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Editing gene: CRIM1 (CAeditome ID:51232)

Gene summary for CRIM1

Gene summary

Gene information	Gene symbol	CRIM1
	Gene ID	51232
	Gene name	cysteine rich transmembrane BMP regulator 1
	Synonyms	CRIM-1\|S52
	Cytomap	2p22.2
	Type of gene	protein-coding
	Description	cysteine-rich motor neuron 1 proteincysteine rich transmembrane BMP regulator 1 (chordin-like)cysteine-rich repeat-containing protein S52
	Modification date	20210518
	UniProtAcc	Q9NZV1
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
CRIM1	GO:0030165	Cysteine-rich motor neuron 1 protein	23209302

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RNA A-to-I events for CRIM1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000150938.8

RNA A-to-I editing events in Cancer.

CAediting_169983(36406417, +), CAediting_169984(36406421, +), CAediting_169985(36406427, +), CAediting_169986(36406428, +), CAediting_169987(36406429, +), CAediting_169988(36406430, +), CAediting_169989(36406451, +), CAediting_169990(36406452, +), CAediting_169991(36406455, +), CAediting_169992(36406468, +), CAediting_169993(36406475, +), CAediting_169994(36406480, +), CAediting_169995(36406485, +), CAediting_169996(36406486, +), CAediting_169997(36406511, +), CAediting_169998(36406516, +), CAediting_169999(36406521, +), CAediting_170000(36406543, +), CAediting_170001(36406545, +), CAediting_170002(36406546, +), CAediting_170003(36406919, +), CAediting_170004(36406922, +), CAediting_170005(36406923, +), CAediting_170006(36406928, +), CAediting_170007(36406937, +), CAediting_170008(36406938, +), CAediting_170009(36406955, +), CAediting_170010(36406987, +), CAediting_170011(36407006, +), CAediting_170012(36407010, +), CAediting_170013(36407011, +), CAediting_170014(36407012, +), CAediting_170015(36407021, +), CAediting_170016(36407026, +), CAediting_170017(36407042, +), CAediting_170018(36407054, +), CAediting_170019(36407061, +), CAediting_170020(36407084, +), CAediting_170021(36427133, +), CAediting_170022(36474609, +), CAediting_170023(36474622, +), CAediting_170024(36474709, +), CAediting_170025(36474721, +), CAediting_170026(36474727, +), CAediting_170027(36474754, +), CAediting_170028(36474769, +), CAediting_170029(36474773, +), CAediting_170030(36500188, +), CAediting_170031(36501586, +), CAediting_170032(36501588, +), CAediting_170033(36503922, +), CAediting_170034(36504076, +), CAediting_170035(36506999, +), CAediting_170036(36507033, +), CAediting_170037(36517403, +), CAediting_170038(36522524, +), CAediting_170039(36522527, +), CAediting_170040(36522546, +), CAediting_170041(36522547, +), CAediting_170042(36522646, +), CAediting_170043(36522652, +), CAediting_170044(36522655, +), CAediting_170045(36522681, +), CAediting_170046(36522682, +), CAediting_170047(36522687, +), CAediting_170048(36522708, +), CAediting_170049(36522714, +), CAediting_170050(36522717, +), CAediting_170051(36522722, +), CAediting_170052(36522723, +), CAediting_170053(36522725, +), CAediting_170054(36522741, +), CAediting_170055(36522751, +), CAediting_170056(36522752, +), CAediting_170057(36522974, +), CAediting_170058(36522978, +), CAediting_170059(36522986, +), CAediting_170060(36522994, +), CAediting_170061(36523024, +), CAediting_170062(36523054, +), CAediting_170063(36523058, +), CAediting_170064(36523059, +), CAediting_170065(36523072, +), CAediting_170066(36523081, +), CAediting_170067(36523084, +), CAediting_170068(36523091, +), CAediting_170069(36523116, +), CAediting_170070(36523120, +), CAediting_170071(36523121, +), CAediting_170072(36523129, +), CAediting_170073(36523134, +), CAediting_170074(36523137, +),

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RNA editing positional annotations for CRIM1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_169983	chr2_36406417_+	intronic
CAediting_169984	chr2_36406421_+	intronic
CAediting_169985	chr2_36406427_+	intronic
CAediting_169986	chr2_36406428_+	intronic
CAediting_169987	chr2_36406429_+	intronic
CAediting_169988	chr2_36406430_+	intronic
CAediting_169989	chr2_36406451_+	intronic
CAediting_169990	chr2_36406452_+	intronic
CAediting_169991	chr2_36406455_+	intronic
CAediting_169992	chr2_36406468_+	intronic
CAediting_169993	chr2_36406475_+	intronic
CAediting_169994	chr2_36406480_+	intronic
CAediting_169995	chr2_36406485_+	intronic
CAediting_169996	chr2_36406486_+	intronic
CAediting_169997	chr2_36406511_+	intronic
CAediting_169998	chr2_36406516_+	intronic
CAediting_169999	chr2_36406521_+	intronic
CAediting_170000	chr2_36406543_+	intronic
CAediting_170001	chr2_36406545_+	intronic
CAediting_170002	chr2_36406546_+	intronic
CAediting_170003	chr2_36406919_+	intronic
CAediting_170004	chr2_36406922_+	intronic
CAediting_170005	chr2_36406923_+	intronic
CAediting_170006	chr2_36406928_+	intronic
CAediting_170007	chr2_36406937_+	intronic
CAediting_170008	chr2_36406938_+	intronic
CAediting_170009	chr2_36406955_+	intronic
CAediting_170010	chr2_36406987_+	intronic
CAediting_170011	chr2_36407006_+	intronic
CAediting_170012	chr2_36407010_+	intronic
CAediting_170013	chr2_36407011_+	intronic
CAediting_170014	chr2_36407012_+	intronic
CAediting_170015	chr2_36407021_+	intronic
CAediting_170016	chr2_36407026_+	intronic
CAediting_170017	chr2_36407042_+	intronic
CAediting_170018	chr2_36407054_+	intronic
CAediting_170019	chr2_36407061_+	intronic
CAediting_170020	chr2_36407084_+	intronic
CAediting_170021	chr2_36427133_+	intronic
CAediting_170022	chr2_36474609_+	intronic
CAediting_170023	chr2_36474622_+	intronic
CAediting_170024	chr2_36474709_+	intronic
CAediting_170025	chr2_36474721_+	intronic
CAediting_170026	chr2_36474727_+	intronic
CAediting_170027	chr2_36474754_+	intronic
CAediting_170028	chr2_36474769_+	intronic
CAediting_170029	chr2_36474773_+	intronic
CAediting_170030	chr2_36500188_+	intronic
CAediting_170031	chr2_36501586_+	intronic
CAediting_170032	chr2_36501588_+	intronic
CAediting_170033	chr2_36503922_+	intronic
CAediting_170034	chr2_36504076_+	intronic
CAediting_170035	chr2_36506999_+	intronic
CAediting_170036	chr2_36507033_+	intronic
CAediting_170037	chr2_36517403_+	exonic
CAediting_170038	chr2_36522524_+	intronic
CAediting_170039	chr2_36522527_+	intronic
CAediting_170040	chr2_36522546_+	intronic
CAediting_170041	chr2_36522547_+	intronic
CAediting_170042	chr2_36522646_+	intronic
CAediting_170043	chr2_36522652_+	intronic
CAediting_170044	chr2_36522655_+	intronic
CAediting_170045	chr2_36522681_+	intronic
CAediting_170046	chr2_36522682_+	intronic
CAediting_170047	chr2_36522687_+	intronic
CAediting_170048	chr2_36522708_+	intronic
CAediting_170049	chr2_36522714_+	intronic
CAediting_170050	chr2_36522717_+	intronic
CAediting_170051	chr2_36522722_+	intronic
CAediting_170052	chr2_36522723_+	intronic
CAediting_170053	chr2_36522725_+	intronic
CAediting_170054	chr2_36522741_+	intronic
CAediting_170055	chr2_36522751_+	intronic
CAediting_170056	chr2_36522752_+	intronic
CAediting_170057	chr2_36522974_+	intronic
CAediting_170058	chr2_36522978_+	intronic
CAediting_170059	chr2_36522986_+	intronic
CAediting_170060	chr2_36522994_+	intronic
CAediting_170061	chr2_36523024_+	intronic
CAediting_170062	chr2_36523054_+	intronic
CAediting_170063	chr2_36523058_+	intronic
CAediting_170064	chr2_36523059_+	intronic
CAediting_170065	chr2_36523072_+	intronic
CAediting_170066	chr2_36523081_+	intronic
CAediting_170067	chr2_36523084_+	intronic
CAediting_170068	chr2_36523091_+	intronic
CAediting_170069	chr2_36523116_+	intronic
CAediting_170070	chr2_36523120_+	intronic
CAediting_170071	chr2_36523121_+	intronic
CAediting_170072	chr2_36523129_+	intronic
CAediting_170073	chr2_36523134_+	intronic
CAediting_170074	chr2_36523137_+	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_170021	chr2_36427133_+	SINE	Alu	AluSg
CAediting_170022	chr2_36474609_+	SINE	Alu	AluSz
CAediting_170023	chr2_36474622_+	SINE	Alu	AluSz
CAediting_170024	chr2_36474709_+	SINE	Alu	AluSz
CAediting_170025	chr2_36474721_+	SINE	Alu	AluSz
CAediting_170026	chr2_36474727_+	SINE	Alu	AluSz
CAediting_170027	chr2_36474754_+	SINE	Alu	AluSz
CAediting_170028	chr2_36474769_+	SINE	Alu	AluSz
CAediting_170029	chr2_36474773_+	SINE	Alu	AluSz
CAediting_170030	chr2_36500188_+	SINE	Alu	AluSx3
CAediting_170031	chr2_36501586_+	SINE	Alu	AluJb
CAediting_170032	chr2_36501588_+	SINE	Alu	AluJb
CAediting_170033	chr2_36503922_+	SINE	Alu	AluJb
CAediting_170034	chr2_36504076_+	SINE	Alu	AluJb
CAediting_170035	chr2_36506999_+	SINE	Alu	AluJr
CAediting_170036	chr2_36507033_+	SINE	Alu	AluJr
CAediting_170038	chr2_36522524_+	SINE	Alu	AluSz
CAediting_170039	chr2_36522527_+	SINE	Alu	AluSz
CAediting_170040	chr2_36522546_+	SINE	Alu	AluSz
CAediting_170041	chr2_36522547_+	SINE	Alu	AluSz
CAediting_170042	chr2_36522646_+	SINE	Alu	AluSz
CAediting_170043	chr2_36522652_+	SINE	Alu	AluSz
CAediting_170044	chr2_36522655_+	SINE	Alu	AluSz
CAediting_170045	chr2_36522681_+	SINE	Alu	AluSz
CAediting_170046	chr2_36522682_+	SINE	Alu	AluSz
CAediting_170047	chr2_36522687_+	SINE	Alu	AluSz
CAediting_170048	chr2_36522708_+	SINE	Alu	AluSz
CAediting_170049	chr2_36522714_+	SINE	Alu	AluSz
CAediting_170050	chr2_36522717_+	SINE	Alu	AluSz
CAediting_170051	chr2_36522722_+	SINE	Alu	AluSz
CAediting_170052	chr2_36522723_+	SINE	Alu	AluSz
CAediting_170053	chr2_36522725_+	SINE	Alu	AluSz
CAediting_170054	chr2_36522741_+	SINE	Alu	AluSz
CAediting_170055	chr2_36522751_+	SINE	Alu	AluSz
CAediting_170056	chr2_36522752_+	SINE	Alu	AluSz
CAediting_170057	chr2_36522974_+	SINE	Alu	AluSg4
CAediting_170058	chr2_36522978_+	SINE	Alu	AluSg4
CAediting_170059	chr2_36522986_+	SINE	Alu	AluSg4
CAediting_170060	chr2_36522994_+	SINE	Alu	AluSg4
CAediting_170061	chr2_36523024_+	SINE	Alu	AluSg4
CAediting_170062	chr2_36523054_+	SINE	Alu	AluSg4
CAediting_170063	chr2_36523058_+	SINE	Alu	AluSg4
CAediting_170064	chr2_36523059_+	SINE	Alu	AluSg4
CAediting_170065	chr2_36523072_+	SINE	Alu	AluSg4
CAediting_170066	chr2_36523081_+	SINE	Alu	AluSg4
CAediting_170067	chr2_36523084_+	SINE	Alu	AluSg4
CAediting_170068	chr2_36523091_+	SINE	Alu	AluSg4
CAediting_170069	chr2_36523116_+	SINE	Alu	AluSg4
CAediting_170070	chr2_36523120_+	SINE	Alu	AluSg4
CAediting_170071	chr2_36523121_+	SINE	Alu	AluSg4
CAediting_170072	chr2_36523129_+	SINE	Alu	AluSg4
CAediting_170073	chr2_36523134_+	SINE	Alu	AluSg4
CAediting_170074	chr2_36523137_+	SINE	Alu	AluSg4

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RNA A-to-I editing events in the alternative splicing sites for CRIM1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000150938.8.CRIM1.

Correlation between RNA A-to-I editing and PSI for ENSG00000150938.8.CRIM1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CRIM1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CRIM1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for CRIM1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000150938.8	ENST00000280527	hsa-miR-200b-3p	36550092	36550098	7mer-m8	36550078	36550099	158	-17.87
CAediting_688080	chr9_63819626_+	ENSG00000150938.8	ENST00000280527	hsa-miR-4477b	36548883	36548889	7mer-m8	36548869	36548890	160	-12.14
CAediting_393	chr1_1167164_+	ENSG00000150938.8	ENST00000428774	hsa-miR-200b-3p	36378385	36378392	8mer-1a	36378371	36378392	140	-12.34
CAediting_117844	chr1_162342605_+	ENSG00000150938.8	ENST00000280527	hsa-miR-556-3p	36550681	36550687	7mer-m8	36550667	36550688	154	-10.23
CAediting_396018	chr5_1062918_-	ENSG00000150938.8	ENST00000280527	hsa-miR-4635	36548884	36548891	8mer-1a	36548873	36548891	143	-14.59
CAediting_524911	chr7_5495852_-	ENSG00000150938.8	ENST00000280527	hsa-miR-589-3p	36549111	36549118	8mer-1a	36549095	36549118	145	-14.25

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1160181	chr17_7017644_-	ENSG00000150938.8	ENST00000280527	hsa-miR-195-3p	36550279	36550285	7mer-m8	36550265	36550286	145	-6.38
CAediting_1524209	chrX_134546392_-	ENSG00000150938.8	ENST00000280527	hsa-miR-503-5p	36549374	36549379	6mer	36549357	36549380	143	-19.02
CAediting_1229413	chr17_67471544_+	ENSG00000150938.8	ENST00000280527	hsa-miR-548aa	36550162	36550168	7mer-m8	36550145	36550169	140	-10.13
CAediting_524911	chr7_5495852_-	ENSG00000150938.8	ENST00000280527	hsa-miR-589-3p	36550474	36550480	7mer-m8	36550457	36550481	148	-12.44
CAediting_524911	chr7_5495852_-	ENSG00000150938.8	ENST00000280527	hsa-miR-589-3p	36549566	36549572	7mer-m8	36549551	36549573	151	-15.07

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CRIM1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000280527.5	protein_coding
ENST00000413985.1	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_170037	ENST00000280527.5	chr2_36517403_+	-1955.50	-1955.00	-1955.50
CAediting_170037	ENST00000413985.1	chr2_36517403_+	-266.80	-266.30	-266.80

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Relation with ADAR for CRIM1

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for CRIM1

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for CRIM1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for CRIM1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CRIM1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
CRIM1	C1865286	MACROPHTHALMIA, COLOBOMATOUS, WITH MICROCORNEA	2	GENOMICS_ENGLAND;ORPHANET

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene