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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: PCOLCE (CAeditome ID:5118) |
Gene summary for PCOLCE |
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Gene information | Gene symbol | PCOLCE | Gene ID | 5118 |
Gene name | procollagen C-endopeptidase enhancer | |
Synonyms | PCPE|PCPE-1|PCPE1 | |
Cytomap | 7q22.1 | |
Type of gene | protein-coding | |
Description | procollagen C-endopeptidase enhancer 1procollagen C-proteinase enhancer 1procollagen COOH-terminal proteinase enhancer 1procollagen, type 1, COOH-terminal proteinase enhancertype 1 procollagen C-proteinase enhancer proteintype I procollagen COOH-term | |
Modification date | 20210518 | |
UniProtAcc | Q15113 | |
Context |
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Gene | GO ID | GO term | PubMed ID |
PCOLCE | GO:0005518 | Procollagen C-endopeptidase enhancer 1 | 12393877 |
PCOLCE | GO:0008201 | Procollagen C-endopeptidase enhancer 1 | 12393877 |
PCOLCE | GO:0016504 | Procollagen C-endopeptidase enhancer 1 | 12393877 |
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RNA A-to-I events for PCOLCE |
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CAediting_581754(100605752, +), CAediting_581755(100606128, +), CAediting_581756(100606254, +), |
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RNA editing positional annotations for PCOLCE using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
CAediting_581754 | chr7_100605752_+ | nonsynonymous SNV | ENST00000223061.5 | c.A665G | p.N222S | T | D | D |
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CAeditome ID | Position | Variant type |
CAediting_581754 | chr7_100605752_+ | exonic |
CAediting_581755 | chr7_100606128_+ | ncRNA_intronic |
CAediting_581756 | chr7_100606254_+ | ncRNA_exonic |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
CAediting_581755 | chr7_100606128_+ | SINE | Alu | AluJb |
CAediting_581756 | chr7_100606254_+ | SINE | Alu | AluJb |
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RNA A-to-I editing events in the alternative splicing sites for PCOLCE |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PCOLCE |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for PCOLCE |
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The effects of the RNA editing to the miRNA binding sites for PCOLCE |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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The effects of the RNA editing to the stability of the RNA structures for PCOLCE |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
CAediting_581754 | ENST00000223061.5 | chr7_100605752_+ | -671.40 | -669.90 | -671.40 |
CAediting_581754 | ENST00000486440.4 | chr7_100605752_+ | -321.90 | -320.50 | -321.90 |
CAediting_581754 | ENST00000490909.1 | chr7_100605752_+ | -121.80 | -119.50 | -121.80 |
CAediting_581756 | ENST00000472348.1 | chr7_100606254_+ | -339.20 | -337.50 | -339.20 |
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Relation with ADAR for PCOLCE |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for PCOLCE |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for PCOLCE |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for PCOLCE |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PCOLCE |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
PCOLCE | C0019193 | Hepatitis, Toxic | 1 | CTD_human |
PCOLCE | C0023890 | Liver Cirrhosis | 1 | CTD_human |
PCOLCE | C0239946 | Fibrosis, Liver | 1 | CTD_human |
PCOLCE | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human |
PCOLCE | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human |
PCOLCE | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human |
PCOLCE | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
PCOLCE | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |