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Editing gene: CLDN18 (CAeditome ID:51208)

Gene summary for CLDN18

Gene summary

Gene information	Gene symbol	CLDN18
	Gene ID	51208
	Gene name	claudin 18
	Synonyms	SFTA5\|SFTPJ
	Cytomap	3q22.3
	Type of gene	protein-coding
	Description	claudin-18surfactant associated 5surfactant associated protein Jsurfactant, pulmonary associated protein J
	Modification date	20210518
	UniProtAcc	P56856
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for CLDN18

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000066405.11

RNA A-to-I editing events in Cancer.

CAediting_311910(138001407, +), CAediting_311911(138001429, +), CAediting_311912(138001496, +), CAediting_311913(138003914, +), CAediting_311914(138003917, +), CAediting_311915(138005443, +), CAediting_311916(138005459, +), CAediting_311917(138007604, +), CAediting_311918(138007625, +), CAediting_311919(138008348, +), CAediting_311920(138008349, +), CAediting_311921(138008379, +), CAediting_311922(138008414, +), CAediting_311923(138008418, +), CAediting_311924(138008524, +), CAediting_311925(138008648, +), CAediting_311926(138008662, +), CAediting_311927(138008688, +), CAediting_311928(138008698, +), CAediting_311929(138008701, +), CAediting_311930(138008912, +), CAediting_311931(138008920, +), CAediting_311932(138018610, +), CAediting_311933(138026445, +), CAediting_311934(138026475, +), CAediting_311935(138026485, +), CAediting_311936(138026486, +), CAediting_311937(138026487, +), CAediting_311938(138026498, +), CAediting_311939(138026551, +), CAediting_311940(138026566, +), CAediting_311941(138026577, +), CAediting_311942(138026602, +), CAediting_311943(138028121, +), CAediting_311944(138028191, +), CAediting_311945(138028285, +), CAediting_311946(138029194, +), CAediting_311947(138029202, +), CAediting_311948(138029207, +), CAediting_311949(138029215, +), CAediting_311950(138029226, +), CAediting_311951(138029239, +), CAediting_311952(138029246, +), CAediting_311953(138029329, +), CAediting_311954(138029335, +), CAediting_311955(138029407, +), CAediting_311956(138029413, +), CAediting_311957(138029419, +), CAediting_311958(138032156, +), CAediting_311959(138032200, +), CAediting_311960(138032205, +), CAediting_311961(138032286, +), CAediting_311962(138032310, +), CAediting_311963(138032340, +), CAediting_311964(138032375, +), CAediting_311965(138032664, +), CAediting_311966(138032679, +), CAediting_311967(138032682, +), CAediting_311968(138032705, +), CAediting_311969(138032718, +), CAediting_311970(138032740, +),

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RNA editing positional annotations for CLDN18 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_311910	chr3_138001407_+	intronic
CAediting_311911	chr3_138001429_+	intronic
CAediting_311912	chr3_138001496_+	intronic
CAediting_311913	chr3_138003914_+	intronic
CAediting_311914	chr3_138003917_+	intronic
CAediting_311915	chr3_138005443_+	intronic
CAediting_311916	chr3_138005459_+	intronic
CAediting_311917	chr3_138007604_+	intronic
CAediting_311918	chr3_138007625_+	intronic
CAediting_311919	chr3_138008348_+	intronic
CAediting_311920	chr3_138008349_+	intronic
CAediting_311921	chr3_138008379_+	intronic
CAediting_311922	chr3_138008414_+	intronic
CAediting_311923	chr3_138008418_+	intronic
CAediting_311924	chr3_138008524_+	intronic
CAediting_311925	chr3_138008648_+	intronic
CAediting_311926	chr3_138008662_+	intronic
CAediting_311927	chr3_138008688_+	intronic
CAediting_311928	chr3_138008698_+	intronic
CAediting_311929	chr3_138008701_+	intronic
CAediting_311930	chr3_138008912_+	intronic
CAediting_311931	chr3_138008920_+	intronic
CAediting_311932	chr3_138018610_+	intronic
CAediting_311933	chr3_138026445_+	intronic
CAediting_311934	chr3_138026475_+	intronic
CAediting_311935	chr3_138026485_+	intronic
CAediting_311936	chr3_138026486_+	intronic
CAediting_311937	chr3_138026487_+	intronic
CAediting_311938	chr3_138026498_+	intronic
CAediting_311939	chr3_138026551_+	intronic
CAediting_311940	chr3_138026566_+	intronic
CAediting_311941	chr3_138026577_+	intronic
CAediting_311942	chr3_138026602_+	intronic
CAediting_311943	chr3_138028121_+	intronic
CAediting_311944	chr3_138028191_+	intronic
CAediting_311945	chr3_138028285_+	intronic
CAediting_311946	chr3_138029194_+	intronic
CAediting_311947	chr3_138029202_+	intronic
CAediting_311948	chr3_138029207_+	intronic
CAediting_311949	chr3_138029215_+	intronic
CAediting_311950	chr3_138029226_+	intronic
CAediting_311951	chr3_138029239_+	intronic
CAediting_311952	chr3_138029246_+	intronic
CAediting_311953	chr3_138029329_+	intronic
CAediting_311954	chr3_138029335_+	intronic
CAediting_311955	chr3_138029407_+	intronic
CAediting_311956	chr3_138029413_+	intronic
CAediting_311957	chr3_138029419_+	intronic
CAediting_311958	chr3_138032156_+	UTR3
CAediting_311959	chr3_138032200_+	UTR3
CAediting_311960	chr3_138032205_+	UTR3
CAediting_311961	chr3_138032286_+	UTR3
CAediting_311962	chr3_138032310_+	UTR3
CAediting_311963	chr3_138032340_+	UTR3
CAediting_311964	chr3_138032375_+	UTR3
CAediting_311965	chr3_138032664_+	UTR3
CAediting_311966	chr3_138032679_+	UTR3
CAediting_311967	chr3_138032682_+	UTR3
CAediting_311968	chr3_138032705_+	UTR3
CAediting_311969	chr3_138032718_+	UTR3
CAediting_311970	chr3_138032740_+	UTR3

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_311910	chr3_138001407_+	SINE	Alu	AluYj4
CAediting_311911	chr3_138001429_+	SINE	Alu	AluYj4
CAediting_311912	chr3_138001496_+	SINE	Alu	AluYj4
CAediting_311913	chr3_138003914_+	SINE	Alu	AluSz
CAediting_311914	chr3_138003917_+	SINE	Alu	AluSz
CAediting_311915	chr3_138005443_+	LINE	L1	L1PA7
CAediting_311916	chr3_138005459_+	LINE	L1	L1PA7
CAediting_311917	chr3_138007604_+	LINE	L1	L1PA8A
CAediting_311918	chr3_138007625_+	LINE	L1	L1PA8A
CAediting_311919	chr3_138008348_+	SINE	Alu	AluSx1
CAediting_311920	chr3_138008349_+	SINE	Alu	AluSx1
CAediting_311921	chr3_138008379_+	SINE	Alu	AluSx1
CAediting_311922	chr3_138008414_+	SINE	Alu	AluSx1
CAediting_311923	chr3_138008418_+	SINE	Alu	AluSx1
CAediting_311924	chr3_138008524_+	SINE	Alu	AluSx1
CAediting_311925	chr3_138008648_+	SINE	Alu	AluSz
CAediting_311926	chr3_138008662_+	SINE	Alu	AluSz
CAediting_311927	chr3_138008688_+	SINE	Alu	AluSz
CAediting_311928	chr3_138008698_+	SINE	Alu	AluSz
CAediting_311929	chr3_138008701_+	SINE	Alu	AluSz
CAediting_311930	chr3_138008912_+	SINE	Alu	AluSz
CAediting_311931	chr3_138008920_+	SINE	Alu	AluSz
CAediting_311932	chr3_138018610_+	SINE	Alu	AluYa5
CAediting_311933	chr3_138026445_+	SINE	Alu	AluSg4
CAediting_311934	chr3_138026475_+	SINE	Alu	AluSg4
CAediting_311935	chr3_138026485_+	SINE	Alu	AluSg4
CAediting_311936	chr3_138026486_+	SINE	Alu	AluSg4
CAediting_311937	chr3_138026487_+	SINE	Alu	AluSg4
CAediting_311938	chr3_138026498_+	SINE	Alu	AluSg4
CAediting_311939	chr3_138026551_+	SINE	Alu	AluSg4
CAediting_311940	chr3_138026566_+	SINE	Alu	AluSg4
CAediting_311941	chr3_138026577_+	SINE	Alu	AluSg4
CAediting_311942	chr3_138026602_+	SINE	Alu	AluSg4
CAediting_311943	chr3_138028121_+	SINE	Alu	AluSx1
CAediting_311944	chr3_138028191_+	SINE	Alu	AluSx1
CAediting_311945	chr3_138028285_+	SINE	Alu	AluSx1
CAediting_311946	chr3_138029194_+	SINE	Alu	AluSx
CAediting_311947	chr3_138029202_+	SINE	Alu	AluSx
CAediting_311948	chr3_138029207_+	SINE	Alu	AluSx
CAediting_311949	chr3_138029215_+	SINE	Alu	AluSx
CAediting_311950	chr3_138029226_+	SINE	Alu	AluSx
CAediting_311951	chr3_138029239_+	SINE	Alu	AluSx
CAediting_311952	chr3_138029246_+	SINE	Alu	AluSx
CAediting_311953	chr3_138029329_+	SINE	Alu	AluSx
CAediting_311954	chr3_138029335_+	SINE	Alu	AluSx
CAediting_311955	chr3_138029407_+	SINE	Alu	AluSx
CAediting_311956	chr3_138029413_+	SINE	Alu	AluSx
CAediting_311957	chr3_138029419_+	SINE	Alu	AluSx
CAediting_311958	chr3_138032156_+	SINE	Alu	AluJb
CAediting_311959	chr3_138032200_+	SINE	Alu	AluJb
CAediting_311960	chr3_138032205_+	SINE	Alu	AluJb
CAediting_311961	chr3_138032286_+	SINE	Alu	AluJb
CAediting_311962	chr3_138032310_+	SINE	Alu	AluJb
CAediting_311963	chr3_138032340_+	SINE	Alu	AluJb
CAediting_311964	chr3_138032375_+	SINE	Alu	AluJb
CAediting_311965	chr3_138032664_+	SINE	Alu	FLAM_A
CAediting_311966	chr3_138032679_+	SINE	Alu	FLAM_A
CAediting_311967	chr3_138032682_+	SINE	Alu	FLAM_A
CAediting_311968	chr3_138032705_+	SINE	Alu	FLAM_A
CAediting_311969	chr3_138032718_+	SINE	Alu	FLAM_A

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RNA A-to-I editing events in the alternative splicing sites for CLDN18

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
IR	CAediting_311961	chr3_138032286_+	138032286:138032294	5SS	3+0i	ATGGTGGCC	-2.41	GTGGTGGCC	-5.07
IR	CAediting_311968	chr3_138032705_+	138032701:138032723	3SS	0+16i	CCCAAGTAGCTGGAATTACAGGT	-23.44	CCCAGGTAGCTGGAATTACAGGT	-22.81
IR	CAediting_311969	chr3_138032718_+	138032701:138032723	3SS	0+3i	CCCAAGTAGCTGGAATTACAGGT	-23.44	CCCAAGTAGCTGGAATTGCAGGT	-33.64

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000066405.11.CLDN18.

Correlation between RNA A-to-I editing and PSI for ENSG00000066405.11.CLDN18.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CLDN18

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

PAAD.CAediting_311970.ENSG00000066405.CLDN18.png
Soverview

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Protein coding region RNA A-to-I editings for CLDN18

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for CLDN18

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_311968	chr3_138032705_+	ENSG00000066405.11	ENST00000343735	hsa-miR-3192-5p	138032698	138032704	7mer-m8	138032683	138032705	157.00	-26.04
CAediting_311968	chr3_138032705_+	ENSG00000066405.11	ENST00000343735	hsa-miR-7851-3p	138032700	138032707	8mer-1a	138032686	138032707	168.00	-28.57
CAediting_311968	chr3_138032705_+	ENSG00000066405.11	ENST00000183605	hsa-miR-3192-5p	138032698	138032704	7mer-m8	138032683	138032705	157.00	-26.04
CAediting_311968	chr3_138032705_+	ENSG00000066405.11	ENST00000183605	hsa-miR-7851-3p	138032700	138032707	8mer-1a	138032686	138032707	168.00	-28.57
CAediting_311970	chr3_138032740_+	ENSG00000066405.11	ENST00000343735	hsa-miR-4676-5p	138032736	138032742	7mer-m8	138032723	138032743	157.00	-20.17
CAediting_311970	chr3_138032740_+	ENSG00000066405.11	ENST00000343735	hsa-miR-575	138032736	138032742	7mer-m8	138032724	138032743	151.00	-19.82
CAediting_311970	chr3_138032740_+	ENSG00000066405.11	ENST00000183605	hsa-miR-4676-5p	138032736	138032742	7mer-m8	138032723	138032743	157.00	-20.17
CAediting_311970	chr3_138032740_+	ENSG00000066405.11	ENST00000183605	hsa-miR-575	138032736	138032742	7mer-m8	138032724	138032743	151.00	-19.82
CAediting_311958	chr3_138032156_+	ENSG00000066405.11	ENST00000343735	hsa-miR-4634	138032153	138032159	7mer-m8	138032137	138032160	147.00	-30.40
CAediting_311958	chr3_138032156_+	ENSG00000066405.11	ENST00000183605	hsa-miR-4634	138032153	138032159	7mer-m8	138032137	138032160	147.00	-30.40
CAediting_311958	chr3_138032156_+	ENSG00000066405.11	ENST00000479660	hsa-miR-4634	138032153	138032159	7mer-m8	138032137	138032160	147.00	-30.40
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000343735	hsa-miR-3136-3p	138032201	138032207	7mer-m8	138032187	138032208	147.00	-16.22
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000343735	hsa-miR-6724-5p	138032203	138032209	7mer-m8	138032189	138032210	145.00	-22.57
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000343735	hsa-miR-6724-5p	138032203	138032209	7mer-m8	138032189	138032210	145.00	-22.57
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000343735	hsa-miR-6724-5p	138032203	138032209	7mer-m8	138032189	138032210	145.00	-22.57
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000343735	hsa-miR-6724-5p	138032203	138032209	7mer-m8	138032189	138032210	145.00	-22.57
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000343735	hsa-miR-6773-5p	138032203	138032209	7mer-m8	138032188	138032210	153.00	-23.04
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000343735	hsa-miR-7155-3p	138032201	138032207	7mer-m8	138032190	138032208	146.00	-17.96
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000183605	hsa-miR-3136-3p	138032201	138032207	7mer-m8	138032187	138032208	147.00	-16.22
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000183605	hsa-miR-6724-5p	138032203	138032209	7mer-m8	138032189	138032210	145.00	-22.57
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000183605	hsa-miR-6724-5p	138032203	138032209	7mer-m8	138032189	138032210	145.00	-22.57
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000183605	hsa-miR-6724-5p	138032203	138032209	7mer-m8	138032189	138032210	145.00	-22.57
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000183605	hsa-miR-6724-5p	138032203	138032209	7mer-m8	138032189	138032210	145.00	-22.57
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000183605	hsa-miR-6773-5p	138032203	138032209	7mer-m8	138032188	138032210	153.00	-23.04
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000183605	hsa-miR-7155-3p	138032201	138032207	7mer-m8	138032190	138032208	146.00	-17.96
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000479660	hsa-miR-3136-3p	138032201	138032207	7mer-m8	138032187	138032208	147.00	-16.22
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000479660	hsa-miR-6724-5p	138032203	138032209	7mer-m8	138032189	138032210	145.00	-22.57
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000479660	hsa-miR-6724-5p	138032203	138032209	7mer-m8	138032189	138032210	145.00	-22.57
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000479660	hsa-miR-6724-5p	138032203	138032209	7mer-m8	138032189	138032210	145.00	-22.57
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000479660	hsa-miR-6724-5p	138032203	138032209	7mer-m8	138032189	138032210	145.00	-22.57
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000479660	hsa-miR-6773-5p	138032203	138032209	7mer-m8	138032188	138032210	153.00	-23.04
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000479660	hsa-miR-7155-3p	138032201	138032207	7mer-m8	138032190	138032208	146.00	-17.96

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000343735	hsa-miR-10400-3p	138032203	138032209	7mer-m8	138032189	138032210	140	-20.55
CAediting_311968	chr3_138032705_+	ENSG00000066405.11	ENST00000343735	hsa-miR-12126	138032700	138032707	8mer-1a	138032683	138032707	153	-20.11
CAediting_311959	chr3_138032200_+	ENSG00000066405.11	ENST00000343735	hsa-miR-1245a	138032195	138032201	7mer-m8	138032182	138032202	141	-15.67
CAediting_311963	chr3_138032340_+	ENSG00000066405.11	ENST00000343735	hsa-miR-1245a	138032335	138032341	7mer-m8	138032322	138032342	145	-18.36
CAediting_311965	chr3_138032664_+	ENSG00000066405.11	ENST00000343735	hsa-miR-1304-5p	138032658	138032665	8mer-1a	138032644	138032665	152	-19.82
CAediting_311967	chr3_138032682_+	ENSG00000066405.11	ENST00000343735	hsa-miR-219b-3p	138032679	138032685	7mer-m8	138032664	138032686	145	-12.93
CAediting_311964	chr3_138032375_+	ENSG00000066405.11	ENST00000343735	hsa-miR-2681-3p	138032372	138032378	7mer-m8	138032359	138032379	146	-15.33
CAediting_311967	chr3_138032682_+	ENSG00000066405.11	ENST00000343735	hsa-miR-302f	138032678	138032684	7mer-m8	138032669	138032685	147	-7.37
CAediting_311962	chr3_138032310_+	ENSG00000066405.11	ENST00000343735	hsa-miR-4298	138032304	138032309	6mer	138032289	138032310	140	-27.5
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000343735	hsa-miR-4437	138032202	138032209	8mer-1a	138032189	138032209	146	-19.6
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000343735	hsa-miR-4674	138032203	138032209	7mer-m8	138032190	138032210	147	-22.8
CAediting_311962	chr3_138032310_+	ENSG00000066405.11	ENST00000343735	hsa-miR-4731-5p	138032306	138032312	7mer-1a	138032292	138032312	142	-22.76
CAediting_311965	chr3_138032664_+	ENSG00000066405.11	ENST00000343735	hsa-miR-6765-5p	138032658	138032664	7mer-1a	138032641	138032664	144	-29.04
CAediting_311958	chr3_138032156_+	ENSG00000066405.11	ENST00000343735	hsa-miR-6807-5p	138032149	138032155	7mer-m8	138032134	138032156	151	-20.9
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000183605	hsa-miR-10400-3p	138032203	138032209	7mer-m8	138032189	138032210	140	-20.55
CAediting_311968	chr3_138032705_+	ENSG00000066405.11	ENST00000183605	hsa-miR-12126	138032700	138032707	8mer-1a	138032683	138032707	153	-20.11
CAediting_311959	chr3_138032200_+	ENSG00000066405.11	ENST00000183605	hsa-miR-1245a	138032195	138032201	7mer-m8	138032182	138032202	141	-15.67
CAediting_311963	chr3_138032340_+	ENSG00000066405.11	ENST00000183605	hsa-miR-1245a	138032335	138032341	7mer-m8	138032322	138032342	145	-18.36
CAediting_311965	chr3_138032664_+	ENSG00000066405.11	ENST00000183605	hsa-miR-1304-5p	138032658	138032665	8mer-1a	138032644	138032665	152	-19.82
CAediting_311967	chr3_138032682_+	ENSG00000066405.11	ENST00000183605	hsa-miR-219b-3p	138032679	138032685	7mer-m8	138032664	138032686	145	-12.93
CAediting_311964	chr3_138032375_+	ENSG00000066405.11	ENST00000183605	hsa-miR-2681-3p	138032372	138032378	7mer-m8	138032359	138032379	146	-15.33
CAediting_311967	chr3_138032682_+	ENSG00000066405.11	ENST00000183605	hsa-miR-302f	138032678	138032684	7mer-m8	138032669	138032685	147	-7.37
CAediting_311962	chr3_138032310_+	ENSG00000066405.11	ENST00000183605	hsa-miR-4298	138032304	138032309	6mer	138032289	138032310	140	-27.5
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000183605	hsa-miR-4437	138032202	138032209	8mer-1a	138032189	138032209	146	-19.6
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000183605	hsa-miR-4674	138032203	138032209	7mer-m8	138032190	138032210	147	-22.8
CAediting_311962	chr3_138032310_+	ENSG00000066405.11	ENST00000183605	hsa-miR-4731-5p	138032306	138032312	7mer-1a	138032292	138032312	142	-22.76
CAediting_311965	chr3_138032664_+	ENSG00000066405.11	ENST00000183605	hsa-miR-6765-5p	138032658	138032664	7mer-1a	138032641	138032664	144	-29.04
CAediting_311958	chr3_138032156_+	ENSG00000066405.11	ENST00000183605	hsa-miR-6807-5p	138032149	138032155	7mer-m8	138032134	138032156	151	-20.9
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000479660	hsa-miR-10400-3p	138032203	138032209	7mer-m8	138032189	138032210	140	-20.55
CAediting_311959	chr3_138032200_+	ENSG00000066405.11	ENST00000479660	hsa-miR-1245a	138032195	138032201	7mer-m8	138032182	138032202	141	-15.67
CAediting_311963	chr3_138032340_+	ENSG00000066405.11	ENST00000479660	hsa-miR-1245a	138032335	138032341	7mer-m8	138032322	138032342	145	-18.36
CAediting_311964	chr3_138032375_+	ENSG00000066405.11	ENST00000479660	hsa-miR-2681-3p	138032372	138032378	7mer-m8	138032359	138032379	146	-15.33
CAediting_311962	chr3_138032310_+	ENSG00000066405.11	ENST00000479660	hsa-miR-4298	138032304	138032309	6mer	138032289	138032310	140	-27.5
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000479660	hsa-miR-4437	138032202	138032209	8mer-1a	138032189	138032209	146	-19.6
CAediting_311960	chr3_138032205_+	ENSG00000066405.11	ENST00000479660	hsa-miR-4674	138032203	138032209	7mer-m8	138032190	138032210	147	-22.8
CAediting_311962	chr3_138032310_+	ENSG00000066405.11	ENST00000479660	hsa-miR-4731-5p	138032306	138032312	7mer-1a	138032292	138032312	142	-22.76
CAediting_311958	chr3_138032156_+	ENSG00000066405.11	ENST00000479660	hsa-miR-6807-5p	138032149	138032155	7mer-m8	138032134	138032156	151	-20.9

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000066405.11	ENST00000343735	hsa-miR-200b-3p	138032308	138032314	7mer-m8	138032294	138032315	140	-9.63
CAediting_393	chr1_1167164_+	ENSG00000066405.11	ENST00000343735	hsa-miR-200b-3p	138032991	138032997	7mer-m8	138032975	138032998	151	-15.68
CAediting_393	chr1_1167164_+	ENSG00000066405.11	ENST00000183605	hsa-miR-200b-3p	138032308	138032314	7mer-m8	138032294	138032315	140	-9.63
CAediting_393	chr1_1167164_+	ENSG00000066405.11	ENST00000183605	hsa-miR-200b-3p	138032991	138032997	7mer-m8	138032975	138032998	151	-15.68
CAediting_393	chr1_1167164_+	ENSG00000066405.11	ENST00000479660	hsa-miR-200b-3p	138032308	138032314	7mer-m8	138032294	138032315	140	-9.63
CAediting_1054808	chr15_66496985_-	ENSG00000066405.11	ENST00000343735	hsa-miR-4512	138032941	138032947	7mer-m8	138032927	138032948	149	-17.73
CAediting_1229414	chr17_67471546_+	ENSG00000066405.11	ENST00000343735	hsa-miR-548aa	138031285	138031292	8mer-1a	138031269	138031292	148	-13.57
CAediting_1399425	chr20_1392958_-	ENSG00000066405.11	ENST00000343735	hsa-miR-6869-5p	138032981	138032987	7mer-m8	138032967	138032988	145	-20.08
CAediting_573000	chr7_92204081_-	ENSG00000066405.11	ENST00000343735	hsa-miR-1285-5p	138032409	138032415	7mer-m8	138032396	138032416	169	-26.97
CAediting_1054808	chr15_66496985_-	ENSG00000066405.11	ENST00000183605	hsa-miR-4512	138032941	138032947	7mer-m8	138032927	138032948	149	-17.73
CAediting_1229414	chr17_67471546_+	ENSG00000066405.11	ENST00000183605	hsa-miR-548aa	138031285	138031292	8mer-1a	138031269	138031292	148	-13.57
CAediting_1399425	chr20_1392958_-	ENSG00000066405.11	ENST00000183605	hsa-miR-6869-5p	138032981	138032987	7mer-m8	138032967	138032988	145	-20.08
CAediting_573000	chr7_92204081_-	ENSG00000066405.11	ENST00000183605	hsa-miR-1285-5p	138032409	138032415	7mer-m8	138032396	138032416	169	-26.97
CAediting_1229414	chr17_67471546_+	ENSG00000066405.11	ENST00000479660	hsa-miR-548aa	138031285	138031292	8mer-1a	138031269	138031292	148	-13.57
CAediting_1229415	chr17_67471547_+	ENSG00000066405.11	ENST00000479660	hsa-miR-548aa	138031041	138031047	7mer-m8	138031024	138031048	150	-16.53
CAediting_573000	chr7_92204081_-	ENSG00000066405.11	ENST00000479660	hsa-miR-1285-5p	138032409	138032415	7mer-m8	138032396	138032416	169	-26.97

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_846604	chr11_93733708_-	ENSG00000066405.11	ENST00000343735	hsa-miR-1304-3p	138033184	138033190	7mer-m8	138033166	138033191	149	-16.52
CAediting_86358	chr1_109598906_+	ENSG00000066405.11	ENST00000343735	hsa-miR-197-5p	138032687	138032693	7mer-m8	138032673	138032694	147	-20.84
CAediting_1054808	chr15_66496985_-	ENSG00000066405.11	ENST00000343735	hsa-miR-4512	138033196	138033202	7mer-m8	138033183	138033203	149	-21.33
CAediting_846604	chr11_93733708_-	ENSG00000066405.11	ENST00000183605	hsa-miR-1304-3p	138033184	138033190	7mer-m8	138033166	138033191	149	-16.52
CAediting_86358	chr1_109598906_+	ENSG00000066405.11	ENST00000183605	hsa-miR-197-5p	138032687	138032693	7mer-m8	138032673	138032694	147	-20.84
CAediting_1054808	chr15_66496985_-	ENSG00000066405.11	ENST00000183605	hsa-miR-4512	138033196	138033202	7mer-m8	138033183	138033203	149	-21.33

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CLDN18

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000343735.7	protein_coding
ENST00000183605.8	protein_coding
ENST00000479660.1	nonsense_mediated_decay

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_311958	ENST00000343735.7	chr3_138032156_+	-1062.90	-1062.90	-1084.20
CAediting_311959	ENST00000343735.7	chr3_138032200_+	-1066.10	-1062.90	-1084.20
CAediting_311960	ENST00000343735.7	chr3_138032205_+	-1062.80	-1062.90	-1084.20
CAediting_311961	ENST00000343735.7	chr3_138032286_+	-1066.00	-1062.90	-1084.20
CAediting_311962	ENST00000343735.7	chr3_138032310_+	-1063.70	-1062.90	-1084.20
CAediting_311963	ENST00000343735.7	chr3_138032340_+	-1066.50	-1062.90	-1084.20
CAediting_311964	ENST00000343735.7	chr3_138032375_+	-1064.50	-1062.90	-1084.20
CAediting_311965	ENST00000343735.7	chr3_138032664_+	-1068.50	-1062.90	-1084.20
CAediting_311966	ENST00000343735.7	chr3_138032679_+	-1062.60	-1062.90	-1084.20
CAediting_311967	ENST00000343735.7	chr3_138032682_+	-1067.10	-1062.90	-1084.20
CAediting_311968	ENST00000343735.7	chr3_138032705_+	-1065.00	-1062.90	-1084.20
CAediting_311969	ENST00000343735.7	chr3_138032718_+	-1062.90	-1062.90	-1084.20
CAediting_311970	ENST00000343735.7	chr3_138032740_+	-1069.50	-1062.90	-1084.20
CAediting_311958	ENST00000183605.8	chr3_138032156_+	-1113.00	-1113.00	-1134.30
CAediting_311959	ENST00000183605.8	chr3_138032200_+	-1116.20	-1113.00	-1134.30
CAediting_311960	ENST00000183605.8	chr3_138032205_+	-1112.90	-1113.00	-1134.30
CAediting_311961	ENST00000183605.8	chr3_138032286_+	-1116.10	-1113.00	-1134.30
CAediting_311962	ENST00000183605.8	chr3_138032310_+	-1113.80	-1113.00	-1134.30
CAediting_311963	ENST00000183605.8	chr3_138032340_+	-1116.60	-1113.00	-1134.30
CAediting_311964	ENST00000183605.8	chr3_138032375_+	-1114.60	-1113.00	-1134.30
CAediting_311965	ENST00000183605.8	chr3_138032664_+	-1118.60	-1113.00	-1134.30
CAediting_311966	ENST00000183605.8	chr3_138032679_+	-1112.70	-1113.00	-1134.30
CAediting_311967	ENST00000183605.8	chr3_138032682_+	-1117.20	-1113.00	-1134.30
CAediting_311968	ENST00000183605.8	chr3_138032705_+	-1115.10	-1113.00	-1134.30
CAediting_311969	ENST00000183605.8	chr3_138032718_+	-1113.00	-1113.00	-1134.30
CAediting_311970	ENST00000183605.8	chr3_138032740_+	-1119.60	-1113.00	-1134.30
CAediting_311958	ENST00000479660.1	chr3_138032156_+	-624.80	-624.80	-630.50
CAediting_311959	ENST00000479660.1	chr3_138032200_+	-624.80	-624.80	-630.50
CAediting_311960	ENST00000479660.1	chr3_138032205_+	-624.70	-624.80	-630.50
CAediting_311961	ENST00000479660.1	chr3_138032286_+	-625.10	-624.80	-630.50
CAediting_311962	ENST00000479660.1	chr3_138032310_+	-629.40	-624.80	-630.50
CAediting_311963	ENST00000479660.1	chr3_138032340_+	-624.10	-624.80	-630.50
CAediting_311964	ENST00000479660.1	chr3_138032375_+	-626.40	-624.80	-630.50

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Relation with ADAR for CLDN18

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
LUAD	CAediting_311965	chr3_138032664_+	0.00566879608725496	0.220525220648783	.	.	.	.
STAD	CAediting_311965	chr3_138032664_+	9.55941785288264e-07	0.380549912635923	.	.	.	.
PAAD	CAediting_311965	chr3_138032664_+	9.33587490566241e-05	0.422821527227656	.	.	.	.
LUAD	CAediting_311970	chr3_138032740_+	0.00259220841851087	0.178105147800724	.	.	.	.
STAD	CAediting_311970	chr3_138032740_+	2.36397650057543e-05	0.251055922345943	.	.	.	.
PAAD	CAediting_311970	chr3_138032740_+	0.000759574374664309	0.285335431123548	.	.	.	.

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Relation with cancer stages for CLDN18

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for CLDN18

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for CLDN18

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CLDN18

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene