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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: NPC1 (CAeditome ID:4864)

Gene summary for NPC1

check button Gene summary
Gene informationGene symbol

NPC1

Gene ID

4864

Gene nameNPC intracellular cholesterol transporter 1
SynonymsNPC|POGZ|SLC65A1
Cytomap

18q11.2

Type of geneprotein-coding
DescriptionNPC intracellular cholesterol transporter 1Niemann-Pick C1 proteintruncated Niemann-Pick C1
Modification date20210518
UniProtAcc

O15118

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
NPC1

GO:0015485

NPC intracellular cholesterol transporter 1

18772377

NPC1

GO:0006486

NPC intracellular cholesterol transporter 1

10821832

NPC1

GO:0030301

NPC intracellular cholesterol transporter 1

18772377

NPC1

GO:0033344

NPC intracellular cholesterol transporter 1

16141411

NPC1

GO:0042632

NPC intracellular cholesterol transporter 1

12719428

NPC1

GO:0090150

NPC intracellular cholesterol transporter 1

23360953

NPC1

GO:0005635

NPC intracellular cholesterol transporter 1

12554680

NPC1

GO:0005783

NPC intracellular cholesterol transporter 1

12554680

NPC1

GO:0005887

NPC intracellular cholesterol transporter 1

10821832

NPC1

GO:0048471

NPC intracellular cholesterol transporter 1

12554680

NPC1

GO:1905103

NPC intracellular cholesterol transporter 1

28784760

NPC1

GO:1905103

NPC intracellular cholesterol transporter 1

9927649


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RNA A-to-I events for NPC1

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000141458.11

check button RNA A-to-I editing events in Cancer.
CAediting_1258228(23532340, -), CAediting_1258229(23532362, -), CAediting_1258230(23532399, -), CAediting_1258231(23532422, -), CAediting_1258232(23532475, -), CAediting_1258233(23532546, -), CAediting_1258234(23532577, -), CAediting_1258235(23532593, -), CAediting_1258236(23532635, -), CAediting_1258237(23532654, -), CAediting_1258238(23532668, -), CAediting_1258239(23532678, -), CAediting_1258240(23533669, -), CAediting_1258241(23533757, -), CAediting_1258242(23545644, -), CAediting_1258243(23545657, -), CAediting_1258244(23545684, -), CAediting_1258245(23545689, -), CAediting_1258246(23545690, -), CAediting_1258247(23545708, -), CAediting_1258248(23545715, -), CAediting_1258249(23545716, -), CAediting_1258250(23545720, -), CAediting_1258251(23545730, -), CAediting_1258252(23545769, -), CAediting_1258253(23545775, -), CAediting_1258254(23545821, -), CAediting_1258255(23545841, -), CAediting_1258256(23547026, -), CAediting_1258257(23547050, -), CAediting_1258258(23547085, -), CAediting_1258259(23547091, -), CAediting_1258260(23547099, -), CAediting_1258261(23547530, -), CAediting_1258262(23547572, -), CAediting_1258263(23547625, -), CAediting_1258264(23547647, -), CAediting_1258265(23547659, -), CAediting_1258266(23547660, -), CAediting_1258267(23547666, -), CAediting_1258268(23547673, -), CAediting_1258269(23547690, -), CAediting_1258270(23548874, -), CAediting_1258271(23548906, -), CAediting_1258272(23548928, -), CAediting_1258273(23548934, -), CAediting_1258274(23548954, -), CAediting_1258275(23548958, -), CAediting_1258276(23548963, -), CAediting_1258277(23548984, -), CAediting_1258278(23548985, -), CAediting_1258279(23549013, -), CAediting_1258280(23549035, -), CAediting_1258281(23549268, -), CAediting_1258282(23549270, -), CAediting_1258283(23549308, -), CAediting_1258284(23549466, -), CAediting_1258285(23549475, -), CAediting_1258286(23549490, -), CAediting_1258287(23549491, -), CAediting_1258288(23549515, -), CAediting_1258289(23549517, -), CAediting_1258290(23549527, -), CAediting_1258291(23549538, -), CAediting_1258292(23549553, -), CAediting_1258293(23549563, -), CAediting_1258294(23549582, -), CAediting_1258295(23549631, -), CAediting_1258296(23549633, -), CAediting_1258297(23549635, -), CAediting_1258298(23549809, -), CAediting_1258299(23549810, -), CAediting_1258300(23549831, -), CAediting_1258301(23549880, -), CAediting_1258302(23549906, -), CAediting_1258303(23549938, -), CAediting_1258304(23550085, -), CAediting_1258305(23550104, -), CAediting_1258306(23550150, -), CAediting_1258307(23550185, -), CAediting_1258308(23550243, -), CAediting_1258309(23550544, -), CAediting_1258310(23550550, -), CAediting_1258311(23550567, -), CAediting_1258312(23550579, -), CAediting_1258313(23550614, -), CAediting_1258314(23550630, -), CAediting_1258315(23550646, -), CAediting_1258316(23550687, -), CAediting_1258317(23550691, -), CAediting_1258318(23550720, -), CAediting_1258319(23550758, -), CAediting_1258320(23550781, -), CAediting_1258321(23554490, -), CAediting_1258322(23554529, -), CAediting_1258323(23554530, -), CAediting_1258324(23557656, -), CAediting_1258325(23557659, -), CAediting_1258326(23559587, -), CAediting_1258327(23559596, -), CAediting_1258328(23559601, -), CAediting_1258329(23559604, -), CAediting_1258330(23559609, -), CAediting_1258331(23559610, -), CAediting_1258332(23559618, -), CAediting_1258333(23559626, -), CAediting_1258334(23559632, -), CAediting_1258335(23559733, -), CAediting_1258336(23559945, -), CAediting_1258337(23562165, -), CAediting_1258338(23562167, -), CAediting_1258339(23562177, -), CAediting_1258340(23563483, -), CAediting_1258341(23563536, -), CAediting_1258342(23563618, -), CAediting_1258343(23563688, -), CAediting_1258344(23564045, -), CAediting_1258345(23564047, -), CAediting_1258346(23564073, -), CAediting_1258347(23564109, -), CAediting_1258348(23564113, -), CAediting_1258349(23564117, -), CAediting_1258350(23564122, -), CAediting_1258351(23564123, -), CAediting_1258352(23564158, -), CAediting_1258353(23564187, -), CAediting_1258354(23564188, -), CAediting_1258355(23564197, -), CAediting_1258356(23564211, -), CAediting_1258357(23564256, -), CAediting_1258358(23564484, -), CAediting_1258359(23564488, -), CAediting_1258360(23564522, -), CAediting_1258361(23564569, -), CAediting_1258362(23565494, -), CAediting_1258363(23565582, -), CAediting_1258364(23566147, -), CAediting_1258365(23566377, -), CAediting_1258366(23569594, -), CAediting_1258367(23571296, -),

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RNA editing positional annotations for NPC1 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1258228chr18_23532340_-ncRNA_intronic
CAediting_1258229chr18_23532362_-ncRNA_intronic
CAediting_1258230chr18_23532399_-ncRNA_intronic
CAediting_1258231chr18_23532422_-ncRNA_intronic
CAediting_1258232chr18_23532475_-ncRNA_intronic
CAediting_1258233chr18_23532546_-ncRNA_intronic
CAediting_1258234chr18_23532577_-ncRNA_intronic
CAediting_1258235chr18_23532593_-ncRNA_intronic
CAediting_1258236chr18_23532635_-ncRNA_intronic
CAediting_1258237chr18_23532654_-ncRNA_intronic
CAediting_1258238chr18_23532668_-ncRNA_intronic
CAediting_1258239chr18_23532678_-ncRNA_intronic
CAediting_1258240chr18_23533669_-ncRNA_exonic
CAediting_1258241chr18_23533757_-ncRNA_exonic
CAediting_1258242chr18_23545644_-ncRNA_intronic
CAediting_1258243chr18_23545657_-ncRNA_intronic
CAediting_1258244chr18_23545684_-ncRNA_intronic
CAediting_1258245chr18_23545689_-ncRNA_intronic
CAediting_1258246chr18_23545690_-ncRNA_intronic
CAediting_1258247chr18_23545708_-ncRNA_intronic
CAediting_1258248chr18_23545715_-ncRNA_intronic
CAediting_1258249chr18_23545716_-ncRNA_intronic
CAediting_1258250chr18_23545720_-ncRNA_intronic
CAediting_1258251chr18_23545730_-ncRNA_intronic
CAediting_1258252chr18_23545769_-ncRNA_intronic
CAediting_1258253chr18_23545775_-ncRNA_intronic
CAediting_1258254chr18_23545821_-ncRNA_intronic
CAediting_1258255chr18_23545841_-ncRNA_intronic
CAediting_1258256chr18_23547026_-ncRNA_intronic
CAediting_1258257chr18_23547050_-ncRNA_intronic
CAediting_1258258chr18_23547085_-ncRNA_intronic
CAediting_1258259chr18_23547091_-ncRNA_intronic
CAediting_1258260chr18_23547099_-ncRNA_intronic
CAediting_1258261chr18_23547530_-ncRNA_intronic
CAediting_1258262chr18_23547572_-ncRNA_intronic
CAediting_1258263chr18_23547625_-ncRNA_intronic
CAediting_1258264chr18_23547647_-ncRNA_intronic
CAediting_1258265chr18_23547659_-ncRNA_intronic
CAediting_1258266chr18_23547660_-ncRNA_intronic
CAediting_1258267chr18_23547666_-ncRNA_intronic
CAediting_1258268chr18_23547673_-ncRNA_intronic
CAediting_1258269chr18_23547690_-ncRNA_intronic
CAediting_1258270chr18_23548874_-ncRNA_intronic
CAediting_1258271chr18_23548906_-ncRNA_intronic
CAediting_1258272chr18_23548928_-ncRNA_intronic
CAediting_1258273chr18_23548934_-ncRNA_intronic
CAediting_1258274chr18_23548954_-ncRNA_intronic
CAediting_1258275chr18_23548958_-ncRNA_intronic
CAediting_1258276chr18_23548963_-ncRNA_intronic
CAediting_1258277chr18_23548984_-ncRNA_intronic
CAediting_1258278chr18_23548985_-ncRNA_intronic
CAediting_1258279chr18_23549013_-ncRNA_intronic
CAediting_1258280chr18_23549035_-ncRNA_intronic
CAediting_1258281chr18_23549268_-ncRNA_intronic
CAediting_1258282chr18_23549270_-ncRNA_intronic
CAediting_1258283chr18_23549308_-ncRNA_intronic
CAediting_1258284chr18_23549466_-ncRNA_intronic
CAediting_1258285chr18_23549475_-ncRNA_intronic
CAediting_1258286chr18_23549490_-ncRNA_intronic
CAediting_1258287chr18_23549491_-ncRNA_intronic
CAediting_1258288chr18_23549515_-ncRNA_intronic
CAediting_1258289chr18_23549517_-ncRNA_intronic
CAediting_1258290chr18_23549527_-ncRNA_intronic
CAediting_1258291chr18_23549538_-ncRNA_intronic
CAediting_1258292chr18_23549553_-ncRNA_intronic
CAediting_1258293chr18_23549563_-ncRNA_intronic
CAediting_1258294chr18_23549582_-ncRNA_intronic
CAediting_1258295chr18_23549631_-ncRNA_intronic
CAediting_1258296chr18_23549633_-ncRNA_intronic
CAediting_1258297chr18_23549635_-ncRNA_intronic
CAediting_1258298chr18_23549809_-ncRNA_intronic
CAediting_1258299chr18_23549810_-ncRNA_intronic
CAediting_1258300chr18_23549831_-ncRNA_intronic
CAediting_1258301chr18_23549880_-ncRNA_intronic
CAediting_1258302chr18_23549906_-ncRNA_intronic
CAediting_1258303chr18_23549938_-ncRNA_intronic
CAediting_1258304chr18_23550085_-ncRNA_intronic
CAediting_1258305chr18_23550104_-ncRNA_intronic
CAediting_1258306chr18_23550150_-ncRNA_intronic
CAediting_1258307chr18_23550185_-ncRNA_intronic
CAediting_1258308chr18_23550243_-ncRNA_intronic
CAediting_1258309chr18_23550544_-ncRNA_intronic
CAediting_1258310chr18_23550550_-ncRNA_intronic
CAediting_1258311chr18_23550567_-ncRNA_intronic
CAediting_1258312chr18_23550579_-ncRNA_intronic
CAediting_1258313chr18_23550614_-ncRNA_intronic
CAediting_1258314chr18_23550630_-ncRNA_intronic
CAediting_1258315chr18_23550646_-ncRNA_intronic
CAediting_1258316chr18_23550687_-ncRNA_intronic
CAediting_1258317chr18_23550691_-ncRNA_intronic
CAediting_1258318chr18_23550720_-ncRNA_intronic
CAediting_1258319chr18_23550758_-ncRNA_intronic
CAediting_1258320chr18_23550781_-ncRNA_intronic
CAediting_1258321chr18_23554490_-ncRNA_intronic
CAediting_1258322chr18_23554529_-ncRNA_intronic
CAediting_1258323chr18_23554530_-ncRNA_intronic
CAediting_1258324chr18_23557656_-ncRNA_intronic
CAediting_1258325chr18_23557659_-ncRNA_intronic
CAediting_1258326chr18_23559587_-ncRNA_intronic
CAediting_1258327chr18_23559596_-ncRNA_intronic
CAediting_1258328chr18_23559601_-ncRNA_intronic
CAediting_1258329chr18_23559604_-ncRNA_intronic
CAediting_1258330chr18_23559609_-ncRNA_intronic
CAediting_1258331chr18_23559610_-ncRNA_intronic
CAediting_1258332chr18_23559618_-ncRNA_intronic
CAediting_1258333chr18_23559626_-ncRNA_intronic
CAediting_1258334chr18_23559632_-ncRNA_intronic
CAediting_1258335chr18_23559733_-ncRNA_intronic
CAediting_1258336chr18_23559945_-ncRNA_intronic
CAediting_1258337chr18_23562165_-ncRNA_intronic
CAediting_1258338chr18_23562167_-ncRNA_intronic
CAediting_1258339chr18_23562177_-ncRNA_intronic
CAediting_1258340chr18_23563483_-ncRNA_intronic
CAediting_1258341chr18_23563536_-ncRNA_intronic
CAediting_1258342chr18_23563618_-ncRNA_intronic
CAediting_1258343chr18_23563688_-ncRNA_intronic
CAediting_1258344chr18_23564045_-ncRNA_intronic
CAediting_1258345chr18_23564047_-ncRNA_intronic
CAediting_1258346chr18_23564073_-ncRNA_intronic
CAediting_1258347chr18_23564109_-ncRNA_intronic
CAediting_1258348chr18_23564113_-ncRNA_intronic
CAediting_1258349chr18_23564117_-ncRNA_intronic
CAediting_1258350chr18_23564122_-ncRNA_intronic
CAediting_1258351chr18_23564123_-ncRNA_intronic
CAediting_1258352chr18_23564158_-ncRNA_intronic
CAediting_1258353chr18_23564187_-ncRNA_intronic
CAediting_1258354chr18_23564188_-ncRNA_intronic
CAediting_1258355chr18_23564197_-ncRNA_intronic
CAediting_1258356chr18_23564211_-ncRNA_intronic
CAediting_1258357chr18_23564256_-ncRNA_intronic
CAediting_1258358chr18_23564484_-ncRNA_intronic
CAediting_1258359chr18_23564488_-ncRNA_intronic
CAediting_1258360chr18_23564522_-ncRNA_intronic
CAediting_1258361chr18_23564569_-ncRNA_intronic
CAediting_1258362chr18_23565494_-ncRNA_intronic
CAediting_1258363chr18_23565582_-ncRNA_intronic
CAediting_1258364chr18_23566147_-ncRNA_intronic
CAediting_1258365chr18_23566377_-ncRNA_intronic
CAediting_1258366chr18_23569594_-ncRNA_intronic
CAediting_1258367chr18_23571296_-ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1258228chr18_23532340_-SINEAluAluJo
CAediting_1258229chr18_23532362_-SINEAluAluJo
CAediting_1258230chr18_23532399_-SINEAluAluJo
CAediting_1258231chr18_23532422_-SINEAluAluJo
CAediting_1258232chr18_23532475_-SINEAluAluJb
CAediting_1258233chr18_23532546_-SINEAluAluJb
CAediting_1258234chr18_23532577_-SINEAluAluJb
CAediting_1258235chr18_23532593_-SINEAluAluJb
CAediting_1258236chr18_23532635_-SINEAluAluJb
CAediting_1258237chr18_23532654_-SINEAluAluJb
CAediting_1258238chr18_23532668_-SINEAluAluJb
CAediting_1258239chr18_23532678_-SINEAluAluJb
CAediting_1258240chr18_23533669_-SINEAluAluSz
CAediting_1258241chr18_23533757_-SINEAluAluSz
CAediting_1258242chr18_23545644_-SINEAluAluJr
CAediting_1258243chr18_23545657_-SINEAluAluJr
CAediting_1258244chr18_23545684_-SINEAluAluJr
CAediting_1258245chr18_23545689_-SINEAluAluJr
CAediting_1258246chr18_23545690_-SINEAluAluJr
CAediting_1258247chr18_23545708_-SINEAluAluJr
CAediting_1258248chr18_23545715_-SINEAluAluJr
CAediting_1258249chr18_23545716_-SINEAluAluJr
CAediting_1258250chr18_23545720_-SINEAluAluJr
CAediting_1258251chr18_23545730_-SINEAluAluJr
CAediting_1258252chr18_23545769_-SINEAluAluJr
CAediting_1258253chr18_23545775_-SINEAluAluJr
CAediting_1258254chr18_23545821_-SINEAluAluJr
CAediting_1258255chr18_23545841_-SINEAluAluJr
CAediting_1258256chr18_23547026_-SINEAluFLAM_C
CAediting_1258257chr18_23547050_-SINEAluFLAM_C
CAediting_1258258chr18_23547085_-SINEAluFLAM_C
CAediting_1258259chr18_23547091_-SINEAluFLAM_C
CAediting_1258260chr18_23547099_-SINEAluFLAM_C
CAediting_1258261chr18_23547530_-SINEAluAluJb
CAediting_1258262chr18_23547572_-SINEAluAluJb
CAediting_1258263chr18_23547625_-SINEAluAluJb
CAediting_1258264chr18_23547647_-SINEAluAluJb
CAediting_1258265chr18_23547659_-SINEAluAluJb
CAediting_1258266chr18_23547660_-SINEAluAluJb
CAediting_1258267chr18_23547666_-SINEAluAluJb
CAediting_1258268chr18_23547673_-SINEAluAluJb
CAediting_1258269chr18_23547690_-SINEAluAluJb
CAediting_1258270chr18_23548874_-SINEAluAluJb
CAediting_1258271chr18_23548906_-SINEAluAluJb
CAediting_1258272chr18_23548928_-SINEAluAluJb
CAediting_1258273chr18_23548934_-SINEAluAluJb
CAediting_1258274chr18_23548954_-SINEAluAluJb
CAediting_1258275chr18_23548958_-SINEAluAluJb
CAediting_1258276chr18_23548963_-SINEAluAluJb
CAediting_1258277chr18_23548984_-SINEAluAluJb
CAediting_1258278chr18_23548985_-SINEAluAluJb
CAediting_1258279chr18_23549013_-SINEAluAluJb
CAediting_1258280chr18_23549035_-SINEAluAluJb
CAediting_1258281chr18_23549268_-SINEAluAluJb
CAediting_1258282chr18_23549270_-SINEAluAluJb
CAediting_1258283chr18_23549308_-SINEAluAluJb
CAediting_1258284chr18_23549466_-SINEAluAluSx
CAediting_1258285chr18_23549475_-SINEAluAluSx
CAediting_1258286chr18_23549490_-SINEAluAluSx
CAediting_1258287chr18_23549491_-SINEAluAluSx
CAediting_1258288chr18_23549515_-SINEAluAluSx
CAediting_1258289chr18_23549517_-SINEAluAluSx
CAediting_1258290chr18_23549527_-SINEAluAluSx
CAediting_1258291chr18_23549538_-SINEAluAluSx
CAediting_1258292chr18_23549553_-SINEAluAluSx
CAediting_1258293chr18_23549563_-SINEAluAluSx
CAediting_1258294chr18_23549582_-SINEAluAluSx
CAediting_1258295chr18_23549631_-SINEAluAluSx
CAediting_1258296chr18_23549633_-SINEAluAluSx
CAediting_1258297chr18_23549635_-SINEAluAluSx
CAediting_1258298chr18_23549809_-SINEAluAluSx3
CAediting_1258299chr18_23549810_-SINEAluAluSx3
CAediting_1258300chr18_23549831_-SINEAluAluSx3
CAediting_1258301chr18_23549880_-SINEAluAluSx3
CAediting_1258302chr18_23549906_-SINEAluAluSx3
CAediting_1258303chr18_23549938_-SINEAluAluSx3
CAediting_1258304chr18_23550085_-SINEAluAluJb
CAediting_1258305chr18_23550104_-SINEAluAluJb
CAediting_1258306chr18_23550150_-SINEAluAluJb
CAediting_1258307chr18_23550185_-SINEAluAluJb
CAediting_1258308chr18_23550243_-SINEAluAluJb
CAediting_1258309chr18_23550544_-SINEAluAluY
CAediting_1258310chr18_23550550_-SINEAluAluY
CAediting_1258311chr18_23550567_-SINEAluAluY
CAediting_1258312chr18_23550579_-SINEAluAluY
CAediting_1258313chr18_23550614_-SINEAluAluY
CAediting_1258314chr18_23550630_-SINEAluAluY
CAediting_1258315chr18_23550646_-SINEAluAluY
CAediting_1258316chr18_23550687_-SINEAluAluY
CAediting_1258317chr18_23550691_-SINEAluAluY
CAediting_1258318chr18_23550720_-SINEAluAluY
CAediting_1258319chr18_23550758_-SINEAluAluY
CAediting_1258320chr18_23550781_-SINEAluAluY
CAediting_1258321chr18_23554490_-SINEAluAluSx
CAediting_1258322chr18_23554529_-SINEAluAluSx
CAediting_1258323chr18_23554530_-SINEAluAluSx
CAediting_1258324chr18_23557656_-SINEAluAluSc5
CAediting_1258325chr18_23557659_-SINEAluAluSc5
CAediting_1258326chr18_23559587_-SINEAluFLAM_C
CAediting_1258327chr18_23559596_-SINEAluFLAM_C
CAediting_1258328chr18_23559601_-SINEAluFLAM_C
CAediting_1258329chr18_23559604_-SINEAluFLAM_C
CAediting_1258330chr18_23559609_-SINEAluFLAM_C
CAediting_1258331chr18_23559610_-SINEAluFLAM_C
CAediting_1258332chr18_23559618_-SINEAluFLAM_C
CAediting_1258333chr18_23559626_-SINEAluFLAM_C
CAediting_1258334chr18_23559632_-SINEAluFLAM_C
CAediting_1258335chr18_23559733_-SINEAluAluSq2
CAediting_1258336chr18_23559945_-SINEAluAluSq2
CAediting_1258337chr18_23562165_-SINEAluAluY
CAediting_1258338chr18_23562167_-SINEAluAluY
CAediting_1258339chr18_23562177_-SINEAluAluY
CAediting_1258340chr18_23563483_-SINEAluAluJb
CAediting_1258341chr18_23563536_-SINEAluAluJb
CAediting_1258342chr18_23563618_-SINEAluAluJb
CAediting_1258343chr18_23563688_-SINEAluAluJb
CAediting_1258344chr18_23564045_-SINEAluAluSx
CAediting_1258345chr18_23564047_-SINEAluAluSx
CAediting_1258346chr18_23564073_-SINEAluAluSx
CAediting_1258347chr18_23564109_-SINEAluAluSx
CAediting_1258348chr18_23564113_-SINEAluAluSx
CAediting_1258349chr18_23564117_-SINEAluAluSx
CAediting_1258350chr18_23564122_-SINEAluAluSx
CAediting_1258351chr18_23564123_-SINEAluAluSx
CAediting_1258352chr18_23564158_-SINEAluAluSx
CAediting_1258353chr18_23564187_-SINEAluAluSx
CAediting_1258354chr18_23564188_-SINEAluAluSx
CAediting_1258355chr18_23564197_-SINEAluAluSx
CAediting_1258356chr18_23564211_-SINEAluAluSx
CAediting_1258357chr18_23564256_-SINEAluAluSx
CAediting_1258358chr18_23564484_-SINEAluAluJo
CAediting_1258359chr18_23564488_-SINEAluAluJo
CAediting_1258360chr18_23564522_-SINEAluAluJo
CAediting_1258361chr18_23564569_-SINEAluAluJo
CAediting_1258362chr18_23565494_-SINEAluAluSc
CAediting_1258363chr18_23565582_-SINEAluAluSc
CAediting_1258364chr18_23566147_-SINEAluAluJr
CAediting_1258365chr18_23566377_-SINEAluAluJr
CAediting_1258366chr18_23569594_-SINEAluAluJr4
CAediting_1258367chr18_23571296_-SINEAluAluJb

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RNA A-to-I editing events in the alternative splicing sites for NPC1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000141458.11.NPC1.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000141458.11.NPC1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for NPC1

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for NPC1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for NPC1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393chr1_1167164_+ENSG00000141458.11ENST00000593280hsa-miR-200b-3p23529453235294608mer-1a2352945323529478146-18.29
CAediting_1229413chr17_67471544_+ENSG00000141458.11ENST00000591107hsa-miR-548aa23506282235062898mer-1a2350628223506306152-13.72
CAediting_1229414chr17_67471546_+ENSG00000141458.11ENST00000590723hsa-miR-548aa23522539235225457mer-m82352253823522562155-15.28
CAediting_1229414chr17_67471546_+ENSG00000141458.11ENST00000593280hsa-miR-548aa23529610235296178mer-1a2352961023529634169-17.26
CAediting_1368054chr19_46709310_-ENSG00000141458.11ENST00000593280hsa-miR-320e23529434235294407mer-m82352943323529452142-17.9
CAediting_117844chr1_162342605_+ENSG00000141458.11ENST00000593280hsa-miR-556-3p23528914235289218mer-1a2352891423528934141-10.56
CAediting_604450chr7_133034877_-ENSG00000141458.11ENST00000593280hsa-miR-365423529243235292508mer-1a2352924323529262152-17.98

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1229414chr17_67471546_+ENSG00000141458.11ENST00000593280hsa-miR-548aa23529508235295147mer-m82352950723529531140-9.32
CAediting_1229415chr17_67471547_+ENSG00000141458.11ENST00000593280hsa-miR-548aa23529508235295147mer-m82352950723529531140-9.32
CAediting_228905chr2_188297554_+ENSG00000141458.11ENST00000593280hsa-miR-561-3p23528445235284517mer-m82352844423528465153-8.01

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for NPC1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for NPC1

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
STADCAediting_1258331chr18_23559610_-0.0004543869882137180.374178117945406....

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Relation with cancer stages for NPC1

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
ESCApathologic_stageCAediting_1258330chr18_23559609_-0.02566385240844620.295451565775672

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Relation with survival for NPC1

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for NPC1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NPC1

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
NPC1C3179455Niemann-Pick Disease, Type C126CTD_human;GENOMICS_ENGLAND;UNIPROT
NPC1C0220756Niemann-Pick Disease, Type C3CTD_human;GENOMICS_ENGLAND
NPC1C0268247Niemann-Pick Disease, Type D2CTD_human;GENOMICS_ENGLAND
NPC1C0004134Ataxia1CTD_human
NPC1C0004153Atherosclerosis1CTD_human
NPC1C0006309Brucellosis1CTD_human
NPC1C0013362Dysarthria1CTD_human
NPC1C0023890Liver Cirrhosis1CTD_human
NPC1C0023895Liver diseases1CTD_human
NPC1C0028754Obesity1CTD_human
NPC1C0029089Ophthalmoplegia1CTD_human
NPC1C0086565Liver Dysfunction1CTD_human
NPC1C0162292External Ophthalmoplegia1CTD_human
NPC1C0238198Gastrointestinal Stromal Tumors1CTD_human
NPC1C0239946Fibrosis, Liver1CTD_human
NPC1C0240952Dysarthria, Scanning1CTD_human
NPC1C0240991Ataxia, Sensory1CTD_human
NPC1C0278161Ataxia, Motor1CTD_human
NPC1C0339693Internal Ophthalmoplegia1CTD_human
NPC1C0427190Ataxia, Truncal1CTD_human
NPC1C0454596Dysarthria, Spastic1CTD_human
NPC1C0454597Dysarthria, Flaccid1CTD_human
NPC1C0454598Dysarthria, Mixed1CTD_human
NPC1C0520966Abnormal coordination1CTD_human
NPC1C0750937Ataxia, Appendicular1CTD_human
NPC1C0750940Tremor, Rubral1CTD_human
NPC1C0751401Ophthalmoparesis1CTD_human
NPC1C1563666Dysarthria, Guttural1CTD_human
NPC1C1563937Atherogenesis1CTD_human
NPC1C2231324Brucellosis, Pulmonary1CTD_human
NPC1C3179349Gastrointestinal Stromal Sarcoma1CTD_human