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Editing gene: PDHA1 (CAeditome ID:5160)

Gene summary for PDHA1

Gene summary

Gene information	Gene symbol	PDHA1
	Gene ID	5160
	Gene name	pyruvate dehydrogenase E1 subunit alpha 1
	Synonyms	PDHA\|PDHAD\|PDHCE1A\|PHE1A
	Cytomap	Xp22.12
	Type of gene	protein-coding
	Description	pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrialPDHE1-A type Ipyruvate dehydrogenase (lipoamide) alpha 1pyruvate dehydrogenase E1 alpha 1 subunitpyruvate dehydrogenase alpha 1pyruvate dehydrogenase complex, E1-alpha poly
	Modification date	20210518
	UniProtAcc	P08559
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
PDHA1	GO:0004739	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	19081061
PDHA1	GO:0006086	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	19081061
PDHA1	GO:0005730	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	0000052
PDHA1	GO:0005739	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	0000052
PDHA1	GO:0045254	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	19081061

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RNA A-to-I events for PDHA1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000131828.12

RNA A-to-I editing events in Cancer.

CAediting_1501378(19345387, +), CAediting_1501379(19345423, +), CAediting_1501380(19345449, +), CAediting_1501381(19345491, +), CAediting_1501382(19346534, +), CAediting_1501383(19346552, +), CAediting_1501384(19346559, +), CAediting_1501385(19352042, +), CAediting_1501386(19352368, +), CAediting_1501387(19352519, +), CAediting_1501388(19354049, +), CAediting_1501389(19354072, +), CAediting_1501390(19354075, +), CAediting_1501391(19354133, +),

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RNA editing positional annotations for PDHA1 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_1501383	chrX_19346552_+	nonsynonymous SNV	ENST00000379806.8	c.A100G	p.R34G	D	.	N
CAediting_1501383	chrX_19346552_+	nonsynonymous SNV	ENST00000423505.4	c.A100G	p.R34G	D	.	N

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1501378	chrX_19345387_+	ncRNA_intronic
CAediting_1501379	chrX_19345423_+	ncRNA_intronic
CAediting_1501380	chrX_19345449_+	ncRNA_intronic
CAediting_1501381	chrX_19345491_+	ncRNA_intronic
CAediting_1501382	chrX_19346534_+	exonic
CAediting_1501383	chrX_19346552_+	exonic
CAediting_1501384	chrX_19346559_+	exonic
CAediting_1501385	chrX_19352042_+	intronic
CAediting_1501386	chrX_19352368_+	intronic
CAediting_1501387	chrX_19352519_+	intronic
CAediting_1501388	chrX_19354049_+	ncRNA_intronic
CAediting_1501389	chrX_19354072_+	ncRNA_intronic
CAediting_1501390	chrX_19354075_+	ncRNA_intronic
CAediting_1501391	chrX_19354133_+	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1501378	chrX_19345387_+	SINE	Alu	AluSq2
CAediting_1501379	chrX_19345423_+	SINE	Alu	AluSq2
CAediting_1501380	chrX_19345449_+	SINE	Alu	AluSq2
CAediting_1501381	chrX_19345491_+	SINE	Alu	AluSq2
CAediting_1501382	chrX_19346534_+	SINE	Alu	AluJo
CAediting_1501383	chrX_19346552_+	SINE	Alu	AluJo
CAediting_1501384	chrX_19346559_+	SINE	Alu	AluJo
CAediting_1501385	chrX_19352042_+	SINE	Alu	AluSx
CAediting_1501386	chrX_19352368_+	SINE	Alu	AluSx1
CAediting_1501387	chrX_19352519_+	SINE	Alu	AluSx1
CAediting_1501388	chrX_19354049_+	SINE	Alu	AluSc5
CAediting_1501389	chrX_19354072_+	SINE	Alu	AluSc5
CAediting_1501390	chrX_19354075_+	SINE	Alu	AluSc5
CAediting_1501391	chrX_19354133_+	SINE	Alu	AluSc5

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RNA A-to-I editing events in the alternative splicing sites for PDHA1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000131828.12.PDHA1.

Correlation between RNA A-to-I editing and PSI for ENSG00000131828.12.PDHA1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PDHA1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for PDHA1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for PDHA1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000131828.12	ENST00000540249	hsa-miR-200b-3p	19359985	19359991	7mer-m8	19359971	19359992	141	-13.32
CAediting_688081	chr9_63819627_+	ENSG00000131828.12	ENST00000540249	hsa-miR-4477b	19360897	19360903	7mer-m8	19360880	19360904	148	-14.38
CAediting_393	chr1_1167164_+	ENSG00000131828.12	ENST00000545074	hsa-miR-200b-3p	19359985	19359991	7mer-m8	19359971	19359992	141	-13.32
CAediting_688081	chr9_63819627_+	ENSG00000131828.12	ENST00000545074	hsa-miR-4477b	19360897	19360903	7mer-m8	19360880	19360904	148	-14.38
CAediting_393	chr1_1167164_+	ENSG00000131828.12	ENST00000379806	hsa-miR-200b-3p	19359985	19359991	7mer-m8	19359971	19359992	141	-13.32
CAediting_688081	chr9_63819627_+	ENSG00000131828.12	ENST00000379806	hsa-miR-4477b	19360897	19360903	7mer-m8	19360880	19360904	148	-14.38
CAediting_1054808	chr15_66496985_-	ENSG00000131828.12	ENST00000540249	hsa-miR-4512	19359976	19359981	6mer	19359961	19359982	143	-19.45
CAediting_1229413	chr17_67471544_+	ENSG00000131828.12	ENST00000540249	hsa-miR-548aa	19360762	19360768	7mer-m8	19360744	19360769	151	-13.36
CAediting_1229415	chr17_67471547_+	ENSG00000131828.12	ENST00000540249	hsa-miR-548aa	19361180	19361186	7mer-m8	19361163	19361187	140	-7.4
CAediting_1229415	chr17_67471547_+	ENSG00000131828.12	ENST00000540249	hsa-miR-548aa	19361204	19361210	7mer-m8	19361187	19361211	140	-8.75
CAediting_1368054	chr19_46709310_-	ENSG00000131828.12	ENST00000540249	hsa-miR-320e	19361140	19361146	7mer-m8	19361130	19361147	140	-15.18
CAediting_86358	chr1_109598906_+	ENSG00000131828.12	ENST00000540249	hsa-miR-197-5p	19361100	19361107	8mer-1a	19361087	19361107	157	-27.62
CAediting_228905	chr2_188297554_+	ENSG00000131828.12	ENST00000540249	hsa-miR-561-3p	19361634	19361640	7mer-m8	19361620	19361641	142	-6.54
CAediting_604450	chr7_133034877_-	ENSG00000131828.12	ENST00000540249	hsa-miR-3654	19361069	19361075	7mer-m8	19361058	19361076	141	-16.03
CAediting_1054808	chr15_66496985_-	ENSG00000131828.12	ENST00000545074	hsa-miR-4512	19359976	19359981	6mer	19359961	19359982	143	-19.45
CAediting_1229413	chr17_67471544_+	ENSG00000131828.12	ENST00000545074	hsa-miR-548aa	19360762	19360768	7mer-m8	19360744	19360769	151	-13.36
CAediting_1229415	chr17_67471547_+	ENSG00000131828.12	ENST00000545074	hsa-miR-548aa	19361180	19361186	7mer-m8	19361163	19361187	140	-7.4
CAediting_1229415	chr17_67471547_+	ENSG00000131828.12	ENST00000545074	hsa-miR-548aa	19361204	19361210	7mer-m8	19361187	19361211	140	-8.75
CAediting_1368054	chr19_46709310_-	ENSG00000131828.12	ENST00000545074	hsa-miR-320e	19361140	19361146	7mer-m8	19361130	19361147	140	-15.18
CAediting_86358	chr1_109598906_+	ENSG00000131828.12	ENST00000545074	hsa-miR-197-5p	19361100	19361107	8mer-1a	19361087	19361107	157	-27.62
CAediting_228905	chr2_188297554_+	ENSG00000131828.12	ENST00000545074	hsa-miR-561-3p	19361634	19361640	7mer-m8	19361620	19361641	142	-6.54
CAediting_604450	chr7_133034877_-	ENSG00000131828.12	ENST00000545074	hsa-miR-3654	19361069	19361075	7mer-m8	19361058	19361076	141	-16.03
CAediting_1054808	chr15_66496985_-	ENSG00000131828.12	ENST00000379806	hsa-miR-4512	19359976	19359981	6mer	19359961	19359982	143	-19.45
CAediting_1229413	chr17_67471544_+	ENSG00000131828.12	ENST00000379806	hsa-miR-548aa	19360762	19360768	7mer-m8	19360744	19360769	151	-13.36
CAediting_1229415	chr17_67471547_+	ENSG00000131828.12	ENST00000379806	hsa-miR-548aa	19361180	19361186	7mer-m8	19361163	19361187	140	-7.4
CAediting_1229415	chr17_67471547_+	ENSG00000131828.12	ENST00000379806	hsa-miR-548aa	19361204	19361210	7mer-m8	19361187	19361211	140	-8.75
CAediting_1368054	chr19_46709310_-	ENSG00000131828.12	ENST00000379806	hsa-miR-320e	19361140	19361146	7mer-m8	19361130	19361147	140	-15.18
CAediting_86358	chr1_109598906_+	ENSG00000131828.12	ENST00000379806	hsa-miR-197-5p	19361100	19361107	8mer-1a	19361087	19361107	157	-27.62
CAediting_228905	chr2_188297554_+	ENSG00000131828.12	ENST00000379806	hsa-miR-561-3p	19361634	19361640	7mer-m8	19361620	19361641	142	-6.54
CAediting_604450	chr7_133034877_-	ENSG00000131828.12	ENST00000379806	hsa-miR-3654	19361069	19361075	7mer-m8	19361058	19361076	141	-16.03

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000131828.12	ENST00000540249	hsa-miR-200b-3p	19360600	19360606	7mer-m8	19360585	19360607	152	-16.13
CAediting_1368054	chr19_46709310_-	ENSG00000131828.12	ENST00000540249	hsa-miR-320e	19361214	19361220	7mer-m8	19361206	19361221	149	-17.99
CAediting_1368054	chr19_46709310_-	ENSG00000131828.12	ENST00000540249	hsa-miR-320e	19360296	19360302	7mer-m8	19360286	19360303	145	-15.07
CAediting_688081	chr9_63819627_+	ENSG00000131828.12	ENST00000540249	hsa-miR-4477b	19361432	19361438	7mer-m8	19361415	19361439	153	-10.33
CAediting_688080	chr9_63819626_+	ENSG00000131828.12	ENST00000540249	hsa-miR-4477b	19361432	19361438	7mer-m8	19361415	19361439	153	-10.33
CAediting_396018	chr5_1062918_-	ENSG00000131828.12	ENST00000540249	hsa-miR-4635	19360868	19360874	7mer-m8	19360854	19360875	145	-9.64
CAediting_393	chr1_1167164_+	ENSG00000131828.12	ENST00000545074	hsa-miR-200b-3p	19360600	19360606	7mer-m8	19360585	19360607	152	-16.13
CAediting_1368054	chr19_46709310_-	ENSG00000131828.12	ENST00000545074	hsa-miR-320e	19361214	19361220	7mer-m8	19361206	19361221	149	-17.99
CAediting_1368054	chr19_46709310_-	ENSG00000131828.12	ENST00000545074	hsa-miR-320e	19360296	19360302	7mer-m8	19360286	19360303	145	-15.07
CAediting_688081	chr9_63819627_+	ENSG00000131828.12	ENST00000545074	hsa-miR-4477b	19361432	19361438	7mer-m8	19361415	19361439	153	-10.33
CAediting_688080	chr9_63819626_+	ENSG00000131828.12	ENST00000545074	hsa-miR-4477b	19361432	19361438	7mer-m8	19361415	19361439	153	-10.33
CAediting_396018	chr5_1062918_-	ENSG00000131828.12	ENST00000545074	hsa-miR-4635	19360868	19360874	7mer-m8	19360854	19360875	145	-9.64
CAediting_393	chr1_1167164_+	ENSG00000131828.12	ENST00000379806	hsa-miR-200b-3p	19360600	19360606	7mer-m8	19360585	19360607	152	-16.13
CAediting_1368054	chr19_46709310_-	ENSG00000131828.12	ENST00000379806	hsa-miR-320e	19361214	19361220	7mer-m8	19361206	19361221	149	-17.99
CAediting_1368054	chr19_46709310_-	ENSG00000131828.12	ENST00000379806	hsa-miR-320e	19360296	19360302	7mer-m8	19360286	19360303	145	-15.07
CAediting_688081	chr9_63819627_+	ENSG00000131828.12	ENST00000379806	hsa-miR-4477b	19361432	19361438	7mer-m8	19361415	19361439	153	-10.33
CAediting_688080	chr9_63819626_+	ENSG00000131828.12	ENST00000379806	hsa-miR-4477b	19361432	19361438	7mer-m8	19361415	19361439	153	-10.33
CAediting_396018	chr5_1062918_-	ENSG00000131828.12	ENST00000379806	hsa-miR-4635	19360868	19360874	7mer-m8	19360854	19360875	145	-9.64

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for PDHA1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for PDHA1

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for PDHA1

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for PDHA1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for PDHA1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
PDHA1	P08559	DB00157	NADH	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	SmallMoleculeDrug	approved\|nutraceutical

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RelatedDiseases for PDHA1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
PDHA1	C1839413	Pyruvate Dehydrogenase E1 Alpha Deficiency	24	GENOMICS_ENGLAND;ORPHANET;UNIPROT
PDHA1	C0023264	Leigh Disease	8	CLINGEN
PDHA1	C1838951	LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY	8	CLINGEN
PDHA1	C1850597	Leigh Syndrome Due To Mitochondrial Complex II Deficiency	8	CLINGEN
PDHA1	C1850598	Leigh Syndrome due to Mitochondrial Complex III Deficiency	8	CLINGEN
PDHA1	C1850599	Leigh Syndrome due to Mitochondrial Complex IV Deficiency	8	CLINGEN
PDHA1	C1850600	Leigh Syndrome due to Mitochondrial Complex V Deficiency	8	CLINGEN
PDHA1	C2931891	Necrotizing encephalopathy, infantile subacute, of Leigh	8	CLINGEN
PDHA1	C0034345	Pyruvate Dehydrogenase Complex Deficiency Disease	4	CTD_human;ORPHANET
PDHA1	C0033578	Prostatic Neoplasms	2	CTD_human
PDHA1	C0376358	Malignant neoplasm of prostate	2	CTD_human
PDHA1	C0001125	Acidosis, Lactic	1	CTD_human
PDHA1	C0024623	Malignant neoplasm of stomach	1	CTD_human
PDHA1	C0029408	Degenerative polyarthritis	1	CTD_human
PDHA1	C0034350	Pyruvate Metabolism, Inborn Errors	1	CTD_human
PDHA1	C0038356	Stomach Neoplasms	1	CTD_human
PDHA1	C0086743	Osteoarthrosis Deformans	1	CTD_human
PDHA1	C0151744	Myocardial Ischemia	1	CTD_human
PDHA1	C0235874	Disease Exacerbation	1	CTD_human
PDHA1	C0751595	Juvenile Pyruvate Dehydrogenase Complex Deficiency Disease	1	CTD_human
PDHA1	C0751596	Pyruvate Dehydrogenase Complex Deficiency Disease, Neonatal	1	CTD_human
PDHA1	C0751597	Ataxia with Lactic Acidosis, Type I	1	CTD_human
PDHA1	C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene