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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: PIK3CA (CAeditome ID:5290)

Gene summary for PIK3CA

check button Gene summary
Gene informationGene symbol

PIK3CA

Gene ID

5290

Gene namephosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
SynonymsCLAPO|CLOVE|CWS5|MCAP|MCM|MCMTC|PI3K|PI3K-alpha|p110-alpha
Cytomap

3q26.32

Type of geneprotein-coding
Descriptionphosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPI3-kinase p110 subunit alphamutant phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaphosphatidylinositol 3-kinase, catalytic, 110-KD, alphaphosphatidyl
Modification date20210524
UniProtAcc

P42336

Context- 31699932(Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kalpha inhibitors)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
PIK3CA

GO:0016310

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

25327288

PIK3CA

GO:0016301

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

25327288

PIK3CA

GO:0016303

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

2174051

PIK3CA

GO:0005943

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

22402981


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RNA A-to-I events for PIK3CA

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000121879.3

check button RNA A-to-I editing events in Cancer.
CAediting_325754(179160681, +), CAediting_325755(179160683, +), CAediting_325756(179160755, +), CAediting_325757(179160757, +), CAediting_325758(179160758, +), CAediting_325759(179160759, +), CAediting_325760(179160760, +), CAediting_325761(179160761, +), CAediting_325762(179160764, +), CAediting_325763(179160773, +), CAediting_325764(179160802, +), CAediting_325765(179160824, +), CAediting_325766(179161447, +), CAediting_325767(179162000, +), CAediting_325768(179162012, +), CAediting_325769(179162017, +), CAediting_325770(179162059, +), CAediting_325771(179162063, +), CAediting_325772(179162065, +), CAediting_325773(179162066, +), CAediting_325774(179162074, +), CAediting_325775(179162081, +), CAediting_325776(179162383, +), CAediting_325777(179162463, +), CAediting_325778(179164612, +), CAediting_325779(179164613, +), CAediting_325780(179164683, +), CAediting_325781(179164690, +), CAediting_325782(179164722, +), CAediting_325783(179164726, +), CAediting_325784(179164730, +), CAediting_325785(179164742, +), CAediting_325786(179164748, +), CAediting_325787(179164749, +), CAediting_325788(179164758, +), CAediting_325789(179164771, +), CAediting_325790(179164790, +), CAediting_325791(179164794, +), CAediting_325792(179164818, +), CAediting_325793(179164821, +), CAediting_325794(179164839, +), CAediting_325795(179164859, +), CAediting_325796(179165424, +), CAediting_325797(179165461, +), CAediting_325798(179165462, +), CAediting_325799(179165492, +), CAediting_325800(179165495, +), CAediting_325801(179173339, +), CAediting_325802(179173342, +), CAediting_325803(179173347, +), CAediting_325804(179173375, +), CAediting_325805(179173377, +), CAediting_325806(179173383, +), CAediting_325807(179173458, +), CAediting_325808(179173464, +), CAediting_325809(179173468, +), CAediting_325810(179173743, +), CAediting_325811(179173775, +), CAediting_325812(179173783, +), CAediting_325813(179173788, +), CAediting_325814(179173791, +), CAediting_325815(179173826, +), CAediting_325816(179173827, +), CAediting_325817(179173852, +), CAediting_325818(179173856, +), CAediting_325819(179173866, +), CAediting_325820(179173868, +), CAediting_325821(179174324, +), CAediting_325822(179174341, +), CAediting_325823(179174350, +), CAediting_325824(179174351, +), CAediting_325825(179174371, +), CAediting_325826(179174390, +), CAediting_325827(179174391, +), CAediting_325828(179174411, +), CAediting_325829(179174415, +), CAediting_325830(179174460, +), CAediting_325831(179177593, +), CAediting_325832(179177978, +), CAediting_325833(179177984, +), CAediting_325834(179177985, +), CAediting_325835(179178038, +), CAediting_325836(179178039, +), CAediting_325837(179178057, +), CAediting_325838(179178143, +), CAediting_325839(179178163, +), CAediting_325840(179178165, +), CAediting_325841(179178198, +), CAediting_325842(179178238, +), CAediting_325843(179182397, +), CAediting_325844(179187283, +), CAediting_325845(179187350, +), CAediting_325846(179187391, +), CAediting_325847(179187417, +), CAediting_325848(179187767, +), CAediting_325849(179189033, +), CAediting_325850(179189034, +), CAediting_325851(179189134, +), CAediting_325852(179204767, +), CAediting_325853(179204832, +), CAediting_325854(179204833, +), CAediting_325855(179204835, +), CAediting_325856(179204839, +), CAediting_325857(179204843, +), CAediting_325858(179204854, +), CAediting_325859(179204857, +), CAediting_325860(179204858, +), CAediting_325861(179204859, +), CAediting_325862(179204860, +), CAediting_325863(179204863, +), CAediting_325864(179204864, +), CAediting_325865(179204874, +), CAediting_325866(179204900, +), CAediting_325867(179204901, +), CAediting_325868(179204906, +), CAediting_325869(179204910, +), CAediting_325870(179206123, +), CAediting_325871(179206242, +), CAediting_325872(179206657, +), CAediting_325873(179206759, +), CAediting_325874(179207649, +), CAediting_325875(179207659, +), CAediting_325876(179212422, +), CAediting_325877(179212462, +), CAediting_325878(179212703, +), CAediting_325879(179230506, +), CAediting_325880(179230633, +), CAediting_325881(179230669, +), CAediting_325882(179231746, +), CAediting_325883(179232906, +), CAediting_325884(179233139, +), CAediting_325885(179234488, +), CAediting_325886(179234489, +), CAediting_325887(179234508, +),

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RNA editing positional annotations for PIK3CA using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_325754chr3_179160681_+intronic
CAediting_325755chr3_179160683_+intronic
CAediting_325756chr3_179160755_+intronic
CAediting_325757chr3_179160757_+intronic
CAediting_325758chr3_179160758_+intronic
CAediting_325759chr3_179160759_+intronic
CAediting_325760chr3_179160760_+intronic
CAediting_325761chr3_179160761_+intronic
CAediting_325762chr3_179160764_+intronic
CAediting_325763chr3_179160773_+intronic
CAediting_325764chr3_179160802_+intronic
CAediting_325765chr3_179160824_+intronic
CAediting_325766chr3_179161447_+intronic
CAediting_325767chr3_179162000_+intronic
CAediting_325768chr3_179162012_+intronic
CAediting_325769chr3_179162017_+intronic
CAediting_325770chr3_179162059_+intronic
CAediting_325771chr3_179162063_+intronic
CAediting_325772chr3_179162065_+intronic
CAediting_325773chr3_179162066_+intronic
CAediting_325774chr3_179162074_+intronic
CAediting_325775chr3_179162081_+intronic
CAediting_325776chr3_179162383_+intronic
CAediting_325777chr3_179162463_+intronic
CAediting_325778chr3_179164612_+intronic
CAediting_325779chr3_179164613_+intronic
CAediting_325780chr3_179164683_+intronic
CAediting_325781chr3_179164690_+intronic
CAediting_325782chr3_179164722_+intronic
CAediting_325783chr3_179164726_+intronic
CAediting_325784chr3_179164730_+intronic
CAediting_325785chr3_179164742_+intronic
CAediting_325786chr3_179164748_+intronic
CAediting_325787chr3_179164749_+intronic
CAediting_325788chr3_179164758_+intronic
CAediting_325789chr3_179164771_+intronic
CAediting_325790chr3_179164790_+intronic
CAediting_325791chr3_179164794_+intronic
CAediting_325792chr3_179164818_+intronic
CAediting_325793chr3_179164821_+intronic
CAediting_325794chr3_179164839_+intronic
CAediting_325795chr3_179164859_+intronic
CAediting_325796chr3_179165424_+intronic
CAediting_325797chr3_179165461_+intronic
CAediting_325798chr3_179165462_+intronic
CAediting_325799chr3_179165492_+intronic
CAediting_325800chr3_179165495_+intronic
CAediting_325801chr3_179173339_+intronic
CAediting_325802chr3_179173342_+intronic
CAediting_325803chr3_179173347_+intronic
CAediting_325804chr3_179173375_+intronic
CAediting_325805chr3_179173377_+intronic
CAediting_325806chr3_179173383_+intronic
CAediting_325807chr3_179173458_+intronic
CAediting_325808chr3_179173464_+intronic
CAediting_325809chr3_179173468_+intronic
CAediting_325810chr3_179173743_+intronic
CAediting_325811chr3_179173775_+intronic
CAediting_325812chr3_179173783_+intronic
CAediting_325813chr3_179173788_+intronic
CAediting_325814chr3_179173791_+intronic
CAediting_325815chr3_179173826_+intronic
CAediting_325816chr3_179173827_+intronic
CAediting_325817chr3_179173852_+intronic
CAediting_325818chr3_179173856_+intronic
CAediting_325819chr3_179173866_+intronic
CAediting_325820chr3_179173868_+intronic
CAediting_325821chr3_179174324_+intronic
CAediting_325822chr3_179174341_+intronic
CAediting_325823chr3_179174350_+intronic
CAediting_325824chr3_179174351_+intronic
CAediting_325825chr3_179174371_+intronic
CAediting_325826chr3_179174390_+intronic
CAediting_325827chr3_179174391_+intronic
CAediting_325828chr3_179174411_+intronic
CAediting_325829chr3_179174415_+intronic
CAediting_325830chr3_179174460_+intronic
CAediting_325831chr3_179177593_+intronic
CAediting_325832chr3_179177978_+intronic
CAediting_325833chr3_179177984_+intronic
CAediting_325834chr3_179177985_+intronic
CAediting_325835chr3_179178038_+intronic
CAediting_325836chr3_179178039_+intronic
CAediting_325837chr3_179178057_+intronic
CAediting_325838chr3_179178143_+intronic
CAediting_325839chr3_179178163_+intronic
CAediting_325840chr3_179178165_+intronic
CAediting_325841chr3_179178198_+intronic
CAediting_325842chr3_179178238_+intronic
CAediting_325843chr3_179182397_+intronic
CAediting_325844chr3_179187283_+intronic
CAediting_325845chr3_179187350_+intronic
CAediting_325846chr3_179187391_+intronic
CAediting_325847chr3_179187417_+intronic
CAediting_325848chr3_179187767_+intronic
CAediting_325849chr3_179189033_+intronic
CAediting_325850chr3_179189034_+intronic
CAediting_325851chr3_179189134_+intronic
CAediting_325852chr3_179204767_+intronic
CAediting_325853chr3_179204832_+intronic
CAediting_325854chr3_179204833_+intronic
CAediting_325855chr3_179204835_+intronic
CAediting_325856chr3_179204839_+intronic
CAediting_325857chr3_179204843_+intronic
CAediting_325858chr3_179204854_+intronic
CAediting_325859chr3_179204857_+intronic
CAediting_325860chr3_179204858_+intronic
CAediting_325861chr3_179204859_+intronic
CAediting_325862chr3_179204860_+intronic
CAediting_325863chr3_179204863_+intronic
CAediting_325864chr3_179204864_+intronic
CAediting_325865chr3_179204874_+intronic
CAediting_325866chr3_179204900_+intronic
CAediting_325867chr3_179204901_+intronic
CAediting_325868chr3_179204906_+intronic
CAediting_325869chr3_179204910_+intronic
CAediting_325870chr3_179206123_+intronic
CAediting_325871chr3_179206242_+intronic
CAediting_325872chr3_179206657_+intronic
CAediting_325873chr3_179206759_+intronic
CAediting_325874chr3_179207649_+intronic
CAediting_325875chr3_179207659_+intronic
CAediting_325876chr3_179212422_+intronic
CAediting_325877chr3_179212462_+intronic
CAediting_325878chr3_179212703_+intronic
CAediting_325879chr3_179230506_+intronic
CAediting_325880chr3_179230633_+intronic
CAediting_325881chr3_179230669_+intronic
CAediting_325882chr3_179231746_+intronic
CAediting_325883chr3_179232906_+intronic
CAediting_325884chr3_179233139_+intronic
CAediting_325885chr3_179234488_+UTR3
CAediting_325886chr3_179234489_+UTR3
CAediting_325887chr3_179234508_+UTR3

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_325766chr3_179161447_+SINEAluAluSz6
CAediting_325776chr3_179162383_+SINEAluAluJo
CAediting_325777chr3_179162463_+SINEAluAluJo
CAediting_325778chr3_179164612_+SINEAluAluSp
CAediting_325779chr3_179164613_+SINEAluAluSp
CAediting_325780chr3_179164683_+SINEAluAluSp
CAediting_325781chr3_179164690_+SINEAluAluSp
CAediting_325782chr3_179164722_+SINEAluAluSp
CAediting_325783chr3_179164726_+SINEAluAluSp
CAediting_325784chr3_179164730_+SINEAluAluSp
CAediting_325785chr3_179164742_+SINEAluAluSp
CAediting_325786chr3_179164748_+SINEAluAluSp
CAediting_325787chr3_179164749_+SINEAluAluSp
CAediting_325788chr3_179164758_+SINEAluAluSp
CAediting_325789chr3_179164771_+SINEAluAluSp
CAediting_325790chr3_179164790_+SINEAluAluSp
CAediting_325791chr3_179164794_+SINEAluAluSp
CAediting_325792chr3_179164818_+SINEAluAluSp
CAediting_325793chr3_179164821_+SINEAluAluSp
CAediting_325794chr3_179164839_+SINEAluAluSp
CAediting_325795chr3_179164859_+SINEAluAluSp
CAediting_325796chr3_179165424_+SINEAluAluJr
CAediting_325797chr3_179165461_+SINEAluAluJr
CAediting_325798chr3_179165462_+SINEAluAluJr
CAediting_325799chr3_179165492_+SINEAluAluJr
CAediting_325800chr3_179165495_+SINEAluAluJr
CAediting_325801chr3_179173339_+SINEAluAluY
CAediting_325802chr3_179173342_+SINEAluAluY
CAediting_325803chr3_179173347_+SINEAluAluY
CAediting_325804chr3_179173375_+SINEAluAluY
CAediting_325805chr3_179173377_+SINEAluAluY
CAediting_325806chr3_179173383_+SINEAluAluY
CAediting_325807chr3_179173458_+SINEAluAluY
CAediting_325808chr3_179173464_+SINEAluAluY
CAediting_325809chr3_179173468_+SINEAluAluY
CAediting_325810chr3_179173743_+SINEAluAluSq2
CAediting_325811chr3_179173775_+SINEAluAluSq2
CAediting_325812chr3_179173783_+SINEAluAluSq2
CAediting_325813chr3_179173788_+SINEAluAluSq2
CAediting_325814chr3_179173791_+SINEAluAluSq2
CAediting_325815chr3_179173826_+SINEAluAluSq2
CAediting_325816chr3_179173827_+SINEAluAluSq2
CAediting_325817chr3_179173852_+SINEAluAluSq2
CAediting_325818chr3_179173856_+SINEAluAluSq2
CAediting_325819chr3_179173866_+SINEAluAluSq2
CAediting_325820chr3_179173868_+SINEAluAluSq2
CAediting_325821chr3_179174324_+SINEAluAluSx3
CAediting_325822chr3_179174341_+SINEAluAluSx3
CAediting_325823chr3_179174350_+SINEAluAluSx3
CAediting_325824chr3_179174351_+SINEAluAluSx3
CAediting_325825chr3_179174371_+SINEAluAluSx3
CAediting_325826chr3_179174390_+SINEAluAluSx3
CAediting_325827chr3_179174391_+SINEAluAluSx3
CAediting_325828chr3_179174411_+SINEAluAluSx3
CAediting_325829chr3_179174415_+SINEAluAluSx3
CAediting_325830chr3_179174460_+SINEAluAluSx3
CAediting_325831chr3_179177593_+SINEAluAluSx1
CAediting_325832chr3_179177978_+SINEAluAluJr
CAediting_325833chr3_179177984_+SINEAluAluJr
CAediting_325834chr3_179177985_+SINEAluAluJr
CAediting_325835chr3_179178038_+SINEAluAluJr
CAediting_325836chr3_179178039_+SINEAluAluJr
CAediting_325837chr3_179178057_+SINEAluAluJr
CAediting_325838chr3_179178143_+SINEAluAluJr
CAediting_325839chr3_179178163_+SINEAluAluJr
CAediting_325840chr3_179178165_+SINEAluAluJr
CAediting_325841chr3_179178198_+SINEAluAluJr
CAediting_325842chr3_179178238_+SINEAluAluJr
CAediting_325843chr3_179182397_+SINEAluAluJb
CAediting_325844chr3_179187283_+SINEAluAluSc8
CAediting_325845chr3_179187350_+SINEAluAluSc8
CAediting_325846chr3_179187391_+SINEAluAluSc8
CAediting_325847chr3_179187417_+SINEAluAluSc8
CAediting_325848chr3_179187767_+SINEAluAluSx3
CAediting_325849chr3_179189033_+SINEAluAluSz
CAediting_325850chr3_179189034_+SINEAluAluSz
CAediting_325851chr3_179189134_+SINEAluAluSz
CAediting_325852chr3_179204767_+SINEAluAluSg4
CAediting_325853chr3_179204832_+SINEAluAluSg4
CAediting_325854chr3_179204833_+SINEAluAluSg4
CAediting_325855chr3_179204835_+SINEAluAluSg4
CAediting_325856chr3_179204839_+SINEAluAluSg4
CAediting_325857chr3_179204843_+SINEAluAluSg4
CAediting_325858chr3_179204854_+SINEAluAluSg4
CAediting_325859chr3_179204857_+SINEAluAluSg4
CAediting_325860chr3_179204858_+SINEAluAluSg4
CAediting_325861chr3_179204859_+SINEAluAluSg4
CAediting_325862chr3_179204860_+SINEAluAluSg4
CAediting_325863chr3_179204863_+SINEAluAluSg4
CAediting_325864chr3_179204864_+SINEAluAluSg4
CAediting_325865chr3_179204874_+SINEAluAluSg4
CAediting_325866chr3_179204900_+SINEAluAluSg4
CAediting_325867chr3_179204901_+SINEAluAluSg4
CAediting_325868chr3_179204906_+SINEAluAluSg4
CAediting_325869chr3_179204910_+SINEAluAluSg4
CAediting_325870chr3_179206123_+SINEAluAluSx3
CAediting_325871chr3_179206242_+SINEAluAluSx3
CAediting_325872chr3_179206657_+SINEAluAluJb
CAediting_325873chr3_179206759_+SINEAluAluJb
CAediting_325874chr3_179207649_+SINEAluAluSx1
CAediting_325875chr3_179207659_+SINEAluAluSx1
CAediting_325876chr3_179212422_+SINEAluAluSg
CAediting_325877chr3_179212462_+SINEAluAluSg
CAediting_325878chr3_179212703_+SINEAluAluJo
CAediting_325879chr3_179230506_+SINEAluAluJr
CAediting_325880chr3_179230633_+SINEAluAluJr
CAediting_325881chr3_179230669_+SINEAluAluJr
CAediting_325882chr3_179231746_+SINEAluAluSp
CAediting_325883chr3_179232906_+SINEAluAluSx
CAediting_325884chr3_179233139_+SINEAluAluSx

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RNA A-to-I editing events in the alternative splicing sites for PIK3CA

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000121879.3.PIK3CA.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000121879.3.PIK3CA.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PIK3CA

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for PIK3CA

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for PIK3CA

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_325886chr3_179234489_+ENSG00000121879.3ENST00000263967hsa-miR-3074-5p1792344851792344917mer-m8179234471179234492153.00-20.87
CAediting_325886chr3_179234489_+ENSG00000121879.3ENST00000263967hsa-miR-370-3p1792344831792344908mer-1a179234469179234490140.00-16.43
CAediting_325886chr3_179234489_+ENSG00000121879.3ENST00000263967hsa-miR-6893-3p1792344831792344908mer-1a179234467179234490142.00-14.90
CAediting_325887chr3_179234508_+ENSG00000121879.3ENST00000263967hsa-let-7f-2-3p1792345051792345128mer-1a179234491179234512160.00-8.84
CAediting_325887chr3_179234508_+ENSG00000121879.3ENST00000263967hsa-miR-1185-1-3p1792345051792345128mer-1a179234491179234512140.00-7.96
CAediting_325887chr3_179234508_+ENSG00000121879.3ENST00000263967hsa-miR-1185-2-3p1792345051792345128mer-1a179234491179234512140.00-9.77
CAediting_325887chr3_179234508_+ENSG00000121879.3ENST00000263967hsa-miR-144-3p1792345021792345098mer-1a179234490179234509140.00-12.04
CAediting_325887chr3_179234508_+ENSG00000121879.3ENST00000263967hsa-miR-16-1-3p1792345011792345077mer-m8179234482179234508149.00-18.45

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_325886chr3_179234489_+ENSG00000121879.3ENST00000263967hsa-miR-4677-5p1792344871792344937mer-m8179234473179234494140-11.3

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_748296chr10_51299626_+ENSG00000121879.3ENST00000263967hsa-miR-605-3p1792375521792375587mer-m8179237539179237559158-19.9
CAediting_393chr1_1167164_+ENSG00000121879.3ENST00000263967hsa-miR-200b-3p1792344681792344758mer-1a179234453179234475147-15.29
CAediting_393chr1_1167164_+ENSG00000121879.3ENST00000263967hsa-miR-200b-3p1792382371792382437mer-m8179238223179238244144-10.38
CAediting_688080chr9_63819626_+ENSG00000121879.3ENST00000263967hsa-miR-4477b1792382511792382577mer-m8179238238179238258150-16.16
CAediting_1160181chr17_7017644_-ENSG00000121879.3ENST00000263967hsa-miR-195-3p1792360531792360597mer-m8179236039179236060150-10.74
CAediting_1160181chr17_7017644_-ENSG00000121879.3ENST00000263967hsa-miR-195-3p1792368161792368238mer-1a179236799179236823153-13.88
CAediting_1351755chr19_40282625_-ENSG00000121879.3ENST00000263967hsa-miR-6411792355751792355828mer-1a179235559179235582140-10.81
CAediting_1351755chr19_40282625_-ENSG00000121879.3ENST00000263967hsa-miR-6411792357681792357758mer-1a179235752179235775158-13.73
CAediting_117844chr1_162342605_+ENSG00000121879.3ENST00000263967hsa-miR-556-3p1792386661792386727mer-m8179238652179238673150-8.56
CAediting_228905chr2_188297554_+ENSG00000121879.3ENST00000263967hsa-miR-561-3p1792363231792363297mer-m8179236307179236330166-18.44
CAediting_442554chr5_154685830_+ENSG00000121879.3ENST00000263967hsa-miR-13031792357351792357428mer-1a179235721179235742145-15.84
CAediting_442554chr5_154685830_+ENSG00000121879.3ENST00000263967hsa-miR-13031792357981792358047mer-m8179235783179235805159-17.77
CAediting_604450chr7_133034877_-ENSG00000121879.3ENST00000263967hsa-miR-36541792386481792386547mer-m8179238638179238655149-19.81

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393chr1_1167164_+ENSG00000121879.3ENST00000263967hsa-miR-200b-3p1792350651792350717mer-m8179235052179235072153-11.59
CAediting_393chr1_1167164_+ENSG00000121879.3ENST00000263967hsa-miR-200b-3p1792351831792351897mer-m8179235169179235190146-10.24
CAediting_688080chr9_63819626_+ENSG00000121879.3ENST00000263967hsa-miR-4477b1792356351792356428mer-1a179235622179235642147-8.57
CAediting_688081chr9_63819627_+ENSG00000121879.3ENST00000263967hsa-miR-4477b1792356351792356428mer-1a179235622179235642147-8.57
CAediting_396018chr5_1062918_-ENSG00000121879.3ENST00000263967hsa-miR-46351792385261792385327mer-m8179238513179238533145-10.68
CAediting_414656chr5_72878640_+ENSG00000121879.3ENST00000263967hsa-miR-4804-3p1792363091792363168mer-1a179236295179236316144-12.57
CAediting_228905chr2_188297554_+ENSG00000121879.3ENST00000263967hsa-miR-561-3p1792346241792346307mer-m8179234610179234631147-12.46
CAediting_1351755chr19_40282625_-ENSG00000121879.3ENST00000263967hsa-miR-6411792381351792381417mer-m8179238120179238142144-13.31
CAediting_468389chr6_31355314_-ENSG00000121879.3ENST00000263967hsa-miR-6891-5p1792365771792365837mer-m8179236566179236584140-13.88
CAediting_468389chr6_31355314_-ENSG00000121879.3ENST00000263967hsa-miR-6891-5p1792389441792389507mer-m8179238933179238951147-12.56

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for PIK3CA

check button - RNA A-to-I editing in mRNA.
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ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000263967.3protein_codingSoverviewSoverview

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
CAediting_325885ENST00000263967.3chr3_179234488_+-2149.70-2148.70-2151.20
CAediting_325886ENST00000263967.3chr3_179234489_+-2148.70-2148.70-2151.20
CAediting_325887ENST00000263967.3chr3_179234508_+-2151.20-2148.70-2151.20

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Relation with ADAR for PIK3CA

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for PIK3CA

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
STADpathologic_stageCAediting_325807chr3_179173458_+0.01796384334304010.299684226098272

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Relation with survival for PIK3CA

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for PIK3CA

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
PIK3CAP42336DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform SmallMoleculeDrugapproved
PIK3CAP42336DB12015AlpelisibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform SmallMoleculeDrugapproved|investigational
PIK3CAP42336DB12483CopanlisibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform SmallMoleculeDrugapproved|investigational

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RelatedDiseases for PIK3CA

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
PIK3CAC0006142Malignant neoplasm of breast9CGI;CTD_human;UNIPROT
PIK3CAC0678222Breast Carcinoma8CGI;CTD_human
PIK3CAC1257931Mammary Neoplasms, Human8CTD_human
PIK3CAC1458155Mammary Neoplasms8CTD_human
PIK3CAC4704874Mammary Carcinoma, Human8CTD_human
PIK3CAC1865285Megalencephaly cutis marmorata telangiectatica congenita5GENOMICS_ENGLAND;ORPHANET;UNIPROT
PIK3CAC2752042Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
PIK3CAC0009402Colorectal Carcinoma2CTD_human;UNIPROT
PIK3CAC0033578Prostatic Neoplasms2CTD_human
PIK3CAC0158570Vascular anomaly2GENOMICS_ENGLAND
PIK3CAC0265552Congenital macrodactylia2GENOMICS_ENGLAND;UNIPROT
PIK3CAC0376358Malignant neoplasm of prostate2CTD_human
PIK3CAC2751313CLAPO Syndrome2GENOMICS_ENGLAND;UNIPROT
PIK3CAC3554518COWDEN SYNDROME 52CTD_human;GENOMICS_ENGLAND;UNIPROT
PIK3CAC0001418Adenocarcinoma1CTD_human
PIK3CAC0007134Renal Cell Carcinoma1CTD_human
PIK3CAC0007137Squamous cell carcinoma1CTD_human
PIK3CAC0010606Adenoid Cystic Carcinoma1CTD_human
PIK3CAC0015923Fetal Alcohol Syndrome1PSYGENET
PIK3CAC0018273Growth Disorders1CTD_human
PIK3CAC0018553Hamartoma Syndrome, Multiple1ORPHANET
PIK3CAC0020507Hyperplasia1CTD_human
PIK3CAC0022603Seborrheic keratosis1CTD_human;UNIPROT
PIK3CAC0024623Malignant neoplasm of stomach1CGI;CTD_human
PIK3CAC0026640Mouth Neoplasms1CTD_human
PIK3CAC0027627Neoplasm Metastasis1CTD_human
PIK3CAC0030849Penile Neoplasms1CTD_human
PIK3CAC0036341Schizophrenia1PSYGENET
PIK3CAC0038356Stomach Neoplasms1CGI;CTD_human
PIK3CAC0043094Weight Gain1CTD_human
PIK3CAC0079744Diffuse Large B-Cell Lymphoma1CTD_human
PIK3CAC0152013Adenocarcinoma of lung (disorder)1CTD_human
PIK3CAC0152427Polydactyly1GENOMICS_ENGLAND
PIK3CAC0153381Malignant neoplasm of mouth1CTD_human
PIK3CAC0153601Malignant neoplasm of penis1CTD_human
PIK3CAC0205641Adenocarcinoma, Basal Cell1CTD_human
PIK3CAC0205642Adenocarcinoma, Oxyphilic1CTD_human
PIK3CAC0205643Carcinoma, Cribriform1CTD_human
PIK3CAC0205644Carcinoma, Granular Cell1CTD_human
PIK3CAC0205645Adenocarcinoma, Tubular1CTD_human
PIK3CAC0205944Sarcoma, Epithelioid1CTD_human
PIK3CAC0205945Sarcoma, Spindle Cell1CTD_human
PIK3CAC0235874Disease Exacerbation1CTD_human
PIK3CAC0242698Ventricular Dysfunction, Left1CTD_human
PIK3CAC0279607Adult Hepatocellular Carcinoma1ORPHANET
PIK3CAC0279628Adenocarcinoma Of Esophagus1CTD_human
PIK3CAC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
PIK3CAC0431380Cortical Dysplasia1CTD_human
PIK3CAC0431391Hemimegalencephaly1ORPHANET
PIK3CAC1112155Hereditary non-polyposis colorectal cancer syndrome1ORPHANET
PIK3CAC1140680Malignant neoplasm of ovary1CGI;CTD_human;UNIPROT
PIK3CAC1168401Squamous cell carcinoma of the head and neck1CTD_human
PIK3CAC1261473Sarcoma1CTD_human
PIK3CAC1266042Chromophobe Renal Cell Carcinoma1CTD_human
PIK3CAC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
PIK3CAC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
PIK3CAC1306837Papillary Renal Cell Carcinoma1CTD_human
PIK3CAC1333990Hereditary Nonpolyposis Colorectal Cancer1ORPHANET
PIK3CAC1368275Pigmented Basal Cell Carcinoma1CTD_human
PIK3CAC1708349Hereditary Diffuse Gastric Cancer1CTD_human
PIK3CAC1863924Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome1CTD_human
PIK3CAC1955869Malformations of Cortical Development1CTD_human
PIK3CAC2239176Liver carcinoma1CGI;CTD_human;UNIPROT
PIK3CAC2931822Nasopharyngeal carcinoma1CTD_human
PIK3CAC2985290Fetal Alcohol Spectrum Disorders1PSYGENET
PIK3CAC4721806Carcinoma, Basal Cell1CTD_human