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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: PFN2 (CAeditome ID:5217) |
Gene summary for PFN2 |
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Gene information | Gene symbol | PFN2 | Gene ID | 5217 |
Gene name | profilin 2 | |
Synonyms | D3S1319E|PFL | |
Cytomap | 3q25.1 | |
Type of gene | protein-coding | |
Description | profilin-2profilin II | |
Modification date | 20210531 | |
UniProtAcc | P35080 | |
Context |
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Gene | GO ID | GO term | PubMed ID |
PFN2 | GO:0005546 | Profilin-2 | 7758455 |
PFN2 | GO:0016887 | Profilin-2 | 7758455 |
PFN2 | GO:0030837 | Profilin-2 | 7758455 |
PFN2 | GO:0032781 | Profilin-2 | 7758455 |
PFN2 | GO:0050821 | Profilin-2 | 18573880 |
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RNA A-to-I events for PFN2 |
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CAediting_317107(149965302, -), CAediting_317108(149970768, -), CAediting_317109(150017558, -), CAediting_317110(150017630, -), CAediting_317111(150017656, -), CAediting_317112(150017665, -), CAediting_317113(150017685, -), CAediting_317114(150017695, -), CAediting_317115(150017724, -), CAediting_317116(150017762, -), CAediting_317117(150017763, -), CAediting_317118(150021060, -), CAediting_317119(150021073, -), CAediting_317120(150021112, -), |
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RNA editing positional annotations for PFN2 using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
CAediting_317107 | chr3_149965302_- | nonsynonymous SNV | ENST00000423691.2 | c.A456G | p.I152M | D | P | N |
CAediting_317108 | chr3_149970768_- | nonsynonymous SNV | ENST00000239940.10 | c.A89G | p.Y30C | T | D | D |
CAediting_317108 | chr3_149970768_- | nonsynonymous SNV | ENST00000423691.2 | c.A89G | p.Y30C | T | D | D |
CAediting_317108 | chr3_149970768_- | nonsynonymous SNV | ENST00000452853.5 | c.A89G | p.Y30C | T | D | D |
CAediting_317108 | chr3_149970768_- | nonsynonymous SNV | ENST00000460404.4 | c.A89G | p.Y30C | T | D | D |
CAediting_317108 | chr3_149970768_- | nonsynonymous SNV | ENST00000461868.1 | c.A89G | p.Y30C | T | D | D |
CAediting_317108 | chr3_149970768_- | nonsynonymous SNV | ENST00000461930.1 | c.A89G | p.Y30C | T | D | D |
CAediting_317108 | chr3_149970768_- | nonsynonymous SNV | ENST00000468323.4 | c.A89G | p.Y30C | T | D | D |
CAediting_317108 | chr3_149970768_- | nonsynonymous SNV | ENST00000490975.1 | c.A89G | p.Y30C | T | D | D |
CAediting_317108 | chr3_149970768_- | nonsynonymous SNV | ENST00000498169.1 | c.A89G | p.Y30C | T | D | D |
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CAeditome ID | Position | Variant type |
CAediting_317107 | chr3_149965302_- | exonic |
CAediting_317108 | chr3_149970768_- | exonic |
CAediting_317109 | chr3_150017558_- | intronic |
CAediting_317110 | chr3_150017630_- | intronic |
CAediting_317111 | chr3_150017656_- | intronic |
CAediting_317112 | chr3_150017665_- | intronic |
CAediting_317113 | chr3_150017685_- | intronic |
CAediting_317114 | chr3_150017695_- | intronic |
CAediting_317115 | chr3_150017724_- | intronic |
CAediting_317116 | chr3_150017762_- | intronic |
CAediting_317117 | chr3_150017763_- | intronic |
CAediting_317118 | chr3_150021060_- | intronic |
CAediting_317119 | chr3_150021073_- | intronic |
CAediting_317120 | chr3_150021112_- | intronic |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
CAediting_317109 | chr3_150017558_- | SINE | Alu | AluSc |
CAediting_317110 | chr3_150017630_- | SINE | Alu | AluSc |
CAediting_317111 | chr3_150017656_- | SINE | Alu | AluSc |
CAediting_317112 | chr3_150017665_- | SINE | Alu | AluSc |
CAediting_317113 | chr3_150017685_- | SINE | Alu | AluSc |
CAediting_317114 | chr3_150017695_- | SINE | Alu | AluSc |
CAediting_317115 | chr3_150017724_- | SINE | Alu | AluSc |
CAediting_317116 | chr3_150017762_- | SINE | Alu | AluSc |
CAediting_317117 | chr3_150017763_- | SINE | Alu | AluSc |
CAediting_317118 | chr3_150021060_- | SINE | Alu | AluSz |
CAediting_317119 | chr3_150021073_- | SINE | Alu | AluSz |
CAediting_317120 | chr3_150021112_- | SINE | Alu | AluSz |
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RNA A-to-I editing events in the alternative splicing sites for PFN2 |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PFN2 |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for PFN2 |
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The effects of the RNA editing to the miRNA binding sites for PFN2 |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_317107 | chr3_149965302_- | ENSG00000070087.12 | ENST00000452853 | hsa-miR-8060 | 149965302 | 149965308 | 7mer-m8 | 149965301 | 149965323 | 154.00 | -20.43 |
CAediting_317107 | chr3_149965302_- | ENSG00000070087.12 | ENST00000239940 | hsa-miR-8060 | 149965302 | 149965308 | 7mer-m8 | 149965301 | 149965323 | 154.00 | -20.43 |
CAediting_317107 | chr3_149965302_- | ENSG00000070087.12 | ENST00000481767 | hsa-miR-8060 | 149965302 | 149965308 | 7mer-m8 | 149965301 | 149965323 | 154.00 | -20.43 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_317107 | chr3_149965302_- | ENSG00000070087.12 | ENST00000452853 | hsa-miR-202-5p | 149965299 | 149965305 | 7mer-m8 | 149965298 | 149965318 | 145 | -10.18 |
CAediting_317107 | chr3_149965302_- | ENSG00000070087.12 | ENST00000239940 | hsa-miR-202-5p | 149965299 | 149965305 | 7mer-m8 | 149965298 | 149965318 | 145 | -10.18 |
CAediting_317107 | chr3_149965302_- | ENSG00000070087.12 | ENST00000481767 | hsa-miR-202-5p | 149965299 | 149965305 | 7mer-m8 | 149965298 | 149965318 | 145 | -10.18 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_748296 | chr10_51299626_+ | ENSG00000070087.12 | ENST00000239940 | hsa-miR-605-3p | 149966317 | 149966323 | 7mer-m8 | 149966316 | 149966337 | 152 | -17.17 |
CAediting_393 | chr1_1167164_+ | ENSG00000070087.12 | ENST00000239940 | hsa-miR-200b-3p | 149966261 | 149966267 | 7mer-m8 | 149966260 | 149966280 | 143 | -11.42 |
CAediting_748296 | chr10_51299626_+ | ENSG00000070087.12 | ENST00000490975 | hsa-miR-605-3p | 149966317 | 149966323 | 7mer-m8 | 149966316 | 149966337 | 152 | -17.17 |
CAediting_393 | chr1_1167164_+ | ENSG00000070087.12 | ENST00000490975 | hsa-miR-200b-3p | 149966261 | 149966267 | 7mer-m8 | 149966260 | 149966280 | 143 | -11.42 |
CAediting_748296 | chr10_51299626_+ | ENSG00000070087.12 | ENST00000497148 | hsa-miR-605-3p | 149966317 | 149966323 | 7mer-m8 | 149966316 | 149966337 | 152 | -17.17 |
CAediting_393 | chr1_1167164_+ | ENSG00000070087.12 | ENST00000497148 | hsa-miR-200b-3p | 149966261 | 149966267 | 7mer-m8 | 149966260 | 149966280 | 143 | -11.42 |
CAediting_748296 | chr10_51299626_+ | ENSG00000070087.12 | ENST00000498169 | hsa-miR-605-3p | 149966317 | 149966323 | 7mer-m8 | 149966316 | 149966337 | 152 | -17.17 |
CAediting_393 | chr1_1167164_+ | ENSG00000070087.12 | ENST00000498169 | hsa-miR-200b-3p | 149966261 | 149966267 | 7mer-m8 | 149966260 | 149966280 | 143 | -11.42 |
CAediting_748296 | chr10_51299626_+ | ENSG00000070087.12 | ENST00000475518 | hsa-miR-605-3p | 149966317 | 149966323 | 7mer-m8 | 149966316 | 149966337 | 152 | -17.17 |
CAediting_393 | chr1_1167164_+ | ENSG00000070087.12 | ENST00000475518 | hsa-miR-200b-3p | 149966261 | 149966267 | 7mer-m8 | 149966260 | 149966280 | 143 | -11.42 |
CAediting_748296 | chr10_51299626_+ | ENSG00000070087.12 | ENST00000481275 | hsa-miR-605-3p | 149966317 | 149966323 | 7mer-m8 | 149966316 | 149966337 | 152 | -17.17 |
CAediting_748296 | chr10_51299626_+ | ENSG00000070087.12 | ENST00000498307 | hsa-miR-605-3p | 149966317 | 149966323 | 7mer-m8 | 149966316 | 149966337 | 152 | -17.17 |
CAediting_748296 | chr10_51299626_+ | ENSG00000070087.12 | ENST00000489155 | hsa-miR-605-3p | 149966317 | 149966323 | 7mer-m8 | 149966316 | 149966337 | 152 | -17.17 |
CAediting_1368054 | chr19_46709310_- | ENSG00000070087.12 | ENST00000452853 | hsa-miR-320e | 149965392 | 149965398 | 7mer-m8 | 149965391 | 149965408 | 152 | -19.1 |
CAediting_1351755 | chr19_40282625_- | ENSG00000070087.12 | ENST00000239940 | hsa-miR-641 | 149966365 | 149966370 | 6mer | 149966364 | 149966387 | 145 | -22.78 |
CAediting_1368054 | chr19_46709310_- | ENSG00000070087.12 | ENST00000239940 | hsa-miR-320e | 149965392 | 149965398 | 7mer-m8 | 149965391 | 149965408 | 152 | -19.1 |
CAediting_1368054 | chr19_46709310_- | ENSG00000070087.12 | ENST00000481767 | hsa-miR-320e | 149965392 | 149965398 | 7mer-m8 | 149965391 | 149965408 | 152 | -19.1 |
CAediting_1351755 | chr19_40282625_- | ENSG00000070087.12 | ENST00000490975 | hsa-miR-641 | 149966365 | 149966370 | 6mer | 149966364 | 149966387 | 145 | -22.78 |
CAediting_1351755 | chr19_40282625_- | ENSG00000070087.12 | ENST00000497148 | hsa-miR-641 | 149966365 | 149966370 | 6mer | 149966364 | 149966387 | 145 | -22.78 |
CAediting_1351755 | chr19_40282625_- | ENSG00000070087.12 | ENST00000498169 | hsa-miR-641 | 149966365 | 149966370 | 6mer | 149966364 | 149966387 | 145 | -22.78 |
CAediting_1351755 | chr19_40282625_- | ENSG00000070087.12 | ENST00000475518 | hsa-miR-641 | 149966365 | 149966370 | 6mer | 149966364 | 149966387 | 145 | -22.78 |
CAediting_1351755 | chr19_40282625_- | ENSG00000070087.12 | ENST00000481275 | hsa-miR-641 | 149966365 | 149966370 | 6mer | 149966364 | 149966387 | 145 | -22.78 |
CAediting_1351755 | chr19_40282625_- | ENSG00000070087.12 | ENST00000498307 | hsa-miR-641 | 149966365 | 149966370 | 6mer | 149966364 | 149966387 | 145 | -22.78 |
CAediting_1351755 | chr19_40282625_- | ENSG00000070087.12 | ENST00000489155 | hsa-miR-641 | 149966365 | 149966370 | 6mer | 149966364 | 149966387 | 145 | -22.78 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_604450 | chr7_133034877_- | ENSG00000070087.12 | ENST00000239940 | hsa-miR-3654 | 149965314 | 149965320 | 7mer-m8 | 149965313 | 149965331 | 153 | -19.56 |
CAediting_1351755 | chr19_40282625_- | ENSG00000070087.12 | ENST00000239940 | hsa-miR-641 | 149965822 | 149965827 | 6mer | 149965821 | 149965844 | 145 | -17.37 |
CAediting_1229413 | chr17_67471544_+ | ENSG00000070087.12 | ENST00000461930 | hsa-miR-548aa | 149968246 | 149968252 | 7mer-m8 | 149968245 | 149968274 | 153 | -14.29 |
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The effects of the RNA editing to the stability of the RNA structures for PFN2 |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
CAediting_317107 | ENST00000239940.10 | chr3_149965302_- | -688.30 | -683.80 | -691.70 |
CAediting_317108 | ENST00000239940.10 | chr3_149970768_- | -687.20 | -683.80 | -691.70 |
CAediting_317107 | ENST00000423691.2 | chr3_149965302_- | -271.90 | -272.60 | -275.30 |
CAediting_317108 | ENST00000423691.2 | chr3_149970768_- | -276.00 | -272.60 | -275.30 |
CAediting_317107 | ENST00000452853.5 | chr3_149965302_- | -498.30 | -493.70 | -501.70 |
CAediting_317108 | ENST00000452853.5 | chr3_149970768_- | -497.10 | -493.70 | -501.70 |
CAediting_317107 | ENST00000481767.4 | chr3_149965302_- | -455.90 | -450.80 | -455.90 |
CAediting_317108 | ENST00000460404.4 | chr3_149970768_- | -291.70 | -288.30 | -291.70 |
CAediting_317108 | ENST00000461868.1 | chr3_149970768_- | -202.40 | -199.00 | -202.40 |
CAediting_317108 | ENST00000461930.1 | chr3_149970768_- | -191.20 | -189.20 | -191.20 |
CAediting_317108 | ENST00000468323.4 | chr3_149970768_- | -275.80 | -273.90 | -275.80 |
CAediting_317108 | ENST00000490975.1 | chr3_149970768_- | -276.90 | -273.50 | -276.90 |
CAediting_317108 | ENST00000498169.1 | chr3_149970768_- | -219.40 | -216.70 | -219.40 |
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Relation with ADAR for PFN2 |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for PFN2 |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for PFN2 |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for PFN2 |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PFN2 |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |