.13 | ENST00000336483 | hsa-miR-26a-2-3p | 68298458 | 68298464 | 7mer-m8 | 68298443 | 68298465 | 150.00 | -12.87 |
CAediting_412056 | chr5_68298465_+ | ENSG00000145675.13 | ENST00000523872 | hsa-miR-26a-1-3p | 68298458 | 68298464 | 7mer-m8 | 68298443 | 68298465 | 148.00 | -14.79 |
CAediting_412056 | chr5_68298465_+ | ENSG00000145675.13 | ENST00000523872 | hsa-miR-26a-2-3p | 68298458 | 68298464 | 7mer-m8 | 68298443 | 68298465 | 150.00 | -12.87 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_412056 | chr5_68298465_+ | ENSG00000145675.13 | ENST00000521381 | hsa-miR-100-3p | 68298463 | 68298468 | 6mer | 68298449 | 68298469 | 154 | -18.7 |
CAediting_412056 | chr5_68298465_+ | ENSG00000145675.13 | ENST00000521381 | hsa-miR-21-5p | 68298461 | 68298467 | 7mer-m8 | 68298445 | 68298468 | 150 | -10.58 |
CAediting_412056 | chr5_68298465_+ | ENSG00000145675.13 | ENST00000521657 | hsa-miR-100-3p | 68298463 | 68298468 | 6mer | 68298449 | 68298469 | 154 | -18.7 |
CAediting_412056 | chr5_68298465_+ | ENSG00000145675.13 | ENST00000521657 | hsa-miR-21-5p | 68298461 | 68298467 | 7mer-m8 | 68298445 | 68298468 | 150 | -10.58 |
CAediting_412056 | chr5_68298465_+ | ENSG00000145675.13 | ENST00000320694 | hsa-miR-100-3p | 68298463 | 68298468 | 6mer | 68298449 | 68298469 | 154 | -18.7 |
CAediting_412056 | chr5_68298465_+ | ENSG00000145675.13 | ENST00000320694 | hsa-miR-21-5p | 68298461 | 68298467 | 7mer-m8 | 68298445 | 68298468 | 150 | -10.58 |
CAediting_412056 | chr5_68298465_+ | ENSG00000145675.13 | ENST00000336483 | hsa-miR-100-3p | 68298463 | 68298468 | 6mer | 68298449 | 68298469 | 154 | -18.7 |
CAediting_412056 | chr5_68298465_+ | ENSG00000145675.13 | ENST00000336483 | hsa-miR-21-5p | 68298461 | 68298467 | 7mer-m8 | 68298445 | 68298468 | 150 | -10.58 |
CAediting_412056 | chr5_68298465_+ | ENSG00000145675.13 | ENST00000523872 | hsa-miR-100-3p | 68298463 | 68298468 | 6mer | 68298449 | 68298469 | 154 | -18.7 |
CAediting_412056 | chr5_68298465_+ | ENSG00000145675.13 | ENST00000523872 | hsa-miR-21-5p | 68298461 | 68298467 | 7mer-m8 | 68298445 | 68298468 | 150 | -10.58 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_393 | chr1_1167164_+ | ENSG00000145675.13 | ENST00000521381 | hsa-miR-200b-3p | 68301318 | 68301324 | 7mer-1a | 68301303 | 68301324 | 144 | -15.18 |
CAediting_393 | chr1_1167164_+ | ENSG00000145675.13 | ENST00000517698 | hsa-miR-200b-3p | 68295270 | 68295277 | 8mer-1a | 68295257 | 68295277 | 141 | -11.77 |
CAediting_1229414 | chr17_67471546_+ | ENSG00000145675.13 | ENST00000521381 | hsa-miR-548aa | 68301621 | 68301627 | 7mer-m8 | 68301604 | 68301628 | 166 | -12.14 |
CAediting_1229415 | chr17_67471547_+ | ENSG00000145675.13 | ENST00000521381 | hsa-miR-548aa | 68300841 | 68300847 | 7mer-m8 | 68300819 | 68300848 | 150 | -16.58 |
CAediting_1351755 | chr19_40282625_- | ENSG00000145675.13 | ENST00000521381 | hsa-miR-641 | 68301166 | 68301173 | 8mer-1a | 68301147 | 68301173 | 144 | -14.99 |
CAediting_604450 | chr7_133034877_- | ENSG00000145675.13 | ENST00000521381 | hsa-miR-3654 | 68298031 | 68298037 | 7mer-m8 | 68298019 | 68298038 | 148 | -19.93 |
CAediting_524911 | chr7_5495852_- | ENSG00000145675.13 | ENST00000521381 | hsa-miR-589-3p | 68299334 | 68299340 | 7mer-m8 | 68299319 | 68299341 | 151 | -17.48 |
CAediting_604450 | chr7_133034877_- | ENSG00000145675.13 | ENST00000521657 | hsa-miR-3654 | 68298031 | 68298037 | 7mer-m8 | 68298019 | 68298038 | 148 | -19.93 |
CAediting_604450 | chr7_133034877_- | ENSG00000145675.13 | ENST00000320694 | hsa-miR-3654 | 68298031 | 68298037 | 7mer-m8 | 68298019 | 68298038 | 148 | -19.93 |
CAediting_604450 | chr7_133034877_- | ENSG00000145675.13 | ENST00000336483 | hsa-miR-3654 | 68298031 | 68298037 | 7mer-m8 | 68298019 | 68298038 | 148 | -19.93 |
CAediting_604450 | chr7_133034877_- | ENSG00000145675.13 | ENST00000523872 | hsa-miR-3654 | 68298031 | 68298037 | 7mer-m8 | 68298019 | 68298038 | 148 | -19.93 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_442554 | chr5_154685830_+ | ENSG00000145675.13 | ENST00000521381 | hsa-miR-1303 | 68299055 | 68299061 | 7mer-m8 | 68299041 | 68299062 | 146 | -13.76 |
CAediting_1160181 | chr17_7017644_- | ENSG00000145675.13 | ENST00000521381 | hsa-miR-195-3p | 68300364 | 68300370 | 7mer-m8 | 68300349 | 68300371 | 155 | -15.29 |
CAediting_1160181 | chr17_7017644_- | ENSG00000145675.13 | ENST00000521381 | hsa-miR-195-3p | 68298315 | 68298321 | 7mer-m8 | 68298303 | 68298322 | 149 | -14.77 |
CAediting_1160181 | chr17_7017644_- | ENSG00000145675.13 | ENST00000521381 | hsa-miR-195-3p | 68298495 | 68298501 | 7mer-m8 | 68298482 | 68298502 | 141 | -7.01 |
CAediting_1229414 | chr17_67471546_+ | ENSG00000145675.13 | ENST00000521381 | hsa-miR-548aa | 68299903 | 68299910 | 8mer-1a | 68299886 | 68299910 | 140 | -6.28 |
CAediting_1229415 | chr17_67471547_+ | ENSG00000145675.13 | ENST00000521381 | hsa-miR-548aa | 68299903 | 68299910 | 8mer-1a | 68299886 | 68299910 | 140 | -6.28 |
CAediting_1229413 | chr17_67471544_+ | ENSG00000145675.13 | ENST00000521381 | hsa-miR-548aa | 68299903 | 68299910 | 8mer-1a | 68299886 | 68299910 | 140 | -6.28 |
CAediting_524911 | chr7_5495852_- | ENSG00000145675.13 | ENST00000521381 | hsa-miR-589-3p | 68300258 | 68300264 | 7mer-m8 | 68300243 | 68300265 | 147 | -11.97 |
CAediting_748296 | chr10_51299626_+ | ENSG00000145675.13 | ENST00000521381 | hsa-miR-605-3p | 68301665 | 68301672 | 8mer-1a | 68301651 | 68301672 | 143 | -10.22 |
CAediting_1399425 | chr20_1392958_- | ENSG00000145675.13 | ENST00000521381 | hsa-miR-6869-5p | 68299793 | 68299799 | 7mer-m8 | 68299779 | 68299800 | 148 | -16.37 |
CAediting_468389 | chr6_31355314_- | ENSG00000145675.13 | ENST00000521381 | hsa-miR-6891-5p | 68301707 | 68301713 | 7mer-m8 | 68301696 | 68301714 | 143 | -14.96 |
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The effects of the RNA editing to the stability of the RNA structures for PIK3R1 |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
CAediting_412056 | ENST00000521381.4 | chr5_68298465_+ | -1952.90 | -1953.30 | -1957.40 |
CAediting_412057 | ENST00000521381.4 | chr5_68300995_+ | -1955.40 | -1953.30 | -1957.40 |
CAediting_412058 | ENST00000521381.4 | chr5_68301325_+ | -1953.80 | -1953.30 | -1957.40 |
CAediting_412059 | ENST00000521381.4 | chr5_68301348_+ | -1954.40 | -1953.30 | -1957.40 |
CAediting_412060 | ENST00000521381.4 | chr5_68301350_+ | -1953.50 | -1953.30 | -1957.40 |
CAediting_412061 | ENST00000521381.4 | chr5_68301356_+ | -1953.00 | -1953.30 | -1957.40 |
CAediting_412056 | ENST00000521657.4 | chr5_68298465_+ | -1071.80 | -1071.50 | -1071.80 |
CAediting_412056 | ENST00000320694.11 | chr5_68298465_+ | -733.60 | -732.30 | -733.60 |
CAediting_412056 | ENST00000336483.8 | chr5_68298465_+ | -587.10 | -587.10 | -587.10 |
CAediting_412056 | ENST00000518813.4 | chr5_68298465_+ | -892.90 | -893.20 | -892.90 |
CAediting_412056 | ENST00000523872.1 | chr5_68298465_+ | -620.20 | -620.10 | -620.20 |
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Relation with ADAR for PIK3R1 |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
OV | CAediting_412058 | chr5_68301325_+ | . | . | . | . | 0.0367453877191963 | 0.290419069307323 |
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Relation with cancer stages for PIK3R1 |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for PIK3R1 |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for PIK3R1 |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
PIK3R1 | P27986 | DB01064 | Isoprenaline | Phosphatidylinositol 3-kinase regulatory subunit alpha | SmallMoleculeDrug | approved|investigational |
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RelatedDiseases for PIK3R1 |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
PIK3R1 | C0878684 | SHORT syndrome | 7 | CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
PIK3R1 | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |
PIK3R1 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
PIK3R1 | C0376358 | Malignant neoplasm of prostate | 2 | CTD_human |
PIK3R1 | C3554689 | AGAMMAGLOBULINEMIA 7, AUTOSOMAL RECESSIVE | 2 | CTD_human;GENOMICS_ENGLAND |
PIK3R1 | C4014934 | IMMUNODEFICIENCY 36 | 2 | CTD_human;GENOMICS_ENGLAND |
PIK3R1 | C0001768 | Agammaglobulinemia | 1 | GENOMICS_ENGLAND |
PIK3R1 | C0006267 | Bronchiectasis | 1 | GENOMICS_ENGLAND |
PIK3R1 | C0006413 | Burkitt Lymphoma | 1 | CTD_human |
PIK3R1 | C0007097 | Carcinoma | 1 | CTD_human |
PIK3R1 | C0021655 | Insulin Resistance | 1 | CTD_human |
PIK3R1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
PIK3R1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
PIK3R1 | C0042900 | Vitiligo | 1 | CTD_human |
PIK3R1 | C0205696 | Anaplastic carcinoma | 1 | CTD_human |
PIK3R1 | C0205697 | Carcinoma, Spindle-Cell | 1 | CTD_human |
PIK3R1 | C0205698 | Undifferentiated carcinoma | 1 | CTD_human |
PIK3R1 | C0205699 | Carcinomatosis | 1 | CTD_human |
PIK3R1 | C0343640 | African Burkitt's lymphoma | 1 | CTD_human |
PIK3R1 | C0494261 | Combined immunodeficiency | 1 | GENOMICS_ENGLAND |
PIK3R1 | C0920563 | Insulin Sensitivity | 1 | CTD_human |
PIK3R1 | C1257925 | Mammary Carcinoma, Animal | 1 | CTD_human |
PIK3R1 | C1832241 | Agammaglobulinemia, non-Bruton type | 1 | ORPHANET |
PIK3R1 | C3714976 | ACTIVATED PI3K-DELTA SYNDROME | 1 | ORPHANET |
PIK3R1 | C4721444 | Burkitt Leukemia | 1 | CTD_human |