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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: PEX6 (CAeditome ID:5190)

Gene summary for PEX6

check button Gene summary
Gene informationGene symbol

PEX6

Gene ID

5190

Gene nameperoxisomal biogenesis factor 6
SynonymsHMLR2|PAF-2|PAF2|PBD4A|PDB4B|PXAAA1
Cytomap

6p21.1

Type of geneprotein-coding
Descriptionperoxisome biogenesis factor 6peroxin-6peroxisomal AAA-type ATPase 1peroxisomal-type ATPase 1peroxisome assembly factor 2
Modification date20210518
UniProtAcc

Q13608

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
PEX6

GO:0044877

Peroxisome assembly factor 2

16854980

PEX6

GO:0005737

Peroxisome assembly factor 2

8670792

PEX6

GO:0005777

Peroxisome assembly factor 2

11439091

PEX6

GO:0005777

Peroxisome assembly factor 2

16854980

PEX6

GO:0005829

Peroxisome assembly factor 2

16854980

PEX6

GO:0097733

Peroxisome assembly factor 2

26593283


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RNA A-to-I events for PEX6

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000124587.12

check button RNA A-to-I editing events in Cancer.
CAediting_483091(42967011, -), CAediting_483092(42968085, -), CAediting_483093(42968450, -), CAediting_483094(42973097, -), CAediting_483095(42973149, -), CAediting_483096(42973476, -), CAediting_483097(42973712, -), CAediting_483098(42973744, -), CAediting_483099(42973795, -), CAediting_483100(42973802, -), CAediting_483101(42973817, -), CAediting_483102(42974518, -), CAediting_483103(42975852, -), CAediting_483104(42975995, -), CAediting_483105(42976143, -), CAediting_483106(42976425, -), CAediting_483107(42976445, -), CAediting_483108(42976460, -), CAediting_483109(42976477, -), CAediting_483110(42976494, -), CAediting_483111(42976500, -), CAediting_483112(42976501, -), CAediting_483113(42976509, -), CAediting_483114(42976522, -), CAediting_483115(42976579, -), CAediting_483116(42976595, -), CAediting_483117(42976609, -), CAediting_483118(42977265, -), CAediting_483119(42977310, -), CAediting_483120(42977315, -), CAediting_483121(42977318, -), CAediting_483122(42977320, -), CAediting_483123(42977329, -), CAediting_483124(42977342, -), CAediting_483125(42977349, -), CAediting_483126(42977350, -), CAediting_483127(42977368, -), CAediting_483128(42977385, -), CAediting_483129(42977390, -), CAediting_483130(42977391, -), CAediting_483131(42977526, -), CAediting_483132(42977535, -), CAediting_483133(42977547, -), CAediting_483134(42977548, -), CAediting_483135(42977574, -), CAediting_483136(42977575, -), CAediting_483137(42977587, -), CAediting_483138(42977594, -), CAediting_483139(42977599, -), CAediting_483140(42977613, -), CAediting_483141(42977616, -), CAediting_483142(42977631, -), CAediting_483143(42977669, -), CAediting_483144(42977682, -), CAediting_483145(42977686, -), CAediting_483146(42977687, -), CAediting_483147(42977693, -), CAediting_483148(42977706, -), CAediting_483149(42977707, -), CAediting_483150(42977722, -), CAediting_483151(42977743, -), CAediting_483152(42977747, -), CAediting_483153(42977767, -), CAediting_483154(42977870, -), CAediting_483155(42977911, -), CAediting_483156(42977912, -), CAediting_483157(42977933, -), CAediting_483158(42977940, -), CAediting_483159(42977941, -), CAediting_483160(42977958, -), CAediting_483161(42977959, -), CAediting_483162(42978011, -), CAediting_483163(42978012, -), CAediting_483164(42978018, -), CAediting_483165(42978021, -), CAediting_483166(42978022, -), CAediting_483167(42978023, -), CAediting_483168(42978024, -), CAediting_483169(42978027, -), CAediting_483170(42978038, -), CAediting_483171(42978039, -), CAediting_483172(42978040, -), CAediting_483173(42978042, -), CAediting_483174(42978046, -), CAediting_483175(42978048, -), CAediting_483176(42978052, -), CAediting_483177(42978058, -), CAediting_483178(42978061, -), CAediting_483179(42978063, -), CAediting_483180(42978082, -), CAediting_483181(42978090, -), CAediting_483182(42978101, -), CAediting_483183(42978109, -), CAediting_483184(42978117, -), CAediting_483185(42978118, -), CAediting_483186(42978126, -),

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RNA editing positional annotations for PEX6 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
CAediting_483093chr6_42968450_-nonsynonymous SNVENST00000244546.4c.A1528Gp.K510ETPN
CAediting_483093chr6_42968450_-nonsynonymous SNVENST00000304611.11c.A1528Gp.K510ETPN

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_483091chr6_42967011_-intronic
CAediting_483092chr6_42968085_-intronic
CAediting_483093chr6_42968450_-exonic
CAediting_483094chr6_42973097_-intronic
CAediting_483095chr6_42973149_-intronic
CAediting_483096chr6_42973476_-intronic
CAediting_483097chr6_42973712_-intronic
CAediting_483098chr6_42973744_-intronic
CAediting_483099chr6_42973795_-intronic
CAediting_483100chr6_42973802_-intronic
CAediting_483101chr6_42973817_-intronic
CAediting_483102chr6_42974518_-intronic
CAediting_483103chr6_42975852_-intronic
CAediting_483104chr6_42975995_-intronic
CAediting_483105chr6_42976143_-intronic
CAediting_483106chr6_42976425_-intronic
CAediting_483107chr6_42976445_-intronic
CAediting_483108chr6_42976460_-intronic
CAediting_483109chr6_42976477_-intronic
CAediting_483110chr6_42976494_-intronic
CAediting_483111chr6_42976500_-intronic
CAediting_483112chr6_42976501_-intronic
CAediting_483113chr6_42976509_-intronic
CAediting_483114chr6_42976522_-intronic
CAediting_483115chr6_42976579_-intronic
CAediting_483116chr6_42976595_-intronic
CAediting_483117chr6_42976609_-intronic
CAediting_483118chr6_42977265_-intronic
CAediting_483119chr6_42977310_-intronic
CAediting_483120chr6_42977315_-intronic
CAediting_483121chr6_42977318_-intronic
CAediting_483122chr6_42977320_-intronic
CAediting_483123chr6_42977329_-intronic
CAediting_483124chr6_42977342_-intronic
CAediting_483125chr6_42977349_-intronic
CAediting_483126chr6_42977350_-intronic
CAediting_483127chr6_42977368_-intronic
CAediting_483128chr6_42977385_-intronic
CAediting_483129chr6_42977390_-intronic
CAediting_483130chr6_42977391_-intronic
CAediting_483131chr6_42977526_-intronic
CAediting_483132chr6_42977535_-intronic
CAediting_483133chr6_42977547_-intronic
CAediting_483134chr6_42977548_-intronic
CAediting_483135chr6_42977574_-intronic
CAediting_483136chr6_42977575_-intronic
CAediting_483137chr6_42977587_-intronic
CAediting_483138chr6_42977594_-intronic
CAediting_483139chr6_42977599_-intronic
CAediting_483140chr6_42977613_-intronic
CAediting_483141chr6_42977616_-intronic
CAediting_483142chr6_42977631_-intronic
CAediting_483143chr6_42977669_-intronic
CAediting_483144chr6_42977682_-intronic
CAediting_483145chr6_42977686_-intronic
CAediting_483146chr6_42977687_-intronic
CAediting_483147chr6_42977693_-intronic
CAediting_483148chr6_42977706_-intronic
CAediting_483149chr6_42977707_-intronic
CAediting_483150chr6_42977722_-intronic
CAediting_483151chr6_42977743_-intronic
CAediting_483152chr6_42977747_-intronic
CAediting_483153chr6_42977767_-intronic
CAediting_483154chr6_42977870_-intronic
CAediting_483155chr6_42977911_-intronic
CAediting_483156chr6_42977912_-intronic
CAediting_483157chr6_42977933_-intronic
CAediting_483158chr6_42977940_-intronic
CAediting_483159chr6_42977941_-intronic
CAediting_483160chr6_42977958_-intronic
CAediting_483161chr6_42977959_-intronic
CAediting_483162chr6_42978011_-intronic
CAediting_483163chr6_42978012_-intronic
CAediting_483164chr6_42978018_-intronic
CAediting_483165chr6_42978021_-intronic
CAediting_483166chr6_42978022_-intronic
CAediting_483167chr6_42978023_-intronic
CAediting_483168chr6_42978024_-intronic
CAediting_483169chr6_42978027_-intronic
CAediting_483170chr6_42978038_-intronic
CAediting_483171chr6_42978039_-intronic
CAediting_483172chr6_42978040_-intronic
CAediting_483173chr6_42978042_-intronic
CAediting_483174chr6_42978046_-intronic
CAediting_483175chr6_42978048_-intronic
CAediting_483176chr6_42978052_-intronic
CAediting_483177chr6_42978058_-intronic
CAediting_483178chr6_42978061_-intronic
CAediting_483179chr6_42978063_-intronic
CAediting_483180chr6_42978082_-intronic
CAediting_483181chr6_42978090_-intronic
CAediting_483182chr6_42978101_-intronic
CAediting_483183chr6_42978109_-intronic
CAediting_483184chr6_42978117_-intronic
CAediting_483185chr6_42978118_-intronic
CAediting_483186chr6_42978126_-intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_483091chr6_42967011_-SINEAluAluSp
CAediting_483092chr6_42968085_-SINEAluAluSq2
CAediting_483094chr6_42973097_-SINEAluAluSx1
CAediting_483095chr6_42973149_-SINEAluAluSx1
CAediting_483096chr6_42973476_-SINEAluAluSx
CAediting_483097chr6_42973712_-SINEAluAluJb
CAediting_483098chr6_42973744_-SINEAluAluJb
CAediting_483099chr6_42973795_-SINEAluAluJb
CAediting_483100chr6_42973802_-SINEAluAluJb
CAediting_483101chr6_42973817_-SINEAluAluJb
CAediting_483102chr6_42974518_-SINEAluAluY
CAediting_483103chr6_42975852_-SINEAluAluSx3
CAediting_483104chr6_42975995_-SINEAluAluSc8
CAediting_483105chr6_42976143_-SINEAluAluSc8
CAediting_483106chr6_42976425_-SINEAluAluSz
CAediting_483107chr6_42976445_-SINEAluAluSz
CAediting_483108chr6_42976460_-SINEAluAluSz
CAediting_483109chr6_42976477_-SINEAluAluSz
CAediting_483110chr6_42976494_-SINEAluAluSz
CAediting_483111chr6_42976500_-SINEAluAluSz
CAediting_483112chr6_42976501_-SINEAluAluSz
CAediting_483113chr6_42976509_-SINEAluAluSz
CAediting_483114chr6_42976522_-SINEAluAluSz
CAediting_483115chr6_42976579_-SINEAluAluSz
CAediting_483116chr6_42976595_-SINEAluAluSz
CAediting_483117chr6_42976609_-SINEAluAluSz
CAediting_483118chr6_42977265_-SINEAluAluSx
CAediting_483119chr6_42977310_-SINEAluAluSx
CAediting_483120chr6_42977315_-SINEAluAluSx
CAediting_483121chr6_42977318_-SINEAluAluSx
CAediting_483122chr6_42977320_-SINEAluAluSx
CAediting_483123chr6_42977329_-SINEAluAluSx
CAediting_483124chr6_42977342_-SINEAluAluSx
CAediting_483125chr6_42977349_-SINEAluAluSx
CAediting_483126chr6_42977350_-SINEAluAluSx
CAediting_483127chr6_42977368_-SINEAluAluSx
CAediting_483128chr6_42977385_-SINEAluAluSx
CAediting_483129chr6_42977390_-SINEAluAluSx
CAediting_483130chr6_42977391_-SINEAluAluSx
CAediting_483131chr6_42977526_-SINEAluAluSx
CAediting_483132chr6_42977535_-SINEAluAluSx
CAediting_483133chr6_42977547_-SINEAluAluSx
CAediting_483134chr6_42977548_-SINEAluAluSx
CAediting_483135chr6_42977574_-SINEAluAluSx
CAediting_483136chr6_42977575_-SINEAluAluSx
CAediting_483137chr6_42977587_-SINEAluAluSx
CAediting_483138chr6_42977594_-SINEAluAluSx
CAediting_483139chr6_42977599_-SINEAluAluSx
CAediting_483140chr6_42977613_-SINEAluAluSx
CAediting_483141chr6_42977616_-SINEAluAluSx
CAediting_483142chr6_42977631_-SINEAluAluSx
CAediting_483143chr6_42977669_-SINEAluAluSx
CAediting_483144chr6_42977682_-SINEAluAluSx
CAediting_483145chr6_42977686_-SINEAluAluSx
CAediting_483146chr6_42977687_-SINEAluAluSx
CAediting_483147chr6_42977693_-SINEAluAluSx
CAediting_483148chr6_42977706_-SINEAluAluSx
CAediting_483149chr6_42977707_-SINEAluAluSx
CAediting_483150chr6_42977722_-SINEAluAluSx
CAediting_483151chr6_42977743_-SINEAluAluSx
CAediting_483152chr6_42977747_-SINEAluAluSx
CAediting_483153chr6_42977767_-SINEAluAluSx
CAediting_483154chr6_42977870_-SINEAluAluSp
CAediting_483155chr6_42977911_-SINEAluAluSp
CAediting_483156chr6_42977912_-SINEAluAluSp
CAediting_483157chr6_42977933_-SINEAluAluSp
CAediting_483158chr6_42977940_-SINEAluAluSp
CAediting_483159chr6_42977941_-SINEAluAluSp
CAediting_483160chr6_42977958_-SINEAluAluSp
CAediting_483161chr6_42977959_-SINEAluAluSp
CAediting_483162chr6_42978011_-SINEAluAluSp
CAediting_483163chr6_42978012_-SINEAluAluSp
CAediting_483164chr6_42978018_-SINEAluAluSp
CAediting_483165chr6_42978021_-SINEAluAluSp
CAediting_483166chr6_42978022_-SINEAluAluSp
CAediting_483167chr6_42978023_-SINEAluAluSp
CAediting_483168chr6_42978024_-SINEAluAluSp
CAediting_483169chr6_42978027_-SINEAluAluSp
CAediting_483170chr6_42978038_-SINEAluAluSp
CAediting_483171chr6_42978039_-SINEAluAluSp
CAediting_483172chr6_42978040_-SINEAluAluSp
CAediting_483173chr6_42978042_-SINEAluAluSp
CAediting_483174chr6_42978046_-SINEAluAluSp
CAediting_483175chr6_42978048_-SINEAluAluSp
CAediting_483176chr6_42978052_-SINEAluAluSp
CAediting_483177chr6_42978058_-SINEAluAluSp
CAediting_483178chr6_42978061_-SINEAluAluSp
CAediting_483179chr6_42978063_-SINEAluAluSp
CAediting_483180chr6_42978082_-SINEAluAluSp
CAediting_483181chr6_42978090_-SINEAluAluSp
CAediting_483182chr6_42978101_-SINEAluAluSp
CAediting_483183chr6_42978109_-SINEAluAluSp
CAediting_483184chr6_42978117_-SINEAluAluSp
CAediting_483185chr6_42978118_-SINEAluAluSp
CAediting_483186chr6_42978126_-SINEAluAluSp

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RNA A-to-I editing events in the alternative splicing sites for PEX6

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000124587.12.PEX6.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000124587.12.PEX6.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PEX6

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for PEX6

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.
all structure


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The effects of the RNA editing to the miRNA binding sites for PEX6

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_748296chr10_51299626_+ENSG00000124587.12ENST00000244546hsa-miR-605-3p42964817429648248mer-1a4296481742964839147-15.1
CAediting_748296chr10_51299626_+ENSG00000124587.12ENST00000244546hsa-miR-605-3p42964877429648837mer-m84296487642964902144-18.4
CAediting_688080chr9_63819626_+ENSG00000124587.12ENST00000244546hsa-miR-4477b42964815429648217mer-1a4296481542964836140-15.69
CAediting_524911chr7_5495852_-ENSG00000124587.12ENST00000244546hsa-miR-589-3p42964837429648448mer-1a4296483742964859143-13.03

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for PEX6

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000244546.4protein_codingSoverviewSoverview
ENST00000304611.11protein_codingSoverviewSoverview

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
CAediting_483093ENST00000244546.4chr6_42968450_--1261.40-1259.30-1261.40
CAediting_483093ENST00000304611.11chr6_42968450_--1600.80-1600.70-1600.80

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Relation with ADAR for PEX6

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for PEX6

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for PEX6

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for PEX6

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PEX6

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
PEX6C3553936PEROXISOME BIOGENESIS DISORDER 4A (ZELLWEGER)10CTD_human;GENOMICS_ENGLAND;UNIPROT
PEX6C3553937PEROXISOME BIOGENESIS DISORDER 4B5CTD_human;GENOMICS_ENGLAND
PEX6C4225267HEIMLER SYNDROME 24GENOMICS_ENGLAND;UNIPROT
PEX6C1832200Peroxisome biogenesis disorders3CTD_human;GENOMICS_ENGLAND
PEX6C0043459Zellweger Syndrome2CTD_human;GENOMICS_ENGLAND
PEX6C0751594Zellweger-Like Syndrome2CTD_human
PEX6C3658299Zellweger Spectrum2CTD_human
PEX6C0020796Profound Mental Retardation1CTD_human
PEX6C0025363Mental Retardation, Psychosocial1CTD_human
PEX6C0917816Mental deficiency1CTD_human
PEX6C1849094SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 31ORPHANET
PEX6C1856186Deafness enamel hypoplasia nail defects1CTD_human;ORPHANET
PEX6C3714756Intellectual Disability1CTD_human