![]() |
||||||
|
![]() | |
![]() | |
![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
![]() | |
![]() | |
![]() | The effects of the RNA editing to the stability of the RNA structures |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Editing gene: DUOX2 (CAeditome ID:50506) |
Gene summary for DUOX2 |
![]() |
Gene information | Gene symbol | DUOX2 | Gene ID | 50506 |
Gene name | dual oxidase 2 | |
Synonyms | LNOX2|NOXEF2|P138-TOX|TDH6|THOX2 | |
Cytomap | 15q21.1 | |
Type of gene | protein-coding | |
Description | dual oxidase 2NADH/NADPH thyroid oxidase p138-toxNADPH oxidase/peroxidase DUOX2NADPH thyroid oxidase 2dual oxidase-like domains 2flavoprotein NADPH oxidaselarge NOX 2long NOX 2nicotinamide adenine dinucleotide phosphate oxidasep138 thyroid oxidas | |
Modification date | 20210531 | |
UniProtAcc | Q9NRD8 | |
Context |
![]() |
Gene | GO ID | GO term | PubMed ID |
DUOX2 | GO:0005509 | Dual oxidase 2 | 15972824 |
DUOX2 | GO:0016174 | Dual oxidase 2 | 15972824 |
DUOX2 | GO:0009615 | Dual oxidase 2 | 16111680 |
DUOX2 | GO:0019221 | Dual oxidase 2 | 16111680 |
DUOX2 | GO:0051591 | Dual oxidase 2 | 15062544 |
DUOX2 | GO:0005783 | Dual oxidase 2 | 19339556 |
DUOX2 | GO:0005829 | Dual oxidase 2 | 19339556 |
DUOX2 | GO:0005886 | Dual oxidase 2 | 19339556 |
DUOX2 | GO:0045177 | Dual oxidase 2 | 25761904 |
Top |
RNA A-to-I events for DUOX2 |
![]() |
![]() |
![]() |
![]() |
CAediting_1037273(45107429, -), |
Top |
RNA editing positional annotations for DUOX2 using Annovar |
![]() |
CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
![]() |
CAeditome ID | Position | Variant type |
CAediting_1037273 | chr15_45107429_- | exonic |
![]() |
CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
Top |
RNA A-to-I editing events in the alternative splicing sites for DUOX2 |
![]() |
AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
![]() |
![]() |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for DUOX2 |
![]() * The grey color means N/A. |
![]() |
![]() * Click on the image to enlarge it in a new window. |
Top |
Protein coding region RNA A-to-I editings for DUOX2 |
![]() * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for DUOX2 |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_1054808 | chr15_66496985_- | ENSG00000140279.11 | ENST00000389039 | hsa-miR-4512 | 45093370 | 45093376 | 7mer-m8 | 45093369 | 45093390 | 141 | -20.04 |
CAediting_1368054 | chr19_46709310_- | ENSG00000140279.11 | ENST00000389039 | hsa-miR-320e | 45093518 | 45093524 | 7mer-m8 | 45093517 | 45093534 | 148 | -20 |
CAediting_1054808 | chr15_66496985_- | ENSG00000140279.11 | ENST00000603300 | hsa-miR-4512 | 45093370 | 45093376 | 7mer-m8 | 45093369 | 45093390 | 141 | -20.04 |
CAediting_1368054 | chr19_46709310_- | ENSG00000140279.11 | ENST00000603300 | hsa-miR-320e | 45093518 | 45093524 | 7mer-m8 | 45093517 | 45093534 | 148 | -20 |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_748296 | chr10_51299626_+ | ENSG00000140279.11 | ENST00000389039 | hsa-miR-605-3p | 45094110 | 45094116 | 7mer-m8 | 45094109 | 45094130 | 145 | -14.67 |
CAediting_748296 | chr10_51299626_+ | ENSG00000140279.11 | ENST00000603300 | hsa-miR-605-3p | 45094110 | 45094116 | 7mer-m8 | 45094109 | 45094130 | 145 | -14.67 |
![]() |
Top |
The effects of the RNA editing to the stability of the RNA structures for DUOX2 |
![]() * Click on the image to enlarge it in a new window. |
ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
![]() |
CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
Top |
Relation with ADAR for DUOX2 |
![]() |
Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
Top |
Relation with cancer stages for DUOX2 |
![]() |
Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
Top |
Relation with survival for DUOX2 |
![]() |
Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
Top |
RelatedDrugs for DUOX2 |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for DUOX2 |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
DUOX2 | C1846632 | Thyroid Dyshormonogenesis 6 | 5 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
DUOX2 | C0010308 | Congenital Hypothyroidism | 3 | CTD_human;GENOMICS_ENGLAND |
DUOX2 | C0342200 | Endemic Cretinism | 2 | CTD_human |
DUOX2 | C1578691 | Myxedema, Congenital | 2 | CTD_human |
DUOX2 | C1848805 | Thyroid Dyshormonogenesis 1 | 2 | ORPHANET |
DUOX2 | C0018021 | Goiter | 1 | GENOMICS_ENGLAND |
DUOX2 | C2750949 | Iodide organification defect | 1 | GENOMICS_ENGLAND |
DUOX2 | C3827793 | Transient hypothyroxinaemia of prematurity | 1 | GENOMICS_ENGLAND |
DUOX2 | C4749351 | Genetic transient congenital hypothyroidism | 1 | ORPHANET |