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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: ARL6IP4 (CAeditome ID:51329)

Gene summary for ARL6IP4

check button Gene summary
Gene informationGene symbol

ARL6IP4

Gene ID

51329

Gene nameADP ribosylation factor like GTPase 6 interacting protein 4
SynonymsSFRS20|SR-25|SRp25|SRrp37
Cytomap

12q24.31

Type of geneprotein-coding
DescriptionADP-ribosylation factor-like protein 6-interacting protein 4ADP-ribosylation factor GTPase 6 interacting protein 4ADP-ribosylation factor-like 6 interacting protein 4ADP-ribosylation-like factor 6 interacting protein 4ARL-6-interacting protein 4HSP-9
Modification date20210522
UniProtAcc

Q66PJ3

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for ARL6IP4

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000182196.12

check button RNA A-to-I editing events in Cancer.
CAediting_943762(122981654, +), CAediting_943763(122981715, +), CAediting_943764(122981718, +), CAediting_943765(122981751, +),

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RNA editing positional annotations for ARL6IP4 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
CAediting_943762chr12_122981654_+nonsynonymous SNVENST00000315580.8c.A796Gp.S266GD.N
CAediting_943762chr12_122981654_+nonsynonymous SNVENST00000357866.4c.A220Gp.S74GD.N
CAediting_943762chr12_122981654_+nonsynonymous SNVENST00000392435.5c.A739Gp.S247GD.N
CAediting_943762chr12_122981654_+nonsynonymous SNVENST00000412505.5c.A187Gp.S63GD.N
CAediting_943762chr12_122981654_+nonsynonymous SNVENST00000413381.5c.A220Gp.S74GD.N
CAediting_943762chr12_122981654_+nonsynonymous SNVENST00000426960.5c.A187Gp.S63GD.N
CAediting_943762chr12_122981654_+nonsynonymous SNVENST00000439686.5c.A220Gp.S74GD.N
CAediting_943762chr12_122981654_+nonsynonymous SNVENST00000453766.5c.A772Gp.S258GD.N
CAediting_943762chr12_122981654_+nonsynonymous SNVENST00000454885.5c.A211Gp.S71GD.N
CAediting_943762chr12_122981654_+nonsynonymous SNVENST00000456762.2c.A190Gp.S64GD.N
CAediting_943762chr12_122981654_+nonsynonymous SNVENST00000542099.4c.A580Gp.S194GD.N
CAediting_943762chr12_122981654_+nonsynonymous SNVENST00000543566.4c.A739Gp.S247GD.N
CAediting_943763chr12_122981715_+nonsynonymous SNVENST00000315580.8c.A857Gp.K286RD.N
CAediting_943763chr12_122981715_+nonsynonymous SNVENST00000357866.4c.A281Gp.K94RD.N
CAediting_943763chr12_122981715_+nonsynonymous SNVENST00000392435.5c.A800Gp.K267RD.N
CAediting_943763chr12_122981715_+nonsynonymous SNVENST00000412505.5c.A248Gp.K83RD.N
CAediting_943763chr12_122981715_+nonsynonymous SNVENST00000413381.5c.A281Gp.K94RD.N
CAediting_943763chr12_122981715_+nonsynonymous SNVENST00000426960.5c.A248Gp.K83RD.N
CAediting_943763chr12_122981715_+nonsynonymous SNVENST00000439686.5c.A281Gp.K94RD.N
CAediting_943763chr12_122981715_+nonsynonymous SNVENST00000453766.5c.A833Gp.K278RD.N
CAediting_943763chr12_122981715_+nonsynonymous SNVENST00000454885.5c.A272Gp.K91RD.N
CAediting_943763chr12_122981715_+nonsynonymous SNVENST00000456762.2c.A251Gp.K84RD.N
CAediting_943763chr12_122981715_+nonsynonymous SNVENST00000539770.4c.A589Gp.R197GD.N
CAediting_943763chr12_122981715_+nonsynonymous SNVENST00000542099.4c.A641Gp.K214RD.N
CAediting_943763chr12_122981715_+nonsynonymous SNVENST00000543566.4c.A800Gp.K267RD.N
CAediting_943764chr12_122981718_+nonsynonymous SNVENST00000315580.8c.A860Gp.K287RD.N
CAediting_943764chr12_122981718_+nonsynonymous SNVENST00000357866.4c.A284Gp.K95RD.N
CAediting_943764chr12_122981718_+nonsynonymous SNVENST00000392435.5c.A803Gp.K268RD.N
CAediting_943764chr12_122981718_+nonsynonymous SNVENST00000412505.5c.A251Gp.K84RD.N
CAediting_943764chr12_122981718_+nonsynonymous SNVENST00000413381.5c.A284Gp.K95RD.N
CAediting_943764chr12_122981718_+nonsynonymous SNVENST00000426960.5c.A251Gp.K84RD.N
CAediting_943764chr12_122981718_+nonsynonymous SNVENST00000439686.5c.A284Gp.K95RD.N
CAediting_943764chr12_122981718_+nonsynonymous SNVENST00000453766.5c.A836Gp.K279RD.N
CAediting_943764chr12_122981718_+nonsynonymous SNVENST00000454885.5c.A275Gp.K92RD.N
CAediting_943764chr12_122981718_+nonsynonymous SNVENST00000456762.2c.A254Gp.K85RD.N
CAediting_943764chr12_122981718_+nonsynonymous SNVENST00000539770.4c.A592Gp.S198GD.N
CAediting_943764chr12_122981718_+nonsynonymous SNVENST00000542099.4c.A644Gp.K215RD.N
CAediting_943764chr12_122981718_+nonsynonymous SNVENST00000543566.4c.A803Gp.K268RD.N
CAediting_943765chr12_122981751_+nonsynonymous SNVENST00000315580.8c.A893Gp.K298RD.N
CAediting_943765chr12_122981751_+nonsynonymous SNVENST00000357866.4c.A317Gp.K106RD.N
CAediting_943765chr12_122981751_+nonsynonymous SNVENST00000392435.5c.A836Gp.K279RD.N
CAediting_943765chr12_122981751_+nonsynonymous SNVENST00000412505.5c.A284Gp.K95RD.N
CAediting_943765chr12_122981751_+nonsynonymous SNVENST00000413381.5c.A317Gp.K106RD.N
CAediting_943765chr12_122981751_+nonsynonymous SNVENST00000426960.5c.A284Gp.K95RD.N
CAediting_943765chr12_122981751_+nonsynonymous SNVENST00000439686.5c.A317Gp.K106RD.N
CAediting_943765chr12_122981751_+nonsynonymous SNVENST00000453766.5c.A869Gp.K290RD.N
CAediting_943765chr12_122981751_+nonsynonymous SNVENST00000454885.5c.A308Gp.K103RD.N
CAediting_943765chr12_122981751_+nonsynonymous SNVENST00000456762.2c.A287Gp.K96RD.N
CAediting_943765chr12_122981751_+nonsynonymous SNVENST00000539770.4c.A625Gp.R209GD.N
CAediting_943765chr12_122981751_+nonsynonymous SNVENST00000542099.4c.A677Gp.K226RD.N
CAediting_943765chr12_122981751_+nonsynonymous SNVENST00000543566.4c.A836Gp.K279RD.N

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_943762chr12_122981654_+exonic;splicing
CAediting_943763chr12_122981715_+exonic
CAediting_943764chr12_122981718_+exonic
CAediting_943765chr12_122981751_+exonic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_943762chr12_122981654_+Simple_repeatSimple_repeat(CTC)n
CAediting_943763chr12_122981715_+Low_complexityLow_complexityGA-rich
CAediting_943764chr12_122981718_+Low_complexityLow_complexityGA-rich
CAediting_943765chr12_122981751_+Low_complexityLow_complexityGA-rich

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RNA A-to-I editing events in the alternative splicing sites for ARL6IP4

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
IRCAediting_943762chr12_122981654_+122981635:1229816573SS0+1iCTCCTCCTCCTCTTCTTCCAGTT-5.39CTCCTCCTCCTCTTCTTCCGGTT3.36
IRCAediting_943763chr12_122981715_+122981709:1229817175SS0+4iGCCGGAAGA-1.89GCCGGAGGA-7.39
IRCAediting_943763chr12_122981715_+122981710:1229817185SS0+3iCCGGAAGAA-5.04CCGGAGGAA-9.92
IRCAediting_943764chr12_122981718_+122981710:1229817185SS0+6iCCGGAAGAA-5.04CCGGAAGAG-4.84
IRCAediting_943765chr12_122981751_+122981732:1229817543SS0+1iAAGGACAAGAGGAGGAAGAAGAA-44.3AAGGACAAGAGGAGGAAGAGGAA-35.55
IRCAediting_943765chr12_122981751_+122981738:1229817603SS0+7iAAGAGGAGGAAGAAGAAGAAGAA-40.4AAGAGGAGGAAGAGGAAGAAGAA-44.9
IRCAediting_943765chr12_122981751_+122981742:1229817643SS0+11iGGAGGAAGAAGAAGAAGAAGAGG-31.73GGAGGAAGAGGAAGAAGAAGAGG-31.62
IRCAediting_943765chr12_122981751_+122981731:1229817533SS1+0iCAAGGACAAGAGGAGGAAGAAGA-43.5CAAGGACAAGAGGAGGAAGAGGA-40.98

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000182196.12.ARL6IP4.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000182196.12.ARL6IP4.
boxplot

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ARL6IP4

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for ARL6IP4

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.
all structure


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The effects of the RNA editing to the miRNA binding sites for ARL6IP4

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1054808chr15_66496985_-ENSG00000182196.12ENST00000315580hsa-miR-45121229828921229828987mer-m8122982878122982899140-15.07
CAediting_1054808chr15_66496985_-ENSG00000182196.12ENST00000543566hsa-miR-45121229828921229828987mer-m8122982878122982899140-15.07
CAediting_1054808chr15_66496985_-ENSG00000182196.12ENST00000539770hsa-miR-45121229828921229828987mer-m8122982878122982899140-15.07
CAediting_1054808chr15_66496985_-ENSG00000182196.12ENST00000453766hsa-miR-45121229828921229828987mer-m8122982878122982899140-15.07
CAediting_1054808chr15_66496985_-ENSG00000182196.12ENST00000454885hsa-miR-45121229828921229828987mer-m8122982878122982899140-15.07

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ARL6IP4

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for ARL6IP4

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
BRCACAediting_943763chr12_122981715_+0.03942718892426650.292283727359546....

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Relation with cancer stages for ARL6IP4

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
BRCApathologic_stageCAediting_943763chr12_122981715_+0.0168530977682349-0.339952964346624

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Relation with survival for ARL6IP4

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for ARL6IP4

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARL6IP4

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource