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Editing gene: CRBN (CAeditome ID:51185)

Gene summary for CRBN

Gene summary

Gene information	Gene symbol	CRBN
	Gene ID	51185
	Gene name	cereblon
	Synonyms	MRT2\|MRT2A
	Cytomap	3p26.2
	Type of gene	protein-coding
	Description	protein cereblonprotein x 0001
	Modification date	20210518
	UniProtAcc	Q96SW2
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
CRBN	GO:0005634	Protein cereblon	20223979
CRBN	GO:0005737	Protein cereblon	20223979
CRBN	GO:0031464	Protein cereblon	20223979

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RNA A-to-I events for CRBN

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000113851.12

RNA A-to-I editing events in Cancer.

CAediting_254062(3151047, -), CAediting_254063(3151652, -), CAediting_254064(3151918, -), CAediting_254065(3151929, -), CAediting_254066(3152198, -), CAediting_254067(3152268, -), CAediting_254068(3152274, -), CAediting_254069(3152301, -), CAediting_254070(3152755, -), CAediting_254071(3155823, -), CAediting_254072(3156027, -), CAediting_254073(3156177, -), CAediting_254074(3156228, -),

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RNA editing positional annotations for CRBN using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_254062	chr3_3151047_-	splicing
CAediting_254063	chr3_3151652_-	ncRNA_intronic
CAediting_254064	chr3_3151918_-	ncRNA_intronic
CAediting_254065	chr3_3151929_-	ncRNA_intronic
CAediting_254066	chr3_3152198_-	ncRNA_intronic
CAediting_254067	chr3_3152268_-	ncRNA_intronic
CAediting_254068	chr3_3152274_-	ncRNA_intronic
CAediting_254069	chr3_3152301_-	ncRNA_intronic
CAediting_254070	chr3_3152755_-	ncRNA_intronic
CAediting_254071	chr3_3155823_-	ncRNA_exonic
CAediting_254072	chr3_3156027_-	ncRNA_exonic
CAediting_254073	chr3_3156177_-	ncRNA_exonic
CAediting_254074	chr3_3156228_-	exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_254066	chr3_3152198_-	SINE	Alu	AluSz6
CAediting_254067	chr3_3152268_-	SINE	Alu	AluSz6
CAediting_254068	chr3_3152274_-	SINE	Alu	AluSz6
CAediting_254069	chr3_3152301_-	SINE	Alu	AluSz6
CAediting_254071	chr3_3155823_-	SINE	Alu	AluJb
CAediting_254072	chr3_3156027_-	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for CRBN

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
IR	CAediting_254062	chr3_3151047_-	3151043:3151065	3SS	0+2i	ATCTTTCCTTAATTTCTTAGGTA	9.44	ATCTTTCCTTAATTTCTTGGGTA	1.48

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000113851.12.CRBN.

Correlation between RNA A-to-I editing and PSI for ENSG00000113851.12.CRBN.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CRBN

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

GBM.CAediting_254062.ENSG00000113851.CRBN.png
Soverview

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Protein coding region RNA A-to-I editings for CRBN

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for CRBN

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_117844	chr1_162342605_+	ENSG00000113851.12	ENST00000450014	hsa-miR-556-3p	3167517	3167523	7mer-m8	3167516	3167537	150	-13.4

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CRBN

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000231948.7	protein_coding
ENST00000424814.4	protein_coding
ENST00000432408.5	protein_coding
ENST00000488263.4	retained_intron
ENST00000491834.4	retained_intron
ENST00000482844.4	retained_intron
ENST00000480249.4	retained_intron

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_254074	ENST00000231948.7	chr3_3156228_-	-537.50	-536.90	-537.50
CAediting_254074	ENST00000424814.4	chr3_3156228_-	-476.90	-476.30	-476.90
CAediting_254074	ENST00000432408.5	chr3_3156228_-	-538.60	-538.00	-538.60
CAediting_254071	ENST00000488263.4	chr3_3155823_-	-1143.00	-1143.30	-1144.60
CAediting_254072	ENST00000488263.4	chr3_3156027_-	-1142.80	-1143.30	-1144.60
CAediting_254073	ENST00000488263.4	chr3_3156177_-	-1145.30	-1143.30	-1144.60
CAediting_254074	ENST00000488263.4	chr3_3156228_-	-1144.70	-1143.30	-1144.60
CAediting_254071	ENST00000491834.4	chr3_3155823_-	-1404.20	-1404.20	-1406.00
CAediting_254072	ENST00000491834.4	chr3_3156027_-	-1403.60	-1404.20	-1406.00
CAediting_254073	ENST00000491834.4	chr3_3156177_-	-1404.70	-1404.20	-1406.00
CAediting_254074	ENST00000491834.4	chr3_3156228_-	-1407.10	-1404.20	-1406.00
CAediting_254074	ENST00000482844.4	chr3_3156228_-	-138.30	-138.30	-138.30
CAediting_254073	ENST00000480249.4	chr3_3156177_-	-122.90	-123.30	-125.80
CAediting_254074	ENST00000480249.4	chr3_3156228_-	-126.20	-123.30	-125.80

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Relation with ADAR for CRBN

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for CRBN

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for CRBN

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for CRBN

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
CRBN	Q96SW2	DB00480	Lenalidomide	Protein cereblon	SmallMoleculeDrug	approved
CRBN	Q96SW2	DB08910	Pomalidomide	Protein cereblon	SmallMoleculeDrug	approved
CRBN	Q96SW2	DB01041	Thalidomide	Protein cereblon	SmallMoleculeDrug	approved\|investigational\|withdrawn

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RelatedDiseases for CRBN

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
CRBN	C1843942	Mental Retardation, Autosomal Recessive 2	3	CTD_human;GENOMICS_ENGLAND;UNIPROT
CRBN	C0000771	Abnormalities, Drug-Induced	1	CTD_human
CRBN	C0026764	Multiple Myeloma	1	CGI;CTD_human
CRBN	C0265541	Cranioschisis	1	CTD_human
CRBN	C0497552	Congenital neurologic anomalies	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene