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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: RTEL1 (CAeditome ID:51750)

Gene summary for RTEL1

check button Gene summary
Gene informationGene symbol

RTEL1

Gene ID

51750

Gene nameregulator of telomere elongation helicase 1
SynonymsC20orf41|DKCA4|DKCB5|NHL|PFBMFT3|RTEL
Cytomap

20q13.33

Type of geneprotein-coding
Descriptionregulator of telomere elongation helicase 1regulator of telomere length
Modification date20210524
UniProtAcc

Q9NZ71

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
RTEL1

GO:0005634

Regulator of telomere elongation helicase 1

23585563


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RNA A-to-I events for RTEL1

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000258366.6

check button RNA A-to-I editing events in Cancer.
CAediting_1442650(63669003, +), CAediting_1442651(63669122, +), CAediting_1442652(63670712, +), CAediting_1442653(63670729, +), CAediting_1442654(63670742, +), CAediting_1442655(63670749, +), CAediting_1442656(63670750, +), CAediting_1442657(63670830, +), CAediting_1442658(63671339, +), CAediting_1442659(63674470, +), CAediting_1442660(63674475, +), CAediting_1442661(63674509, +), CAediting_1442662(63674554, +), CAediting_1442663(63674558, +), CAediting_1442664(63674603, +), CAediting_1442665(63674604, +), CAediting_1442666(63674621, +), CAediting_1442667(63674633, +), CAediting_1442668(63674655, +), CAediting_1442669(63675537, +), CAediting_1442670(63675545, +), CAediting_1442671(63675575, +), CAediting_1442672(63675577, +), CAediting_1442673(63675631, +), CAediting_1442674(63676088, +), CAediting_1442675(63676100, +), CAediting_1442676(63676119, +), CAediting_1442677(63676133, +), CAediting_1442678(63676136, +), CAediting_1442679(63676184, +), CAediting_1442680(63676185, +), CAediting_1442681(63677339, +), CAediting_1442682(63677360, +), CAediting_1442683(63677381, +), CAediting_1442684(63677453, +), CAediting_1442685(63677456, +), CAediting_1442686(63677457, +), CAediting_1442687(63677468, +), CAediting_1442688(63677488, +), CAediting_1442689(63677494, +), CAediting_1442690(63677504, +), CAediting_1442691(63677534, +), CAediting_1442692(63695848, +), CAediting_1442693(63695858, +),

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RNA editing positional annotations for RTEL1 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
CAediting_1442692chr20_63695848_+nonsynonymous SNVENST00000360203.8c.A3893Gp.E1298GDBN

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1442650chr20_63669003_+ncRNA_intronic
CAediting_1442651chr20_63669122_+ncRNA_intronic
CAediting_1442652chr20_63670712_+ncRNA_intronic
CAediting_1442653chr20_63670729_+ncRNA_intronic
CAediting_1442654chr20_63670742_+ncRNA_intronic
CAediting_1442655chr20_63670749_+ncRNA_intronic
CAediting_1442656chr20_63670750_+ncRNA_intronic
CAediting_1442657chr20_63670830_+ncRNA_intronic
CAediting_1442658chr20_63671339_+ncRNA_intronic
CAediting_1442659chr20_63674470_+intronic
CAediting_1442660chr20_63674475_+intronic
CAediting_1442661chr20_63674509_+intronic
CAediting_1442662chr20_63674554_+intronic
CAediting_1442663chr20_63674558_+intronic
CAediting_1442664chr20_63674603_+intronic
CAediting_1442665chr20_63674604_+intronic
CAediting_1442666chr20_63674621_+intronic
CAediting_1442667chr20_63674633_+intronic
CAediting_1442668chr20_63674655_+intronic
CAediting_1442669chr20_63675537_+intronic
CAediting_1442670chr20_63675545_+intronic
CAediting_1442671chr20_63675575_+intronic
CAediting_1442672chr20_63675577_+intronic
CAediting_1442673chr20_63675631_+intronic
CAediting_1442674chr20_63676088_+intronic
CAediting_1442675chr20_63676100_+intronic
CAediting_1442676chr20_63676119_+intronic
CAediting_1442677chr20_63676133_+intronic
CAediting_1442678chr20_63676136_+intronic
CAediting_1442679chr20_63676184_+intronic
CAediting_1442680chr20_63676185_+intronic
CAediting_1442681chr20_63677339_+intronic
CAediting_1442682chr20_63677360_+intronic
CAediting_1442683chr20_63677381_+intronic
CAediting_1442684chr20_63677453_+intronic
CAediting_1442685chr20_63677456_+intronic
CAediting_1442686chr20_63677457_+intronic
CAediting_1442687chr20_63677468_+intronic
CAediting_1442688chr20_63677488_+intronic
CAediting_1442689chr20_63677494_+intronic
CAediting_1442690chr20_63677504_+intronic
CAediting_1442691chr20_63677534_+intronic
CAediting_1442692chr20_63695848_+exonic
CAediting_1442693chr20_63695858_+exonic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1442650chr20_63669003_+SINEAluAluSx
CAediting_1442651chr20_63669122_+SINEAluAluSx
CAediting_1442652chr20_63670712_+SINEAluFLAM_C
CAediting_1442653chr20_63670729_+SINEAluFLAM_C
CAediting_1442654chr20_63670742_+SINEAluFLAM_C
CAediting_1442655chr20_63670749_+SINEAluFLAM_C
CAediting_1442656chr20_63670750_+SINEAluFLAM_C
CAediting_1442657chr20_63670830_+SINEAluFLAM_C
CAediting_1442658chr20_63671339_+SINEAluAluSg
CAediting_1442659chr20_63674470_+SINEAluAluJb
CAediting_1442660chr20_63674475_+SINEAluAluJb
CAediting_1442661chr20_63674509_+SINEAluAluJb
CAediting_1442662chr20_63674554_+SINEAluAluJb
CAediting_1442663chr20_63674558_+SINEAluAluJb
CAediting_1442664chr20_63674603_+SINEAluAluJb
CAediting_1442665chr20_63674604_+SINEAluAluJb
CAediting_1442666chr20_63674621_+SINEAluAluJb
CAediting_1442667chr20_63674633_+SINEAluAluJb
CAediting_1442668chr20_63674655_+SINEAluAluJb
CAediting_1442669chr20_63675537_+SINEAluAluJr
CAediting_1442670chr20_63675545_+SINEAluAluJr
CAediting_1442671chr20_63675575_+SINEAluAluJr
CAediting_1442672chr20_63675577_+SINEAluAluJr
CAediting_1442673chr20_63675631_+SINEAluAluJr
CAediting_1442674chr20_63676088_+SINEAluAluJb
CAediting_1442675chr20_63676100_+SINEAluAluJb
CAediting_1442676chr20_63676119_+SINEAluAluJb
CAediting_1442677chr20_63676133_+SINEAluAluJb
CAediting_1442678chr20_63676136_+SINEAluAluJb
CAediting_1442679chr20_63676184_+SINEAluAluJb
CAediting_1442680chr20_63676185_+SINEAluAluJb
CAediting_1442681chr20_63677339_+SINEAluAluSx
CAediting_1442682chr20_63677360_+SINEAluAluSx
CAediting_1442683chr20_63677381_+SINEAluAluSx
CAediting_1442684chr20_63677453_+SINEAluAluSx
CAediting_1442685chr20_63677456_+SINEAluAluSx
CAediting_1442686chr20_63677457_+SINEAluAluSx
CAediting_1442687chr20_63677468_+SINEAluAluSx
CAediting_1442688chr20_63677488_+SINEAluAluSx
CAediting_1442689chr20_63677494_+SINEAluAluSx
CAediting_1442690chr20_63677504_+SINEAluAluSx
CAediting_1442691chr20_63677534_+SINEAluAluSx

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RNA A-to-I editing events in the alternative splicing sites for RTEL1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
IRCAediting_1442693chr20_63695858_+63695852:636958605SS0+4iCCAGTGAGT8.28CCAGTGGGT3.07

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000258366.6.RTEL1.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000258366.6.RTEL1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for RTEL1

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for RTEL1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for RTEL1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1442692chr20_63695848_+ENSG00000258366.6ENST00000370018hsa-miR-6775-3p63695844636958507mer-m86369583163695851147.00-20.33
CAediting_1442692chr20_63695848_+ENSG00000258366.6ENST00000508582hsa-miR-6775-3p63695844636958507mer-m86369583163695851147.00-20.33
CAediting_1442692chr20_63695848_+ENSG00000258366.6ENST00000496816hsa-miR-6775-3p63695844636958507mer-m86369583163695851147.00-20.33

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1442693chr20_63695858_+ENSG00000258366.6ENST00000370018hsa-miR-1304-3p63695852636958587mer-m86369583763695859147-17.39
CAediting_1442693chr20_63695858_+ENSG00000258366.6ENST00000370018hsa-miR-3680-5p63695853636958597mer-m86369583963695860140-17.86
CAediting_1442693chr20_63695858_+ENSG00000258366.6ENST00000370018hsa-miR-3680-5p63695853636958597mer-m86369583963695860140-17.86
CAediting_1442692chr20_63695848_+ENSG00000258366.6ENST00000370018hsa-miR-428363695846636958538mer-1a6369583663695853145-21.24
CAediting_1442692chr20_63695848_+ENSG00000258366.6ENST00000370018hsa-miR-428363695846636958538mer-1a6369583663695853145-21.24
CAediting_1442693chr20_63695858_+ENSG00000258366.6ENST00000370018hsa-miR-653-3p63695851636958577mer-m86369583763695858151-17.76
CAediting_1442692chr20_63695848_+ENSG00000258366.6ENST00000370018hsa-miR-76063695844636958507mer-m86369583363695851148-20.49
CAediting_1442693chr20_63695858_+ENSG00000258366.6ENST00000508582hsa-miR-1304-3p63695852636958587mer-m86369583763695859147-17.39
CAediting_1442693chr20_63695858_+ENSG00000258366.6ENST00000508582hsa-miR-3680-5p63695853636958597mer-m86369583963695860140-17.86
CAediting_1442693chr20_63695858_+ENSG00000258366.6ENST00000508582hsa-miR-3680-5p63695853636958597mer-m86369583963695860140-17.86
CAediting_1442692chr20_63695848_+ENSG00000258366.6ENST00000508582hsa-miR-428363695846636958538mer-1a6369583663695853145-21.24
CAediting_1442692chr20_63695848_+ENSG00000258366.6ENST00000508582hsa-miR-428363695846636958538mer-1a6369583663695853145-21.24
CAediting_1442693chr20_63695858_+ENSG00000258366.6ENST00000508582hsa-miR-653-3p63695851636958577mer-m86369583763695858151-17.76
CAediting_1442692chr20_63695848_+ENSG00000258366.6ENST00000508582hsa-miR-76063695844636958507mer-m86369583363695851148-20.49
CAediting_1442693chr20_63695858_+ENSG00000258366.6ENST00000496816hsa-miR-1304-3p63695852636958587mer-m86369583763695859147-17.39
CAediting_1442693chr20_63695858_+ENSG00000258366.6ENST00000496816hsa-miR-3680-5p63695853636958597mer-m86369583963695860140-17.86
CAediting_1442693chr20_63695858_+ENSG00000258366.6ENST00000496816hsa-miR-3680-5p63695853636958597mer-m86369583963695860140-17.86
CAediting_1442692chr20_63695848_+ENSG00000258366.6ENST00000496816hsa-miR-428363695846636958538mer-1a6369583663695853145-21.24
CAediting_1442692chr20_63695848_+ENSG00000258366.6ENST00000496816hsa-miR-428363695846636958538mer-1a6369583663695853145-21.24
CAediting_1442693chr20_63695858_+ENSG00000258366.6ENST00000496816hsa-miR-653-3p63695851636958577mer-m86369583763695858151-17.76
CAediting_1442692chr20_63695848_+ENSG00000258366.6ENST00000496816hsa-miR-76063695844636958507mer-m86369583363695851148-20.49

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1054808chr15_66496985_-ENSG00000258366.6ENST00000370018hsa-miR-451263695868636958747mer-m86369585463695875149-22.37
CAediting_1368054chr19_46709310_-ENSG00000258366.6ENST00000370018hsa-miR-320e63695909636959157mer-m86369589963695916144-21.24
CAediting_77128chr1_85133844_+ENSG00000258366.6ENST00000370018hsa-miR-4423-3p63696238636962447mer-m86369622363696245143-17.43
CAediting_77128chr1_85133844_+ENSG00000258366.6ENST00000370018hsa-miR-4423-3p63695858636958647mer-m86369584463695865141-15.29
CAediting_604450chr7_133034877_-ENSG00000258366.6ENST00000370018hsa-miR-365463695907636959137mer-m86369589663695914154-20.92
CAediting_1054808chr15_66496985_-ENSG00000258366.6ENST00000508582hsa-miR-451263695868636958747mer-m86369585463695875149-22.37
CAediting_1368054chr19_46709310_-ENSG00000258366.6ENST00000508582hsa-miR-320e63695909636959157mer-m86369589963695916144-21.24
CAediting_77128chr1_85133844_+ENSG00000258366.6ENST00000508582hsa-miR-4423-3p63695858636958647mer-m86369584463695865141-15.29
CAediting_604450chr7_133034877_-ENSG00000258366.6ENST00000508582hsa-miR-365463695907636959137mer-m86369589663695914154-20.92
CAediting_1054808chr15_66496985_-ENSG00000258366.6ENST00000496816hsa-miR-451263694454636944618mer-1a6369443963694461153-20.47
CAediting_77128chr1_85133844_+ENSG00000258366.6ENST00000496816hsa-miR-4423-3p63694775636947817mer-m86369476063694782142-14.99
CAediting_1399425chr20_1392958_-ENSG00000258366.6ENST00000496816hsa-miR-6869-5p63695198636952036mer6369518363695204140-27.07
CAediting_1054808chr15_66496985_-ENSG00000258366.6ENST00000496816hsa-miR-451263695534636955396mer6369551963695540140-22.65
CAediting_1054808chr15_66496985_-ENSG00000258366.6ENST00000496816hsa-miR-451263695868636958747mer-m86369585463695875149-22.37
CAediting_1368054chr19_46709310_-ENSG00000258366.6ENST00000496816hsa-miR-320e63695909636959157mer-m86369589963695916144-21.24
CAediting_77128chr1_85133844_+ENSG00000258366.6ENST00000496816hsa-miR-4423-3p63696238636962447mer-m86369622363696244143-16.66
CAediting_77128chr1_85133844_+ENSG00000258366.6ENST00000496816hsa-miR-4423-3p63695858636958647mer-m86369584463695865141-15.29
CAediting_604450chr7_133034877_-ENSG00000258366.6ENST00000496816hsa-miR-365463695907636959137mer-m86369589663695914154-20.92
CAediting_1524209chrX_134546392_-ENSG00000258366.6ENST00000496816hsa-miR-503-5p63695617636956248mer-1a6369560063695624147-24.82

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for RTEL1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for RTEL1

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for RTEL1

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for RTEL1

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for RTEL1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RTEL1

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
RTEL1C3554656DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 58CTD_human;GENOMICS_ENGLAND;UNIPROT
RTEL1C4225346PULMONARY FIBROSIS AND/OR BONE MARROW FAILURE, TELOMERE-RELATED, 34CTD_human;GENOMICS_ENGLAND;UNIPROT
RTEL1C0017638Glioma2CTD_human
RTEL1C0259783mixed gliomas2CTD_human
RTEL1C0265965Dyskeratosis Congenita2GENOMICS_ENGLAND;ORPHANET
RTEL1C0555198Malignant Glioma2CTD_human
RTEL1C1846142HOYERAAL-HREIDARSSON SYNDROME2GENOMICS_ENGLAND;ORPHANET
RTEL1C0024121Lung Neoplasms1CTD_human
RTEL1C0085786Hamman-Rich syndrome1ORPHANET
RTEL1C0242379Malignant neoplasm of lung1CTD_human
RTEL1C1800706Idiopathic Pulmonary Fibrosis1CTD_human;ORPHANET
RTEL1C4721508Hamman-Rich Disease1CTD_human
RTEL1C4721509Usual Interstitial Pneumonia1CTD_human
RTEL1C4721952Familial Idiopathic Pulmonary Fibrosis1CTD_human