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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: ZDHHC3 (CAeditome ID:51304)

Gene summary for ZDHHC3

check button Gene summary
Gene informationGene symbol

ZDHHC3

Gene ID

51304

Gene namezinc finger DHHC-type palmitoyltransferase 3
SynonymsDHHC-3|DHHC3|GODZ|ZNF373
Cytomap

3p21.31

Type of geneprotein-coding
Descriptionpalmitoyltransferase ZDHHC3DHHC1 proteinGolgi apparatus-specific protein with DHHC zinc finger domainacyltransferase ZDHHC3golgi-specific DHHC Zinc Finger Proteinzinc finger DHHC domain-containing protein 3zinc finger DHHC-type containing 3zinc fin
Modification date20210518
UniProtAcc

Q9NYG2

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
ZDHHC3

GO:0016409

Palmitoyltransferase ZDHHC3

21926431

ZDHHC3

GO:0016409

Palmitoyltransferase ZDHHC3

23034182

ZDHHC3

GO:0016409

Palmitoyltransferase ZDHHC3

27613864

ZDHHC3

GO:0018345

Palmitoyltransferase ZDHHC3

21926431

ZDHHC3

GO:0018345

Palmitoyltransferase ZDHHC3

23034182

ZDHHC3

GO:0072659

Palmitoyltransferase ZDHHC3

22240897

ZDHHC3

GO:1903546

Palmitoyltransferase ZDHHC3

27613864

ZDHHC3

GO:0005794

Palmitoyltransferase ZDHHC3

16647879

ZDHHC3

GO:0005794

Palmitoyltransferase ZDHHC3

19001095

ZDHHC3

GO:0005794

Palmitoyltransferase ZDHHC3

21926431

ZDHHC3

GO:0005794

Palmitoyltransferase ZDHHC3

27613864


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RNA A-to-I events for ZDHHC3

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000163812.12
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_270772(44923111, -), CAediting_270773(44923136, -), CAediting_270774(44923172, -), CAediting_270775(44923173, -), CAediting_270776(44923187, -), CAediting_270777(44923197, -), CAediting_270778(44923208, -), CAediting_270779(44923224, -), CAediting_270780(44923240, -), CAediting_270781(44923243, -), CAediting_270782(44923244, -), CAediting_270783(44923245, -), CAediting_270784(44923246, -), CAediting_270785(44923247, -), CAediting_270786(44923248, -), CAediting_270787(44923256, -), CAediting_270788(44923257, -), CAediting_270789(44923279, -), CAediting_270790(44923281, -), CAediting_270791(44923348, -), CAediting_270792(44923349, -), CAediting_270793(44923557, -), CAediting_270794(44923567, -), CAediting_270795(44923580, -), CAediting_270796(44923609, -), CAediting_270797(44923630, -), CAediting_270798(44923638, -), CAediting_270799(44923639, -), CAediting_270800(44923654, -), CAediting_270801(44923655, -), CAediting_270802(44923671, -), CAediting_270803(44923675, -), CAediting_270804(44923679, -), CAediting_270805(44923681, -), CAediting_270806(44923687, -), CAediting_270807(44923720, -), CAediting_270808(44923721, -), CAediting_270809(44923741, -), CAediting_270810(44923759, -), CAediting_270811(44923769, -), CAediting_270812(44923781, -), CAediting_270813(44923796, -), CAediting_270814(44923797, -), CAediting_270815(44923799, -), CAediting_270816(44923801, -), CAediting_270817(44937179, -), CAediting_270818(44937223, -), CAediting_270819(44937224, -), CAediting_270820(44937227, -), CAediting_270821(44937228, -), CAediting_270822(44937252, -), CAediting_270823(44937272, -), CAediting_270824(44937295, -), CAediting_270825(44937296, -), CAediting_270826(44937320, -), CAediting_270827(44937335, -), CAediting_270828(44937344, -), CAediting_270829(44937361, -), CAediting_270830(44937362, -), CAediting_270831(44937397, -), CAediting_270832(44937405, -), CAediting_270833(44937417, -), CAediting_270834(44937443, -), CAediting_270835(44937476, -), CAediting_270836(44937485, -), CAediting_270837(44937488, -), CAediting_270838(44937489, -), CAediting_270839(44937501, -), CAediting_270840(44937526, -), CAediting_270841(44937534, -), CAediting_270842(44943761, -), CAediting_270843(44943762, -), CAediting_270844(44943776, -), CAediting_270845(44943788, -), CAediting_270846(44943920, -), CAediting_270847(44943936, -), CAediting_270848(44944499, -), CAediting_270849(44944501, -), CAediting_270850(44945669, -), CAediting_270851(44949441, -), CAediting_270852(44961211, -),

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RNA editing positional annotations for ZDHHC3 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_270772chr3_44923111_-intronic
CAediting_270773chr3_44923136_-intronic
CAediting_270774chr3_44923172_-intronic
CAediting_270775chr3_44923173_-intronic
CAediting_270776chr3_44923187_-intronic
CAediting_270777chr3_44923197_-intronic
CAediting_270778chr3_44923208_-intronic
CAediting_270779chr3_44923224_-intronic
CAediting_270780chr3_44923240_-intronic
CAediting_270781chr3_44923243_-intronic
CAediting_270782chr3_44923244_-intronic
CAediting_270783chr3_44923245_-intronic
CAediting_270784chr3_44923246_-intronic
CAediting_270785chr3_44923247_-intronic
CAediting_270786chr3_44923248_-intronic
CAediting_270787chr3_44923256_-intronic
CAediting_270788chr3_44923257_-intronic
CAediting_270789chr3_44923279_-intronic
CAediting_270790chr3_44923281_-intronic
CAediting_270791chr3_44923348_-intronic
CAediting_270792chr3_44923349_-intronic
CAediting_270793chr3_44923557_-intronic
CAediting_270794chr3_44923567_-intronic
CAediting_270795chr3_44923580_-intronic
CAediting_270796chr3_44923609_-intronic
CAediting_270797chr3_44923630_-intronic
CAediting_270798chr3_44923638_-intronic
CAediting_270799chr3_44923639_-intronic
CAediting_270800chr3_44923654_-intronic
CAediting_270801chr3_44923655_-intronic
CAediting_270802chr3_44923671_-intronic
CAediting_270803chr3_44923675_-intronic
CAediting_270804chr3_44923679_-intronic
CAediting_270805chr3_44923681_-intronic
CAediting_270806chr3_44923687_-intronic
CAediting_270807chr3_44923720_-intronic
CAediting_270808chr3_44923721_-intronic
CAediting_270809chr3_44923741_-intronic
CAediting_270810chr3_44923759_-intronic
CAediting_270811chr3_44923769_-intronic
CAediting_270812chr3_44923781_-intronic
CAediting_270813chr3_44923796_-intronic
CAediting_270814chr3_44923797_-intronic
CAediting_270815chr3_44923799_-intronic
CAediting_270816chr3_44923801_-intronic
CAediting_270817chr3_44937179_-intronic
CAediting_270818chr3_44937223_-intronic
CAediting_270819chr3_44937224_-intronic
CAediting_270820chr3_44937227_-intronic
CAediting_270821chr3_44937228_-intronic
CAediting_270822chr3_44937252_-intronic
CAediting_270823chr3_44937272_-intronic
CAediting_270824chr3_44937295_-intronic
CAediting_270825chr3_44937296_-intronic
CAediting_270826chr3_44937320_-intronic
CAediting_270827chr3_44937335_-intronic
CAediting_270828chr3_44937344_-intronic
CAediting_270829chr3_44937361_-intronic
CAediting_270830chr3_44937362_-intronic
CAediting_270831chr3_44937397_-intronic
CAediting_270832chr3_44937405_-intronic
CAediting_270833chr3_44937417_-intronic
CAediting_270834chr3_44937443_-intronic
CAediting_270835chr3_44937476_-intronic
CAediting_270836chr3_44937485_-intronic
CAediting_270837chr3_44937488_-intronic
CAediting_270838chr3_44937489_-intronic
CAediting_270839chr3_44937501_-intronic
CAediting_270840chr3_44937526_-intronic
CAediting_270841chr3_44937534_-intronic
CAediting_270842chr3_44943761_-intronic
CAediting_270843chr3_44943762_-intronic
CAediting_270844chr3_44943776_-intronic
CAediting_270845chr3_44943788_-intronic
CAediting_270846chr3_44943920_-intronic
CAediting_270847chr3_44943936_-intronic
CAediting_270848chr3_44944499_-intronic
CAediting_270849chr3_44944501_-intronic
CAediting_270850chr3_44945669_-ncRNA_intronic
CAediting_270851chr3_44949441_-ncRNA_intronic
CAediting_270852chr3_44961211_-ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_270772chr3_44923111_-SINEAluAluY
CAediting_270773chr3_44923136_-SINEAluAluY
CAediting_270774chr3_44923172_-SINEAluAluY
CAediting_270775chr3_44923173_-SINEAluAluY
CAediting_270776chr3_44923187_-SINEAluAluY
CAediting_270777chr3_44923197_-SINEAluAluY
CAediting_270778chr3_44923208_-SINEAluAluY
CAediting_270779chr3_44923224_-SINEAluAluY
CAediting_270780chr3_44923240_-SINEAluAluY
CAediting_270781chr3_44923243_-SINEAluAluY
CAediting_270782chr3_44923244_-SINEAluAluY
CAediting_270783chr3_44923245_-SINEAluAluY
CAediting_270784chr3_44923246_-SINEAluAluY
CAediting_270785chr3_44923247_-SINEAluAluY
CAediting_270786chr3_44923248_-SINEAluAluY
CAediting_270787chr3_44923256_-SINEAluAluY
CAediting_270788chr3_44923257_-SINEAluAluY
CAediting_270789chr3_44923279_-SINEAluAluY
CAediting_270790chr3_44923281_-SINEAluAluY
CAediting_270791chr3_44923348_-SINEAluAluY
CAediting_270792chr3_44923349_-SINEAluAluY
CAediting_270793chr3_44923557_-SINEAluAluJr
CAediting_270794chr3_44923567_-SINEAluAluJr
CAediting_270795chr3_44923580_-SINEAluAluJr
CAediting_270796chr3_44923609_-SINEAluAluJr
CAediting_270797chr3_44923630_-SINEAluAluJr
CAediting_270798chr3_44923638_-SINEAluAluJr
CAediting_270799chr3_44923639_-SINEAluAluJr
CAediting_270800chr3_44923654_-SINEAluAluJr
CAediting_270801chr3_44923655_-SINEAluAluJr
CAediting_270802chr3_44923671_-SINEAluAluJr
CAediting_270803chr3_44923675_-SINEAluAluJr
CAediting_270804chr3_44923679_-SINEAluAluJr
CAediting_270805chr3_44923681_-SINEAluAluJr
CAediting_270806chr3_44923687_-SINEAluAluJr
CAediting_270807chr3_44923720_-SINEAluAluJr
CAediting_270808chr3_44923721_-SINEAluAluJr
CAediting_270809chr3_44923741_-SINEAluAluJr
CAediting_270810chr3_44923759_-SINEAluAluJr
CAediting_270811chr3_44923769_-SINEAluAluJr
CAediting_270812chr3_44923781_-SINEAluAluJr
CAediting_270813chr3_44923796_-SINEAluAluJr
CAediting_270814chr3_44923797_-SINEAluAluJr
CAediting_270815chr3_44923799_-SINEAluAluJr
CAediting_270816chr3_44923801_-SINEAluAluJr
CAediting_270817chr3_44937179_-SINEAluAluJb
CAediting_270818chr3_44937223_-SINEAluAluJb
CAediting_270819chr3_44937224_-SINEAluAluJb
CAediting_270820chr3_44937227_-SINEAluAluJb
CAediting_270821chr3_44937228_-SINEAluAluJb
CAediting_270822chr3_44937252_-SINEAluAluJb
CAediting_270823chr3_44937272_-SINEAluAluJb
CAediting_270824chr3_44937295_-SINEAluAluJb
CAediting_270825chr3_44937296_-SINEAluAluJb
CAediting_270826chr3_44937320_-SINEAluAluJb
CAediting_270827chr3_44937335_-SINEAluAluJb
CAediting_270828chr3_44937344_-SINEAluAluJb
CAediting_270829chr3_44937361_-SINEAluAluJb
CAediting_270830chr3_44937362_-SINEAluAluJb
CAediting_270831chr3_44937397_-SINEAluAluJb
CAediting_270832chr3_44937405_-SINEAluAluJb
CAediting_270834chr3_44937443_-SINEAluFLAM_C
CAediting_270835chr3_44937476_-SINEAluFLAM_C
CAediting_270836chr3_44937485_-SINEAluFLAM_C
CAediting_270837chr3_44937488_-SINEAluFLAM_C
CAediting_270838chr3_44937489_-SINEAluFLAM_C
CAediting_270839chr3_44937501_-SINEAluFLAM_C
CAediting_270840chr3_44937526_-SINEAluFLAM_C
CAediting_270841chr3_44937534_-SINEAluFLAM_C
CAediting_270842chr3_44943761_-SINEAluAluJo
CAediting_270843chr3_44943762_-SINEAluAluJo
CAediting_270844chr3_44943776_-SINEAluAluJo
CAediting_270845chr3_44943788_-SINEAluAluJo
CAediting_270846chr3_44943920_-SINEAluAluJo
CAediting_270847chr3_44943936_-SINEAluAluJo
CAediting_270848chr3_44944499_-SINEAluAluJo
CAediting_270849chr3_44944501_-SINEAluAluJo
CAediting_270850chr3_44945669_-SINEAluAluSx3
CAediting_270851chr3_44949441_-SINEAluFLAM_C
CAediting_270852chr3_44961211_-SINEAluAluY

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RNA A-to-I editing events in the alternative splicing sites for ZDHHC3

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000163812.12.ZDHHC3.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000163812.12.ZDHHC3.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ZDHHC3

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for ZDHHC3

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for ZDHHC3

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_748296chr10_51299626_+ENSG00000163812.12ENST00000339420hsa-miR-605-3p44916805449168117mer-m84491680444916825140-17.4
CAediting_688081chr9_63819627_+ENSG00000163812.12ENST00000339420hsa-miR-4477b44917049449170557mer-m84491704844917071142-11.92
CAediting_748296chr10_51299626_+ENSG00000163812.12ENST00000296127hsa-miR-605-3p44925439449254457mer-m84492543844925459150-19.5
CAediting_1229415chr17_67471547_+ENSG00000163812.12ENST00000339420hsa-miR-548aa44917601449176077mer-m84491760044917622159-14.55
CAediting_1229415chr17_67471547_+ENSG00000163812.12ENST00000339420hsa-miR-548aa44917527449175337mer-m84491752644917554154-15.67
CAediting_1229415chr17_67471547_+ENSG00000163812.12ENST00000339420hsa-miR-548aa44917474449174807mer-m84491747344917497140-12.46
CAediting_1306323chr19_13836462_-ENSG00000163812.12ENST00000339420hsa-miR-27a-3p44916381449163877mer-m84491638044916400167-26.62
CAediting_1368054chr19_46709310_-ENSG00000163812.12ENST00000339420hsa-miR-320e44916500449165067mer-m84491649944916516142-17.19
CAediting_77128chr1_85133844_+ENSG00000163812.12ENST00000339420hsa-miR-4423-3p44916924449169307mer-m84491692344916943155-20.24
CAediting_442554chr5_154685830_+ENSG00000163812.12ENST00000339420hsa-miR-130344916195449162017mer-m84491619444916212147-12.91
CAediting_442554chr5_154685830_+ENSG00000163812.12ENST00000339420hsa-miR-130344915538449155447mer-m84491553744915558167-26.2
CAediting_442554chr5_154685830_+ENSG00000163812.12ENST00000339420hsa-miR-130344917615449176217mer-m84491761444917635168-25.25
CAediting_604450chr7_133034877_-ENSG00000163812.12ENST00000339420hsa-miR-365444917222449172298mer-1a4491722244917242149-18.14
CAediting_524911chr7_5495852_-ENSG00000163812.12ENST00000339420hsa-miR-589-3p44915973449159808mer-1a4491597344915993146-21.65
CAediting_524911chr7_5495852_-ENSG00000163812.12ENST00000339420hsa-miR-589-3p44915619449156257mer-m84491561844915638146-18.57
CAediting_1160181chr17_7017644_-ENSG00000163812.12ENST00000443879hsa-miR-195-3p44920117449201237mer-m84492011644920136146-12.76
CAediting_1229413chr17_67471544_+ENSG00000163812.12ENST00000296127hsa-miR-548aa44926427449264337mer-m84492642644926450142-12.28
CAediting_77128chr1_85133844_+ENSG00000163812.12ENST00000296127hsa-miR-4423-3p44926370449263767mer-m84492636944926389140-14.52
CAediting_77128chr1_85133844_+ENSG00000163812.12ENST00000296127hsa-miR-4423-3p44925787449257948mer-1a4492578744925807140-12.62
CAediting_524911chr7_5495852_-ENSG00000163812.12ENST00000296127hsa-miR-589-3p44925068449250747mer-m84492506744925092157-23.45
CAediting_573001chr7_92204086_-ENSG00000163812.12ENST00000296127hsa-miR-1285-5p44926349449263568mer-1a4492634944926369159-18.68
CAediting_468389chr6_31355314_-ENSG00000163812.12ENST00000339420hsa-miR-6891-5p44915701449157066mer4491569744915715145-22.39

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_524911chr7_5495852_-ENSG00000163812.12ENST00000339420hsa-miR-589-3p44915506449155127mer-m84491550544915528141-12.86
CAediting_524911chr7_5495852_-ENSG00000163812.12ENST00000296127hsa-miR-589-3p44925163449251708mer-1a4492516344925186140-12.83
CAediting_1351755chr19_40282625_-ENSG00000163812.12ENST00000296127hsa-miR-64144925685449256917mer-1a4492568544925707144-18.6

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ZDHHC3

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for ZDHHC3

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for ZDHHC3

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
ESCApathologic_stageCAediting_270814chr3_44923797_-0.03822734009131230.31352740825045

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Relation with survival for ZDHHC3

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for ZDHHC3

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZDHHC3

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource