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Editing gene: PFAS (CAeditome ID:5198)

Gene summary for PFAS

Gene summary

Gene information	Gene symbol	PFAS
	Gene ID	5198
	Gene name	phosphoribosylformylglycinamidine synthase
	Synonyms	FGAMS\|FGAR-AT\|FGARAT\|GATD8\|PURL
	Cytomap	17p13.1
	Type of gene	protein-coding
	Description	phosphoribosylformylglycinamidine synthaseFGAM synthaseFGAR amidotransferaseIKZF1/PFAS fusionformylglycinamide ribonucleotide amidotransferaseformylglycinamide ribotide amidotransferaseformylglycinamide ribotide synthetase
	Modification date	20210518
	UniProtAcc	O15067
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
PFAS	GO:0004642	Phosphoribosylformylglycinamidine synthase	10548741

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RNA A-to-I events for PFAS

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000178921.12

RNA A-to-I editing events in Cancer.

CAediting_1161895(8254593, +), CAediting_1161896(8260764, +), CAediting_1161897(8260774, +), CAediting_1161898(8269899, +), CAediting_1161899(8269903, +), CAediting_1161900(8269909, +), CAediting_1161901(8269917, +), CAediting_1161902(8269921, +), CAediting_1161903(8269931, +), CAediting_1161904(8269952, +), CAediting_1161905(8269957, +), CAediting_1161906(8269958, +), CAediting_1161907(8269977, +), CAediting_1161908(8269978, +), CAediting_1161909(8269982, +), CAediting_1161910(8269995, +), CAediting_1161911(8270004, +), CAediting_1161912(8270007, +), CAediting_1161913(8270014, +), CAediting_1161914(8270017, +), CAediting_1161915(8270019, +), CAediting_1161916(8270023, +), CAediting_1161917(8270025, +), CAediting_1161918(8270033, +), CAediting_1161919(8270035, +), CAediting_1161920(8270039, +), CAediting_1161921(8270058, +), CAediting_1161922(8270061, +), CAediting_1161923(8270067, +), CAediting_1161924(8270087, +), CAediting_1161925(8270098, +), CAediting_1161926(8270099, +), CAediting_1161927(8270106, +), CAediting_1161928(8270107, +), CAediting_1161929(8270112, +), CAediting_1161930(8270113, +), CAediting_1161931(8270138, +), CAediting_1161932(8270139, +), CAediting_1161933(8270140, +), CAediting_1161934(8270152, +), CAediting_1161935(8270154, +), CAediting_1161936(8270161, +),

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RNA editing positional annotations for PFAS using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1161895	chr17_8254593_+	intronic
CAediting_1161896	chr17_8260764_+	intronic
CAediting_1161897	chr17_8260774_+	intronic
CAediting_1161898	chr17_8269899_+	UTR3
CAediting_1161899	chr17_8269903_+	UTR3
CAediting_1161900	chr17_8269909_+	UTR3
CAediting_1161901	chr17_8269917_+	UTR3
CAediting_1161902	chr17_8269921_+	UTR3
CAediting_1161903	chr17_8269931_+	UTR3
CAediting_1161904	chr17_8269952_+	UTR3
CAediting_1161905	chr17_8269957_+	UTR3
CAediting_1161906	chr17_8269958_+	UTR3
CAediting_1161907	chr17_8269977_+	UTR3
CAediting_1161908	chr17_8269978_+	UTR3
CAediting_1161909	chr17_8269982_+	UTR3
CAediting_1161910	chr17_8269995_+	UTR3
CAediting_1161911	chr17_8270004_+	UTR3
CAediting_1161912	chr17_8270007_+	UTR3
CAediting_1161913	chr17_8270014_+	UTR3
CAediting_1161914	chr17_8270017_+	UTR3
CAediting_1161915	chr17_8270019_+	UTR3
CAediting_1161916	chr17_8270023_+	UTR3
CAediting_1161917	chr17_8270025_+	UTR3
CAediting_1161918	chr17_8270033_+	UTR3
CAediting_1161919	chr17_8270035_+	UTR3
CAediting_1161920	chr17_8270039_+	UTR3
CAediting_1161921	chr17_8270058_+	UTR3
CAediting_1161922	chr17_8270061_+	UTR3
CAediting_1161923	chr17_8270067_+	UTR3
CAediting_1161924	chr17_8270087_+	UTR3
CAediting_1161925	chr17_8270098_+	UTR3
CAediting_1161926	chr17_8270099_+	UTR3
CAediting_1161927	chr17_8270106_+	UTR3
CAediting_1161928	chr17_8270107_+	UTR3
CAediting_1161929	chr17_8270112_+	UTR3
CAediting_1161930	chr17_8270113_+	UTR3
CAediting_1161931	chr17_8270138_+	UTR3
CAediting_1161932	chr17_8270139_+	UTR3
CAediting_1161933	chr17_8270140_+	UTR3
CAediting_1161934	chr17_8270152_+	UTR3
CAediting_1161935	chr17_8270154_+	UTR3
CAediting_1161936	chr17_8270161_+	UTR3

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1161895	chr17_8254593_+	SINE	Alu	AluY
CAediting_1161896	chr17_8260764_+	SINE	Alu	AluY
CAediting_1161897	chr17_8260774_+	SINE	Alu	AluY
CAediting_1161898	chr17_8269899_+	SINE	Alu	AluSz
CAediting_1161899	chr17_8269903_+	SINE	Alu	AluSz
CAediting_1161900	chr17_8269909_+	SINE	Alu	AluSz
CAediting_1161901	chr17_8269917_+	SINE	Alu	AluSz
CAediting_1161902	chr17_8269921_+	SINE	Alu	AluSz
CAediting_1161903	chr17_8269931_+	SINE	Alu	AluSz
CAediting_1161904	chr17_8269952_+	SINE	Alu	AluSz
CAediting_1161905	chr17_8269957_+	SINE	Alu	AluSz
CAediting_1161906	chr17_8269958_+	SINE	Alu	AluSz
CAediting_1161907	chr17_8269977_+	SINE	Alu	AluSz
CAediting_1161908	chr17_8269978_+	SINE	Alu	AluSz
CAediting_1161909	chr17_8269982_+	SINE	Alu	AluSz
CAediting_1161910	chr17_8269995_+	SINE	Alu	AluSz
CAediting_1161911	chr17_8270004_+	SINE	Alu	AluSz
CAediting_1161912	chr17_8270007_+	SINE	Alu	AluSz
CAediting_1161913	chr17_8270014_+	SINE	Alu	AluSz
CAediting_1161914	chr17_8270017_+	SINE	Alu	AluSz
CAediting_1161915	chr17_8270019_+	SINE	Alu	AluSz
CAediting_1161916	chr17_8270023_+	SINE	Alu	AluSz
CAediting_1161917	chr17_8270025_+	SINE	Alu	AluSz
CAediting_1161918	chr17_8270033_+	SINE	Alu	AluSz
CAediting_1161919	chr17_8270035_+	SINE	Alu	AluSz
CAediting_1161920	chr17_8270039_+	SINE	Alu	AluSz
CAediting_1161921	chr17_8270058_+	SINE	Alu	AluSz
CAediting_1161922	chr17_8270061_+	SINE	Alu	AluSz
CAediting_1161923	chr17_8270067_+	SINE	Alu	AluSz
CAediting_1161924	chr17_8270087_+	SINE	Alu	AluSz
CAediting_1161925	chr17_8270098_+	SINE	Alu	AluSz
CAediting_1161926	chr17_8270099_+	SINE	Alu	AluSz
CAediting_1161927	chr17_8270106_+	SINE	Alu	AluSz
CAediting_1161928	chr17_8270107_+	SINE	Alu	AluSz
CAediting_1161929	chr17_8270112_+	SINE	Alu	AluSz
CAediting_1161930	chr17_8270113_+	SINE	Alu	AluSz
CAediting_1161931	chr17_8270138_+	SINE	Alu	AluSz
CAediting_1161932	chr17_8270139_+	SINE	Alu	AluSz
CAediting_1161933	chr17_8270140_+	SINE	Alu	AluSz
CAediting_1161934	chr17_8270152_+	SINE	Alu	AluSz
CAediting_1161935	chr17_8270154_+	SINE	Alu	AluSz
CAediting_1161936	chr17_8270161_+	SINE	Alu	AluSz

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RNA A-to-I editing events in the alternative splicing sites for PFAS

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000178921.12.PFAS.

Correlation between RNA A-to-I editing and PSI for ENSG00000178921.12.PFAS.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PFAS

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

OV.CAediting_1161908.ENSG00000178921.PFAS.png
Soverview

OV.CAediting_1161923.ENSG00000178921.PFAS.png
Soverview

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Protein coding region RNA A-to-I editings for PFAS

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for PFAS

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1161901	chr17_8269917_+	ENSG00000178921.12	ENST00000546020	hsa-miR-1285-3p	8269916	8269921	6mer	8269901	8269922	160.00	-31.86
CAediting_1161901	chr17_8269917_+	ENSG00000178921.12	ENST00000546020	hsa-miR-1285-3p	8269916	8269921	6mer	8269901	8269922	160.00	-31.86
CAediting_1161901	chr17_8269917_+	ENSG00000178921.12	ENST00000546020	hsa-miR-196b-3p	8269911	8269916	6mer	8269896	8269917	144.00	-24.30
CAediting_1161901	chr17_8269917_+	ENSG00000178921.12	ENST00000546020	hsa-miR-4486	8269915	8269921	7mer-m8	8269904	8269922	146.00	-18.47
CAediting_1161906	chr17_8269958_+	ENSG00000178921.12	ENST00000546020	hsa-miR-17-3p	8269951	8269957	7mer-m8	8269939	8269958	147.00	-18.05
CAediting_1161906	chr17_8269958_+	ENSG00000178921.12	ENST00000546020	hsa-miR-485-5p	8269955	8269961	7mer-m8	8269942	8269962	148.00	-21.49
CAediting_1161906	chr17_8269958_+	ENSG00000178921.12	ENST00000546020	hsa-miR-6884-5p	8269955	8269961	7mer-m8	8269939	8269962	150.00	-22.30
CAediting_1161909	chr17_8269982_+	ENSG00000178921.12	ENST00000546020	hsa-miR-548a-3p	8269979	8269985	7mer-m8	8269965	8269986	140.00	-8.35
CAediting_1161909	chr17_8269982_+	ENSG00000178921.12	ENST00000546020	hsa-miR-548a-3p	8269979	8269985	7mer-m8	8269965	8269986	140.00	-8.35
CAediting_1161909	chr17_8269982_+	ENSG00000178921.12	ENST00000546020	hsa-miR-548a-3p	8269979	8269985	7mer-m8	8269965	8269986	140.00	-8.35
CAediting_1161909	chr17_8269982_+	ENSG00000178921.12	ENST00000546020	hsa-miR-548ar-3p	8269979	8269985	7mer-m8	8269966	8269986	145.00	-9.72
CAediting_1161909	chr17_8269982_+	ENSG00000178921.12	ENST00000546020	hsa-miR-548av-3p	8269978	8269984	7mer-m8	8269966	8269985	140.00	-12.21
CAediting_1161909	chr17_8269982_+	ENSG00000178921.12	ENST00000546020	hsa-miR-548az-3p	8269979	8269985	7mer-m8	8269966	8269986	145.00	-11.29
CAediting_1161909	chr17_8269982_+	ENSG00000178921.12	ENST00000546020	hsa-miR-548bc	8269979	8269985	7mer-m8	8269964	8269986	142.00	-11.31
CAediting_1161909	chr17_8269982_+	ENSG00000178921.12	ENST00000546020	hsa-miR-548e-3p	8269979	8269985	7mer-m8	8269965	8269986	140.00	-10.38
CAediting_1161909	chr17_8269982_+	ENSG00000178921.12	ENST00000546020	hsa-miR-548f-3p	8269979	8269985	7mer-m8	8269968	8269986	141.00	-8.52
CAediting_1161909	chr17_8269982_+	ENSG00000178921.12	ENST00000546020	hsa-miR-548f-3p	8269979	8269985	7mer-m8	8269968	8269986	141.00	-8.52
CAediting_1161909	chr17_8269982_+	ENSG00000178921.12	ENST00000546020	hsa-miR-548f-3p	8269979	8269985	7mer-m8	8269968	8269986	141.00	-8.52
CAediting_1161909	chr17_8269982_+	ENSG00000178921.12	ENST00000546020	hsa-miR-548f-3p	8269979	8269985	7mer-m8	8269968	8269986	141.00	-8.52
CAediting_1161909	chr17_8269982_+	ENSG00000178921.12	ENST00000546020	hsa-miR-548f-3p	8269979	8269985	7mer-m8	8269968	8269986	141.00	-8.52
CAediting_1161912	chr17_8270007_+	ENSG00000178921.12	ENST00000546020	hsa-miR-4691-3p	8270004	8270010	7mer-m8	8269984	8270011	150.00	-26.36
CAediting_1161933	chr17_8270140_+	ENSG00000178921.12	ENST00000546020	hsa-miR-3189-3p	8270134	8270140	7mer-m8	8270122	8270141	145.00	-25.82
CAediting_1161933	chr17_8270140_+	ENSG00000178921.12	ENST00000546020	hsa-miR-6813-3p	8270135	8270141	7mer-m8	8270122	8270142	140.00	-12.15
CAediting_1161934	chr17_8270152_+	ENSG00000178921.12	ENST00000546020	hsa-miR-106a-3p	8270148	8270153	6mer	8270133	8270154	141.00	-21.13
CAediting_1161898	chr17_8269899_+	ENSG00000178921.12	ENST00000546020	hsa-miR-1913	8269897	8269903	7mer-m8	8269883	8269904	140.00	-14.92
CAediting_1161898	chr17_8269899_+	ENSG00000178921.12	ENST00000546020	hsa-miR-5699-5p	8269895	8269902	8mer-1a	8269881	8269902	168.00	-20.89
CAediting_1161902	chr17_8269921_+	ENSG00000178921.12	ENST00000546020	hsa-miR-3940-3p	8269918	8269924	7mer-m8	8269904	8269925	151.00	-22.47
CAediting_1161903	chr17_8269931_+	ENSG00000178921.12	ENST00000546020	hsa-miR-25-3p	8269928	8269934	7mer-m8	8269912	8269935	161.00	-25.27
CAediting_1161903	chr17_8269931_+	ENSG00000178921.12	ENST00000546020	hsa-miR-32-5p	8269928	8269934	7mer-m8	8269913	8269935	147.00	-12.53
CAediting_1161903	chr17_8269931_+	ENSG00000178921.12	ENST00000546020	hsa-miR-363-3p	8269928	8269934	7mer-m8	8269914	8269935	147.00	-16.12
CAediting_1161903	chr17_8269931_+	ENSG00000178921.12	ENST00000546020	hsa-miR-367-3p	8269928	8269934	7mer-m8	8269914	8269935	168.00	-26.49
CAediting_1161903	chr17_8269931_+	ENSG00000178921.12	ENST00000546020	hsa-miR-7703	8269926	8269933	8mer-1a	8269911	8269933	162.00	-25.75
CAediting_1161903	chr17_8269931_+	ENSG00000178921.12	ENST00000546020	hsa-miR-92a-3p	8269928	8269934	7mer-m8	8269918	8269935	155.00	-26.92
CAediting_1161903	chr17_8269931_+	ENSG00000178921.12	ENST00000546020	hsa-miR-92a-3p	8269928	8269934	7mer-m8	8269918	8269935	155.00	-26.92
CAediting_1161903	chr17_8269931_+	ENSG00000178921.12	ENST00000546020	hsa-miR-92b-3p	8269928	8269934	7mer-m8	8269913	8269935	156.00	-23.65
CAediting_1161911	chr17_8270004_+	ENSG00000178921.12	ENST00000546020	hsa-miR-1247-3p	8269998	8270004	7mer-m8	8269983	8270005	160.00	-24.83
CAediting_1161913	chr17_8270014_+	ENSG00000178921.12	ENST00000546020	hsa-miR-361-3p	8270008	8270014	7mer-m8	8269989	8270015	147.00	-21.86
CAediting_1161913	chr17_8270014_+	ENSG00000178921.12	ENST00000546020	hsa-miR-6798-3p	8270010	8270016	7mer-m8	8269997	8270017	140.00	-12.47
CAediting_1161914	chr17_8270017_+	ENSG00000178921.12	ENST00000546020	hsa-miR-4793-3p	8270013	8270019	7mer-m8	8269998	8270020	157.00	-26.00
CAediting_1161914	chr17_8270017_+	ENSG00000178921.12	ENST00000546020	hsa-miR-7703	8270012	8270018	7mer-m8	8269997	8270019	158.00	-20.76
CAediting_1161916	chr17_8270023_+	ENSG00000178921.12	ENST00000546020	hsa-miR-6720-3p	8270017	8270024	8mer-1a	8270003	8270024	144.00	-18.25
CAediting_1161918	chr17_8270033_+	ENSG00000178921.12	ENST00000546020	hsa-miR-4466	8270030	8270036	7mer-m8	8270020	8270037	140.00	-22.11
CAediting_1161918	chr17_8270033_+	ENSG00000178921.12	ENST00000546020	hsa-miR-675-5p	8270030	8270036	7mer-m8	8270015	8270037	142.00	-18.42
CAediting_1161919	chr17_8270035_+	ENSG00000178921.12	ENST00000546020	hsa-miR-4486	8270033	8270039	7mer-m8	8270025	8270040	153.00	-26.36
CAediting_1161924	chr17_8270087_+	ENSG00000178921.12	ENST00000546020	hsa-miR-1247-3p	8270082	8270088	7mer-m8	8270065	8270089	156.00	-24.10
CAediting_1161924	chr17_8270087_+	ENSG00000178921.12	ENST00000546020	hsa-miR-3940-3p	8270084	8270090	7mer-m8	8270070	8270091	140.00	-18.92
CAediting_1161924	chr17_8270087_+	ENSG00000178921.12	ENST00000546020	hsa-miR-6746-5p	8270080	8270086	7mer-m8	8270064	8270087	150.00	-30.67
CAediting_1161927	chr17_8270106_+	ENSG00000178921.12	ENST00000546020	hsa-miR-4433a-3p	8270099	8270106	8mer-1a	8270085	8270106	146.00	-21.16
CAediting_1161928	chr17_8270107_+	ENSG00000178921.12	ENST00000546020	hsa-miR-3975	8270104	8270111	8mer-1a	8270090	8270111	140.00	-12.68
CAediting_1161928	chr17_8270107_+	ENSG00000178921.12	ENST00000546020	hsa-miR-6069	8270102	8270108	7mer-m8	8270088	8270109	145.00	-18.18
CAediting_1161930	chr17_8270113_+	ENSG00000178921.12	ENST00000546020	hsa-miR-3622a-3p	8270109	8270116	8mer-1a	8270095	8270116	140.00	-12.75
CAediting_1161930	chr17_8270113_+	ENSG00000178921.12	ENST00000546020	hsa-miR-3622b-3p	8270109	8270116	8mer-1a	8270096	8270116	147.00	-16.66
CAediting_1161930	chr17_8270113_+	ENSG00000178921.12	ENST00000546020	hsa-miR-544b	8270107	8270113	7mer-m8	8270093	8270114	162.00	-19.42
CAediting_1161930	chr17_8270113_+	ENSG00000178921.12	ENST00000546020	hsa-miR-7162-3p	8270106	8270112	7mer-m8	8270093	8270113	142.00	-15.93
CAediting_1161932	chr17_8270139_+	ENSG00000178921.12	ENST00000546020	hsa-miR-326	8270134	8270140	7mer-m8	8270122	8270141	140.00	-14.60
CAediting_1161932	chr17_8270139_+	ENSG00000178921.12	ENST00000546020	hsa-miR-330-5p	8270134	8270140	7mer-m8	8270120	8270141	140.00	-22.38
CAediting_1161932	chr17_8270139_+	ENSG00000178921.12	ENST00000546020	hsa-miR-4314	8270133	8270139	7mer-m8	8270123	8270140	140.00	-21.61
CAediting_1161932	chr17_8270139_+	ENSG00000178921.12	ENST00000546020	hsa-miR-514a-5p	8270135	8270141	7mer-m8	8270119	8270142	146.00	-18.62
CAediting_1161932	chr17_8270139_+	ENSG00000178921.12	ENST00000546020	hsa-miR-514a-5p	8270135	8270141	7mer-m8	8270119	8270142	146.00	-18.62
CAediting_1161932	chr17_8270139_+	ENSG00000178921.12	ENST00000546020	hsa-miR-514a-5p	8270135	8270141	7mer-m8	8270119	8270142	146.00	-18.62
CAediting_1161935	chr17_8270154_+	ENSG00000178921.12	ENST00000546020	hsa-miR-100-5p	8270150	8270156	7mer-m8	8270135	8270157	162.00	-22.89
CAediting_1161935	chr17_8270154_+	ENSG00000178921.12	ENST00000546020	hsa-miR-99a-5p	8270150	8270156	7mer-m8	8270134	8270157	155.00	-21.46
CAediting_1161935	chr17_8270154_+	ENSG00000178921.12	ENST00000546020	hsa-miR-99b-5p	8270150	8270156	7mer-m8	8270134	8270157	155.00	-25.13
CAediting_1161936	chr17_8270161_+	ENSG00000178921.12	ENST00000546020	hsa-miR-328-3p	8270159	8270164	6mer	8270143	8270165	143.00	-25.35
CAediting_1161936	chr17_8270161_+	ENSG00000178921.12	ENST00000546020	hsa-miR-663b	8270159	8270165	7mer-m8	8270149	8270166	145.00	-25.06
CAediting_1161926	chr17_8270099_+	ENSG00000178921.12	ENST00000546020	hsa-miR-12119	8270094	8270099	6mer	8270073	8270100	145.00	-20.91
CAediting_1161926	chr17_8270099_+	ENSG00000178921.12	ENST00000546020	hsa-miR-4294	8270097	8270103	7mer-m8	8270087	8270104	150.00	-18.29
CAediting_1161926	chr17_8270099_+	ENSG00000178921.12	ENST00000546020	hsa-miR-4329	8270092	8270099	8mer-1a	8270081	8270099	145.00	-14.90
CAediting_1161931	chr17_8270138_+	ENSG00000178921.12	ENST00000546020	hsa-miR-6771-5p	8270132	8270139	8mer-1a	8270120	8270139	157.00	-31.04

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1161936	chr17_8270161_+	ENSG00000178921.12	ENST00000546020	hsa-miR-10398-5p	8270157	8270164	8mer-1a	8270144	8270164	150	-22.57
CAediting_1161927	chr17_8270106_+	ENSG00000178921.12	ENST00000546020	hsa-miR-1258	8270101	8270107	7mer-m8	8270085	8270108	146	-13.38
CAediting_1161928	chr17_8270107_+	ENSG00000178921.12	ENST00000546020	hsa-miR-1258	8270101	8270107	7mer-m8	8270085	8270108	146	-13.38
CAediting_1161936	chr17_8270161_+	ENSG00000178921.12	ENST00000546020	hsa-miR-1260a	8270154	8270160	7mer-m8	8270144	8270161	148	-18.76
CAediting_1161936	chr17_8270161_+	ENSG00000178921.12	ENST00000546020	hsa-miR-1260b	8270154	8270160	7mer-m8	8270140	8270161	144	-16.78
CAediting_1161901	chr17_8269917_+	ENSG00000178921.12	ENST00000546020	hsa-miR-1262	8269914	8269920	7mer-m8	8269899	8269921	144	-17.92
CAediting_1161902	chr17_8269921_+	ENSG00000178921.12	ENST00000546020	hsa-miR-1262	8269914	8269920	7mer-m8	8269899	8269921	144	-17.92
CAediting_1161915	chr17_8270019_+	ENSG00000178921.12	ENST00000546020	hsa-miR-1271-3p	8270017	8270024	8mer-1a	8270005	8270024	155	-21.02
CAediting_1161916	chr17_8270023_+	ENSG00000178921.12	ENST00000546020	hsa-miR-1271-3p	8270017	8270024	8mer-1a	8270005	8270024	155	-21.02
CAediting_1161904	chr17_8269952_+	ENSG00000178921.12	ENST00000546020	hsa-miR-194-3p	8269948	8269954	7mer-m8	8269935	8269955	149	-17.95
CAediting_1161909	chr17_8269982_+	ENSG00000178921.12	ENST00000546020	hsa-miR-302f	8269977	8269983	7mer-m8	8269968	8269984	145	-9.45
CAediting_1161931	chr17_8270138_+	ENSG00000178921.12	ENST00000546020	hsa-miR-30b-3p	8270131	8270138	8mer-1a	8270117	8270138	151	-17.42
CAediting_1161924	chr17_8270087_+	ENSG00000178921.12	ENST00000546020	hsa-miR-30c-1-3p	8270080	8270086	7mer-m8	8270065	8270087	141	-24.28
CAediting_1161924	chr17_8270087_+	ENSG00000178921.12	ENST00000546020	hsa-miR-30c-2-3p	8270080	8270086	7mer-m8	8270065	8270087	145	-25.41
CAediting_1161924	chr17_8270087_+	ENSG00000178921.12	ENST00000546020	hsa-miR-3192-5p	8270081	8270087	7mer-m8	8270065	8270088	146	-21.59
CAediting_1161917	chr17_8270025_+	ENSG00000178921.12	ENST00000546020	hsa-miR-3650	8270022	8270029	8mer-1a	8270009	8270029	152	-21.95
CAediting_1161900	chr17_8269909_+	ENSG00000178921.12	ENST00000546020	hsa-miR-3672	8269902	8269908	7mer-m8	8269887	8269909	155	-11.29
CAediting_1161922	chr17_8270061_+	ENSG00000178921.12	ENST00000546020	hsa-miR-3675-3p	8270059	8270066	8mer-1a	8270045	8270066	145	-8.07
CAediting_1161931	chr17_8270138_+	ENSG00000178921.12	ENST00000546020	hsa-miR-3689a-3p	8270131	8270138	8mer-1a	8270118	8270138	143	-18.79
CAediting_1161931	chr17_8270138_+	ENSG00000178921.12	ENST00000546020	hsa-miR-3689b-3p	8270131	8270138	8mer-1a	8270118	8270138	143	-18.27
CAediting_1161931	chr17_8270138_+	ENSG00000178921.12	ENST00000546020	hsa-miR-3689c	8270131	8270138	8mer-1a	8270118	8270138	143	-18.27
CAediting_1161898	chr17_8269899_+	ENSG00000178921.12	ENST00000546020	hsa-miR-371b-5p	8269893	8269899	7mer-m8	8269879	8269900	146	-7.7
CAediting_1161898	chr17_8269899_+	ENSG00000178921.12	ENST00000546020	hsa-miR-373-5p	8269893	8269899	7mer-m8	8269879	8269900	142	-8.26
CAediting_1161905	chr17_8269957_+	ENSG00000178921.12	ENST00000546020	hsa-miR-377-5p	8269955	8269961	7mer-m8	8269939	8269962	154	-20.45
CAediting_1161906	chr17_8269958_+	ENSG00000178921.12	ENST00000546020	hsa-miR-377-5p	8269955	8269961	7mer-m8	8269939	8269962	154	-20.45
CAediting_1161910	chr17_8269995_+	ENSG00000178921.12	ENST00000546020	hsa-miR-3929	8269992	8269998	7mer-m8	8269977	8269999	154	-17
CAediting_1161918	chr17_8270033_+	ENSG00000178921.12	ENST00000546020	hsa-miR-4455	8270031	8270038	8mer-1a	8270020	8270038	149	-16.89
CAediting_1161919	chr17_8270035_+	ENSG00000178921.12	ENST00000546020	hsa-miR-4455	8270031	8270038	8mer-1a	8270020	8270038	149	-16.89
CAediting_1161910	chr17_8269995_+	ENSG00000178921.12	ENST00000546020	hsa-miR-4478	8269992	8269998	7mer-m8	8269984	8269999	149	-23.48
CAediting_1161923	chr17_8270067_+	ENSG00000178921.12	ENST00000546020	hsa-miR-454-5p	8270063	8270069	7mer-m8	8270049	8270070	151	-16.55
CAediting_1161910	chr17_8269995_+	ENSG00000178921.12	ENST00000546020	hsa-miR-4649-3p	8269989	8269995	7mer-m8	8269976	8269996	140	-14.11
CAediting_1161910	chr17_8269995_+	ENSG00000178921.12	ENST00000546020	hsa-miR-485-5p	8269993	8269999	7mer-m8	8269979	8270000	153	-17.2
CAediting_1161899	chr17_8269903_+	ENSG00000178921.12	ENST00000546020	hsa-miR-5002-3p	8269899	8269905	7mer-m8	8269886	8269906	155	-18.2
CAediting_1161936	chr17_8270161_+	ENSG00000178921.12	ENST00000546020	hsa-miR-532-3p	8270155	8270161	7mer-m8	8270135	8270162	141	-21.55
CAediting_1161915	chr17_8270019_+	ENSG00000178921.12	ENST00000546020	hsa-miR-550a-3-5p	8270017	8270024	8mer-1a	8270005	8270024	140	-12.84
CAediting_1161916	chr17_8270023_+	ENSG00000178921.12	ENST00000546020	hsa-miR-550a-3-5p	8270017	8270024	8mer-1a	8270005	8270024	140	-12.84
CAediting_1161915	chr17_8270019_+	ENSG00000178921.12	ENST00000546020	hsa-miR-550a-5p	8270017	8270024	8mer-1a	8270002	8270024	140	-17.77
CAediting_1161916	chr17_8270023_+	ENSG00000178921.12	ENST00000546020	hsa-miR-550a-5p	8270017	8270024	8mer-1a	8270002	8270024	140	-17.77
CAediting_1161915	chr17_8270019_+	ENSG00000178921.12	ENST00000546020	hsa-miR-550a-5p	8270017	8270024	8mer-1a	8270002	8270024	140	-17.77
CAediting_1161916	chr17_8270023_+	ENSG00000178921.12	ENST00000546020	hsa-miR-550a-5p	8270017	8270024	8mer-1a	8270002	8270024	140	-17.77
CAediting_1161916	chr17_8270023_+	ENSG00000178921.12	ENST00000546020	hsa-miR-550b-2-5p	8270018	8270024	7mer-m8	8270004	8270025	145	-14.48
CAediting_1161917	chr17_8270025_+	ENSG00000178921.12	ENST00000546020	hsa-miR-550b-2-5p	8270018	8270024	7mer-m8	8270004	8270025	145	-14.48
CAediting_1161916	chr17_8270023_+	ENSG00000178921.12	ENST00000546020	hsa-miR-550b-2-5p	8270018	8270024	7mer-m8	8270004	8270025	145	-14.48
CAediting_1161917	chr17_8270025_+	ENSG00000178921.12	ENST00000546020	hsa-miR-550b-2-5p	8270018	8270024	7mer-m8	8270004	8270025	145	-14.48
CAediting_1161900	chr17_8269909_+	ENSG00000178921.12	ENST00000546020	hsa-miR-5586-3p	8269906	8269912	7mer-m8	8269894	8269913	149	-18.9
CAediting_1161920	chr17_8270039_+	ENSG00000178921.12	ENST00000546020	hsa-miR-5589-5p	8270034	8270040	7mer-m8	8270021	8270041	153	-21.02
CAediting_1161912	chr17_8270007_+	ENSG00000178921.12	ENST00000546020	hsa-miR-5690	8270004	8270010	7mer-m8	8269991	8270011	145	-16.75
CAediting_1161905	chr17_8269957_+	ENSG00000178921.12	ENST00000546020	hsa-miR-6086	8269955	8269961	7mer-m8	8269943	8269962	154	-24.13
CAediting_1161906	chr17_8269958_+	ENSG00000178921.12	ENST00000546020	hsa-miR-6086	8269955	8269961	7mer-m8	8269943	8269962	154	-24.13
CAediting_1161898	chr17_8269899_+	ENSG00000178921.12	ENST00000546020	hsa-miR-616-5p	8269893	8269899	7mer-m8	8269879	8269900	140	-5.62
CAediting_1161905	chr17_8269957_+	ENSG00000178921.12	ENST00000546020	hsa-miR-6516-5p	8269951	8269957	7mer-m8	8269937	8269958	140	-14.88
CAediting_1161906	chr17_8269958_+	ENSG00000178921.12	ENST00000546020	hsa-miR-6516-5p	8269951	8269957	7mer-m8	8269937	8269958	140	-14.88
CAediting_1161923	chr17_8270067_+	ENSG00000178921.12	ENST00000546020	hsa-miR-652-5p	8270065	8270071	7mer-m8	8270048	8270072	140	-12.14
CAediting_1161927	chr17_8270106_+	ENSG00000178921.12	ENST00000546020	hsa-miR-655-5p	8270104	8270111	8mer-1a	8270090	8270111	145	-9.41
CAediting_1161928	chr17_8270107_+	ENSG00000178921.12	ENST00000546020	hsa-miR-655-5p	8270104	8270111	8mer-1a	8270090	8270111	145	-9.41
CAediting_1161924	chr17_8270087_+	ENSG00000178921.12	ENST00000546020	hsa-miR-661	8270083	8270089	7mer-m8	8270066	8270090	142	-20.33
CAediting_1161902	chr17_8269921_+	ENSG00000178921.12	ENST00000546020	hsa-miR-661	8269917	8269923	7mer-m8	8269901	8269924	147	-18.48
CAediting_1161923	chr17_8270067_+	ENSG00000178921.12	ENST00000546020	hsa-miR-6732-3p	8270066	8270071	6mer	8270051	8270072	142	-17.02
CAediting_1161901	chr17_8269917_+	ENSG00000178921.12	ENST00000546020	hsa-miR-6736-5p	8269914	8269920	7mer-m8	8269901	8269921	143	-20.94
CAediting_1161902	chr17_8269921_+	ENSG00000178921.12	ENST00000546020	hsa-miR-6736-5p	8269914	8269920	7mer-m8	8269901	8269921	143	-20.94
CAediting_1161902	chr17_8269921_+	ENSG00000178921.12	ENST00000546020	hsa-miR-6742-3p	8269916	8269922	7mer-m8	8269904	8269923	140	-13.49
CAediting_1161931	chr17_8270138_+	ENSG00000178921.12	ENST00000546020	hsa-miR-6779-5p	8270131	8270138	8mer-1a	8270120	8270138	144	-22.9
CAediting_1161914	chr17_8270017_+	ENSG00000178921.12	ENST00000546020	hsa-miR-6811-3p	8270016	8270022	7mer-1a	8270002	8270022	143	-22.47
CAediting_1161915	chr17_8270019_+	ENSG00000178921.12	ENST00000546020	hsa-miR-6811-3p	8270016	8270022	7mer-1a	8270002	8270022	143	-22.47
CAediting_1161900	chr17_8269909_+	ENSG00000178921.12	ENST00000546020	hsa-miR-6864-3p	8269902	8269908	7mer-m8	8269890	8269909	148	-17.44
CAediting_1161916	chr17_8270023_+	ENSG00000178921.12	ENST00000546020	hsa-miR-6867-5p	8270021	8270027	7mer-m8	8270006	8270028	141	-13.93
CAediting_1161917	chr17_8270025_+	ENSG00000178921.12	ENST00000546020	hsa-miR-6867-5p	8270021	8270027	7mer-m8	8270006	8270028	141	-13.93
CAediting_1161910	chr17_8269995_+	ENSG00000178921.12	ENST00000546020	hsa-miR-7160-5p	8269990	8269996	7mer-m8	8269978	8269997	144	-18.64
CAediting_1161900	chr17_8269909_+	ENSG00000178921.12	ENST00000546020	hsa-miR-759	8269907	8269913	7mer-m8	8269894	8269914	146	-12.38
CAediting_1161913	chr17_8270014_+	ENSG00000178921.12	ENST00000546020	hsa-miR-7977	8270007	8270013	7mer-m8	8269997	8270014	142	-15.79
CAediting_1161899	chr17_8269903_+	ENSG00000178921.12	ENST00000546020	hsa-miR-873-3p	8269901	8269908	8mer-1a	8269887	8269908	140	-14.17
CAediting_1161931	chr17_8270138_+	ENSG00000178921.12	ENST00000546020	hsa-miR-887-5p	8270132	8270139	8mer-1a	8270118	8270139	150	-16.01
CAediting_1161932	chr17_8270139_+	ENSG00000178921.12	ENST00000546020	hsa-miR-887-5p	8270132	8270139	8mer-1a	8270118	8270139	150	-16.01

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_688080	chr9_63819626_+	ENSG00000178921.12	ENST00000580356	hsa-miR-4477b	8256382	8256389	8mer-1a	8256366	8256389	158	-14.45
CAediting_846604	chr11_93733708_-	ENSG00000178921.12	ENST00000580356	hsa-miR-1304-3p	8263150	8263156	7mer-m8	8263134	8263157	165	-30.53
CAediting_393	chr1_1167164_+	ENSG00000178921.12	ENST00000546020	hsa-miR-200b-3p	8269842	8269848	7mer-m8	8269831	8269849	147	-13.59
CAediting_1368054	chr19_46709310_-	ENSG00000178921.12	ENST00000580356	hsa-miR-320e	8256296	8256302	7mer-m8	8256283	8256303	150	-20.52
CAediting_1054808	chr15_66496985_-	ENSG00000178921.12	ENST00000580356	hsa-miR-4512	8258184	8258191	8mer-1a	8258170	8258191	152	-21.69
CAediting_1368054	chr19_46709310_-	ENSG00000178921.12	ENST00000580356	hsa-miR-320e	8258092	8258098	7mer-m8	8258082	8258099	141	-17.39
CAediting_1054808	chr15_66496985_-	ENSG00000178921.12	ENST00000580356	hsa-miR-4512	8263208	8263214	7mer-m8	8263195	8263215	150	-27.22
CAediting_1054808	chr15_66496985_-	ENSG00000178921.12	ENST00000580356	hsa-miR-4512	8264940	8264945	6mer	8264926	8264946	149	-26.71
CAediting_396018	chr5_1062918_-	ENSG00000178921.12	ENST00000580356	hsa-miR-4635	8265616	8265622	7mer-m8	8265603	8265623	152	-18.37
CAediting_524911	chr7_5495852_-	ENSG00000178921.12	ENST00000580356	hsa-miR-589-3p	8267577	8267583	7mer-m8	8267560	8267584	148	-17.52
CAediting_1229415	chr17_67471547_+	ENSG00000178921.12	ENST00000580356	hsa-miR-548aa	8269292	8269298	7mer-m8	8269275	8269299	140	-16.12
CAediting_1368054	chr19_46709310_-	ENSG00000178921.12	ENST00000580356	hsa-miR-320e	8269215	8269221	7mer-m8	8269205	8269222	146	-19.76
CAediting_1229415	chr17_67471547_+	ENSG00000178921.12	ENST00000546020	hsa-miR-548aa	8269292	8269298	7mer-m8	8269275	8269299	140	-16.12
CAediting_1351755	chr19_40282625_-	ENSG00000178921.12	ENST00000546020	hsa-miR-641	8270077	8270083	7mer-m8	8270062	8270084	149	-17.89
CAediting_1368054	chr19_46709310_-	ENSG00000178921.12	ENST00000546020	hsa-miR-320e	8269215	8269221	7mer-m8	8269205	8269222	146	-19.76
CAediting_396018	chr5_1062918_-	ENSG00000178921.12	ENST00000546020	hsa-miR-4635	8270107	8270113	7mer-m8	8270094	8270114	154	-14.7

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1368054	chr19_46709310_-	ENSG00000178921.12	ENST00000580356	hsa-miR-320e	8265934	8265940	7mer-m8	8265924	8265941	152	-19.34

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for PFAS

- RNA A-to-I editing in mRNA.
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ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for PFAS

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
STAD	CAediting_1161909	chr17_8269982_+	.	.	0.00182847707101317	0.349625484444618	.	.

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Relation with cancer stages for PFAS

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for PFAS

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for PFAS

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
PFAS	O15067	DB00142	Glutamic acid	Phosphoribosylformylglycinamidine synthase	SmallMoleculeDrug	approved\|nutraceutical

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RelatedDiseases for PFAS

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene