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Editing gene: GPR143 (CAeditome ID:4935)

Gene summary for GPR143

Gene summary

Gene information	Gene symbol	GPR143
	Gene ID	4935
	Gene name	G protein-coupled receptor 143
	Synonyms	NYS6\|OA1
	Cytomap	Xp22.2
	Type of gene	protein-coding
	Description	G-protein coupled receptor 143ocular albinism 1ocular albinism type 1 protein
	Modification date	20210531
	UniProtAcc	P51810
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
GPR143	GO:0004930	G-protein coupled receptor 143	16524428
GPR143	GO:0035240	G-protein coupled receptor 143	18828673
GPR143	GO:0035643	G-protein coupled receptor 143	18828673
GPR143	GO:0072544	G-protein coupled receptor 143	18828673
GPR143	GO:0072545	G-protein coupled receptor 143	18828673
GPR143	GO:0007186	G-protein coupled receptor 143	16524428
GPR143	GO:0032400	G-protein coupled receptor 143	19717472
GPR143	GO:0032402	G-protein coupled receptor 143	19717472
GPR143	GO:0035584	G-protein coupled receptor 143	18828673
GPR143	GO:0048015	G-protein coupled receptor 143	16524428
GPR143	GO:0050848	G-protein coupled receptor 143	18828673
GPR143	GO:0005765	G-protein coupled receptor 143	16621890
GPR143	GO:0005794	G-protein coupled receptor 143	19717472
GPR143	GO:0005886	G-protein coupled receptor 143	16524428
GPR143	GO:0016324	G-protein coupled receptor 143	18828673
GPR143	GO:0033162	G-protein coupled receptor 143	16621890
GPR143	GO:0042470	G-protein coupled receptor 143	10471510

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RNA A-to-I events for GPR143

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000101850.11

RNA A-to-I editing events in Cancer.

CAediting_1498401(9741798, -), CAediting_1498402(9749460, -), CAediting_1498403(9749470, -), CAediting_1498404(9749482, -), CAediting_1498405(9749495, -), CAediting_1498406(9749505, -), CAediting_1498407(9749509, -), CAediting_1498408(9749518, -), CAediting_1498409(9749528, -), CAediting_1498410(9749530, -), CAediting_1498411(9749535, -), CAediting_1498412(9749553, -), CAediting_1498413(9749566, -), CAediting_1498414(9749963, -), CAediting_1498415(9749970, -), CAediting_1498416(9750038, -), CAediting_1498417(9750257, -), CAediting_1498418(9750278, -), CAediting_1498419(9750302, -), CAediting_1498420(9750308, -), CAediting_1498421(9750338, -), CAediting_1498422(9750389, -), CAediting_1498423(9750392, -), CAediting_1498424(9750405, -), CAediting_1498425(9750408, -), CAediting_1498426(9750426, -), CAediting_1498427(9750692, -), CAediting_1498428(9750701, -), CAediting_1498429(9752137, -), CAediting_1498430(9752147, -), CAediting_1498431(9752151, -), CAediting_1498432(9752190, -), CAediting_1498433(9752200, -), CAediting_1498434(9752263, -), CAediting_1498435(9752264, -), CAediting_1498436(9752267, -), CAediting_1498437(9752271, -), CAediting_1498438(9752272, -), CAediting_1498439(9752281, -), CAediting_1498440(9752318, -), CAediting_1498441(9752363, -), CAediting_1498442(9752789, -), CAediting_1498443(9752794, -), CAediting_1498444(9752813, -), CAediting_1498445(9753119, -), CAediting_1498446(9758013, -), CAediting_1498447(9758667, -), CAediting_1498448(9758681, -), CAediting_1498449(9758682, -), CAediting_1498450(9758702, -), CAediting_1498451(9758727, -), CAediting_1498452(9759078, -), CAediting_1498453(9768846, -), CAediting_1498454(9773629, -), CAediting_1498455(9773655, -), CAediting_1498456(9773701, -), CAediting_1498457(9773752, -), CAediting_1498458(9773756, -), CAediting_1498459(9773764, -), CAediting_1498460(9774980, -), CAediting_1498461(9775061, -), CAediting_1498462(9775113, -), CAediting_1498463(9776524, -), CAediting_1498464(9776608, -), CAediting_1498465(9776661, -), CAediting_1498466(9776668, -), CAediting_1498467(9776678, -), CAediting_1498468(9777090, -), CAediting_1498469(9777098, -), CAediting_1498470(9777120, -), CAediting_1498471(9777125, -), CAediting_1498472(9777355, -), CAediting_1498473(9777566, -), CAediting_1498474(9778625, -), CAediting_1498475(9778631, -), CAediting_1498476(9778633, -), CAediting_1498477(9781289, -), CAediting_1498478(9781299, -), CAediting_1498479(9781301, -), CAediting_1498480(9781359, -), CAediting_1498481(9782110, -),

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RNA editing positional annotations for GPR143 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1498401	chrX_9741798_-	intronic
CAediting_1498402	chrX_9749460_-	ncRNA_intronic
CAediting_1498403	chrX_9749470_-	ncRNA_intronic
CAediting_1498404	chrX_9749482_-	ncRNA_intronic
CAediting_1498405	chrX_9749495_-	ncRNA_intronic
CAediting_1498406	chrX_9749505_-	ncRNA_intronic
CAediting_1498407	chrX_9749509_-	ncRNA_intronic
CAediting_1498408	chrX_9749518_-	ncRNA_intronic
CAediting_1498409	chrX_9749528_-	ncRNA_intronic
CAediting_1498410	chrX_9749530_-	ncRNA_intronic
CAediting_1498411	chrX_9749535_-	ncRNA_intronic
CAediting_1498412	chrX_9749553_-	ncRNA_intronic
CAediting_1498413	chrX_9749566_-	ncRNA_intronic
CAediting_1498414	chrX_9749963_-	ncRNA_intronic
CAediting_1498415	chrX_9749970_-	ncRNA_intronic
CAediting_1498416	chrX_9750038_-	ncRNA_intronic
CAediting_1498417	chrX_9750257_-	ncRNA_intronic
CAediting_1498418	chrX_9750278_-	ncRNA_intronic
CAediting_1498419	chrX_9750302_-	ncRNA_intronic
CAediting_1498420	chrX_9750308_-	ncRNA_intronic
CAediting_1498421	chrX_9750338_-	ncRNA_intronic
CAediting_1498422	chrX_9750389_-	ncRNA_intronic
CAediting_1498423	chrX_9750392_-	ncRNA_intronic
CAediting_1498424	chrX_9750405_-	ncRNA_intronic
CAediting_1498425	chrX_9750408_-	ncRNA_intronic
CAediting_1498426	chrX_9750426_-	ncRNA_intronic
CAediting_1498427	chrX_9750692_-	ncRNA_intronic
CAediting_1498428	chrX_9750701_-	ncRNA_intronic
CAediting_1498429	chrX_9752137_-	ncRNA_intronic
CAediting_1498430	chrX_9752147_-	ncRNA_intronic
CAediting_1498431	chrX_9752151_-	ncRNA_intronic
CAediting_1498432	chrX_9752190_-	ncRNA_intronic
CAediting_1498433	chrX_9752200_-	ncRNA_intronic
CAediting_1498434	chrX_9752263_-	ncRNA_intronic
CAediting_1498435	chrX_9752264_-	ncRNA_intronic
CAediting_1498436	chrX_9752267_-	ncRNA_intronic
CAediting_1498437	chrX_9752271_-	ncRNA_intronic
CAediting_1498438	chrX_9752272_-	ncRNA_intronic
CAediting_1498439	chrX_9752281_-	ncRNA_intronic
CAediting_1498440	chrX_9752318_-	ncRNA_intronic
CAediting_1498441	chrX_9752363_-	ncRNA_intronic
CAediting_1498442	chrX_9752789_-	ncRNA_intronic
CAediting_1498443	chrX_9752794_-	ncRNA_intronic
CAediting_1498444	chrX_9752813_-	ncRNA_intronic
CAediting_1498445	chrX_9753119_-	ncRNA_intronic
CAediting_1498446	chrX_9758013_-	ncRNA_intronic
CAediting_1498447	chrX_9758667_-	ncRNA_intronic
CAediting_1498448	chrX_9758681_-	ncRNA_intronic
CAediting_1498449	chrX_9758682_-	ncRNA_intronic
CAediting_1498450	chrX_9758702_-	ncRNA_intronic
CAediting_1498451	chrX_9758727_-	ncRNA_intronic
CAediting_1498452	chrX_9759078_-	ncRNA_intronic
CAediting_1498453	chrX_9768846_-	intronic
CAediting_1498454	chrX_9773629_-	intronic
CAediting_1498455	chrX_9773655_-	intronic
CAediting_1498456	chrX_9773701_-	intronic
CAediting_1498457	chrX_9773752_-	intronic
CAediting_1498458	chrX_9773756_-	intronic
CAediting_1498459	chrX_9773764_-	intronic
CAediting_1498460	chrX_9774980_-	intronic
CAediting_1498461	chrX_9775061_-	intronic
CAediting_1498462	chrX_9775113_-	intronic
CAediting_1498463	chrX_9776524_-	intronic
CAediting_1498464	chrX_9776608_-	intronic
CAediting_1498465	chrX_9776661_-	intronic
CAediting_1498466	chrX_9776668_-	intronic
CAediting_1498467	chrX_9776678_-	intronic
CAediting_1498468	chrX_9777090_-	intronic
CAediting_1498469	chrX_9777098_-	intronic
CAediting_1498470	chrX_9777120_-	intronic
CAediting_1498471	chrX_9777125_-	intronic
CAediting_1498472	chrX_9777355_-	intronic
CAediting_1498473	chrX_9777566_-	intronic
CAediting_1498474	chrX_9778625_-	intronic
CAediting_1498475	chrX_9778631_-	intronic
CAediting_1498476	chrX_9778633_-	intronic
CAediting_1498477	chrX_9781289_-	intronic
CAediting_1498478	chrX_9781299_-	intronic
CAediting_1498479	chrX_9781301_-	intronic
CAediting_1498480	chrX_9781359_-	intronic
CAediting_1498481	chrX_9782110_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1498401	chrX_9741798_-	SINE	Alu	AluJo
CAediting_1498402	chrX_9749460_-	LINE	L1	L1MB5
CAediting_1498403	chrX_9749470_-	LINE	L1	L1MB5
CAediting_1498404	chrX_9749482_-	LINE	L1	L1MB5
CAediting_1498405	chrX_9749495_-	LINE	L1	L1MB5
CAediting_1498406	chrX_9749505_-	LINE	L1	L1MB5
CAediting_1498407	chrX_9749509_-	LINE	L1	L1MB5
CAediting_1498408	chrX_9749518_-	LINE	L1	L1MB5
CAediting_1498409	chrX_9749528_-	LINE	L1	L1MB5
CAediting_1498410	chrX_9749530_-	LINE	L1	L1MB5
CAediting_1498411	chrX_9749535_-	LINE	L1	L1MB5
CAediting_1498412	chrX_9749553_-	LINE	L1	L1MB5
CAediting_1498413	chrX_9749566_-	LINE	L1	L1MB5
CAediting_1498414	chrX_9749963_-	SINE	Alu	AluJb
CAediting_1498415	chrX_9749970_-	SINE	Alu	AluJb
CAediting_1498416	chrX_9750038_-	SINE	Alu	AluJb
CAediting_1498417	chrX_9750257_-	SINE	Alu	AluJr
CAediting_1498418	chrX_9750278_-	SINE	Alu	AluJr
CAediting_1498419	chrX_9750302_-	SINE	Alu	AluJr
CAediting_1498420	chrX_9750308_-	SINE	Alu	AluJr
CAediting_1498421	chrX_9750338_-	SINE	Alu	AluJr
CAediting_1498422	chrX_9750389_-	SINE	Alu	AluJr
CAediting_1498423	chrX_9750392_-	SINE	Alu	AluJr
CAediting_1498424	chrX_9750405_-	SINE	Alu	AluJr
CAediting_1498425	chrX_9750408_-	SINE	Alu	AluJr
CAediting_1498426	chrX_9750426_-	SINE	Alu	AluJr
CAediting_1498427	chrX_9750692_-	SINE	Alu	AluSx1
CAediting_1498428	chrX_9750701_-	SINE	Alu	AluSx1
CAediting_1498429	chrX_9752137_-	SINE	Alu	AluJr4
CAediting_1498430	chrX_9752147_-	SINE	Alu	AluJr4
CAediting_1498431	chrX_9752151_-	SINE	Alu	AluJr4
CAediting_1498432	chrX_9752190_-	SINE	Alu	AluJr4
CAediting_1498433	chrX_9752200_-	SINE	Alu	AluJr4
CAediting_1498434	chrX_9752263_-	SINE	Alu	AluJr4
CAediting_1498435	chrX_9752264_-	SINE	Alu	AluJr4
CAediting_1498436	chrX_9752267_-	SINE	Alu	AluJr4
CAediting_1498437	chrX_9752271_-	SINE	Alu	AluJr4
CAediting_1498438	chrX_9752272_-	SINE	Alu	AluJr4
CAediting_1498439	chrX_9752281_-	SINE	Alu	AluJr4
CAediting_1498440	chrX_9752318_-	SINE	Alu	AluJr4
CAediting_1498441	chrX_9752363_-	SINE	Alu	AluJr4
CAediting_1498442	chrX_9752789_-	SINE	Alu	AluJr
CAediting_1498443	chrX_9752794_-	SINE	Alu	AluJr
CAediting_1498444	chrX_9752813_-	SINE	Alu	AluJr
CAediting_1498445	chrX_9753119_-	SINE	Alu	AluSx1
CAediting_1498446	chrX_9758013_-	SINE	Alu	AluJo
CAediting_1498447	chrX_9758667_-	SINE	Alu	AluJr
CAediting_1498448	chrX_9758681_-	SINE	Alu	AluJr
CAediting_1498449	chrX_9758682_-	SINE	Alu	AluJr
CAediting_1498450	chrX_9758702_-	SINE	Alu	AluJr
CAediting_1498451	chrX_9758727_-	SINE	Alu	AluJr
CAediting_1498452	chrX_9759078_-	SINE	Alu	FLAM_A
CAediting_1498453	chrX_9768846_-	SINE	Alu	AluSz6
CAediting_1498454	chrX_9773629_-	SINE	Alu	AluJb
CAediting_1498455	chrX_9773655_-	SINE	Alu	AluJb
CAediting_1498456	chrX_9773701_-	SINE	Alu	AluJb
CAediting_1498457	chrX_9773752_-	SINE	Alu	AluJb
CAediting_1498458	chrX_9773756_-	SINE	Alu	AluJb
CAediting_1498459	chrX_9773764_-	SINE	Alu	AluJb
CAediting_1498460	chrX_9774980_-	SINE	Alu	AluJr
CAediting_1498461	chrX_9775061_-	SINE	Alu	AluJr
CAediting_1498462	chrX_9775113_-	SINE	Alu	AluJr
CAediting_1498463	chrX_9776524_-	SINE	Alu	AluJr
CAediting_1498464	chrX_9776608_-	SINE	Alu	AluJr
CAediting_1498465	chrX_9776661_-	SINE	Alu	AluJr
CAediting_1498466	chrX_9776668_-	SINE	Alu	AluJr
CAediting_1498467	chrX_9776678_-	SINE	Alu	AluJr
CAediting_1498468	chrX_9777090_-	DNA	hAT-Charlie	MER58A
CAediting_1498469	chrX_9777098_-	DNA	hAT-Charlie	MER58A
CAediting_1498472	chrX_9777355_-	SINE	Alu	AluJr
CAediting_1498473	chrX_9777566_-	DNA	hAT-Charlie	MER58A
CAediting_1498474	chrX_9778625_-	SINE	Alu	AluJb
CAediting_1498475	chrX_9778631_-	SINE	Alu	AluJb
CAediting_1498476	chrX_9778633_-	SINE	Alu	AluJb
CAediting_1498477	chrX_9781289_-	SINE	Alu	AluJr
CAediting_1498478	chrX_9781299_-	SINE	Alu	AluJr
CAediting_1498479	chrX_9781301_-	SINE	Alu	AluJr
CAediting_1498480	chrX_9781359_-	SINE	Alu	AluJr
CAediting_1498481	chrX_9782110_-	SINE	Alu	AluJo

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RNA A-to-I editing events in the alternative splicing sites for GPR143

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000101850.11.GPR143.

Correlation between RNA A-to-I editing and PSI for ENSG00000101850.11.GPR143.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GPR143

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for GPR143

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for GPR143

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for GPR143

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for GPR143

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
SKCM	CAediting_1498429	chrX_9752137_-	0.0202256362283789	0.309623668527055	.	.	.	.

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Relation with cancer stages for GPR143

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for GPR143

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
SKCM	CAediting_1498413	chrX_9749566_-	0.0325608582230427	0.0457247	0.0473363

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RelatedDrugs for GPR143

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for GPR143

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
GPR143	C0342684	Ocular albinism, type I	14	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
GPR143	C3151752	NYSTAGMUS 6, CONGENITAL, X-LINKED	3	CTD_human;GENOMICS_ENGLAND;UNIPROT
GPR143	C0015397	Disorder of eye	1	GENOMICS_ENGLAND
GPR143	C0028738	Nystagmus	1	GENOMICS_ENGLAND
GPR143	C1963184	Nystagmus, CTCAE 3.0	1	GENOMICS_ENGLAND
GPR143	C4554036	Nystagmus, CTCAE 5.0	1	GENOMICS_ENGLAND

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene