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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: TPRKB (CAeditome ID:51002)

Gene summary for TPRKB

check button Gene summary
Gene informationGene symbol

TPRKB

Gene ID

51002

Gene nameTP53RK binding protein
SynonymsCGI-121|CGI121|GAMOS5
Cytomap

2p13.1

Type of geneprotein-coding
DescriptionEKC/KEOPS complex subunit TPRKBPRPK (p53-related protein kinase)-binding protein
Modification date20210518
UniProtAcc

Q9Y3C4

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
TPRKB

GO:0002949

EKC/KEOPS complex subunit TPRKB

28805828

TPRKB

GO:0005634

EKC/KEOPS complex subunit TPRKB

12659830

TPRKB

GO:0005634

EKC/KEOPS complex subunit TPRKB

28805828

TPRKB

GO:0005737

EKC/KEOPS complex subunit TPRKB

28805828

TPRKB

GO:0005829

EKC/KEOPS complex subunit TPRKB

0000052

TPRKB

GO:0005829

EKC/KEOPS complex subunit TPRKB

12659830

TPRKB

GO:0000408

EKC/KEOPS complex subunit TPRKB

27903914

TPRKB

GO:0000408

EKC/KEOPS complex subunit TPRKB

28805828


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RNA A-to-I events for TPRKB

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000144034.13
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_194139(73729229, -), CAediting_194140(73729255, -), CAediting_194141(73729267, -), CAediting_194142(73729270, -), CAediting_194143(73729281, -), CAediting_194144(73729307, -), CAediting_194145(73729548, -), CAediting_194146(73729553, -), CAediting_194147(73729570, -), CAediting_194148(73729582, -), CAediting_194149(73729587, -), CAediting_194150(73729611, -), CAediting_194151(73729612, -), CAediting_194152(73729620, -), CAediting_194153(73729626, -), CAediting_194154(73729628, -), CAediting_194155(73729630, -), CAediting_194156(73729636, -), CAediting_194157(73729647, -), CAediting_194158(73729652, -), CAediting_194159(73729653, -), CAediting_194160(73729663, -), CAediting_194161(73729679, -), CAediting_194162(73729691, -), CAediting_194163(73729696, -), CAediting_194164(73729727, -), CAediting_194165(73729732, -), CAediting_194166(73729733, -), CAediting_194167(73729770, -), CAediting_194168(73729778, -), CAediting_194169(73732461, -), CAediting_194170(73732468, -), CAediting_194171(73732495, -), CAediting_194172(73732543, -), CAediting_194173(73732585, -), CAediting_194174(73732587, -), CAediting_194175(73732590, -), CAediting_194176(73732609, -), CAediting_194177(73732623, -), CAediting_194178(73732626, -), CAediting_194179(73732627, -), CAediting_194180(73732646, -), CAediting_194181(73732652, -), CAediting_194182(73732662, -), CAediting_194183(73732696, -), CAediting_194184(73733335, -), CAediting_194185(73733337, -), CAediting_194186(73733355, -), CAediting_194187(73733361, -), CAediting_194188(73733397, -), CAediting_194189(73733903, -), CAediting_194190(73733915, -), CAediting_194191(73733929, -), CAediting_194192(73733942, -), CAediting_194193(73733977, -), CAediting_194194(73733983, -), CAediting_194195(73733984, -), CAediting_194196(73734236, -), CAediting_194197(73734237, -), CAediting_194198(73734358, -), CAediting_194199(73735163, -),

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RNA editing positional annotations for TPRKB using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
CAediting_194176chr2_73732609_-nonsynonymous SNVENST00000318190.7c.A233Gp.Q78RD.N
CAediting_194176chr2_73732609_-nonsynonymous SNVENST00000409716.5c.A233Gp.Q78RD.N
CAediting_194179chr2_73732627_-nonsynonymous SNVENST00000318190.7c.A215Gp.Q72RD.N
CAediting_194179chr2_73732627_-nonsynonymous SNVENST00000409716.5c.A215Gp.Q72RD.N
CAediting_194180chr2_73732646_-nonsynonymous SNVENST00000318190.7c.A196Gp.T66AD.N
CAediting_194180chr2_73732646_-nonsynonymous SNVENST00000409716.5c.A196Gp.T66AD.N
CAediting_194181chr2_73732652_-nonsynonymous SNVENST00000318190.7c.A190Gp.T64AD.N
CAediting_194181chr2_73732652_-nonsynonymous SNVENST00000409716.5c.A190Gp.T64AD.N
CAediting_194183chr2_73732696_-nonsynonymous SNVENST00000318190.7c.A146Gp.H49RDBN
CAediting_194183chr2_73732696_-nonsynonymous SNVENST00000409716.5c.A146Gp.H49RDBN

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_194139chr2_73729229_-ncRNA_exonic
CAediting_194140chr2_73729255_-ncRNA_exonic
CAediting_194141chr2_73729267_-ncRNA_exonic
CAediting_194142chr2_73729270_-ncRNA_exonic
CAediting_194143chr2_73729281_-ncRNA_exonic
CAediting_194144chr2_73729307_-ncRNA_splicing
CAediting_194145chr2_73729548_-ncRNA_intronic
CAediting_194146chr2_73729553_-ncRNA_intronic
CAediting_194147chr2_73729570_-ncRNA_intronic
CAediting_194148chr2_73729582_-ncRNA_intronic
CAediting_194149chr2_73729587_-ncRNA_intronic
CAediting_194150chr2_73729611_-ncRNA_intronic
CAediting_194151chr2_73729612_-ncRNA_intronic
CAediting_194152chr2_73729620_-ncRNA_intronic
CAediting_194153chr2_73729626_-ncRNA_intronic
CAediting_194154chr2_73729628_-ncRNA_intronic
CAediting_194155chr2_73729630_-ncRNA_intronic
CAediting_194156chr2_73729636_-ncRNA_intronic
CAediting_194157chr2_73729647_-ncRNA_intronic
CAediting_194158chr2_73729652_-ncRNA_intronic
CAediting_194159chr2_73729653_-ncRNA_intronic
CAediting_194160chr2_73729663_-ncRNA_intronic
CAediting_194161chr2_73729679_-ncRNA_intronic
CAediting_194162chr2_73729691_-ncRNA_intronic
CAediting_194163chr2_73729696_-ncRNA_intronic
CAediting_194164chr2_73729727_-ncRNA_intronic
CAediting_194165chr2_73729732_-ncRNA_intronic
CAediting_194166chr2_73729733_-ncRNA_intronic
CAediting_194167chr2_73729770_-ncRNA_intronic
CAediting_194168chr2_73729778_-ncRNA_intronic
CAediting_194169chr2_73732461_-ncRNA_intronic
CAediting_194170chr2_73732468_-ncRNA_intronic
CAediting_194171chr2_73732495_-ncRNA_intronic
CAediting_194172chr2_73732543_-ncRNA_intronic
CAediting_194173chr2_73732585_-exonic
CAediting_194174chr2_73732587_-exonic
CAediting_194175chr2_73732590_-exonic
CAediting_194176chr2_73732609_-exonic
CAediting_194177chr2_73732623_-exonic
CAediting_194178chr2_73732626_-exonic
CAediting_194179chr2_73732627_-exonic
CAediting_194180chr2_73732646_-exonic
CAediting_194181chr2_73732652_-exonic
CAediting_194182chr2_73732662_-exonic
CAediting_194183chr2_73732696_-exonic
CAediting_194184chr2_73733335_-ncRNA_intronic
CAediting_194185chr2_73733337_-ncRNA_intronic
CAediting_194186chr2_73733355_-ncRNA_intronic
CAediting_194187chr2_73733361_-ncRNA_intronic
CAediting_194188chr2_73733397_-ncRNA_intronic
CAediting_194189chr2_73733903_-ncRNA_intronic
CAediting_194190chr2_73733915_-ncRNA_intronic
CAediting_194191chr2_73733929_-ncRNA_intronic
CAediting_194192chr2_73733942_-ncRNA_intronic
CAediting_194193chr2_73733977_-ncRNA_intronic
CAediting_194194chr2_73733983_-ncRNA_intronic
CAediting_194195chr2_73733984_-ncRNA_intronic
CAediting_194196chr2_73734236_-ncRNA_intronic
CAediting_194197chr2_73734237_-ncRNA_intronic
CAediting_194198chr2_73734358_-ncRNA_intronic
CAediting_194199chr2_73735163_-ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_194139chr2_73729229_-SINEAluFLAM_C
CAediting_194140chr2_73729255_-SINEAluFLAM_C
CAediting_194141chr2_73729267_-SINEAluFLAM_C
CAediting_194142chr2_73729270_-SINEAluFLAM_C
CAediting_194143chr2_73729281_-SINEAluFLAM_C
CAediting_194144chr2_73729307_-SINEAluFLAM_C
CAediting_194145chr2_73729548_-SINEAluAluSx1
CAediting_194146chr2_73729553_-SINEAluAluSx1
CAediting_194147chr2_73729570_-SINEAluAluSx1
CAediting_194148chr2_73729582_-SINEAluAluSx1
CAediting_194149chr2_73729587_-SINEAluAluSx1
CAediting_194150chr2_73729611_-SINEAluAluSx1
CAediting_194151chr2_73729612_-SINEAluAluSx1
CAediting_194152chr2_73729620_-SINEAluAluSx1
CAediting_194153chr2_73729626_-SINEAluAluSx1
CAediting_194154chr2_73729628_-SINEAluAluSx1
CAediting_194155chr2_73729630_-SINEAluAluSx1
CAediting_194156chr2_73729636_-SINEAluAluSx1
CAediting_194157chr2_73729647_-SINEAluAluSx1
CAediting_194158chr2_73729652_-SINEAluAluSx1
CAediting_194159chr2_73729653_-SINEAluAluSx1
CAediting_194160chr2_73729663_-SINEAluAluSx1
CAediting_194161chr2_73729679_-SINEAluAluSx1
CAediting_194162chr2_73729691_-SINEAluAluSx1
CAediting_194163chr2_73729696_-SINEAluAluSx1
CAediting_194164chr2_73729727_-SINEAluAluSx1
CAediting_194165chr2_73729732_-SINEAluAluSx1
CAediting_194166chr2_73729733_-SINEAluAluSx1
CAediting_194167chr2_73729770_-SINEAluAluSx1
CAediting_194168chr2_73729778_-SINEAluAluSx1
CAediting_194169chr2_73732461_-SINEAluAluSq2
CAediting_194170chr2_73732468_-SINEAluAluSq2
CAediting_194171chr2_73732495_-SINEAluAluSq2
CAediting_194172chr2_73732543_-SINEAluAluSq2
CAediting_194173chr2_73732585_-SINEAluAluSq2
CAediting_194174chr2_73732587_-SINEAluAluSq2
CAediting_194175chr2_73732590_-SINEAluAluSq2
CAediting_194176chr2_73732609_-SINEAluAluSq2
CAediting_194177chr2_73732623_-SINEAluAluSq2
CAediting_194178chr2_73732626_-SINEAluAluSq2
CAediting_194179chr2_73732627_-SINEAluAluSq2
CAediting_194180chr2_73732646_-SINEAluAluSq2
CAediting_194181chr2_73732652_-SINEAluAluSq2
CAediting_194182chr2_73732662_-SINEAluAluSq2
CAediting_194183chr2_73732696_-SINEAluAluSq2
CAediting_194184chr2_73733335_-SINEAluAluSz6
CAediting_194185chr2_73733337_-SINEAluAluSz6
CAediting_194186chr2_73733355_-SINEAluAluSz6
CAediting_194187chr2_73733361_-SINEAluAluSz6
CAediting_194188chr2_73733397_-SINEAluAluSz6
CAediting_194189chr2_73733903_-SINEAluAluSx1
CAediting_194190chr2_73733915_-SINEAluAluSx1
CAediting_194191chr2_73733929_-SINEAluAluSx1
CAediting_194192chr2_73733942_-SINEAluAluSx1
CAediting_194193chr2_73733977_-SINEAluAluSx1
CAediting_194194chr2_73733983_-SINEAluAluSx1
CAediting_194195chr2_73733984_-SINEAluAluSx1
CAediting_194196chr2_73734236_-SINEAluAluSq2
CAediting_194197chr2_73734237_-SINEAluAluSq2
CAediting_194198chr2_73734358_-SINEAluAluSq2
CAediting_194199chr2_73735163_-SINEAluAluSp

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RNA A-to-I editing events in the alternative splicing sites for TPRKB

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESCAediting_194173chr2_73732585_-73732577:737325855SS3+0iAGGTGCGTG-24.83GGGTGCGTG-27.74
IRCAediting_194173chr2_73732585_-73732577:737325855SS3+0iAGGTGCGTG-24.83GGGTGCGTG-27.74
MEX_2CAediting_194173chr2_73732585_-73732577:737325855SS3+0iAGGTGCGTG-24.83GGGTGCGTG-27.74
MEX_1CAediting_194173chr2_73732585_-73732577:737325855SS3+0iAGGTGCGTG-24.83GGGTGCGTG-27.74
ESCAediting_194183chr2_73732696_-73732679:737327013SS0+15iGTTTCACTCTTGTTGCCCAGGCT5.41GTTTCGCTCTTGTTGCCCAGGCT5.5

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000144034.13.TPRKB.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000144034.13.TPRKB.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TPRKB

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for TPRKB

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for TPRKB

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393chr1_1167164_+ENSG00000144034.13ENST00000318190hsa-miR-200b-3p73729908737299158mer-1a7372990873729929140-10.5
CAediting_393chr1_1167164_+ENSG00000144034.13ENST00000409716hsa-miR-200b-3p73729908737299158mer-1a7372990873729929140-10.5
CAediting_1160181chr17_7017644_-ENSG00000144034.13ENST00000318190hsa-miR-195-3p73729895737299028mer-1a7372989573729916164-17.2
CAediting_1160181chr17_7017644_-ENSG00000144034.13ENST00000409716hsa-miR-195-3p73729895737299028mer-1a7372989573729916164-17.2

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TPRKB

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000463231.4processed_transcriptSoverviewSoverview
ENST00000489476.4processed_transcriptSoverviewSoverview
ENST00000484969.4processed_transcriptSoverviewSoverview
ENST00000318190.7protein_codingSoverviewSoverview
ENST00000409716.5protein_codingSoverviewSoverview
ENST00000470012.1retained_intronSoverviewSoverview

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
CAediting_194139ENST00000463231.4chr2_73729229_--143.70-142.80-151.60
CAediting_194140ENST00000463231.4chr2_73729255_--147.30-142.80-151.60
CAediting_194141ENST00000463231.4chr2_73729267_--147.30-142.80-151.60
CAediting_194142ENST00000463231.4chr2_73729270_--142.80-142.80-151.60
CAediting_194143ENST00000463231.4chr2_73729281_--145.30-142.80-151.60
CAediting_194139ENST00000489476.4chr2_73729229_--121.30-120.40-129.20
CAediting_194140ENST00000489476.4chr2_73729255_--124.90-120.40-129.20
CAediting_194141ENST00000489476.4chr2_73729267_--124.90-120.40-129.20
CAediting_194142ENST00000489476.4chr2_73729270_--120.40-120.40-129.20
CAediting_194143ENST00000489476.4chr2_73729281_--122.90-120.40-129.20
CAediting_194140ENST00000484969.4chr2_73729255_--137.80-134.20-140.50
CAediting_194141ENST00000484969.4chr2_73729267_--136.30-134.20-140.50
CAediting_194142ENST00000484969.4chr2_73729270_--136.60-134.20-140.50
CAediting_194143ENST00000484969.4chr2_73729281_--135.20-134.20-140.50
CAediting_194173ENST00000318190.7chr2_73732585_--195.70-196.50-204.20
CAediting_194174ENST00000318190.7chr2_73732587_--196.10-196.50-204.20
CAediting_194175ENST00000318190.7chr2_73732590_--195.90-196.50-204.20
CAediting_194176ENST00000318190.7chr2_73732609_--197.80-196.50-204.20
CAediting_194177ENST00000318190.7chr2_73732623_--198.50-196.50-204.20
CAediting_194178ENST00000318190.7chr2_73732626_--198.80-196.50-204.20
CAediting_194179ENST00000318190.7chr2_73732627_--199.00-196.50-204.20
CAediting_194180ENST00000318190.7chr2_73732646_--198.30-196.50-204.20
CAediting_194181ENST00000318190.7chr2_73732652_--199.60-196.50-204.20
CAediting_194182ENST00000318190.7chr2_73732662_--198.30-196.50-204.20
CAediting_194183ENST00000318190.7chr2_73732696_--196.80-196.50-204.20
CAediting_194173ENST00000409716.5chr2_73732585_--195.60-196.40-202.70
CAediting_194174ENST00000409716.5chr2_73732587_--195.00-196.40-202.70
CAediting_194175ENST00000409716.5chr2_73732590_--195.80-196.40-202.70
CAediting_194176ENST00000409716.5chr2_73732609_--196.70-196.40-202.70
CAediting_194177ENST00000409716.5chr2_73732623_--197.40-196.40-202.70
CAediting_194178ENST00000409716.5chr2_73732626_--197.90-196.40-202.70
CAediting_194179ENST00000409716.5chr2_73732627_--197.90-196.40-202.70
CAediting_194180ENST00000409716.5chr2_73732646_--197.20-196.40-202.70
CAediting_194181ENST00000409716.5chr2_73732652_--198.50-196.40-202.70
CAediting_194182ENST00000409716.5chr2_73732662_--198.20-196.40-202.70
CAediting_194183ENST00000409716.5chr2_73732696_--196.00-196.40-202.70
CAediting_194173ENST00000470012.1chr2_73732585_--187.20-184.80-198.10
CAediting_194174ENST00000470012.1chr2_73732587_--189.10-184.80-198.10
CAediting_194175ENST00000470012.1chr2_73732590_--187.60-184.80-198.10
CAediting_194176ENST00000470012.1chr2_73732609_--186.90-184.80-198.10
CAediting_194177ENST00000470012.1chr2_73732623_--186.80-184.80-198.10
CAediting_194178ENST00000470012.1chr2_73732626_--186.70-184.80-198.10
CAediting_194179ENST00000470012.1chr2_73732627_--187.30-184.80-198.10
CAediting_194180ENST00000470012.1chr2_73732646_--186.80-184.80-198.10
CAediting_194181ENST00000470012.1chr2_73732652_--187.80-184.80-198.10
CAediting_194182ENST00000470012.1chr2_73732662_--186.60-184.80-198.10
CAediting_194183ENST00000470012.1chr2_73732696_--184.40-184.80-198.10

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Relation with ADAR for TPRKB

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for TPRKB

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for TPRKB

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for TPRKB

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TPRKB

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
TPRKBC4540274GALLOWAY-MOWAT SYNDROME 52GENOMICS_ENGLAND;UNIPROT
TPRKBC0795949Galloway Mowat syndrome1CTD_human;ORPHANET