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Editing gene: RNF141 (CAeditome ID:50862)

Gene summary for RNF141

Gene summary

Gene information	Gene symbol	RNF141
	Gene ID	50862
	Gene name	ring finger protein 141
	Synonyms	RFP141\|ZFP26\|ZNF230
	Cytomap	11p15.4\|11p15
	Type of gene	protein-coding
	Description	RING finger protein 141C3HC4-like zinc finger proteinzinc finger protein 230
	Modification date	20210518
	UniProtAcc	Q8WVD5
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
RNF141	GO:0004842	RING finger protein 141	24105792
RNF141	GO:0051865	RING finger protein 141	24105792

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RNA A-to-I events for RNF141

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000110315.5

RNA A-to-I editing events in Cancer.

CAediting_798175(10512041, -), CAediting_798176(10512090, -), CAediting_798177(10512113, -), CAediting_798178(10512300, -), CAediting_798179(10512378, -), CAediting_798180(10512566, -), CAediting_798181(10512591, -), CAediting_798182(10512716, -), CAediting_798183(10512735, -), CAediting_798184(10512951, -), CAediting_798185(10513059, -), CAediting_798186(10513415, -), CAediting_798187(10513683, -), CAediting_798188(10513684, -), CAediting_798189(10513740, -), CAediting_798190(10513742, -), CAediting_798191(10513747, -), CAediting_798192(10513772, -), CAediting_798193(10513792, -), CAediting_798194(10513809, -), CAediting_798195(10513815, -), CAediting_798196(10513825, -), CAediting_798197(10513833, -), CAediting_798198(10513841, -), CAediting_798199(10513845, -), CAediting_798200(10513846, -), CAediting_798201(10513848, -), CAediting_798202(10513850, -), CAediting_798203(10513853, -), CAediting_798204(10513854, -), CAediting_798205(10513870, -), CAediting_798206(10513889, -), CAediting_798207(10513908, -), CAediting_798208(10513948, -), CAediting_798209(10513949, -), CAediting_798210(10513955, -), CAediting_798211(10513965, -), CAediting_798212(10513970, -), CAediting_798213(10514461, -), CAediting_798214(10514997, -),

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RNA editing positional annotations for RNF141 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_798175	chr11_10512041_-	ncRNA_exonic
CAediting_798176	chr11_10512090_-	ncRNA_exonic
CAediting_798177	chr11_10512113_-	ncRNA_exonic
CAediting_798178	chr11_10512300_-	ncRNA_exonic
CAediting_798179	chr11_10512378_-	ncRNA_exonic
CAediting_798180	chr11_10512566_-	ncRNA_exonic
CAediting_798181	chr11_10512591_-	ncRNA_exonic
CAediting_798182	chr11_10512716_-	ncRNA_exonic
CAediting_798183	chr11_10512735_-	ncRNA_exonic
CAediting_798184	chr11_10512951_-	ncRNA_exonic
CAediting_798185	chr11_10513059_-	ncRNA_exonic
CAediting_798186	chr11_10513415_-	ncRNA_exonic
CAediting_798187	chr11_10513683_-	ncRNA_exonic
CAediting_798188	chr11_10513684_-	ncRNA_exonic
CAediting_798189	chr11_10513740_-	ncRNA_exonic
CAediting_798190	chr11_10513742_-	ncRNA_exonic
CAediting_798191	chr11_10513747_-	ncRNA_exonic
CAediting_798192	chr11_10513772_-	ncRNA_exonic
CAediting_798193	chr11_10513792_-	ncRNA_exonic
CAediting_798194	chr11_10513809_-	ncRNA_exonic
CAediting_798195	chr11_10513815_-	ncRNA_exonic
CAediting_798196	chr11_10513825_-	ncRNA_exonic
CAediting_798197	chr11_10513833_-	ncRNA_exonic
CAediting_798198	chr11_10513841_-	ncRNA_exonic
CAediting_798199	chr11_10513845_-	ncRNA_exonic
CAediting_798200	chr11_10513846_-	ncRNA_exonic
CAediting_798201	chr11_10513848_-	ncRNA_exonic
CAediting_798202	chr11_10513850_-	ncRNA_exonic
CAediting_798203	chr11_10513853_-	ncRNA_exonic
CAediting_798204	chr11_10513854_-	ncRNA_exonic
CAediting_798205	chr11_10513870_-	ncRNA_exonic
CAediting_798206	chr11_10513889_-	ncRNA_exonic
CAediting_798207	chr11_10513908_-	ncRNA_exonic
CAediting_798208	chr11_10513948_-	ncRNA_exonic
CAediting_798209	chr11_10513949_-	ncRNA_exonic
CAediting_798210	chr11_10513955_-	ncRNA_exonic
CAediting_798211	chr11_10513965_-	ncRNA_exonic
CAediting_798212	chr11_10513970_-	ncRNA_exonic
CAediting_798213	chr11_10514461_-	ncRNA_exonic
CAediting_798214	chr11_10514997_-	exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_798182	chr11_10512716_-	DNA	hAT-Charlie	Charlie15b
CAediting_798183	chr11_10512735_-	DNA	hAT-Charlie	Charlie15b
CAediting_798185	chr11_10513059_-	SINE	MIR	MIRc
CAediting_798187	chr11_10513683_-	SINE	Alu	AluSx1
CAediting_798188	chr11_10513684_-	SINE	Alu	AluSx1
CAediting_798189	chr11_10513740_-	SINE	Alu	AluSx1
CAediting_798190	chr11_10513742_-	SINE	Alu	AluSx1
CAediting_798191	chr11_10513747_-	SINE	Alu	AluSx1
CAediting_798192	chr11_10513772_-	SINE	Alu	AluSx1
CAediting_798193	chr11_10513792_-	SINE	Alu	AluSx1
CAediting_798194	chr11_10513809_-	SINE	Alu	AluSx1
CAediting_798195	chr11_10513815_-	SINE	Alu	AluSx1
CAediting_798196	chr11_10513825_-	SINE	Alu	AluSx1
CAediting_798197	chr11_10513833_-	SINE	Alu	AluSx1
CAediting_798198	chr11_10513841_-	SINE	Alu	AluSx1
CAediting_798199	chr11_10513845_-	SINE	Alu	AluSx1
CAediting_798200	chr11_10513846_-	SINE	Alu	AluSx1
CAediting_798201	chr11_10513848_-	SINE	Alu	AluSx1
CAediting_798202	chr11_10513850_-	SINE	Alu	AluSx1
CAediting_798203	chr11_10513853_-	SINE	Alu	AluSx1
CAediting_798204	chr11_10513854_-	SINE	Alu	AluSx1
CAediting_798205	chr11_10513870_-	SINE	Alu	AluSx1
CAediting_798206	chr11_10513889_-	SINE	Alu	AluSx1
CAediting_798207	chr11_10513908_-	SINE	Alu	AluSx1
CAediting_798208	chr11_10513948_-	SINE	Alu	AluSx1
CAediting_798209	chr11_10513949_-	SINE	Alu	AluSx1
CAediting_798210	chr11_10513955_-	SINE	Alu	AluSx1
CAediting_798211	chr11_10513965_-	SINE	Alu	AluSx1
CAediting_798212	chr11_10513970_-	SINE	Alu	AluSx1

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RNA A-to-I editing events in the alternative splicing sites for RNF141

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000110315.5.RNF141.

Correlation between RNA A-to-I editing and PSI for ENSG00000110315.5.RNF141.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for RNF141

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for RNF141

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for RNF141

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_414656	chr5_72878640_+	ENSG00000110315.5	ENST00000530156	hsa-miR-4804-3p	10525284	10525291	8mer-1a	10525284	10525303	146	-15.18

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_468389	chr6_31355314_-	ENSG00000110315.5	ENST00000528665	hsa-miR-6891-5p	10518749	10518755	7mer-m8	10518748	10518766	153	-22.98

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for RNF141

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for RNF141

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for RNF141

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for RNF141

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for RNF141

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for RNF141

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene