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Editing gene: ORC1 (CAeditome ID:4998)

Gene summary for ORC1

Gene summary

Gene information	Gene symbol	ORC1
	Gene ID	4998
	Gene name	origin recognition complex subunit 1
	Synonyms	HSORC1\|ORC1L\|PARC1
	Cytomap	1p32.3
	Type of gene	protein-coding
	Description	origin recognition complex subunit 1origin recognition complex, subunit 1 homologreplication control protein 1
	Modification date	20210518
	UniProtAcc	Q13415
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
ORC1	GO:0000781	Origin recognition complex subunit 1	24270157
ORC1	GO:0005654	Origin recognition complex subunit 1	0000052
ORC1	GO:0000808	Origin recognition complex subunit 1	17716973
ORC1	GO:0005664	Origin recognition complex subunit 1	20932478
ORC1	GO:0005664	Origin recognition complex subunit 1	21029866

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RNA A-to-I events for ORC1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000085840.11

RNA A-to-I editing events in Cancer.

CAediting_64480(52372948, -), CAediting_64481(52372957, -), CAediting_64482(52372960, -), CAediting_64483(52372968, -), CAediting_64484(52372988, -), CAediting_64485(52373004, -), CAediting_64486(52373008, -), CAediting_64487(52373010, -), CAediting_64488(52373015, -), CAediting_64489(52373024, -), CAediting_64490(52373056, -), CAediting_64491(52373075, -), CAediting_64492(52373085, -), CAediting_64493(52373088, -), CAediting_64494(52373126, -), CAediting_64495(52373130, -), CAediting_64496(52376477, -), CAediting_64497(52377194, -), CAediting_64498(52379320, -), CAediting_64499(52379448, -), CAediting_64500(52386741, -), CAediting_64501(52386953, -), CAediting_64502(52387560, -), CAediting_64503(52392294, -), CAediting_64504(52392297, -),

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RNA editing positional annotations for ORC1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_64480	chr1_52372948_-	UTR3
CAediting_64481	chr1_52372957_-	UTR3
CAediting_64482	chr1_52372960_-	UTR3
CAediting_64483	chr1_52372968_-	UTR3
CAediting_64484	chr1_52372988_-	UTR3
CAediting_64485	chr1_52373004_-	UTR3
CAediting_64486	chr1_52373008_-	UTR3
CAediting_64487	chr1_52373010_-	UTR3
CAediting_64488	chr1_52373015_-	UTR3
CAediting_64489	chr1_52373024_-	UTR3
CAediting_64490	chr1_52373056_-	UTR3
CAediting_64491	chr1_52373075_-	UTR3
CAediting_64492	chr1_52373085_-	UTR3
CAediting_64493	chr1_52373088_-	UTR3
CAediting_64494	chr1_52373126_-	UTR3
CAediting_64495	chr1_52373130_-	UTR3
CAediting_64496	chr1_52376477_-	intronic
CAediting_64497	chr1_52377194_-	intronic
CAediting_64498	chr1_52379320_-	intronic
CAediting_64499	chr1_52379448_-	intronic
CAediting_64500	chr1_52386741_-	intronic
CAediting_64501	chr1_52386953_-	intronic
CAediting_64502	chr1_52387560_-	intronic
CAediting_64503	chr1_52392294_-	intronic
CAediting_64504	chr1_52392297_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_64480	chr1_52372948_-	SINE	Alu	AluJb
CAediting_64481	chr1_52372957_-	SINE	Alu	AluJb
CAediting_64482	chr1_52372960_-	SINE	Alu	AluJb
CAediting_64483	chr1_52372968_-	SINE	Alu	AluJb
CAediting_64484	chr1_52372988_-	SINE	Alu	AluJb
CAediting_64485	chr1_52373004_-	SINE	Alu	AluJb
CAediting_64486	chr1_52373008_-	SINE	Alu	AluJb
CAediting_64487	chr1_52373010_-	SINE	Alu	AluJb
CAediting_64488	chr1_52373015_-	SINE	Alu	AluJb
CAediting_64489	chr1_52373024_-	SINE	Alu	AluJb
CAediting_64490	chr1_52373056_-	SINE	Alu	AluJb
CAediting_64491	chr1_52373075_-	SINE	Alu	AluJb
CAediting_64492	chr1_52373085_-	SINE	Alu	AluJb
CAediting_64493	chr1_52373088_-	SINE	Alu	AluJb
CAediting_64494	chr1_52373126_-	SINE	Alu	AluJb
CAediting_64495	chr1_52373130_-	SINE	Alu	AluJb
CAediting_64496	chr1_52376477_-	SINE	Alu	AluSz
CAediting_64497	chr1_52377194_-	SINE	Alu	AluSq
CAediting_64498	chr1_52379320_-	SINE	Alu	AluSc8
CAediting_64499	chr1_52379448_-	SINE	Alu	AluSc8
CAediting_64500	chr1_52386741_-	SINE	Alu	AluJb
CAediting_64501	chr1_52386953_-	SINE	Alu	AluJb
CAediting_64502	chr1_52387560_-	SINE	Alu	AluSx1
CAediting_64503	chr1_52392294_-	SINE	Alu	AluY
CAediting_64504	chr1_52392297_-	SINE	Alu	AluY

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RNA A-to-I editing events in the alternative splicing sites for ORC1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000085840.11.ORC1.

Correlation between RNA A-to-I editing and PSI for ENSG00000085840.11.ORC1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ORC1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for ORC1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for ORC1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_64483	chr1_52372968_-	ENSG00000085840.11	ENST00000371568	hsa-miR-340-3p	52372967	52372973	7mer-m8	52372966	52372987	141.00	-16.87
CAediting_64483	chr1_52372968_-	ENSG00000085840.11	ENST00000371568	hsa-miR-6827-3p	52372967	52372973	7mer-m8	52372966	52372986	147.00	-16.75
CAediting_64483	chr1_52372968_-	ENSG00000085840.11	ENST00000371566	hsa-miR-340-3p	52372967	52372973	7mer-m8	52372966	52372987	141.00	-16.87
CAediting_64483	chr1_52372968_-	ENSG00000085840.11	ENST00000371566	hsa-miR-6827-3p	52372967	52372973	7mer-m8	52372966	52372986	147.00	-16.75
CAediting_64485	chr1_52373004_-	ENSG00000085840.11	ENST00000371568	hsa-miR-4787-3p	52373001	52373007	7mer-m8	52373000	52373023	140.00	-17.83
CAediting_64485	chr1_52373004_-	ENSG00000085840.11	ENST00000371568	hsa-miR-6720-3p	52373002	52373009	8mer-1a	52373002	52373023	148.00	-17.61
CAediting_64485	chr1_52373004_-	ENSG00000085840.11	ENST00000371566	hsa-miR-4787-3p	52373001	52373007	7mer-m8	52373000	52373023	140.00	-17.83
CAediting_64485	chr1_52373004_-	ENSG00000085840.11	ENST00000371566	hsa-miR-6720-3p	52373002	52373009	8mer-1a	52373002	52373023	148.00	-17.61
CAediting_64487	chr1_52373010_-	ENSG00000085840.11	ENST00000371568	hsa-miR-17-3p	52373007	52373013	7mer-m8	52373006	52373028	158.00	-24.19
CAediting_64487	chr1_52373010_-	ENSG00000085840.11	ENST00000371566	hsa-miR-17-3p	52373007	52373013	7mer-m8	52373006	52373028	158.00	-24.19
CAediting_64488	chr1_52373015_-	ENSG00000085840.11	ENST00000371568	hsa-miR-6512-3p	52373013	52373020	8mer-1a	52373013	52373035	146.00	-22.21
CAediting_64488	chr1_52373015_-	ENSG00000085840.11	ENST00000371568	hsa-miR-6720-5p	52373013	52373020	8mer-1a	52373013	52373037	159.00	-25.56
CAediting_64488	chr1_52373015_-	ENSG00000085840.11	ENST00000371566	hsa-miR-6512-3p	52373013	52373020	8mer-1a	52373013	52373035	146.00	-22.21
CAediting_64488	chr1_52373015_-	ENSG00000085840.11	ENST00000371566	hsa-miR-6720-5p	52373013	52373020	8mer-1a	52373013	52373037	159.00	-25.56
CAediting_64489	chr1_52373024_-	ENSG00000085840.11	ENST00000371568	hsa-miR-1247-3p	52373022	52373028	7mer-m8	52373021	52373043	155.00	-23.38
CAediting_64489	chr1_52373024_-	ENSG00000085840.11	ENST00000371566	hsa-miR-1247-3p	52373022	52373028	7mer-m8	52373021	52373043	155.00	-23.38
CAediting_64490	chr1_52373056_-	ENSG00000085840.11	ENST00000371568	hsa-miR-4740-3p	52373054	52373060	7mer-m8	52373053	52373073	147.00	-26.32
CAediting_64490	chr1_52373056_-	ENSG00000085840.11	ENST00000371566	hsa-miR-4740-3p	52373054	52373060	7mer-m8	52373053	52373073	147.00	-26.32
CAediting_64494	chr1_52373126_-	ENSG00000085840.11	ENST00000371568	hsa-miR-340-3p	52373125	52373131	7mer-m8	52373124	52373145	146.00	-19.58
CAediting_64494	chr1_52373126_-	ENSG00000085840.11	ENST00000371568	hsa-miR-6827-3p	52373125	52373131	7mer-m8	52373124	52373144	140.00	-14.58
CAediting_64494	chr1_52373126_-	ENSG00000085840.11	ENST00000371566	hsa-miR-340-3p	52373125	52373131	7mer-m8	52373124	52373145	146.00	-19.58
CAediting_64494	chr1_52373126_-	ENSG00000085840.11	ENST00000371566	hsa-miR-6827-3p	52373125	52373131	7mer-m8	52373124	52373144	140.00	-14.58
CAediting_64480	chr1_52372948_-	ENSG00000085840.11	ENST00000371568	hsa-miR-221-5p	52372947	52372953	7mer-m8	52372946	52372966	153.00	-16.75
CAediting_64480	chr1_52372948_-	ENSG00000085840.11	ENST00000371568	hsa-miR-3128	52372948	52372954	7mer-m8	52372947	52372973	144.00	-17.05
CAediting_64480	chr1_52372948_-	ENSG00000085840.11	ENST00000371568	hsa-miR-6868-5p	52372948	52372953	6mer	52372947	52372968	147.00	-20.81
CAediting_64480	chr1_52372948_-	ENSG00000085840.11	ENST00000371568	hsa-miR-8073	52372947	52372953	7mer-m8	52372946	52372967	160.00	-27.31
CAediting_64480	chr1_52372948_-	ENSG00000085840.11	ENST00000371566	hsa-miR-221-5p	52372947	52372953	7mer-m8	52372946	52372966	153.00	-16.75
CAediting_64480	chr1_52372948_-	ENSG00000085840.11	ENST00000371566	hsa-miR-3128	52372948	52372954	7mer-m8	52372947	52372973	144.00	-17.05
CAediting_64480	chr1_52372948_-	ENSG00000085840.11	ENST00000371566	hsa-miR-6868-5p	52372948	52372953	6mer	52372947	52372968	147.00	-20.81
CAediting_64480	chr1_52372948_-	ENSG00000085840.11	ENST00000371566	hsa-miR-8073	52372947	52372953	7mer-m8	52372946	52372967	160.00	-27.31
CAediting_64481	chr1_52372957_-	ENSG00000085840.11	ENST00000371568	hsa-miR-433-5p	52372956	52372962	7mer-m8	52372955	52372978	167.00	-27.32
CAediting_64481	chr1_52372957_-	ENSG00000085840.11	ENST00000371566	hsa-miR-433-5p	52372956	52372962	7mer-m8	52372955	52372978	167.00	-27.32
CAediting_64495	chr1_52373130_-	ENSG00000085840.11	ENST00000371568	hsa-miR-4433b-5p	52373126	52373132	7mer-m8	52373125	52373145	140.00	-13.05
CAediting_64495	chr1_52373130_-	ENSG00000085840.11	ENST00000371566	hsa-miR-4433b-5p	52373126	52373132	7mer-m8	52373125	52373145	140.00	-13.05

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_64494	chr1_52373126_-	ENSG00000085840.11	ENST00000371568	hsa-miR-10a-5p	52373122	52373128	7mer-m8	52373121	52373141	142	-12.31
CAediting_64494	chr1_52373126_-	ENSG00000085840.11	ENST00000371568	hsa-miR-10b-5p	52373122	52373128	7mer-m8	52373121	52373147	148	-15.56
CAediting_64484	chr1_52372988_-	ENSG00000085840.11	ENST00000371568	hsa-miR-1207-3p	52372983	52372990	8mer-1a	52372983	52373000	144	-14.68
CAediting_64493	chr1_52373088_-	ENSG00000085840.11	ENST00000371568	hsa-miR-1227-3p	52373087	52373093	7mer-m8	52373086	52373105	148	-22.88
CAediting_64485	chr1_52373004_-	ENSG00000085840.11	ENST00000371568	hsa-miR-1271-3p	52373002	52373009	8mer-1a	52373002	52373021	151	-19.63
CAediting_64486	chr1_52373008_-	ENSG00000085840.11	ENST00000371568	hsa-miR-1271-3p	52373002	52373009	8mer-1a	52373002	52373021	151	-19.63
CAediting_64489	chr1_52373024_-	ENSG00000085840.11	ENST00000371568	hsa-miR-1273h-5p	52373024	52373030	7mer-m8	52373023	52373043	153	-23.48
CAediting_64484	chr1_52372988_-	ENSG00000085840.11	ENST00000371568	hsa-miR-1285-3p	52372987	52372993	7mer-m8	52372986	52373007	140	-16.01
CAediting_64484	chr1_52372988_-	ENSG00000085840.11	ENST00000371568	hsa-miR-1285-3p	52372987	52372993	7mer-m8	52372986	52373007	140	-16.01
CAediting_64488	chr1_52373015_-	ENSG00000085840.11	ENST00000371568	hsa-miR-3157-5p	52373014	52373021	8mer-1a	52373014	52373035	140	-15.08
CAediting_64489	chr1_52373024_-	ENSG00000085840.11	ENST00000371568	hsa-miR-3689a-3p	52373024	52373030	7mer-m8	52373023	52373043	150	-24.33
CAediting_64495	chr1_52373130_-	ENSG00000085840.11	ENST00000371568	hsa-miR-371b-5p	52373128	52373135	8mer-1a	52373128	52373149	149	-14.09
CAediting_64495	chr1_52373130_-	ENSG00000085840.11	ENST00000371568	hsa-miR-373-5p	52373128	52373135	8mer-1a	52373128	52373149	140	-10.37
CAediting_64490	chr1_52373056_-	ENSG00000085840.11	ENST00000371568	hsa-miR-4251	52373055	52373061	7mer-m8	52373054	52373072	145	-20.83
CAediting_64490	chr1_52373056_-	ENSG00000085840.11	ENST00000371568	hsa-miR-4293	52373052	52373058	7mer-m8	52373051	52373067	148	-13.64
CAediting_64490	chr1_52373056_-	ENSG00000085840.11	ENST00000371568	hsa-miR-4324	52373054	52373060	7mer-m8	52373053	52373072	142	-10.33
CAediting_64494	chr1_52373126_-	ENSG00000085840.11	ENST00000371568	hsa-miR-4421	52373124	52373130	7mer-m8	52373123	52373144	155	-16.7
CAediting_64480	chr1_52372948_-	ENSG00000085840.11	ENST00000371568	hsa-miR-4453	52372944	52372951	8mer-1a	52372944	52372963	141	-13.7
CAediting_64480	chr1_52372948_-	ENSG00000085840.11	ENST00000371568	hsa-miR-4538	52372944	52372951	8mer-1a	52372944	52372964	147	-17.64
CAediting_64485	chr1_52373004_-	ENSG00000085840.11	ENST00000371568	hsa-miR-455-5p	52373001	52373007	7mer-m8	52373000	52373021	153	-17.28
CAediting_64494	chr1_52373126_-	ENSG00000085840.11	ENST00000371568	hsa-miR-4725-5p	52373121	52373127	7mer-m8	52373120	52373140	140	-15.96
CAediting_64494	chr1_52373126_-	ENSG00000085840.11	ENST00000371568	hsa-miR-504-5p	52373121	52373127	7mer-m8	52373120	52373139	147	-18.15
CAediting_64484	chr1_52372988_-	ENSG00000085840.11	ENST00000371568	hsa-miR-5189-5p	52372987	52372993	7mer-m8	52372986	52373009	151	-22.21
CAediting_64485	chr1_52373004_-	ENSG00000085840.11	ENST00000371568	hsa-miR-550a-3-5p	52373002	52373009	8mer-1a	52373002	52373021	143	-15.32
CAediting_64486	chr1_52373008_-	ENSG00000085840.11	ENST00000371568	hsa-miR-550a-3-5p	52373002	52373009	8mer-1a	52373002	52373021	143	-15.32
CAediting_64485	chr1_52373004_-	ENSG00000085840.11	ENST00000371568	hsa-miR-550a-5p	52373002	52373009	8mer-1a	52373002	52373024	143	-20.03
CAediting_64486	chr1_52373008_-	ENSG00000085840.11	ENST00000371568	hsa-miR-550a-5p	52373002	52373009	8mer-1a	52373002	52373024	143	-20.03
CAediting_64485	chr1_52373004_-	ENSG00000085840.11	ENST00000371568	hsa-miR-550a-5p	52373002	52373009	8mer-1a	52373002	52373024	143	-20.03
CAediting_64486	chr1_52373008_-	ENSG00000085840.11	ENST00000371568	hsa-miR-550a-5p	52373002	52373009	8mer-1a	52373002	52373024	143	-20.03
CAediting_64485	chr1_52373004_-	ENSG00000085840.11	ENST00000371568	hsa-miR-550b-2-5p	52373002	52373008	7mer-m8	52373001	52373022	148	-19.05
CAediting_64485	chr1_52373004_-	ENSG00000085840.11	ENST00000371568	hsa-miR-550b-2-5p	52373002	52373008	7mer-m8	52373001	52373022	148	-19.05
CAediting_64483	chr1_52372968_-	ENSG00000085840.11	ENST00000371568	hsa-miR-5699-3p	52372966	52372972	7mer-m8	52372965	52372986	148	-16.39
CAediting_64494	chr1_52373126_-	ENSG00000085840.11	ENST00000371568	hsa-miR-5699-3p	52373124	52373130	7mer-m8	52373123	52373144	141	-16.39
CAediting_64484	chr1_52372988_-	ENSG00000085840.11	ENST00000371568	hsa-miR-612	52372987	52372993	7mer-m8	52372986	52373011	152	-25.88
CAediting_64495	chr1_52373130_-	ENSG00000085840.11	ENST00000371568	hsa-miR-616-5p	52373128	52373135	8mer-1a	52373128	52373153	142	-16.35
CAediting_64485	chr1_52373004_-	ENSG00000085840.11	ENST00000371568	hsa-miR-6514-3p	52373004	52373010	7mer-m8	52373003	52373023	154	-17.17
CAediting_64486	chr1_52373008_-	ENSG00000085840.11	ENST00000371568	hsa-miR-6514-3p	52373004	52373010	7mer-m8	52373003	52373023	154	-17.17
CAediting_64489	chr1_52373024_-	ENSG00000085840.11	ENST00000371568	hsa-miR-6765-3p	52373020	52373026	7mer-m8	52373019	52373039	144	-19.25
CAediting_64489	chr1_52373024_-	ENSG00000085840.11	ENST00000371568	hsa-miR-6780a-5p	52373024	52373030	7mer-m8	52373023	52373043	148	-19.64
CAediting_64491	chr1_52373075_-	ENSG00000085840.11	ENST00000371568	hsa-miR-6807-5p	52373075	52373081	7mer-m8	52373074	52373094	142	-18.32
CAediting_64483	chr1_52372968_-	ENSG00000085840.11	ENST00000371568	hsa-miR-6818-3p	52372968	52372974	7mer-m8	52372967	52372988	140	-14.18
CAediting_64489	chr1_52373024_-	ENSG00000085840.11	ENST00000371568	hsa-miR-6852-5p	52373022	52373027	6mer	52373021	52373041	140	-22.33
CAediting_64484	chr1_52372988_-	ENSG00000085840.11	ENST00000371568	hsa-miR-6860	52372987	52372993	7mer-m8	52372986	52373008	154	-25.14
CAediting_64494	chr1_52373126_-	ENSG00000085840.11	ENST00000371566	hsa-miR-10a-5p	52373122	52373128	7mer-m8	52373121	52373141	142	-12.31
CAediting_64494	chr1_52373126_-	ENSG00000085840.11	ENST00000371566	hsa-miR-10b-5p	52373122	52373128	7mer-m8	52373121	52373147	148	-15.56
CAediting_64484	chr1_52372988_-	ENSG00000085840.11	ENST00000371566	hsa-miR-1207-3p	52372983	52372990	8mer-1a	52372983	52373000	144	-14.68
CAediting_64493	chr1_52373088_-	ENSG00000085840.11	ENST00000371566	hsa-miR-1227-3p	52373087	52373093	7mer-m8	52373086	52373105	148	-22.88
CAediting_64485	chr1_52373004_-	ENSG00000085840.11	ENST00000371566	hsa-miR-1271-3p	52373002	52373009	8mer-1a	52373002	52373021	151	-19.63
CAediting_64486	chr1_52373008_-	ENSG00000085840.11	ENST00000371566	hsa-miR-1271-3p	52373002	52373009	8mer-1a	52373002	52373021	151	-19.63
CAediting_64489	chr1_52373024_-	ENSG00000085840.11	ENST00000371566	hsa-miR-1273h-5p	52373024	52373030	7mer-m8	52373023	52373043	153	-23.48
CAediting_64484	chr1_52372988_-	ENSG00000085840.11	ENST00000371566	hsa-miR-1285-3p	52372987	52372993	7mer-m8	52372986	52373007	140	-16.01
CAediting_64484	chr1_52372988_-	ENSG00000085840.11	ENST00000371566	hsa-miR-1285-3p	52372987	52372993	7mer-m8	52372986	52373007	140	-16.01
CAediting_64488	chr1_52373015_-	ENSG00000085840.11	ENST00000371566	hsa-miR-3157-5p	52373014	52373021	8mer-1a	52373014	52373035	140	-15.08
CAediting_64489	chr1_52373024_-	ENSG00000085840.11	ENST00000371566	hsa-miR-3689a-3p	52373024	52373030	7mer-m8	52373023	52373043	150	-24.33
CAediting_64495	chr1_52373130_-	ENSG00000085840.11	ENST00000371566	hsa-miR-371b-5p	52373128	52373135	8mer-1a	52373128	52373149	149	-14.09
CAediting_64495	chr1_52373130_-	ENSG00000085840.11	ENST00000371566	hsa-miR-373-5p	52373128	52373135	8mer-1a	52373128	52373149	140	-10.37
CAediting_64490	chr1_52373056_-	ENSG00000085840.11	ENST00000371566	hsa-miR-4251	52373055	52373061	7mer-m8	52373054	52373072	145	-20.83
CAediting_64490	chr1_52373056_-	ENSG00000085840.11	ENST00000371566	hsa-miR-4293	52373052	52373058	7mer-m8	52373051	52373067	148	-13.64
CAediting_64490	chr1_52373056_-	ENSG00000085840.11	ENST00000371566	hsa-miR-4324	52373054	52373060	7mer-m8	52373053	52373072	142	-10.33
CAediting_64494	chr1_52373126_-	ENSG00000085840.11	ENST00000371566	hsa-miR-4421	52373124	52373130	7mer-m8	52373123	52373144	155	-16.7
CAediting_64480	chr1_52372948_-	ENSG00000085840.11	ENST00000371566	hsa-miR-4453	52372944	52372951	8mer-1a	52372944	52372963	141	-13.7
CAediting_64480	chr1_52372948_-	ENSG00000085840.11	ENST00000371566	hsa-miR-4538	52372944	52372951	8mer-1a	52372944	52372964	147	-17.64
CAediting_64485	chr1_52373004_-	ENSG00000085840.11	ENST00000371566	hsa-miR-455-5p	52373001	52373007	7mer-m8	52373000	52373021	153	-17.28
CAediting_64494	chr1_52373126_-	ENSG00000085840.11	ENST00000371566	hsa-miR-4725-5p	52373121	52373127	7mer-m8	52373120	52373140	140	-15.96
CAediting_64494	chr1_52373126_-	ENSG00000085840.11	ENST00000371566	hsa-miR-504-5p	52373121	52373127	7mer-m8	52373120	52373139	147	-18.15
CAediting_64484	chr1_52372988_-	ENSG00000085840.11	ENST00000371566	hsa-miR-5189-5p	52372987	52372993	7mer-m8	52372986	52373009	151	-22.21
CAediting_64485	chr1_52373004_-	ENSG00000085840.11	ENST00000371566	hsa-miR-550a-3-5p	52373002	52373009	8mer-1a	52373002	52373021	143	-15.32
CAediting_64486	chr1_52373008_-	ENSG00000085840.11	ENST00000371566	hsa-miR-550a-3-5p	52373002	52373009	8mer-1a	52373002	52373021	143	-15.32
CAediting_64485	chr1_52373004_-	ENSG00000085840.11	ENST00000371566	hsa-miR-550a-5p	52373002	52373009	8mer-1a	52373002	52373024	143	-20.03
CAediting_64486	chr1_52373008_-	ENSG00000085840.11	ENST00000371566	hsa-miR-550a-5p	52373002	52373009	8mer-1a	52373002	52373024	143	-20.03
CAediting_64485	chr1_52373004_-	ENSG00000085840.11	ENST00000371566	hsa-miR-550a-5p	52373002	52373009	8mer-1a	52373002	52373024	143	-20.03
CAediting_64486	chr1_52373008_-	ENSG00000085840.11	ENST00000371566	hsa-miR-550a-5p	52373002	52373009	8mer-1a	52373002	52373024	143	-20.03
CAediting_64485	chr1_52373004_-	ENSG00000085840.11	ENST00000371566	hsa-miR-550b-2-5p	52373002	52373008	7mer-m8	52373001	52373022	148	-19.05
CAediting_64485	chr1_52373004_-	ENSG00000085840.11	ENST00000371566	hsa-miR-550b-2-5p	52373002	52373008	7mer-m8	52373001	52373022	148	-19.05
CAediting_64483	chr1_52372968_-	ENSG00000085840.11	ENST00000371566	hsa-miR-5699-3p	52372966	52372972	7mer-m8	52372965	52372986	148	-16.39
CAediting_64494	chr1_52373126_-	ENSG00000085840.11	ENST00000371566	hsa-miR-5699-3p	52373124	52373130	7mer-m8	52373123	52373144	141	-16.39
CAediting_64484	chr1_52372988_-	ENSG00000085840.11	ENST00000371566	hsa-miR-612	52372987	52372993	7mer-m8	52372986	52373011	152	-25.88
CAediting_64495	chr1_52373130_-	ENSG00000085840.11	ENST00000371566	hsa-miR-616-5p	52373128	52373135	8mer-1a	52373128	52373153	142	-16.35
CAediting_64485	chr1_52373004_-	ENSG00000085840.11	ENST00000371566	hsa-miR-6514-3p	52373004	52373010	7mer-m8	52373003	52373023	154	-17.17
CAediting_64486	chr1_52373008_-	ENSG00000085840.11	ENST00000371566	hsa-miR-6514-3p	52373004	52373010	7mer-m8	52373003	52373023	154	-17.17
CAediting_64489	chr1_52373024_-	ENSG00000085840.11	ENST00000371566	hsa-miR-6765-3p	52373020	52373026	7mer-m8	52373019	52373039	144	-19.25
CAediting_64489	chr1_52373024_-	ENSG00000085840.11	ENST00000371566	hsa-miR-6780a-5p	52373024	52373030	7mer-m8	52373023	52373043	148	-19.64
CAediting_64491	chr1_52373075_-	ENSG00000085840.11	ENST00000371566	hsa-miR-6807-5p	52373075	52373081	7mer-m8	52373074	52373094	142	-18.32
CAediting_64483	chr1_52372968_-	ENSG00000085840.11	ENST00000371566	hsa-miR-6818-3p	52372968	52372974	7mer-m8	52372967	52372988	140	-14.18
CAediting_64489	chr1_52373024_-	ENSG00000085840.11	ENST00000371566	hsa-miR-6852-5p	52373022	52373027	6mer	52373021	52373041	140	-22.33
CAediting_64484	chr1_52372988_-	ENSG00000085840.11	ENST00000371566	hsa-miR-6860	52372987	52372993	7mer-m8	52372986	52373008	154	-25.14

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_524911	chr7_5495852_-	ENSG00000085840.11	ENST00000371568	hsa-miR-589-3p	52373113	52373119	7mer-m8	52373112	52373135	158	-17.61
CAediting_524911	chr7_5495852_-	ENSG00000085840.11	ENST00000371566	hsa-miR-589-3p	52373113	52373119	7mer-m8	52373112	52373135	158	-17.61

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ORC1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000371566.1	protein_coding
ENST00000371568.6	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_64480	ENST00000371566.1	chr1_52372948_-	-1020.80	-1021.10	-1036.70
CAediting_64481	ENST00000371566.1	chr1_52372957_-	-1019.70	-1021.10	-1036.70
CAediting_64482	ENST00000371566.1	chr1_52372960_-	-1021.60	-1021.10	-1036.70
CAediting_64483	ENST00000371566.1	chr1_52372968_-	-1020.40	-1021.10	-1036.70
CAediting_64484	ENST00000371566.1	chr1_52372988_-	-1021.00	-1021.10	-1036.70
CAediting_64485	ENST00000371566.1	chr1_52373004_-	-1021.70	-1021.10	-1036.70
CAediting_64486	ENST00000371566.1	chr1_52373008_-	-1025.90	-1021.10	-1036.70
CAediting_64487	ENST00000371566.1	chr1_52373010_-	-1021.10	-1021.10	-1036.70
CAediting_64488	ENST00000371566.1	chr1_52373015_-	-1022.30	-1021.10	-1036.70
CAediting_64489	ENST00000371566.1	chr1_52373024_-	-1021.90	-1021.10	-1036.70
CAediting_64490	ENST00000371566.1	chr1_52373056_-	-1021.10	-1021.10	-1036.70
CAediting_64491	ENST00000371566.1	chr1_52373075_-	-1020.70	-1021.10	-1036.70
CAediting_64492	ENST00000371566.1	chr1_52373085_-	-1023.40	-1021.10	-1036.70
CAediting_64493	ENST00000371566.1	chr1_52373088_-	-1022.20	-1021.10	-1036.70
CAediting_64494	ENST00000371566.1	chr1_52373126_-	-1020.40	-1021.10	-1036.70
CAediting_64495	ENST00000371566.1	chr1_52373130_-	-1022.70	-1021.10	-1036.70
CAediting_64480	ENST00000371568.6	chr1_52372948_-	-1050.10	-1049.50	-1064.10
CAediting_64481	ENST00000371568.6	chr1_52372957_-	-1049.50	-1049.50	-1064.10
CAediting_64482	ENST00000371568.6	chr1_52372960_-	-1051.40	-1049.50	-1064.10
CAediting_64483	ENST00000371568.6	chr1_52372968_-	-1050.10	-1049.50	-1064.10
CAediting_64484	ENST00000371568.6	chr1_52372988_-	-1048.80	-1049.50	-1064.10
CAediting_64485	ENST00000371568.6	chr1_52373004_-	-1049.80	-1049.50	-1064.10
CAediting_64486	ENST00000371568.6	chr1_52373008_-	-1050.80	-1049.50	-1064.10
CAediting_64487	ENST00000371568.6	chr1_52373010_-	-1049.70	-1049.50	-1064.10
CAediting_64488	ENST00000371568.6	chr1_52373015_-	-1050.90	-1049.50	-1064.10
CAediting_64489	ENST00000371568.6	chr1_52373024_-	-1051.00	-1049.50	-1064.10
CAediting_64490	ENST00000371568.6	chr1_52373056_-	-1051.10	-1049.50	-1064.10
CAediting_64491	ENST00000371568.6	chr1_52373075_-	-1049.10	-1049.50	-1064.10
CAediting_64492	ENST00000371568.6	chr1_52373085_-	-1052.20	-1049.50	-1064.10
CAediting_64493	ENST00000371568.6	chr1_52373088_-	-1050.30	-1049.50	-1064.10
CAediting_64494	ENST00000371568.6	chr1_52373126_-	-1049.60	-1049.50	-1064.10
CAediting_64495	ENST00000371568.6	chr1_52373130_-	-1050.10	-1049.50	-1064.10

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Relation with ADAR for ORC1

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for ORC1

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
OV	clinical_stage	CAediting_64494	chr1_52373126_-	0.0497470561852787	0.222962234988143

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Relation with survival for ORC1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

Top

RelatedDrugs for ORC1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ORC1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
ORC1	C4552001	MEIER-GORLIN SYNDROME 1	5	GENOMICS_ENGLAND;UNIPROT
ORC1	C1868684	EAR, PATELLA, SHORT STATURE SYNDROME	2	CTD_human;ORPHANET
ORC1	C0013336	Dwarfism	1	CTD_human
ORC1	C0015934	Fetal Growth Retardation	1	CTD_human
ORC1	C0025958	Microcephaly	1	CTD_human
ORC1	C0152423	Congenital small ears	1	GENOMICS_ENGLAND
ORC1	C0265202	Seckel syndrome	1	GENOMICS_ENGLAND
ORC1	C1292778	Chronic myeloproliferative disorder	1	GENOMICS_ENGLAND
ORC1	C1956147	Microlissencephaly	1	CTD_human
ORC1	C2239176	Liver carcinoma	1	CTD_human
ORC1	C3853041	Severe Congenital Microcephaly	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene