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Editing gene: SERPINF1 (CAeditome ID:5176)

Gene summary for SERPINF1

Gene summary

Gene information	Gene symbol	SERPINF1
	Gene ID	5176
	Gene name	serpin family F member 1
	Synonyms	EPC-1\|OI12\|OI6\|PEDF\|PIG35
	Cytomap	17p13.3
	Type of gene	protein-coding
	Description	pigment epithelium-derived factoralpha-2 antiplasmincell proliferation-inducing gene 35 proteinserine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1serpin peptidase inhibitor, clade F (al
	Modification date	20210524
	UniProtAcc	P36955
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
SERPINF1	GO:0016525	Pigment epithelium-derived factor	11562499
SERPINF1	GO:0050769	Pigment epithelium-derived factor	8226833
SERPINF1	GO:0005576	Pigment epithelium-derived factor	12737624

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RNA A-to-I events for SERPINF1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000132386.9

RNA A-to-I editing events in Cancer.

CAediting_1151713(1763982, +), CAediting_1151714(1764018, +), CAediting_1151715(1764022, +), CAediting_1151716(1764036, +), CAediting_1151717(1764062, +), CAediting_1151718(1764117, +), CAediting_1151719(1764944, +), CAediting_1151720(1765106, +), CAediting_1151721(1765806, +), CAediting_1151722(1765830, +), CAediting_1151723(1766360, +), CAediting_1151724(1766435, +), CAediting_1151725(1767284, +), CAediting_1151726(1773363, +), CAediting_1151727(1773420, +), CAediting_1151728(1773477, +), CAediting_1151729(1773508, +), CAediting_1151730(1773510, +), CAediting_1151731(1774246, +), CAediting_1151732(1774265, +), CAediting_1151733(1774289, +), CAediting_1151734(1774345, +), CAediting_1151735(1774361, +), CAediting_1151736(1774552, +), CAediting_1151737(1774561, +), CAediting_1151738(1774579, +), CAediting_1151739(1774725, +), CAediting_1151740(1775810, +), CAediting_1151741(1775824, +), CAediting_1151742(1777398, +), CAediting_1151743(1777487, +),

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RNA editing positional annotations for SERPINF1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1151713	chr17_1763982_+	ncRNA_intronic
CAediting_1151714	chr17_1764018_+	ncRNA_intronic
CAediting_1151715	chr17_1764022_+	ncRNA_intronic
CAediting_1151716	chr17_1764036_+	ncRNA_intronic
CAediting_1151717	chr17_1764062_+	ncRNA_intronic
CAediting_1151718	chr17_1764117_+	ncRNA_intronic
CAediting_1151719	chr17_1764944_+	ncRNA_intronic
CAediting_1151720	chr17_1765106_+	ncRNA_intronic
CAediting_1151721	chr17_1765806_+	ncRNA_intronic
CAediting_1151722	chr17_1765830_+	ncRNA_intronic
CAediting_1151723	chr17_1766360_+	ncRNA_intronic
CAediting_1151724	chr17_1766435_+	ncRNA_intronic
CAediting_1151725	chr17_1767284_+	ncRNA_intronic
CAediting_1151726	chr17_1773363_+	intronic
CAediting_1151727	chr17_1773420_+	intronic
CAediting_1151728	chr17_1773477_+	intronic
CAediting_1151729	chr17_1773508_+	intronic
CAediting_1151730	chr17_1773510_+	intronic
CAediting_1151731	chr17_1774246_+	intronic
CAediting_1151732	chr17_1774265_+	intronic
CAediting_1151733	chr17_1774289_+	intronic
CAediting_1151734	chr17_1774345_+	intronic
CAediting_1151735	chr17_1774361_+	intronic
CAediting_1151736	chr17_1774552_+	intronic
CAediting_1151737	chr17_1774561_+	intronic
CAediting_1151738	chr17_1774579_+	intronic
CAediting_1151739	chr17_1774725_+	intronic
CAediting_1151740	chr17_1775810_+	intronic
CAediting_1151741	chr17_1775824_+	intronic
CAediting_1151742	chr17_1777398_+	exonic
CAediting_1151743	chr17_1777487_+	ncRNA_exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1151713	chr17_1763982_+	SINE	Alu	AluSq2
CAediting_1151714	chr17_1764018_+	SINE	Alu	AluSq2
CAediting_1151715	chr17_1764022_+	SINE	Alu	AluSq2
CAediting_1151716	chr17_1764036_+	SINE	Alu	AluSq2
CAediting_1151717	chr17_1764062_+	SINE	Alu	AluSq2
CAediting_1151718	chr17_1764117_+	SINE	Alu	AluSq2
CAediting_1151719	chr17_1764944_+	SINE	Alu	AluSx
CAediting_1151720	chr17_1765106_+	SINE	Alu	AluSx
CAediting_1151721	chr17_1765806_+	SINE	Alu	FAM
CAediting_1151722	chr17_1765830_+	SINE	Alu	FAM
CAediting_1151723	chr17_1766360_+	SINE	Alu	AluSx1
CAediting_1151724	chr17_1766435_+	SINE	Alu	AluSx1
CAediting_1151725	chr17_1767284_+	SINE	Alu	AluSp
CAediting_1151726	chr17_1773363_+	SINE	Alu	AluSx1
CAediting_1151727	chr17_1773420_+	SINE	Alu	AluSx1
CAediting_1151728	chr17_1773477_+	SINE	Alu	AluSx1
CAediting_1151729	chr17_1773508_+	SINE	Alu	AluSx1
CAediting_1151730	chr17_1773510_+	SINE	Alu	AluSx1
CAediting_1151731	chr17_1774246_+	SINE	Alu	AluSq
CAediting_1151732	chr17_1774265_+	SINE	Alu	AluSq
CAediting_1151733	chr17_1774289_+	SINE	Alu	AluSq
CAediting_1151734	chr17_1774345_+	SINE	Alu	AluSq
CAediting_1151735	chr17_1774361_+	SINE	Alu	AluSq
CAediting_1151736	chr17_1774552_+	SINE	Alu	AluSz
CAediting_1151737	chr17_1774561_+	SINE	Alu	AluSz
CAediting_1151738	chr17_1774579_+	SINE	Alu	AluSz
CAediting_1151739	chr17_1774725_+	SINE	Alu	AluSz
CAediting_1151740	chr17_1775810_+	SINE	Alu	AluSx
CAediting_1151741	chr17_1775824_+	SINE	Alu	AluSx

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RNA A-to-I editing events in the alternative splicing sites for SERPINF1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
IR	CAediting_1151742	chr17_1777398_+	1777388:1777410	3SS	0+10i	ACACAGACACAGGGGCCCTTCTC	-27.27	ACACAGACACGGGGGCCCTTCTC	-21.73

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000132386.9.SERPINF1.

Correlation between RNA A-to-I editing and PSI for ENSG00000132386.9.SERPINF1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SERPINF1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for SERPINF1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for SERPINF1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_396018	chr5_1062918_-	ENSG00000132386.9	ENST00000573770	hsa-miR-4635	1771149	1771156	8mer-1a	1771136	1771156	145	-14.54

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SERPINF1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for SERPINF1

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for SERPINF1

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for SERPINF1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for SERPINF1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
SERPINF1	P36955	DB09130	Copper	Pigment epithelium-derived factor	SmallMoleculeDrug	approved\|investigational

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RelatedDiseases for SERPINF1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
SERPINF1	C0268362	Osteogenesis imperfecta type III (disorder)	2	ORPHANET
SERPINF1	C0010043	Corneal Ulcer	1	CTD_human
SERPINF1	C0010606	Adenoid Cystic Carcinoma	1	CTD_human
SERPINF1	C0011875	Diabetic Angiopathies	1	CTD_human
SERPINF1	C0022548	Keloid	1	CTD_human
SERPINF1	C0025945	Microangiopathy, Diabetic	1	CTD_human
SERPINF1	C0029434	Osteogenesis Imperfecta	1	GENOMICS_ENGLAND
SERPINF1	C0033578	Prostatic Neoplasms	1	CTD_human
SERPINF1	C0036095	Salivary Gland Neoplasms	1	CTD_human
SERPINF1	C0042164	Uveitis	1	CTD_human
SERPINF1	C0220636	Malignant neoplasm of salivary gland	1	CTD_human
SERPINF1	C0268363	Osteogenesis imperfecta type IV (disorder)	1	ORPHANET
SERPINF1	C0376358	Malignant neoplasm of prostate	1	CTD_human
SERPINF1	C3279564	Osteogenesis Imperfecta, Type VI	1	CTD_human;GENOMICS_ENGLAND

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene