Home

Download

Statistics

Examples

Help

Contact

Editing gene: DEF6 (CAeditome ID:50619)

Gene summary for DEF6

Gene summary

Gene information	Gene symbol	DEF6
	Gene ID	50619
	Gene name	DEF6 guanine nucleotide exchange factor
	Synonyms	IBP\|SLAT\|SWAP70L
	Cytomap	6p21.31
	Type of gene	protein-coding
	Description	differentially expressed in FDCP 6 homologDEF-6IRF4-binding proteinSWAP-70-like adaptor protein of T cells
	Modification date	20210518
	UniProtAcc	Q9H4E7
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
DEF6	GO:0005654	Differentially expressed in FDCP 6 homolog	0000052
DEF6	GO:0005829	Differentially expressed in FDCP 6 homolog	0000052

Top

RNA A-to-I events for DEF6

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000023892.10

RNA A-to-I editing events in Cancer.

CAediting_471714(35300091, +), CAediting_471715(35302098, +), CAediting_471716(35302180, +), CAediting_471717(35304013, +), CAediting_471718(35304039, +), CAediting_471719(35304072, +), CAediting_471720(35304262, +), CAediting_471721(35305275, +), CAediting_471722(35305375, +), CAediting_471723(35305379, +), CAediting_471724(35305393, +), CAediting_471725(35305438, +), CAediting_471726(35305441, +), CAediting_471727(35305465, +), CAediting_471728(35305673, +), CAediting_471729(35305730, +), CAediting_471730(35305734, +), CAediting_471731(35305753, +), CAediting_471732(35305756, +), CAediting_471733(35306408, +), CAediting_471734(35314116, +), CAediting_471735(35314130, +), CAediting_471736(35314136, +), CAediting_471737(35314152, +), CAediting_471738(35314153, +), CAediting_471739(35314169, +), CAediting_471740(35314193, +), CAediting_471741(35314207, +), CAediting_471742(35314209, +), CAediting_471743(35314212, +), CAediting_471744(35314222, +), CAediting_471745(35314230, +), CAediting_471746(35314287, +), CAediting_471747(35314288, +), CAediting_471748(35314293, +), CAediting_471749(35314297, +), CAediting_471750(35314301, +), CAediting_471751(35314317, +), CAediting_471752(35314320, +), CAediting_471753(35314328, +), CAediting_471754(35314329, +), CAediting_471755(35314356, +), CAediting_471756(35314357, +), CAediting_471757(35314359, +), CAediting_471758(35314364, +), CAediting_471759(35315207, +), CAediting_471760(35315213, +), CAediting_471761(35315257, +), CAediting_471762(35315259, +), CAediting_471763(35315290, +), CAediting_471764(35315308, +), CAediting_471765(35315317, +), CAediting_471766(35315318, +), CAediting_471767(35315320, +), CAediting_471768(35315895, +), CAediting_471769(35315920, +), CAediting_471770(35315958, +), CAediting_471771(35315959, +), CAediting_471772(35315984, +), CAediting_471773(35315999, +), CAediting_471774(35316017, +), CAediting_471775(35316078, +), CAediting_471776(35316089, +), CAediting_471777(35316090, +), CAediting_471778(35316091, +), CAediting_471779(35316143, +), CAediting_471780(35316152, +), CAediting_471781(35316183, +), CAediting_471782(35316194, +), CAediting_471783(35316202, +), CAediting_471784(35316214, +), CAediting_471785(35316239, +), CAediting_471786(35316240, +), CAediting_471787(35316243, +), CAediting_471788(35316244, +), CAediting_471789(35316252, +), CAediting_471790(35316257, +), CAediting_471791(35316267, +), CAediting_471792(35316273, +), CAediting_471793(35316279, +), CAediting_471794(35316282, +),

Top

RNA editing positional annotations for DEF6 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_471714	chr6_35300091_+	intronic
CAediting_471715	chr6_35302098_+	intronic
CAediting_471716	chr6_35302180_+	intronic
CAediting_471717	chr6_35304013_+	intronic
CAediting_471718	chr6_35304039_+	intronic
CAediting_471719	chr6_35304072_+	intronic
CAediting_471720	chr6_35304262_+	intronic
CAediting_471721	chr6_35305275_+	intronic
CAediting_471722	chr6_35305375_+	intronic
CAediting_471723	chr6_35305379_+	intronic
CAediting_471724	chr6_35305393_+	intronic
CAediting_471725	chr6_35305438_+	intronic
CAediting_471726	chr6_35305441_+	intronic
CAediting_471727	chr6_35305465_+	intronic
CAediting_471728	chr6_35305673_+	intronic
CAediting_471729	chr6_35305730_+	intronic
CAediting_471730	chr6_35305734_+	intronic
CAediting_471731	chr6_35305753_+	intronic
CAediting_471732	chr6_35305756_+	intronic
CAediting_471733	chr6_35306408_+	intronic
CAediting_471734	chr6_35314116_+	intronic
CAediting_471735	chr6_35314130_+	intronic
CAediting_471736	chr6_35314136_+	intronic
CAediting_471737	chr6_35314152_+	intronic
CAediting_471738	chr6_35314153_+	intronic
CAediting_471739	chr6_35314169_+	intronic
CAediting_471740	chr6_35314193_+	intronic
CAediting_471741	chr6_35314207_+	intronic
CAediting_471742	chr6_35314209_+	intronic
CAediting_471743	chr6_35314212_+	intronic
CAediting_471744	chr6_35314222_+	intronic
CAediting_471745	chr6_35314230_+	intronic
CAediting_471746	chr6_35314287_+	intronic
CAediting_471747	chr6_35314288_+	intronic
CAediting_471748	chr6_35314293_+	intronic
CAediting_471749	chr6_35314297_+	intronic
CAediting_471750	chr6_35314301_+	intronic
CAediting_471751	chr6_35314317_+	intronic
CAediting_471752	chr6_35314320_+	intronic
CAediting_471753	chr6_35314328_+	intronic
CAediting_471754	chr6_35314329_+	intronic
CAediting_471755	chr6_35314356_+	intronic
CAediting_471756	chr6_35314357_+	intronic
CAediting_471757	chr6_35314359_+	intronic
CAediting_471758	chr6_35314364_+	intronic
CAediting_471759	chr6_35315207_+	intronic
CAediting_471760	chr6_35315213_+	intronic
CAediting_471761	chr6_35315257_+	intronic
CAediting_471762	chr6_35315259_+	intronic
CAediting_471763	chr6_35315290_+	intronic
CAediting_471764	chr6_35315308_+	intronic
CAediting_471765	chr6_35315317_+	intronic
CAediting_471766	chr6_35315318_+	intronic
CAediting_471767	chr6_35315320_+	intronic
CAediting_471768	chr6_35315895_+	intronic
CAediting_471769	chr6_35315920_+	intronic
CAediting_471770	chr6_35315958_+	intronic
CAediting_471771	chr6_35315959_+	intronic
CAediting_471772	chr6_35315984_+	intronic
CAediting_471773	chr6_35315999_+	intronic
CAediting_471774	chr6_35316017_+	intronic
CAediting_471775	chr6_35316078_+	intronic
CAediting_471776	chr6_35316089_+	intronic
CAediting_471777	chr6_35316090_+	intronic
CAediting_471778	chr6_35316091_+	intronic
CAediting_471779	chr6_35316143_+	intronic
CAediting_471780	chr6_35316152_+	intronic
CAediting_471781	chr6_35316183_+	intronic
CAediting_471782	chr6_35316194_+	intronic
CAediting_471783	chr6_35316202_+	intronic
CAediting_471784	chr6_35316214_+	intronic
CAediting_471785	chr6_35316239_+	intronic
CAediting_471786	chr6_35316240_+	intronic
CAediting_471787	chr6_35316243_+	intronic
CAediting_471788	chr6_35316244_+	intronic
CAediting_471789	chr6_35316252_+	intronic
CAediting_471790	chr6_35316257_+	intronic
CAediting_471791	chr6_35316267_+	intronic
CAediting_471792	chr6_35316273_+	intronic
CAediting_471793	chr6_35316279_+	intronic
CAediting_471794	chr6_35316282_+	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_471714	chr6_35300091_+	SINE	Alu	AluJr
CAediting_471715	chr6_35302098_+	SINE	Alu	AluJb
CAediting_471716	chr6_35302180_+	SINE	Alu	AluJb
CAediting_471717	chr6_35304013_+	SINE	Alu	AluSq2
CAediting_471718	chr6_35304039_+	SINE	Alu	AluSq2
CAediting_471719	chr6_35304072_+	SINE	Alu	AluSq2
CAediting_471720	chr6_35304262_+	SINE	Alu	AluJb
CAediting_471721	chr6_35305275_+	SINE	Alu	AluJb
CAediting_471722	chr6_35305375_+	SINE	Alu	AluSc8
CAediting_471723	chr6_35305379_+	SINE	Alu	AluSc8
CAediting_471724	chr6_35305393_+	SINE	Alu	AluSc8
CAediting_471725	chr6_35305438_+	SINE	Alu	AluSc8
CAediting_471726	chr6_35305441_+	SINE	Alu	AluSc8
CAediting_471727	chr6_35305465_+	SINE	Alu	AluSc8
CAediting_471728	chr6_35305673_+	SINE	Alu	AluSx1
CAediting_471729	chr6_35305730_+	SINE	Alu	AluSx1
CAediting_471730	chr6_35305734_+	SINE	Alu	AluSx1
CAediting_471731	chr6_35305753_+	SINE	Alu	AluSx1
CAediting_471732	chr6_35305756_+	SINE	Alu	AluSx1
CAediting_471733	chr6_35306408_+	SINE	Alu	AluSq2
CAediting_471734	chr6_35314116_+	LINE	L1	L1MA4
CAediting_471735	chr6_35314130_+	SINE	Alu	AluSq2
CAediting_471736	chr6_35314136_+	SINE	Alu	AluSq2
CAediting_471737	chr6_35314152_+	SINE	Alu	AluSq2
CAediting_471738	chr6_35314153_+	SINE	Alu	AluSq2
CAediting_471739	chr6_35314169_+	SINE	Alu	AluSq2
CAediting_471740	chr6_35314193_+	SINE	Alu	AluSq2
CAediting_471741	chr6_35314207_+	SINE	Alu	AluSq2
CAediting_471742	chr6_35314209_+	SINE	Alu	AluSq2
CAediting_471743	chr6_35314212_+	SINE	Alu	AluSq2
CAediting_471744	chr6_35314222_+	SINE	Alu	AluSq2
CAediting_471745	chr6_35314230_+	SINE	Alu	AluSq2
CAediting_471746	chr6_35314287_+	SINE	Alu	AluSq2
CAediting_471747	chr6_35314288_+	SINE	Alu	AluSq2
CAediting_471748	chr6_35314293_+	SINE	Alu	AluSq2
CAediting_471749	chr6_35314297_+	SINE	Alu	AluSq2
CAediting_471750	chr6_35314301_+	SINE	Alu	AluSq2
CAediting_471751	chr6_35314317_+	SINE	Alu	AluSq2
CAediting_471752	chr6_35314320_+	SINE	Alu	AluSq2
CAediting_471753	chr6_35314328_+	SINE	Alu	AluSq2
CAediting_471754	chr6_35314329_+	SINE	Alu	AluSq2
CAediting_471755	chr6_35314356_+	SINE	Alu	AluSq2
CAediting_471756	chr6_35314357_+	SINE	Alu	AluSq2
CAediting_471757	chr6_35314359_+	SINE	Alu	AluSq2
CAediting_471758	chr6_35314364_+	SINE	Alu	AluSq2
CAediting_471759	chr6_35315207_+	SINE	Alu	AluJo
CAediting_471760	chr6_35315213_+	SINE	Alu	AluJo
CAediting_471761	chr6_35315257_+	SINE	Alu	AluJo
CAediting_471762	chr6_35315259_+	SINE	Alu	AluJo
CAediting_471763	chr6_35315290_+	SINE	Alu	AluJo
CAediting_471764	chr6_35315308_+	SINE	Alu	AluJo
CAediting_471765	chr6_35315317_+	SINE	Alu	AluJo
CAediting_471766	chr6_35315318_+	SINE	Alu	AluJo
CAediting_471767	chr6_35315320_+	SINE	Alu	AluJo
CAediting_471768	chr6_35315895_+	SINE	Alu	AluSq2
CAediting_471769	chr6_35315920_+	SINE	Alu	AluSq2
CAediting_471770	chr6_35315958_+	SINE	Alu	AluSq2
CAediting_471771	chr6_35315959_+	SINE	Alu	AluSq2
CAediting_471772	chr6_35315984_+	SINE	Alu	AluSq2
CAediting_471773	chr6_35315999_+	SINE	Alu	AluSq2
CAediting_471774	chr6_35316017_+	SINE	Alu	AluSq2
CAediting_471775	chr6_35316078_+	SINE	Alu	AluSq2
CAediting_471776	chr6_35316089_+	SINE	Alu	AluSq2
CAediting_471777	chr6_35316090_+	SINE	Alu	AluSq2
CAediting_471778	chr6_35316091_+	SINE	Alu	AluSq2
CAediting_471779	chr6_35316143_+	SINE	Alu	AluSq2
CAediting_471780	chr6_35316152_+	SINE	Alu	AluSq2
CAediting_471781	chr6_35316183_+	SINE	Alu	FLAM_C
CAediting_471782	chr6_35316194_+	SINE	Alu	FLAM_C
CAediting_471783	chr6_35316202_+	SINE	Alu	FLAM_C
CAediting_471784	chr6_35316214_+	SINE	Alu	FLAM_C
CAediting_471785	chr6_35316239_+	SINE	Alu	FLAM_C
CAediting_471786	chr6_35316240_+	SINE	Alu	FLAM_C
CAediting_471787	chr6_35316243_+	SINE	Alu	FLAM_C
CAediting_471788	chr6_35316244_+	SINE	Alu	FLAM_C
CAediting_471789	chr6_35316252_+	SINE	Alu	FLAM_C
CAediting_471790	chr6_35316257_+	SINE	Alu	FLAM_C
CAediting_471791	chr6_35316267_+	SINE	Alu	FLAM_C
CAediting_471792	chr6_35316273_+	SINE	Alu	FLAM_C
CAediting_471793	chr6_35316279_+	SINE	Alu	FLAM_C
CAediting_471794	chr6_35316282_+	SINE	Alu	FLAM_C

Top

RNA A-to-I editing events in the alternative splicing sites for DEF6

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
ES	CAediting_471780	chr6_35316152_+	35316144:35316152	5SS	0+6i	CAGGTATAA	7.46	CAGGTATAG	8.73
MEX_2	CAediting_471780	chr6_35316152_+	35316144:35316152	5SS	0+6i	CAGGTATAA	7.46	CAGGTATAG	8.73

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000023892.10.DEF6.

Correlation between RNA A-to-I editing and PSI for ENSG00000023892.10.DEF6.

Top

Differntial gene expression between RNA A-to-I edited versus non-edited samples for DEF6

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

Top

Protein coding region RNA A-to-I editings for DEF6

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

Top

The effects of the RNA editing to the miRNA binding sites for DEF6

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1368054	chr19_46709310_-	ENSG00000023892.10	ENST00000316637	hsa-miR-320e	35321580	35321586	7mer-m8	35321570	35321587	150	-19.96
CAediting_1368054	chr19_46709310_-	ENSG00000023892.10	ENST00000316637	hsa-miR-320e	35321482	35321488	7mer-m8	35321472	35321489	149	-18.09

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for DEF6

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

Top

Relation with ADAR for DEF6

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

Top

Relation with cancer stages for DEF6

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

Top

Relation with survival for DEF6

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

Top

RelatedDrugs for DEF6

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for DEF6

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
DEF6	C0024141	Lupus Erythematosus, Systemic	1	CTD_human
DEF6	C0242380	Libman-Sacks Disease	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene