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Editing gene: LGSN (CAeditome ID:51557)

Gene summary for LGSN

Gene summary

Gene information	Gene symbol	LGSN
	Gene ID	51557
	Gene name	lengsin, lens protein with glutamine synthetase domain
	Synonyms	GLULD1\|LGS
	Cytomap	6q12
	Type of gene	protein-coding
	Description	lengsinglutamate-ammonia ligase (glutamine synthase) domain containing 1glutamate-ammonia ligase domain-containing protein 1
	Modification date	20210518
	UniProtAcc	Q5TDP6
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for LGSN

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000146166.15

RNA A-to-I editing events in Cancer.

CAediting_488214(63277834, -), CAediting_488215(63277860, -), CAediting_488216(63277868, -), CAediting_488217(63277873, -), CAediting_488218(63277900, -), CAediting_488219(63277902, -), CAediting_488220(63277919, -), CAediting_488221(63277962, -), CAediting_488222(63277965, -), CAediting_488223(63277974, -), CAediting_488224(63277987, -), CAediting_488225(63277988, -), CAediting_488226(63277991, -), CAediting_488227(63278011, -), CAediting_488228(63278012, -), CAediting_488229(63278017, -), CAediting_488230(63278043, -), CAediting_488231(63278044, -), CAediting_488232(63278074, -), CAediting_488233(63278485, -), CAediting_488234(63278516, -), CAediting_488235(63278526, -), CAediting_488236(63278533, -), CAediting_488237(63278539, -), CAediting_488238(63278547, -), CAediting_488239(63278565, -), CAediting_488240(63278571, -), CAediting_488241(63278578, -), CAediting_488242(63278582, -), CAediting_488243(63278588, -), CAediting_488244(63278596, -), CAediting_488245(63278606, -), CAediting_488246(63278651, -), CAediting_488247(63278665, -), CAediting_488248(63278676, -), CAediting_488249(63278679, -), CAediting_488250(63278702, -), CAediting_488251(63278703, -), CAediting_488252(63278719, -), CAediting_488253(63293196, -),

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RNA editing positional annotations for LGSN using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_488214	chr6_63277834_-	UTR3
CAediting_488215	chr6_63277860_-	UTR3
CAediting_488216	chr6_63277868_-	UTR3
CAediting_488217	chr6_63277873_-	UTR3
CAediting_488218	chr6_63277900_-	UTR3
CAediting_488219	chr6_63277902_-	UTR3
CAediting_488220	chr6_63277919_-	UTR3
CAediting_488221	chr6_63277962_-	UTR3
CAediting_488222	chr6_63277965_-	UTR3
CAediting_488223	chr6_63277974_-	UTR3
CAediting_488224	chr6_63277987_-	UTR3
CAediting_488225	chr6_63277988_-	UTR3
CAediting_488226	chr6_63277991_-	UTR3
CAediting_488227	chr6_63278011_-	UTR3
CAediting_488228	chr6_63278012_-	UTR3
CAediting_488229	chr6_63278017_-	UTR3
CAediting_488230	chr6_63278043_-	UTR3
CAediting_488231	chr6_63278044_-	UTR3
CAediting_488232	chr6_63278074_-	UTR3
CAediting_488233	chr6_63278485_-	UTR3
CAediting_488234	chr6_63278516_-	UTR3
CAediting_488235	chr6_63278526_-	UTR3
CAediting_488236	chr6_63278533_-	UTR3
CAediting_488237	chr6_63278539_-	UTR3
CAediting_488238	chr6_63278547_-	UTR3
CAediting_488239	chr6_63278565_-	UTR3
CAediting_488240	chr6_63278571_-	UTR3
CAediting_488241	chr6_63278578_-	UTR3
CAediting_488242	chr6_63278582_-	UTR3
CAediting_488243	chr6_63278588_-	UTR3
CAediting_488244	chr6_63278596_-	UTR3
CAediting_488245	chr6_63278606_-	UTR3
CAediting_488246	chr6_63278651_-	UTR3
CAediting_488247	chr6_63278665_-	UTR3
CAediting_488248	chr6_63278676_-	UTR3
CAediting_488249	chr6_63278679_-	UTR3
CAediting_488250	chr6_63278702_-	UTR3
CAediting_488251	chr6_63278703_-	UTR3
CAediting_488252	chr6_63278719_-	UTR3
CAediting_488253	chr6_63293196_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_488214	chr6_63277834_-	SINE	Alu	AluSx1
CAediting_488215	chr6_63277860_-	SINE	Alu	AluSx1
CAediting_488216	chr6_63277868_-	SINE	Alu	AluSx1
CAediting_488217	chr6_63277873_-	SINE	Alu	AluSx1
CAediting_488218	chr6_63277900_-	SINE	Alu	AluSx1
CAediting_488219	chr6_63277902_-	SINE	Alu	AluSx1
CAediting_488220	chr6_63277919_-	SINE	Alu	AluSx1
CAediting_488221	chr6_63277962_-	SINE	Alu	AluSx1
CAediting_488222	chr6_63277965_-	SINE	Alu	AluSx1
CAediting_488223	chr6_63277974_-	SINE	Alu	AluSx1
CAediting_488224	chr6_63277987_-	SINE	Alu	AluSx1
CAediting_488225	chr6_63277988_-	SINE	Alu	AluSx1
CAediting_488226	chr6_63277991_-	SINE	Alu	AluSx1
CAediting_488227	chr6_63278011_-	SINE	Alu	AluSx1
CAediting_488228	chr6_63278012_-	SINE	Alu	AluSx1
CAediting_488229	chr6_63278017_-	SINE	Alu	AluSx1
CAediting_488230	chr6_63278043_-	SINE	Alu	AluSx1
CAediting_488231	chr6_63278044_-	SINE	Alu	AluSx1
CAediting_488232	chr6_63278074_-	SINE	Alu	AluSx1
CAediting_488233	chr6_63278485_-	SINE	Alu	AluJr
CAediting_488234	chr6_63278516_-	SINE	Alu	AluJr
CAediting_488235	chr6_63278526_-	SINE	Alu	AluJr
CAediting_488236	chr6_63278533_-	SINE	Alu	AluJr
CAediting_488237	chr6_63278539_-	SINE	Alu	AluJr
CAediting_488238	chr6_63278547_-	SINE	Alu	AluJr
CAediting_488239	chr6_63278565_-	SINE	Alu	AluJr
CAediting_488240	chr6_63278571_-	SINE	Alu	AluJr
CAediting_488241	chr6_63278578_-	SINE	Alu	AluJr
CAediting_488242	chr6_63278582_-	SINE	Alu	AluJr
CAediting_488243	chr6_63278588_-	SINE	Alu	AluJr
CAediting_488244	chr6_63278596_-	SINE	Alu	AluJr
CAediting_488245	chr6_63278606_-	SINE	Alu	AluJr
CAediting_488246	chr6_63278651_-	SINE	Alu	AluJr
CAediting_488247	chr6_63278665_-	SINE	Alu	AluJr
CAediting_488248	chr6_63278676_-	SINE	Alu	AluJr
CAediting_488249	chr6_63278679_-	SINE	Alu	AluJr
CAediting_488250	chr6_63278702_-	SINE	Alu	AluJr
CAediting_488251	chr6_63278703_-	SINE	Alu	AluJr
CAediting_488252	chr6_63278719_-	SINE	Alu	AluJr
CAediting_488253	chr6_63293196_-	SINE	Alu	AluJr

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RNA A-to-I editing events in the alternative splicing sites for LGSN

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
IR	CAediting_488246	chr6_63278651_-	63278644:63278652	5SS	2+0i	TAGTGAGAC	-12.37	TGGTGAGAC	-16.57

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000146166.15.LGSN.

Correlation between RNA A-to-I editing and PSI for ENSG00000146166.15.LGSN.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for LGSN

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for LGSN

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for LGSN

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_488221	chr6_63277962_-	ENSG00000146166.15	ENST00000370658	hsa-miR-4691-3p	63277958	63277964	7mer-m8	63277957	63277984	150.00	-26.36
CAediting_488222	chr6_63277965_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6852-5p	63277964	63277969	6mer	63277963	63277982	149.00	-26.62
CAediting_488230	chr6_63278043_-	ENSG00000146166.15	ENST00000370658	hsa-miR-500a-3p	63278037	63278044	8mer-1a	63278037	63278058	154.00	-20.12
CAediting_488231	chr6_63278044_-	ENSG00000146166.15	ENST00000370658	hsa-miR-508-5p	63278041	63278047	7mer-m8	63278040	63278062	150.00	-20.11
CAediting_488231	chr6_63278044_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6512-3p	63278043	63278049	7mer-m8	63278042	63278063	140.00	-17.07
CAediting_488231	chr6_63278044_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6720-5p	63278043	63278049	7mer-m8	63278042	63278063	152.00	-29.10
CAediting_488231	chr6_63278044_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6849-3p	63278043	63278050	8mer-1a	63278043	63278064	152.00	-16.90
CAediting_488231	chr6_63278044_-	ENSG00000146166.15	ENST00000370658	hsa-miR-766-3p	63278042	63278048	7mer-m8	63278041	63278062	145.00	-18.73
CAediting_488238	chr6_63278547_-	ENSG00000146166.15	ENST00000370658	hsa-miR-3136-3p	63278544	63278550	7mer-m8	63278543	63278564	155.00	-15.96
CAediting_488238	chr6_63278547_-	ENSG00000146166.15	ENST00000370658	hsa-miR-4747-3p	63278543	63278548	6mer	63278542	63278563	164.00	-36.24
CAediting_488238	chr6_63278547_-	ENSG00000146166.15	ENST00000370658	hsa-miR-7155-3p	63278544	63278550	7mer-m8	63278543	63278564	148.00	-23.22
CAediting_488244	chr6_63278596_-	ENSG00000146166.15	ENST00000370658	hsa-miR-3622a-5p	63278591	63278597	7mer-m8	63278590	63278611	152.00	-26.87
CAediting_488244	chr6_63278596_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6767-3p	63278594	63278600	7mer-m8	63278593	63278614	146.00	-15.87
CAediting_488246	chr6_63278651_-	ENSG00000146166.15	ENST00000370658	hsa-miR-10226	63278651	63278656	6mer	63278650	63278672	142.00	-33.55
CAediting_488246	chr6_63278651_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6511a-3p	63278645	63278652	8mer-1a	63278645	63278667	147.00	-17.38
CAediting_488246	chr6_63278651_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6511a-3p	63278645	63278652	8mer-1a	63278645	63278667	147.00	-17.38
CAediting_488246	chr6_63278651_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6511a-3p	63278645	63278652	8mer-1a	63278645	63278667	147.00	-17.38
CAediting_488246	chr6_63278651_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6511a-3p	63278645	63278652	8mer-1a	63278645	63278667	147.00	-17.38
CAediting_488246	chr6_63278651_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6511b-3p	63278645	63278652	8mer-1a	63278645	63278668	144.00	-15.84
CAediting_488246	chr6_63278651_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6511b-3p	63278645	63278652	8mer-1a	63278645	63278668	144.00	-15.84
CAediting_488250	chr6_63278702_-	ENSG00000146166.15	ENST00000370658	hsa-miR-3176	63278702	63278708	7mer-m8	63278701	63278719	140.00	-15.24
CAediting_488250	chr6_63278702_-	ENSG00000146166.15	ENST00000370658	hsa-miR-3922-3p	63278702	63278708	7mer-m8	63278701	63278722	141.00	-19.73
CAediting_488250	chr6_63278702_-	ENSG00000146166.15	ENST00000370658	hsa-miR-874-3p	63278698	63278704	7mer-m8	63278697	63278720	156.00	-31.64
CAediting_488214	chr6_63277834_-	ENSG00000146166.15	ENST00000370658	hsa-miR-383-3p	63277834	63277840	7mer-m8	63277833	63277853	144.00	-19.36
CAediting_488214	chr6_63277834_-	ENSG00000146166.15	ENST00000370658	hsa-miR-7977	63277831	63277837	7mer-m8	63277830	63277847	140.00	-13.07
CAediting_488217	chr6_63277873_-	ENSG00000146166.15	ENST00000370658	hsa-miR-665	63277872	63277879	8mer-1a	63277872	63277891	157.00	-22.69
CAediting_488219	chr6_63277902_-	ENSG00000146166.15	ENST00000370658	hsa-miR-433-5p	63277900	63277907	8mer-1a	63277900	63277923	159.00	-23.97
CAediting_488224	chr6_63277987_-	ENSG00000146166.15	ENST00000370658	hsa-miR-146a-5p	63277982	63277988	7mer-m8	63277981	63278005	153.00	-21.42
CAediting_488224	chr6_63277987_-	ENSG00000146166.15	ENST00000370658	hsa-miR-146b-5p	63277982	63277988	7mer-m8	63277981	63278006	145.00	-18.78
CAediting_488224	chr6_63277987_-	ENSG00000146166.15	ENST00000370658	hsa-miR-606	63277985	63277991	7mer-m8	63277984	63278004	152.00	-10.66
CAediting_488224	chr6_63277987_-	ENSG00000146166.15	ENST00000370658	hsa-miR-7153-5p	63277982	63277988	7mer-m8	63277981	63278003	141.00	-14.94
CAediting_488225	chr6_63277988_-	ENSG00000146166.15	ENST00000370658	hsa-miR-34b-3p	63277985	63277991	7mer-m8	63277984	63278007	148.00	-11.84
CAediting_488225	chr6_63277988_-	ENSG00000146166.15	ENST00000370658	hsa-miR-3614-5p	63277987	63277993	7mer-1a	63277987	63278010	143.00	-20.38
CAediting_488227	chr6_63278011_-	ENSG00000146166.15	ENST00000370658	hsa-miR-17-3p	63278011	63278017	7mer-m8	63278010	63278030	153.00	-18.96
CAediting_488227	chr6_63278011_-	ENSG00000146166.15	ENST00000370658	hsa-miR-3929	63278008	63278013	6mer	63278007	63278031	143.00	-31.22
CAediting_488227	chr6_63278011_-	ENSG00000146166.15	ENST00000370658	hsa-miR-485-5p	63278007	63278013	7mer-m8	63278006	63278026	153.00	-19.66
CAediting_488227	chr6_63278011_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6884-5p	63278007	63278013	7mer-m8	63278006	63278028	146.00	-21.96
CAediting_488234	chr6_63278516_-	ENSG00000146166.15	ENST00000370658	hsa-miR-2681-3p	63278514	63278520	7mer-m8	63278513	63278533	146.00	-15.33
CAediting_488236	chr6_63278533_-	ENSG00000146166.15	ENST00000370658	hsa-miR-3940-3p	63278529	63278534	6mer	63278528	63278552	149.00	-30.07
CAediting_488237	chr6_63278539_-	ENSG00000146166.15	ENST00000370658	hsa-miR-361-3p	63278538	63278544	7mer-m8	63278537	63278563	157.00	-31.05
CAediting_488237	chr6_63278539_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6771-3p	63278535	63278541	7mer-m8	63278534	63278555	144.00	-14.97
CAediting_488239	chr6_63278565_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6734-3p	63278560	63278566	7mer-m8	63278559	63278581	148.00	-25.87
CAediting_488239	chr6_63278565_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6849-3p	63278565	63278571	7mer-m8	63278564	63278582	146.00	-20.01
CAediting_488239	chr6_63278565_-	ENSG00000146166.15	ENST00000370658	hsa-miR-7977	63278562	63278569	8mer-1a	63278562	63278578	150.00	-22.09
CAediting_488240	chr6_63278571_-	ENSG00000146166.15	ENST00000370658	hsa-miR-3943	63278567	63278573	7mer-m8	63278566	63278587	147.00	-22.28
CAediting_488241	chr6_63278578_-	ENSG00000146166.15	ENST00000370658	hsa-miR-1207-3p	63278578	63278584	7mer-m8	63278577	63278595	145.00	-13.53
CAediting_488243	chr6_63278588_-	ENSG00000146166.15	ENST00000370658	hsa-miR-140-3p	63278586	63278592	7mer-m8	63278585	63278605	155.00	-20.70
CAediting_488247	chr6_63278665_-	ENSG00000146166.15	ENST00000370658	hsa-miR-4743-5p	63278662	63278668	7mer-m8	63278661	63278684	148.00	-23.34
CAediting_488248	chr6_63278676_-	ENSG00000146166.15	ENST00000370658	hsa-miR-331-3p	63278675	63278681	7mer-m8	63278674	63278694	146.00	-22.34
CAediting_488248	chr6_63278676_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6771-3p	63278672	63278678	7mer-m8	63278671	63278691	159.00	-25.85
CAediting_488252	chr6_63278719_-	ENSG00000146166.15	ENST00000370658	hsa-miR-371a-3p	63278714	63278720	7mer-m8	63278713	63278735	157.00	-17.31

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_488232	chr6_63278074_-	ENSG00000146166.15	ENST00000370658	hsa-miR-10399-3p	63278072	63278078	7mer-m8	63278071	63278091	148	-11.28
CAediting_488235	chr6_63278526_-	ENSG00000146166.15	ENST00000370658	hsa-miR-1184	63278525	63278531	7mer-m8	63278524	63278550	148	-22.38
CAediting_488235	chr6_63278526_-	ENSG00000146166.15	ENST00000370658	hsa-miR-1184	63278525	63278531	7mer-m8	63278524	63278550	148	-22.38
CAediting_488235	chr6_63278526_-	ENSG00000146166.15	ENST00000370658	hsa-miR-1184	63278525	63278531	7mer-m8	63278524	63278550	148	-22.38
CAediting_488252	chr6_63278719_-	ENSG00000146166.15	ENST00000370658	hsa-miR-204-3p	63278718	63278724	7mer-m8	63278717	63278737	140	-14.37
CAediting_488238	chr6_63278547_-	ENSG00000146166.15	ENST00000370658	hsa-miR-3155a	63278542	63278548	7mer-m8	63278541	63278562	141	-24.95
CAediting_488238	chr6_63278547_-	ENSG00000146166.15	ENST00000370658	hsa-miR-3155b	63278542	63278548	7mer-m8	63278541	63278559	141	-22.98
CAediting_488249	chr6_63278679_-	ENSG00000146166.15	ENST00000370658	hsa-miR-3176	63278678	63278684	7mer-m8	63278677	63278695	145	-17.46
CAediting_488239	chr6_63278565_-	ENSG00000146166.15	ENST00000370658	hsa-miR-320a-5p	63278560	63278566	7mer-m8	63278559	63278584	146	-20.68
CAediting_488216	chr6_63277868_-	ENSG00000146166.15	ENST00000370658	hsa-miR-3622a-3p	63277863	63277870	8mer-1a	63277863	63277884	144	-14.02
CAediting_488216	chr6_63277868_-	ENSG00000146166.15	ENST00000370658	hsa-miR-3622b-3p	63277863	63277870	8mer-1a	63277863	63277883	153	-19.33
CAediting_488247	chr6_63278665_-	ENSG00000146166.15	ENST00000370658	hsa-miR-3652	63278662	63278668	7mer-m8	63278661	63278678	140	-11.92
CAediting_488233	chr6_63278485_-	ENSG00000146166.15	ENST00000370658	hsa-miR-3664-5p	63278481	63278487	7mer-m8	63278480	63278502	151	-19.11
CAediting_488220	chr6_63277919_-	ENSG00000146166.15	ENST00000370658	hsa-miR-3675-3p	63277914	63277920	7mer-m8	63277913	63277934	146	-14.8
CAediting_488227	chr6_63278011_-	ENSG00000146166.15	ENST00000370658	hsa-miR-377-5p	63278007	63278013	7mer-m8	63278006	63278027	155	-19.35
CAediting_488228	chr6_63278012_-	ENSG00000146166.15	ENST00000370658	hsa-miR-377-5p	63278007	63278013	7mer-m8	63278006	63278027	155	-19.35
CAediting_488247	chr6_63278665_-	ENSG00000146166.15	ENST00000370658	hsa-miR-378a-3p	63278664	63278670	7mer-m8	63278663	63278684	155	-21.71
CAediting_488247	chr6_63278665_-	ENSG00000146166.15	ENST00000370658	hsa-miR-378b	63278664	63278670	7mer-m8	63278663	63278681	148	-15.07
CAediting_488247	chr6_63278665_-	ENSG00000146166.15	ENST00000370658	hsa-miR-378c	63278664	63278670	7mer-m8	63278663	63278687	155	-19.17
CAediting_488247	chr6_63278665_-	ENSG00000146166.15	ENST00000370658	hsa-miR-378d	63278664	63278670	7mer-m8	63278663	63278682	155	-17.72
CAediting_488247	chr6_63278665_-	ENSG00000146166.15	ENST00000370658	hsa-miR-378d	63278664	63278670	7mer-m8	63278663	63278682	155	-17.72
CAediting_488247	chr6_63278665_-	ENSG00000146166.15	ENST00000370658	hsa-miR-378e	63278664	63278670	7mer-m8	63278663	63278681	155	-19.73
CAediting_488247	chr6_63278665_-	ENSG00000146166.15	ENST00000370658	hsa-miR-378f	63278664	63278670	7mer-m8	63278663	63278682	148	-17.25
CAediting_488247	chr6_63278665_-	ENSG00000146166.15	ENST00000370658	hsa-miR-378h	63278664	63278670	7mer-m8	63278663	63278683	147	-18.94
CAediting_488247	chr6_63278665_-	ENSG00000146166.15	ENST00000370658	hsa-miR-378i	63278664	63278670	7mer-m8	63278663	63278683	151	-17.4
CAediting_488249	chr6_63278679_-	ENSG00000146166.15	ENST00000370658	hsa-miR-3922-3p	63278678	63278684	7mer-m8	63278677	63278697	150	-19.59
CAediting_488215	chr6_63277860_-	ENSG00000146166.15	ENST00000370658	hsa-miR-3929	63277856	63277862	7mer-m8	63277855	63277880	150	-19.34
CAediting_488247	chr6_63278665_-	ENSG00000146166.15	ENST00000370658	hsa-miR-422a	63278664	63278670	7mer-m8	63278663	63278684	155	-24.31
CAediting_488236	chr6_63278533_-	ENSG00000146166.15	ENST00000370658	hsa-miR-4293	63278529	63278535	7mer-m8	63278528	63278544	142	-17.47
CAediting_488230	chr6_63278043_-	ENSG00000146166.15	ENST00000370658	hsa-miR-4325	63278037	63278044	8mer-1a	63278037	63278056	147	-17.91
CAediting_488235	chr6_63278526_-	ENSG00000146166.15	ENST00000370658	hsa-miR-4418	63278524	63278530	7mer-m8	63278523	63278539	141	-16.92
CAediting_488247	chr6_63278665_-	ENSG00000146166.15	ENST00000370658	hsa-miR-4430	63278662	63278668	7mer-m8	63278661	63278678	145	-17.47
CAediting_488223	chr6_63277974_-	ENSG00000146166.15	ENST00000370658	hsa-miR-4478	63277970	63277976	7mer-m8	63277969	63277984	149	-25.05
CAediting_488215	chr6_63277860_-	ENSG00000146166.15	ENST00000370658	hsa-miR-4478	63277856	63277862	7mer-m8	63277855	63277874	145	-19.61
CAediting_488247	chr6_63278665_-	ENSG00000146166.15	ENST00000370658	hsa-miR-4505	63278662	63278667	6mer	63278661	63278678	143	-23.8
CAediting_488218	chr6_63277900_-	ENSG00000146166.15	ENST00000370658	hsa-miR-4517	63277898	63277903	6mer	63277897	63277920	152	-19.07
CAediting_488219	chr6_63277902_-	ENSG00000146166.15	ENST00000370658	hsa-miR-4517	63277898	63277903	6mer	63277897	63277920	152	-19.07
CAediting_488244	chr6_63278596_-	ENSG00000146166.15	ENST00000370658	hsa-miR-455-5p	63278595	63278601	7mer-m8	63278594	63278617	143	-14.99
CAediting_488252	chr6_63278719_-	ENSG00000146166.15	ENST00000370658	hsa-miR-4646-5p	63278718	63278724	7mer-m8	63278717	63278738	140	-12.79
CAediting_488223	chr6_63277974_-	ENSG00000146166.15	ENST00000370658	hsa-miR-4649-3p	63277973	63277979	7mer-m8	63277972	63277992	140	-14.11
CAediting_488216	chr6_63277868_-	ENSG00000146166.15	ENST00000370658	hsa-miR-4682	63277867	63277873	7mer-m8	63277866	63277887	153	-21.7
CAediting_488220	chr6_63277919_-	ENSG00000146166.15	ENST00000370658	hsa-miR-4684-5p	63277915	63277921	7mer-m8	63277914	63277935	154	-14.02
CAediting_488242	chr6_63278582_-	ENSG00000146166.15	ENST00000370658	hsa-miR-4731-5p	63278580	63278585	6mer	63278579	63278599	142	-19.83
CAediting_488245	chr6_63278606_-	ENSG00000146166.15	ENST00000370658	hsa-miR-4737	63278606	63278612	7mer-m8	63278605	63278625	141	-15.16
CAediting_488235	chr6_63278526_-	ENSG00000146166.15	ENST00000370658	hsa-miR-509-3-5p	63278524	63278530	7mer-m8	63278523	63278543	153	-18.05
CAediting_488235	chr6_63278526_-	ENSG00000146166.15	ENST00000370658	hsa-miR-509-5p	63278524	63278530	7mer-m8	63278523	63278543	148	-16.1
CAediting_488235	chr6_63278526_-	ENSG00000146166.15	ENST00000370658	hsa-miR-509-5p	63278524	63278530	7mer-m8	63278523	63278543	148	-16.1
CAediting_488252	chr6_63278719_-	ENSG00000146166.15	ENST00000370658	hsa-miR-512-3p	63278714	63278720	7mer-m8	63278713	63278734	140	-15.09
CAediting_488252	chr6_63278719_-	ENSG00000146166.15	ENST00000370658	hsa-miR-512-3p	63278714	63278720	7mer-m8	63278713	63278734	140	-15.09
CAediting_488240	chr6_63278571_-	ENSG00000146166.15	ENST00000370658	hsa-miR-532-3p	63278570	63278576	7mer-m8	63278569	63278592	141	-22.37
CAediting_488218	chr6_63277900_-	ENSG00000146166.15	ENST00000370658	hsa-miR-5583-3p	63277898	63277904	7mer-m8	63277897	63277918	143	-8.55
CAediting_488219	chr6_63277902_-	ENSG00000146166.15	ENST00000370658	hsa-miR-5583-3p	63277898	63277904	7mer-m8	63277897	63277918	143	-8.55
CAediting_488218	chr6_63277900_-	ENSG00000146166.15	ENST00000370658	hsa-miR-5583-3p	63277898	63277904	7mer-m8	63277897	63277918	143	-8.55
CAediting_488219	chr6_63277902_-	ENSG00000146166.15	ENST00000370658	hsa-miR-5583-3p	63277898	63277904	7mer-m8	63277897	63277918	143	-8.55
CAediting_488221	chr6_63277962_-	ENSG00000146166.15	ENST00000370658	hsa-miR-5690	63277958	63277964	7mer-m8	63277957	63277977	145	-16.74
CAediting_488227	chr6_63278011_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6086	63278007	63278013	7mer-m8	63278006	63278025	148	-19
CAediting_488228	chr6_63278012_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6086	63278007	63278013	7mer-m8	63278006	63278025	148	-19
CAediting_488227	chr6_63278011_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6516-5p	63278011	63278017	7mer-m8	63278010	63278033	145	-11.89
CAediting_488228	chr6_63278012_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6516-5p	63278011	63278017	7mer-m8	63278010	63278033	145	-11.89
CAediting_488233	chr6_63278485_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6773-3p	63278483	63278490	8mer-1a	63278483	63278504	142	-15.63
CAediting_488240	chr6_63278571_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6778-3p	63278568	63278574	7mer-m8	63278567	63278587	140	-16.13
CAediting_488229	chr6_63278017_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6807-5p	63278017	63278023	7mer-m8	63278016	63278037	141	-16.22
CAediting_488240	chr6_63278571_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6829-3p	63278568	63278573	6mer	63278567	63278586	147	-23.64
CAediting_488251	chr6_63278703_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6878-3p	63278702	63278709	8mer-1a	63278702	63278722	142	-14.14
CAediting_488249	chr6_63278679_-	ENSG00000146166.15	ENST00000370658	hsa-miR-6878-3p	63278679	63278685	7mer-m8	63278678	63278700	150	-27.54
CAediting_488243	chr6_63278588_-	ENSG00000146166.15	ENST00000370658	hsa-miR-7151-3p	63278588	63278594	7mer-m8	63278587	63278603	142	-17.85
CAediting_488235	chr6_63278526_-	ENSG00000146166.15	ENST00000370658	hsa-miR-7156-3p	63278526	63278532	7mer-m8	63278525	63278542	141	-21.02
CAediting_488223	chr6_63277974_-	ENSG00000146166.15	ENST00000370658	hsa-miR-7160-5p	63277972	63277978	7mer-m8	63277971	63277991	146	-18.09
CAediting_488219	chr6_63277902_-	ENSG00000146166.15	ENST00000370658	hsa-miR-7855-5p	63277902	63277907	6mer	63277901	63277920	148	-26.03
CAediting_488243	chr6_63278588_-	ENSG00000146166.15	ENST00000370658	hsa-miR-8052	63278582	63278588	7mer-1a	63278582	63278600	143	-23.77
CAediting_488247	chr6_63278665_-	ENSG00000146166.15	ENST00000370658	hsa-miR-8058	63278665	63278670	6mer	63278664	63278686	143	-22.46
CAediting_488222	chr6_63277965_-	ENSG00000146166.15	ENST00000370658	hsa-miR-887-5p	63277965	63277971	7mer-m8	63277964	63277983	143	-19.73

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_688080	chr9_63819626_+	ENSG00000146166.15	ENST00000370658	hsa-miR-4477b	63279386	63279392	7mer-m8	63279385	63279405	165	-19.5
CAediting_688080	chr9_63819626_+	ENSG00000146166.15	ENST00000370658	hsa-miR-4477b	63277393	63277399	7mer-m8	63277392	63277412	153	-12.88
CAediting_688081	chr9_63819627_+	ENSG00000146166.15	ENST00000370658	hsa-miR-4477b	63279371	63279377	7mer-m8	63279370	63279389	152	-16
CAediting_1229414	chr17_67471546_+	ENSG00000146166.15	ENST00000370658	hsa-miR-548aa	63277883	63277889	7mer-m8	63277882	63277906	144	-10.86
CAediting_1229414	chr17_67471546_+	ENSG00000146166.15	ENST00000370658	hsa-miR-548aa	63279519	63279525	7mer-m8	63279518	63279542	154	-15.41
CAediting_117844	chr1_162342605_+	ENSG00000146166.15	ENST00000370658	hsa-miR-556-3p	63279717	63279724	8mer-1a	63279717	63279738	147	-12.06
CAediting_604450	chr7_133034877_-	ENSG00000146166.15	ENST00000370658	hsa-miR-3654	63278663	63278669	7mer-m8	63278662	63278682	148	-21.48
CAediting_524911	chr7_5495852_-	ENSG00000146166.15	ENST00000370658	hsa-miR-589-3p	63279175	63279181	7mer-m8	63279174	63279196	150	-19.87
CAediting_524911	chr7_5495852_-	ENSG00000146166.15	ENST00000370658	hsa-miR-589-3p	63277759	63277765	7mer-m8	63277758	63277781	150	-18.03
CAediting_1229415	chr17_67471547_+	ENSG00000146166.15	ENST00000622415	hsa-miR-548aa	63280951	63280957	7mer-m8	63280950	63280974	142	-12.68
CAediting_1524209	chrX_134546392_-	ENSG00000146166.15	ENST00000370658	hsa-miR-503-5p	63280273	63280278	6mer	63280272	63280292	140	-27.46
CAediting_1524209	chrX_134546392_-	ENSG00000146166.15	ENST00000370658	hsa-miR-503-5p	63276032	63276037	6mer	63276031	63276055	143	-18.65
CAediting_468389	chr6_31355314_-	ENSG00000146166.15	ENST00000622415	hsa-miR-6891-5p	63280772	63280778	7mer-m8	63280771	63280789	148	-16.49
CAediting_1524209	chrX_134546392_-	ENSG00000146166.15	ENST00000622415	hsa-miR-503-5p	63280273	63280278	6mer	63280272	63280292	140	-27.46

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000146166.15	ENST00000370658	hsa-miR-200b-3p	63277087	63277094	8mer-1a	63277087	63277107	154	-15.55
CAediting_1368054	chr19_46709310_-	ENSG00000146166.15	ENST00000370658	hsa-miR-320e	63278493	63278499	7mer-m8	63278492	63278510	149	-16.68
CAediting_396018	chr5_1062918_-	ENSG00000146166.15	ENST00000370658	hsa-miR-4635	63276367	63276372	6mer	63276366	63276386	140	-12.76
CAediting_1524209	chrX_134546392_-	ENSG00000146166.15	ENST00000370658	hsa-miR-503-5p	63279093	63279098	6mer	63279092	63279114	144	-19.93
CAediting_1368054	chr19_46709310_-	ENSG00000146166.15	ENST00000622415	hsa-miR-320e	63280646	63280652	7mer-m8	63280645	63280663	142	-11.64
CAediting_77128	chr1_85133844_+	ENSG00000146166.15	ENST00000622415	hsa-miR-4423-3p	63280407	63280413	7mer-m8	63280406	63280426	140	-10.45

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for LGSN

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000370658.8	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_488214	ENST00000370658.8	chr6_63277834_-	-1543.00	-1536.40	-1577.20
CAediting_488215	ENST00000370658.8	chr6_63277860_-	-1536.00	-1536.40	-1577.20
CAediting_488216	ENST00000370658.8	chr6_63277868_-	-1535.60	-1536.40	-1577.20
CAediting_488217	ENST00000370658.8	chr6_63277873_-	-1538.40	-1536.40	-1577.20
CAediting_488218	ENST00000370658.8	chr6_63277900_-	-1540.50	-1536.40	-1577.20
CAediting_488219	ENST00000370658.8	chr6_63277902_-	-1536.60	-1536.40	-1577.20
CAediting_488220	ENST00000370658.8	chr6_63277919_-	-1536.10	-1536.40	-1577.20
CAediting_488221	ENST00000370658.8	chr6_63277962_-	-1536.10	-1536.40	-1577.20
CAediting_488222	ENST00000370658.8	chr6_63277965_-	-1539.00	-1536.40	-1577.20
CAediting_488223	ENST00000370658.8	chr6_63277974_-	-1535.70	-1536.40	-1577.20
CAediting_488224	ENST00000370658.8	chr6_63277987_-	-1536.70	-1536.40	-1577.20
CAediting_488225	ENST00000370658.8	chr6_63277988_-	-1542.10	-1536.40	-1577.20
CAediting_488226	ENST00000370658.8	chr6_63277991_-	-1536.10	-1536.40	-1577.20
CAediting_488227	ENST00000370658.8	chr6_63278011_-	-1543.10	-1536.40	-1577.20
CAediting_488228	ENST00000370658.8	chr6_63278012_-	-1535.70	-1536.40	-1577.20
CAediting_488229	ENST00000370658.8	chr6_63278017_-	-1536.00	-1536.40	-1577.20
CAediting_488230	ENST00000370658.8	chr6_63278043_-	-1536.40	-1536.40	-1577.20
CAediting_488231	ENST00000370658.8	chr6_63278044_-	-1543.30	-1536.40	-1577.20
CAediting_488232	ENST00000370658.8	chr6_63278074_-	-1535.60	-1536.40	-1577.20
CAediting_488233	ENST00000370658.8	chr6_63278485_-	-1535.60	-1536.40	-1577.20
CAediting_488234	ENST00000370658.8	chr6_63278516_-	-1539.20	-1536.40	-1577.20
CAediting_488235	ENST00000370658.8	chr6_63278526_-	-1535.70	-1536.40	-1577.20
CAediting_488236	ENST00000370658.8	chr6_63278533_-	-1536.40	-1536.40	-1577.20
CAediting_488237	ENST00000370658.8	chr6_63278539_-	-1543.30	-1536.40	-1577.20
CAediting_488238	ENST00000370658.8	chr6_63278547_-	-1535.40	-1536.40	-1577.20
CAediting_488239	ENST00000370658.8	chr6_63278565_-	-1535.50	-1536.40	-1577.20
CAediting_488240	ENST00000370658.8	chr6_63278571_-	-1535.50	-1536.40	-1577.20
CAediting_488241	ENST00000370658.8	chr6_63278578_-	-1536.40	-1536.40	-1577.20
CAediting_488242	ENST00000370658.8	chr6_63278582_-	-1535.70	-1536.40	-1577.20
CAediting_488243	ENST00000370658.8	chr6_63278588_-	-1539.20	-1536.40	-1577.20
CAediting_488244	ENST00000370658.8	chr6_63278596_-	-1540.60	-1536.40	-1577.20
CAediting_488245	ENST00000370658.8	chr6_63278606_-	-1536.00	-1536.40	-1577.20
CAediting_488246	ENST00000370658.8	chr6_63278651_-	-1542.90	-1536.40	-1577.20
CAediting_488247	ENST00000370658.8	chr6_63278665_-	-1535.70	-1536.40	-1577.20
CAediting_488248	ENST00000370658.8	chr6_63278676_-	-1535.50	-1536.40	-1577.20
CAediting_488249	ENST00000370658.8	chr6_63278679_-	-1535.70	-1536.40	-1577.20
CAediting_488250	ENST00000370658.8	chr6_63278702_-	-1536.10	-1536.40	-1577.20
CAediting_488251	ENST00000370658.8	chr6_63278703_-	-1536.10	-1536.40	-1577.20
CAediting_488252	ENST00000370658.8	chr6_63278719_-	-1536.40	-1536.40	-1577.20

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Relation with ADAR for LGSN

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
LUAD	CAediting_488216	chr6_63277868_-	0.0340606243292343	0.223687184625273	.	.	.	.
LUAD	CAediting_488218	chr6_63277900_-	0.00559808472940565	0.28666915440232	.	.	.	.
LUAD	CAediting_488219	chr6_63277902_-	2.40956879746919e-07	0.500474965296194	.	.	.	.
LUAD	CAediting_488227	chr6_63278011_-	0.0390775699522182	0.176516158886828	.	.	.	.
LUAD	CAediting_488230	chr6_63278043_-	7.11924108832623e-08	0.351976333086715	.	.	.	.
LUAD	CAediting_488231	chr6_63278044_-	0.000121853763063159	0.258482827527663	.	.	.	.
LUAD	CAediting_488236	chr6_63278533_-	0.0444815354231986	0.197491742154224	.	.	.	.
LUAD	CAediting_488246	chr6_63278651_-	0.000121015115328846	0.30016211492085	.	.	.	.

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Relation with cancer stages for LGSN

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
LUAD	pathologic_stage	CAediting_488230	chr6_63278043_-	0.00273544261006204	0.20152320679124
LUAD	pathologic_stage	CAediting_488231	chr6_63278044_-	0.0152052039391704	0.166146424568084

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Relation with survival for LGSN

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for LGSN

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for LGSN

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene