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Editing gene: TMEM69 (CAeditome ID:51249)

Gene summary for TMEM69

Gene summary

Gene information	Gene symbol	TMEM69
	Gene ID	51249
	Gene name	transmembrane protein 69
	Synonyms	C1orf154
	Cytomap	1p34.1
	Type of gene	protein-coding
	Description	transmembrane protein 69
	Modification date	20210518
	UniProtAcc	Q5SWH9
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for TMEM69

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000159596.6

RNA A-to-I editing events in Cancer.

CAediting_58253(45688960, +), CAediting_58254(45689151, +), CAediting_58255(45689442, +), CAediting_58256(45689717, +), CAediting_58257(45689723, +), CAediting_58258(45689795, +), CAediting_58259(45690269, +), CAediting_58260(45690292, +), CAediting_58261(45690343, +), CAediting_58262(45690346, +), CAediting_58263(45690351, +), CAediting_58264(45690359, +), CAediting_58265(45690381, +), CAediting_58266(45690434, +), CAediting_58267(45690451, +), CAediting_58268(45690452, +), CAediting_58269(45691468, +), CAediting_58270(45691762, +), CAediting_58271(45691773, +), CAediting_58272(45691782, +), CAediting_58273(45693591, +), CAediting_58274(45694129, +), CAediting_58275(45694169, +), CAediting_58276(45694275, +),

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RNA editing positional annotations for TMEM69 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_58273	chr1_45693591_+	nonsynonymous SNV	ENST00000372025.4	c.A430G	p.R144G	D	D	D

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_58253	chr1_45688960_+	ncRNA_intronic
CAediting_58254	chr1_45689151_+	ncRNA_intronic
CAediting_58255	chr1_45689442_+	ncRNA_intronic
CAediting_58256	chr1_45689717_+	ncRNA_intronic
CAediting_58257	chr1_45689723_+	ncRNA_intronic
CAediting_58258	chr1_45689795_+	ncRNA_intronic
CAediting_58259	chr1_45690269_+	ncRNA_intronic
CAediting_58260	chr1_45690292_+	ncRNA_intronic
CAediting_58261	chr1_45690343_+	ncRNA_intronic
CAediting_58262	chr1_45690346_+	ncRNA_intronic
CAediting_58263	chr1_45690351_+	ncRNA_intronic
CAediting_58264	chr1_45690359_+	ncRNA_intronic
CAediting_58265	chr1_45690381_+	ncRNA_intronic
CAediting_58266	chr1_45690434_+	ncRNA_intronic
CAediting_58267	chr1_45690451_+	ncRNA_intronic
CAediting_58268	chr1_45690452_+	ncRNA_intronic
CAediting_58269	chr1_45691468_+	ncRNA_intronic
CAediting_58270	chr1_45691762_+	ncRNA_intronic
CAediting_58271	chr1_45691773_+	ncRNA_intronic
CAediting_58272	chr1_45691782_+	ncRNA_intronic
CAediting_58273	chr1_45693591_+	exonic
CAediting_58274	chr1_45694129_+	UTR3
CAediting_58275	chr1_45694169_+	UTR3
CAediting_58276	chr1_45694275_+	UTR3

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_58253	chr1_45688960_+	SINE	Alu	AluSx3
CAediting_58254	chr1_45689151_+	SINE	Alu	AluSx3
CAediting_58255	chr1_45689442_+	SINE	Alu	AluJb
CAediting_58256	chr1_45689717_+	SINE	Alu	AluY
CAediting_58257	chr1_45689723_+	SINE	Alu	AluY
CAediting_58258	chr1_45689795_+	SINE	Alu	AluY
CAediting_58259	chr1_45690269_+	SINE	Alu	AluSx1
CAediting_58260	chr1_45690292_+	SINE	Alu	AluSx1
CAediting_58261	chr1_45690343_+	SINE	Alu	AluSx1
CAediting_58262	chr1_45690346_+	SINE	Alu	AluSx1
CAediting_58263	chr1_45690351_+	SINE	Alu	AluSx1
CAediting_58264	chr1_45690359_+	SINE	Alu	AluSx1
CAediting_58265	chr1_45690381_+	SINE	Alu	AluSx1
CAediting_58266	chr1_45690434_+	SINE	Alu	AluSx1
CAediting_58267	chr1_45690451_+	SINE	Alu	AluSx1
CAediting_58268	chr1_45690452_+	SINE	Alu	AluSx1
CAediting_58269	chr1_45691468_+	SINE	Alu	AluJb
CAediting_58270	chr1_45691762_+	SINE	Alu	AluSx1
CAediting_58271	chr1_45691773_+	SINE	Alu	AluSx1
CAediting_58272	chr1_45691782_+	SINE	Alu	AluSx1

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RNA A-to-I editing events in the alternative splicing sites for TMEM69

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000159596.6.TMEM69.

Correlation between RNA A-to-I editing and PSI for ENSG00000159596.6.TMEM69.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TMEM69

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for TMEM69

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for TMEM69

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TMEM69

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000372025.4	protein_coding
ENST00000496366.1	processed_transcript

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_58273	ENST00000372025.4	chr1_45693591_+	-661.20	-657.90	-662.60
CAediting_58274	ENST00000372025.4	chr1_45694129_+	-661.00	-657.90	-662.60
CAediting_58275	ENST00000372025.4	chr1_45694169_+	-657.90	-657.90	-662.60
CAediting_58276	ENST00000372025.4	chr1_45694275_+	-658.20	-657.90	-662.60
CAediting_58273	ENST00000496366.1	chr1_45693591_+	-179.60	-179.60	-179.60

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Relation with ADAR for TMEM69

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for TMEM69

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for TMEM69

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for TMEM69

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for TMEM69

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene