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Editing gene: NOVA1 (CAeditome ID:4857)

Gene summary for NOVA1

Gene summary

Gene information	Gene symbol	NOVA1
	Gene ID	4857
	Gene name	NOVA alternative splicing regulator 1
	Synonyms	Nova-1
	Cytomap	14q12
	Type of gene	protein-coding
	Description	RNA-binding protein Nova-1neuro-oncological ventral antigen 1onconeural ventral antigen 1paraneoplastic Ri antigenventral neuron-specific protein 1
	Modification date	20210518
	UniProtAcc	P51513
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
NOVA1	GO:0005654	RNA-binding protein Nova-1	0000052
NOVA1	GO:0005730	RNA-binding protein Nova-1	0000052
NOVA1	GO:0043231	RNA-binding protein Nova-1	0000052

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RNA A-to-I events for NOVA1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000139910.18

RNA A-to-I editing events in Cancer.

CAediting_979688(26448309, -), CAediting_979689(26448324, -), CAediting_979690(26451488, -), CAediting_979691(26451496, -), CAediting_979692(26451619, -), CAediting_979693(26453300, -), CAediting_979694(26458556, -), CAediting_979695(26458579, -), CAediting_979696(26458585, -), CAediting_979697(26458595, -), CAediting_979698(26458596, -), CAediting_979699(26460117, -), CAediting_979700(26460131, -), CAediting_979701(26460132, -), CAediting_979702(26460139, -), CAediting_979703(26460140, -), CAediting_979704(26461712, -), CAediting_979705(26461864, -), CAediting_979706(26465271, -), CAediting_979707(26469833, -), CAediting_979708(26471040, -), CAediting_979709(26471164, -), CAediting_979710(26489724, -), CAediting_979711(26489727, -), CAediting_979712(26490752, -), CAediting_979713(26529365, -), CAediting_979714(26579126, -), CAediting_979715(26579196, -), CAediting_979716(26579251, -), CAediting_979717(26579336, -),

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RNA editing positional annotations for NOVA1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_979688	chr14_26448309_-	exonic
CAediting_979689	chr14_26448324_-	exonic
CAediting_979690	chr14_26451488_-	intronic
CAediting_979691	chr14_26451496_-	intronic
CAediting_979692	chr14_26451619_-	intronic
CAediting_979693	chr14_26453300_-	intronic
CAediting_979694	chr14_26458556_-	intronic
CAediting_979695	chr14_26458579_-	intronic
CAediting_979696	chr14_26458585_-	intronic
CAediting_979697	chr14_26458595_-	intronic
CAediting_979698	chr14_26458596_-	intronic
CAediting_979699	chr14_26460117_-	intronic
CAediting_979700	chr14_26460131_-	intronic
CAediting_979701	chr14_26460132_-	intronic
CAediting_979702	chr14_26460139_-	intronic
CAediting_979703	chr14_26460140_-	intronic
CAediting_979704	chr14_26461712_-	intronic
CAediting_979705	chr14_26461864_-	intronic
CAediting_979706	chr14_26465271_-	intronic
CAediting_979707	chr14_26469833_-	intronic
CAediting_979708	chr14_26471040_-	intronic
CAediting_979709	chr14_26471164_-	intronic
CAediting_979710	chr14_26489724_-	intronic
CAediting_979711	chr14_26489727_-	intronic
CAediting_979712	chr14_26490752_-	intronic
CAediting_979713	chr14_26529365_-	ncRNA_intronic
CAediting_979714	chr14_26579126_-	ncRNA_intronic
CAediting_979715	chr14_26579196_-	ncRNA_intronic
CAediting_979716	chr14_26579251_-	ncRNA_intronic
CAediting_979717	chr14_26579336_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_979690	chr14_26451488_-	SINE	Alu	AluSx
CAediting_979691	chr14_26451496_-	SINE	Alu	AluSx
CAediting_979692	chr14_26451619_-	SINE	Alu	AluSx
CAediting_979693	chr14_26453300_-	SINE	Alu	FRAM
CAediting_979694	chr14_26458556_-	LINE	L1	L1PA16
CAediting_979695	chr14_26458579_-	LINE	L1	L1PA16
CAediting_979696	chr14_26458585_-	LINE	L1	L1PA16
CAediting_979697	chr14_26458595_-	LINE	L1	L1PA16
CAediting_979698	chr14_26458596_-	LINE	L1	L1PA16
CAediting_979699	chr14_26460117_-	LINE	L1	L1PA17
CAediting_979700	chr14_26460131_-	LINE	L1	L1PA17
CAediting_979701	chr14_26460132_-	LINE	L1	L1PA17
CAediting_979702	chr14_26460139_-	LINE	L1	L1PA17
CAediting_979703	chr14_26460140_-	LINE	L1	L1PA17
CAediting_979704	chr14_26461712_-	SINE	Alu	AluSp
CAediting_979705	chr14_26461864_-	SINE	Alu	AluSp
CAediting_979706	chr14_26465271_-	SINE	Alu	AluSz
CAediting_979707	chr14_26469833_-	SINE	Alu	AluJr
CAediting_979710	chr14_26489724_-	SINE	Alu	AluSx
CAediting_979711	chr14_26489727_-	SINE	Alu	AluSx
CAediting_979712	chr14_26490752_-	SINE	Alu	AluJr
CAediting_979713	chr14_26529365_-	SINE	Alu	AluSx1
CAediting_979714	chr14_26579126_-	SINE	Alu	AluSc
CAediting_979715	chr14_26579196_-	SINE	Alu	AluSc
CAediting_979716	chr14_26579251_-	SINE	Alu	AluSc
CAediting_979717	chr14_26579336_-	SINE	Alu	AluSc

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RNA A-to-I editing events in the alternative splicing sites for NOVA1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000139910.18.NOVA1.

Correlation between RNA A-to-I editing and PSI for ENSG00000139910.18.NOVA1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for NOVA1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

LGG.CAediting_979689.ENSG00000139910.NOVA1.png
Soverview

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Protein coding region RNA A-to-I editings for NOVA1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for NOVA1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_979689	chr14_26448324_-	ENSG00000139910.18	ENST00000483536	hsa-miR-1972	26448319	26448325	7mer-m8	26448318	26448337	142.00	-18.21
CAediting_979689	chr14_26448324_-	ENSG00000139910.18	ENST00000483536	hsa-miR-1972	26448319	26448325	7mer-m8	26448318	26448337	142.00	-18.21
CAediting_979689	chr14_26448324_-	ENSG00000139910.18	ENST00000483536	hsa-miR-4717-5p	26448320	26448326	7mer-m8	26448319	26448340	140.00	-18.31

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000139910.18	ENST00000483536	hsa-miR-200b-3p	26480019	26480025	7mer-m8	26480018	26480039	166	-20.14
CAediting_393	chr1_1167164_+	ENSG00000139910.18	ENST00000483536	hsa-miR-200b-3p	26447676	26447683	8mer-1a	26447676	26447695	146	-14.32
CAediting_688080	chr9_63819626_+	ENSG00000139910.18	ENST00000483536	hsa-miR-4477b	26444934	26444940	7mer-m8	26444933	26444957	146	-12.72
CAediting_393	chr1_1167164_+	ENSG00000139910.18	ENST00000465357	hsa-miR-200b-3p	26447676	26447683	8mer-1a	26447676	26447695	146	-14.32
CAediting_393	chr1_1167164_+	ENSG00000139910.18	ENST00000546546	hsa-miR-200b-3p	26480019	26480025	7mer-m8	26480018	26480039	166	-20.14
CAediting_1054808	chr15_66496985_-	ENSG00000139910.18	ENST00000483536	hsa-miR-4512	26445739	26445745	7mer-1a	26445739	26445759	146	-22.04
CAediting_1229413	chr17_67471544_+	ENSG00000139910.18	ENST00000483536	hsa-miR-548aa	26443712	26443718	7mer-m8	26443711	26443735	140	-9.63
CAediting_1160181	chr17_7017644_-	ENSG00000139910.18	ENST00000483536	hsa-miR-195-3p	26446144	26446150	7mer-m8	26446143	26446164	142	-14.65
CAediting_1160181	chr17_7017644_-	ENSG00000139910.18	ENST00000483536	hsa-miR-195-3p	26444789	26444795	7mer-m8	26444788	26444808	160	-20.78
CAediting_442554	chr5_154685830_+	ENSG00000139910.18	ENST00000483536	hsa-miR-1303	26443990	26443996	7mer-m8	26443989	26444007	147	-16.48
CAediting_442554	chr5_154685830_+	ENSG00000139910.18	ENST00000483536	hsa-miR-1303	26448106	26448113	8mer-1a	26448106	26448129	157	-21.44
CAediting_414656	chr5_72878640_+	ENSG00000139910.18	ENST00000483536	hsa-miR-4804-3p	26448466	26448473	8mer-1a	26448466	26448486	151	-15.64
CAediting_604450	chr7_133034877_-	ENSG00000139910.18	ENST00000483536	hsa-miR-3654	26446360	26446366	7mer-m8	26446359	26446378	152	-21.22
CAediting_1160181	chr17_7017644_-	ENSG00000139910.18	ENST00000465357	hsa-miR-195-3p	26446144	26446150	7mer-m8	26446143	26446164	142	-14.65
CAediting_604450	chr7_133034877_-	ENSG00000139910.18	ENST00000465357	hsa-miR-3654	26446360	26446366	7mer-m8	26446359	26446378	152	-21.22
CAediting_228905	chr2_188297554_+	ENSG00000139910.18	ENST00000574031	hsa-miR-561-3p	26479255	26479261	7mer-m8	26479254	26479275	152	-10.83
CAediting_468389	chr6_31355314_-	ENSG00000139910.18	ENST00000483536	hsa-miR-6891-5p	26446584	26446591	8mer-1a	26446584	26446602	153	-25.02
CAediting_468389	chr6_31355314_-	ENSG00000139910.18	ENST00000465357	hsa-miR-6891-5p	26446584	26446591	8mer-1a	26446584	26446602	153	-25.02

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_442554	chr5_154685830_+	ENSG00000139910.18	ENST00000483536	hsa-miR-1303	26446109	26446116	8mer-1a	26446109	26446129	150	-20.01
CAediting_442554	chr5_154685830_+	ENSG00000139910.18	ENST00000483536	hsa-miR-1303	26443118	26443124	7mer-m8	26443117	26443138	140	-8.46
CAediting_1160181	chr17_7017644_-	ENSG00000139910.18	ENST00000483536	hsa-miR-195-3p	26443687	26443693	7mer-m8	26443686	26443708	151	-7.96
CAediting_1160181	chr17_7017644_-	ENSG00000139910.18	ENST00000483536	hsa-miR-195-3p	26443501	26443508	8mer-1a	26443501	26443522	140	-4.28
CAediting_1160181	chr17_7017644_-	ENSG00000139910.18	ENST00000483536	hsa-miR-195-3p	26443378	26443384	7mer-m8	26443377	26443398	144	-6.85
CAediting_393	chr1_1167164_+	ENSG00000139910.18	ENST00000483536	hsa-miR-200b-3p	26447622	26447629	8mer-1a	26447622	26447645	142	-12.17
CAediting_1306324	chr19_13836464_-	ENSG00000139910.18	ENST00000483536	hsa-miR-27a-3p	26446958	26446965	8mer-1a	26446958	26446981	153	-18.45
CAediting_1306323	chr19_13836462_-	ENSG00000139910.18	ENST00000483536	hsa-miR-27a-3p	26446958	26446965	8mer-1a	26446958	26446981	153	-18.45
CAediting_1306324	chr19_13836464_-	ENSG00000139910.18	ENST00000483536	hsa-miR-27a-3p	26446343	26446349	7mer-m8	26446342	26446362	140	-12.42
CAediting_1306323	chr19_13836462_-	ENSG00000139910.18	ENST00000483536	hsa-miR-27a-3p	26446343	26446349	7mer-m8	26446342	26446362	140	-12.42
CAediting_604450	chr7_133034877_-	ENSG00000139910.18	ENST00000483536	hsa-miR-3654	26448698	26448704	7mer-m8	26448697	26448715	140	-13.47
CAediting_1054808	chr15_66496985_-	ENSG00000139910.18	ENST00000483536	hsa-miR-4512	26444162	26444169	8mer-1a	26444162	26444184	146	-16.54
CAediting_117844	chr1_162342605_+	ENSG00000139910.18	ENST00000483536	hsa-miR-556-3p	26444131	26444137	7mer-m8	26444130	26444151	152	-12.23
CAediting_228905	chr2_188297554_+	ENSG00000139910.18	ENST00000483536	hsa-miR-561-3p	26444490	26444496	7mer-m8	26444489	26444510	140	-6.72
CAediting_748296	chr10_51299626_+	ENSG00000139910.18	ENST00000483536	hsa-miR-605-3p	26444761	26444767	7mer-m8	26444760	26444786	145	-14.11
CAediting_1351755	chr19_40282625_-	ENSG00000139910.18	ENST00000483536	hsa-miR-641	26443660	26443666	7mer-m8	26443659	26443687	148	-15.62
CAediting_468389	chr6_31355314_-	ENSG00000139910.18	ENST00000483536	hsa-miR-6891-5p	26447920	26447926	7mer-m8	26447919	26447936	151	-20.76
CAediting_393	chr1_1167164_+	ENSG00000139910.18	ENST00000465357	hsa-miR-200b-3p	26447622	26447629	8mer-1a	26447622	26447645	142	-12.17
CAediting_468389	chr6_31355314_-	ENSG00000139910.18	ENST00000465357	hsa-miR-6891-5p	26447920	26447926	7mer-m8	26447919	26447936	151	-20.76
CAediting_228905	chr2_188297554_+	ENSG00000139910.18	ENST00000574031	hsa-miR-561-3p	26479885	26479891	7mer-m8	26479884	26479909	147	-5.87

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for NOVA1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for NOVA1

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
LGG	CAediting_979689	chr14_26448324_-	.	.	3.77017913054783e-09	0.673281266725468	.	.
LGG	CAediting_979708	chr14_26471040_-	3.35139703899015e-08	0.396265421123262	.	.	.	.
GBM	CAediting_979708	chr14_26471040_-	0.0355463590042081	0.246474416389601	.	.	.	.

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Relation with cancer stages for NOVA1

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for NOVA1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for NOVA1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for NOVA1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene