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Editing gene: SLC22A18 (CAeditome ID:5002)

Gene summary for SLC22A18

Gene summary

Gene information	Gene symbol	SLC22A18
	Gene ID	5002
	Gene name	solute carrier family 22 member 18
	Synonyms	BWR1A\|BWSCR1A\|HET\|IMPT1\|ITM\|ORCTL2\|SLC22A1L\|TSSC5\|p45-BWR1A
	Cytomap	11p15.4
	Type of gene	protein-coding
	Description	solute carrier family 22 member 18beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A proteinefflux transporter-like proteinimprinted multi-membrane-spanning polyspecific transporter-related protein 1organic cation transporter-like prote
	Modification date	20210518
	UniProtAcc	Q96BI1
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
SLC22A18	GO:0022857	Solute carrier family 22 member 18	9744804
SLC22A18	GO:0042908	Solute carrier family 22 member 18	9744804
SLC22A18	GO:1990961	Solute carrier family 22 member 18	9744804
SLC22A18	GO:0005635	Solute carrier family 22 member 18	16314844
SLC22A18	GO:0005737	Solute carrier family 22 member 18	16314844
SLC22A18	GO:0016324	Solute carrier family 22 member 18	9744804

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RNA A-to-I events for SLC22A18

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000110628.12

RNA A-to-I editing events in Cancer.

CAediting_792970(2905462, +), CAediting_792971(2905469, +), CAediting_792972(2905494, +), CAediting_792973(2905495, +), CAediting_792974(2905562, +), CAediting_792975(2906402, +), CAediting_792976(2906405, +), CAediting_792977(2906406, +), CAediting_792978(2906410, +), CAediting_792979(2906446, +), CAediting_792980(2906448, +), CAediting_792981(2906453, +), CAediting_792982(2906462, +), CAediting_792983(2906472, +), CAediting_792984(2906481, +), CAediting_792985(2906497, +), CAediting_792986(2906502, +), CAediting_792987(2906503, +), CAediting_792988(2906510, +), CAediting_792989(2906514, +), CAediting_792990(2906517, +), CAediting_792991(2906518, +), CAediting_792992(2906526, +), CAediting_792993(2906535, +), CAediting_792994(2906542, +), CAediting_792995(2906557, +), CAediting_792996(2906568, +), CAediting_792997(2906585, +), CAediting_792998(2906602, +), CAediting_792999(2909284, +), CAediting_793000(2918767, +), CAediting_793001(2918917, +), CAediting_793002(2921084, +), CAediting_793003(2921110, +), CAediting_793004(2921152, +),

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RNA editing positional annotations for SLC22A18 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_792999	chr11_2909284_+	nonsynonymous SNV	ENST00000347936.5	c.A331G	p.S111G	D	P	D
CAediting_792999	chr11_2909284_+	nonsynonymous SNV	ENST00000380574.4	c.A331G	p.S111G	D	P	D
CAediting_792999	chr11_2909284_+	nonsynonymous SNV	ENST00000485423.1	c.A331G	p.S111G	D	P	D

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_792970	chr11_2905462_+	ncRNA_intronic
CAediting_792971	chr11_2905469_+	ncRNA_intronic
CAediting_792972	chr11_2905494_+	ncRNA_intronic
CAediting_792973	chr11_2905495_+	ncRNA_intronic
CAediting_792974	chr11_2905562_+	ncRNA_intronic
CAediting_792975	chr11_2906402_+	ncRNA_intronic
CAediting_792976	chr11_2906405_+	ncRNA_intronic
CAediting_792977	chr11_2906406_+	ncRNA_intronic
CAediting_792978	chr11_2906410_+	ncRNA_intronic
CAediting_792979	chr11_2906446_+	ncRNA_intronic
CAediting_792980	chr11_2906448_+	ncRNA_intronic
CAediting_792981	chr11_2906453_+	ncRNA_intronic
CAediting_792982	chr11_2906462_+	ncRNA_intronic
CAediting_792983	chr11_2906472_+	ncRNA_intronic
CAediting_792984	chr11_2906481_+	ncRNA_intronic
CAediting_792985	chr11_2906497_+	ncRNA_intronic
CAediting_792986	chr11_2906502_+	ncRNA_intronic
CAediting_792987	chr11_2906503_+	ncRNA_intronic
CAediting_792988	chr11_2906510_+	ncRNA_intronic
CAediting_792989	chr11_2906514_+	ncRNA_intronic
CAediting_792990	chr11_2906517_+	ncRNA_intronic
CAediting_792991	chr11_2906518_+	ncRNA_intronic
CAediting_792992	chr11_2906526_+	ncRNA_intronic
CAediting_792993	chr11_2906535_+	ncRNA_intronic
CAediting_792994	chr11_2906542_+	ncRNA_intronic
CAediting_792995	chr11_2906557_+	ncRNA_intronic
CAediting_792996	chr11_2906568_+	ncRNA_intronic
CAediting_792997	chr11_2906585_+	ncRNA_intronic
CAediting_792998	chr11_2906602_+	ncRNA_intronic
CAediting_792999	chr11_2909284_+	exonic
CAediting_793000	chr11_2918767_+	ncRNA_intronic
CAediting_793001	chr11_2918917_+	ncRNA_exonic
CAediting_793002	chr11_2921084_+	ncRNA_exonic
CAediting_793003	chr11_2921110_+	ncRNA_exonic
CAediting_793004	chr11_2921152_+	ncRNA_exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_792970	chr11_2905462_+	LINE	L1	L1PA5
CAediting_792971	chr11_2905469_+	LINE	L1	L1PA5
CAediting_792972	chr11_2905494_+	LINE	L1	L1PA5
CAediting_792973	chr11_2905495_+	LINE	L1	L1PA5
CAediting_792974	chr11_2905562_+	LINE	L1	L1PA5
CAediting_792975	chr11_2906402_+	LINE	L1	L1PA6
CAediting_792976	chr11_2906405_+	LINE	L1	L1PA6
CAediting_792977	chr11_2906406_+	LINE	L1	L1PA6
CAediting_792978	chr11_2906410_+	LINE	L1	L1PA6
CAediting_792979	chr11_2906446_+	LINE	L1	L1PA6
CAediting_792980	chr11_2906448_+	LINE	L1	L1PA6
CAediting_792981	chr11_2906453_+	LINE	L1	L1PA6
CAediting_792982	chr11_2906462_+	LINE	L1	L1PA6
CAediting_792983	chr11_2906472_+	LINE	L1	L1PA6
CAediting_792984	chr11_2906481_+	LINE	L1	L1PA6
CAediting_792985	chr11_2906497_+	LINE	L1	L1PA6
CAediting_792986	chr11_2906502_+	LINE	L1	L1PA6
CAediting_792987	chr11_2906503_+	LINE	L1	L1PA6
CAediting_792988	chr11_2906510_+	LINE	L1	L1PA6
CAediting_792989	chr11_2906514_+	LINE	L1	L1PA6
CAediting_792990	chr11_2906517_+	LINE	L1	L1PA6
CAediting_792991	chr11_2906518_+	LINE	L1	L1PA6
CAediting_792992	chr11_2906526_+	LINE	L1	L1PA6
CAediting_792993	chr11_2906535_+	LINE	L1	L1PA6
CAediting_792994	chr11_2906542_+	LINE	L1	L1PA6
CAediting_792995	chr11_2906557_+	LINE	L1	L1PA6
CAediting_792996	chr11_2906568_+	LINE	L1	L1PA6
CAediting_792997	chr11_2906585_+	LINE	L1	L1PA6
CAediting_792998	chr11_2906602_+	LINE	L1	L1PA6
CAediting_793000	chr11_2918767_+	SINE	Alu	AluJb
CAediting_793001	chr11_2918917_+	SINE	Alu	AluJb
CAediting_793002	chr11_2921084_+	SINE	Alu	AluY
CAediting_793003	chr11_2921110_+	SINE	Alu	AluY
CAediting_793004	chr11_2921152_+	SINE	Alu	AluY

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RNA A-to-I editing events in the alternative splicing sites for SLC22A18

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000110628.12.SLC22A18.

Correlation between RNA A-to-I editing and PSI for ENSG00000110628.12.SLC22A18.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SLC22A18

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for SLC22A18

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for SLC22A18

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_117844	chr1_162342605_+	ENSG00000110628.12	ENST00000347936	hsa-miR-556-3p	2925217	2925224	8mer-1a	2925203	2925224	147	-11.02
CAediting_117844	chr1_162342605_+	ENSG00000110628.12	ENST00000449793	hsa-miR-556-3p	2925217	2925224	8mer-1a	2925203	2925224	147	-11.02
CAediting_117844	chr1_162342605_+	ENSG00000110628.12	ENST00000380574	hsa-miR-556-3p	2925217	2925224	8mer-1a	2925203	2925224	147	-11.02

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SLC22A18

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for SLC22A18

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for SLC22A18

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for SLC22A18

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for SLC22A18

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SLC22A18

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
SLC22A18	C0001973	Alcoholic Intoxication, Chronic	1	PSYGENET
SLC22A18	C0206656	Embryonal Rhabdomyosarcoma	1	ORPHANET
SLC22A18	C0684249	Carcinoma of lung	1	CGI;UNIPROT

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene