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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: NOTCH4 (CAeditome ID:4855) |
Gene summary for NOTCH4 |
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Gene information | Gene symbol | NOTCH4 | Gene ID | 4855 |
Gene name | notch receptor 4 | |
Synonyms | INT3 | |
Cytomap | 6p21.32 | |
Type of gene | protein-coding | |
Description | neurogenic locus notch homolog protein 4Notch homolog 4notch 4 | |
Modification date | 20210518 | |
UniProtAcc | Q99466 | |
Context |
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Gene | GO ID | GO term | PubMed ID |
NOTCH4 | GO:0030879 | Neurogenic locus notch homolog protein 4 | 9576833 |
NOTCH4 | GO:0009986 | Neurogenic locus notch homolog protein 4 | 11823422 |
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RNA A-to-I events for NOTCH4 |
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CAediting_469338(32199332, -), CAediting_469339(32199432, -), CAediting_469340(32199698, -), CAediting_469341(32199794, -), CAediting_469342(32199829, -), CAediting_469343(32199845, -), CAediting_469344(32200481, -), CAediting_469345(32200484, -), CAediting_469346(32200498, -), CAediting_469347(32206941, -), CAediting_469348(32206961, -), CAediting_469349(32206967, -), CAediting_469350(32206998, -), CAediting_469351(32207006, -), CAediting_469352(32207022, -), CAediting_469353(32207026, -), CAediting_469354(32207054, -), CAediting_469355(32207058, -), CAediting_469356(32207163, -), CAediting_469357(32207201, -), CAediting_469358(32207202, -), CAediting_469359(32207367, -), CAediting_469360(32207379, -), CAediting_469361(32207439, -), CAediting_469362(32207441, -), CAediting_469363(32207444, -), CAediting_469364(32207461, -), CAediting_469365(32207494, -), CAediting_469366(32207502, -), CAediting_469367(32207512, -), CAediting_469368(32207524, -), CAediting_469369(32207548, -), CAediting_469370(32207572, -), CAediting_469371(32207586, -), CAediting_469372(32207626, -), CAediting_469373(32207799, -), CAediting_469374(32207810, -), CAediting_469375(32207819, -), CAediting_469376(32207839, -), CAediting_469377(32207855, -), CAediting_469378(32207881, -), CAediting_469379(32207892, -), CAediting_469380(32207894, -), CAediting_469381(32207896, -), CAediting_469382(32207917, -), CAediting_469383(32207921, -), CAediting_469384(32207922, -), CAediting_469385(32207941, -), CAediting_469386(32207956, -), CAediting_469387(32207999, -), CAediting_469388(32209239, -), CAediting_469389(32210508, -), CAediting_469390(32210512, -), CAediting_469391(32210514, -), CAediting_469392(32210539, -), |
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RNA editing positional annotations for NOTCH4 using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
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CAeditome ID | Position | Variant type |
CAediting_469338 | chr6_32199332_- | ncRNA_intronic |
CAediting_469339 | chr6_32199432_- | ncRNA_intronic |
CAediting_469340 | chr6_32199698_- | ncRNA_intronic |
CAediting_469341 | chr6_32199794_- | ncRNA_intronic |
CAediting_469342 | chr6_32199829_- | ncRNA_intronic |
CAediting_469343 | chr6_32199845_- | ncRNA_intronic |
CAediting_469344 | chr6_32200481_- | ncRNA_intronic |
CAediting_469345 | chr6_32200484_- | ncRNA_intronic |
CAediting_469346 | chr6_32200498_- | ncRNA_intronic |
CAediting_469347 | chr6_32206941_- | intronic |
CAediting_469348 | chr6_32206961_- | intronic |
CAediting_469349 | chr6_32206967_- | intronic |
CAediting_469350 | chr6_32206998_- | intronic |
CAediting_469351 | chr6_32207006_- | intronic |
CAediting_469352 | chr6_32207022_- | intronic |
CAediting_469353 | chr6_32207026_- | intronic |
CAediting_469354 | chr6_32207054_- | intronic |
CAediting_469355 | chr6_32207058_- | intronic |
CAediting_469356 | chr6_32207163_- | intronic |
CAediting_469357 | chr6_32207201_- | intronic |
CAediting_469358 | chr6_32207202_- | intronic |
CAediting_469359 | chr6_32207367_- | intronic |
CAediting_469360 | chr6_32207379_- | intronic |
CAediting_469361 | chr6_32207439_- | intronic |
CAediting_469362 | chr6_32207441_- | intronic |
CAediting_469363 | chr6_32207444_- | intronic |
CAediting_469364 | chr6_32207461_- | intronic |
CAediting_469365 | chr6_32207494_- | intronic |
CAediting_469366 | chr6_32207502_- | intronic |
CAediting_469367 | chr6_32207512_- | intronic |
CAediting_469368 | chr6_32207524_- | intronic |
CAediting_469369 | chr6_32207548_- | intronic |
CAediting_469370 | chr6_32207572_- | intronic |
CAediting_469371 | chr6_32207586_- | intronic |
CAediting_469372 | chr6_32207626_- | intronic |
CAediting_469373 | chr6_32207799_- | intronic |
CAediting_469374 | chr6_32207810_- | intronic |
CAediting_469375 | chr6_32207819_- | intronic |
CAediting_469376 | chr6_32207839_- | intronic |
CAediting_469377 | chr6_32207855_- | intronic |
CAediting_469378 | chr6_32207881_- | intronic |
CAediting_469379 | chr6_32207892_- | intronic |
CAediting_469380 | chr6_32207894_- | intronic |
CAediting_469381 | chr6_32207896_- | intronic |
CAediting_469382 | chr6_32207917_- | intronic |
CAediting_469383 | chr6_32207921_- | intronic |
CAediting_469384 | chr6_32207922_- | intronic |
CAediting_469385 | chr6_32207941_- | intronic |
CAediting_469386 | chr6_32207956_- | intronic |
CAediting_469387 | chr6_32207999_- | intronic |
CAediting_469388 | chr6_32209239_- | intronic |
CAediting_469389 | chr6_32210508_- | intronic |
CAediting_469390 | chr6_32210512_- | intronic |
CAediting_469391 | chr6_32210514_- | intronic |
CAediting_469392 | chr6_32210539_- | intronic |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
CAediting_469338 | chr6_32199332_- | SINE | Alu | AluSz6 |
CAediting_469339 | chr6_32199432_- | SINE | Alu | AluY |
CAediting_469340 | chr6_32199698_- | SINE | Alu | AluY |
CAediting_469341 | chr6_32199794_- | SINE | Alu | AluSz6 |
CAediting_469342 | chr6_32199829_- | SINE | Alu | AluSz6 |
CAediting_469343 | chr6_32199845_- | SINE | Alu | AluSz6 |
CAediting_469344 | chr6_32200481_- | SINE | Alu | AluY |
CAediting_469345 | chr6_32200484_- | SINE | Alu | AluY |
CAediting_469346 | chr6_32200498_- | SINE | Alu | AluY |
CAediting_469347 | chr6_32206941_- | SINE | Alu | AluSg |
CAediting_469348 | chr6_32206961_- | SINE | Alu | AluSg |
CAediting_469349 | chr6_32206967_- | SINE | Alu | AluSg |
CAediting_469350 | chr6_32206998_- | SINE | Alu | AluSg |
CAediting_469351 | chr6_32207006_- | SINE | Alu | AluSg |
CAediting_469352 | chr6_32207022_- | SINE | Alu | AluSg |
CAediting_469353 | chr6_32207026_- | SINE | Alu | AluSg |
CAediting_469354 | chr6_32207054_- | SINE | Alu | AluSg |
CAediting_469355 | chr6_32207058_- | SINE | Alu | AluSg |
CAediting_469356 | chr6_32207163_- | SINE | Alu | AluSg |
CAediting_469357 | chr6_32207201_- | SINE | Alu | AluSg |
CAediting_469358 | chr6_32207202_- | SINE | Alu | AluSg |
CAediting_469359 | chr6_32207367_- | SINE | Alu | AluSx |
CAediting_469360 | chr6_32207379_- | SINE | Alu | AluSx |
CAediting_469361 | chr6_32207439_- | SINE | Alu | AluSx |
CAediting_469362 | chr6_32207441_- | SINE | Alu | AluSx |
CAediting_469363 | chr6_32207444_- | SINE | Alu | AluSx |
CAediting_469364 | chr6_32207461_- | SINE | Alu | AluSx |
CAediting_469365 | chr6_32207494_- | SINE | Alu | AluSx |
CAediting_469366 | chr6_32207502_- | SINE | Alu | AluSx |
CAediting_469367 | chr6_32207512_- | SINE | Alu | AluSx |
CAediting_469368 | chr6_32207524_- | SINE | Alu | AluSx |
CAediting_469369 | chr6_32207548_- | SINE | Alu | AluSx |
CAediting_469370 | chr6_32207572_- | SINE | Alu | AluSx |
CAediting_469371 | chr6_32207586_- | SINE | Alu | AluSx |
CAediting_469372 | chr6_32207626_- | SINE | Alu | AluSx |
CAediting_469373 | chr6_32207799_- | SINE | Alu | AluSx3 |
CAediting_469374 | chr6_32207810_- | SINE | Alu | AluSx3 |
CAediting_469375 | chr6_32207819_- | SINE | Alu | AluSx3 |
CAediting_469376 | chr6_32207839_- | SINE | Alu | AluSx3 |
CAediting_469377 | chr6_32207855_- | SINE | Alu | AluSx3 |
CAediting_469378 | chr6_32207881_- | SINE | Alu | AluSx3 |
CAediting_469379 | chr6_32207892_- | SINE | Alu | AluSx3 |
CAediting_469380 | chr6_32207894_- | SINE | Alu | AluSx3 |
CAediting_469381 | chr6_32207896_- | SINE | Alu | AluSx3 |
CAediting_469382 | chr6_32207917_- | SINE | Alu | AluSx3 |
CAediting_469383 | chr6_32207921_- | SINE | Alu | AluSx3 |
CAediting_469384 | chr6_32207922_- | SINE | Alu | AluSx3 |
CAediting_469385 | chr6_32207941_- | SINE | Alu | AluSx3 |
CAediting_469386 | chr6_32207956_- | SINE | Alu | AluSx3 |
CAediting_469387 | chr6_32207999_- | SINE | Alu | AluSx3 |
CAediting_469388 | chr6_32209239_- | LINE | L1 | L1MA3 |
CAediting_469389 | chr6_32210508_- | LINE | L2 | L2c |
CAediting_469390 | chr6_32210512_- | LINE | L2 | L2c |
CAediting_469391 | chr6_32210514_- | LINE | L2 | L2c |
CAediting_469392 | chr6_32210539_- | LINE | L2 | L2c |
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RNA A-to-I editing events in the alternative splicing sites for NOTCH4 |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for NOTCH4 |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for NOTCH4 |
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The effects of the RNA editing to the miRNA binding sites for NOTCH4 |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_1229413 | chr17_67471544_+ | ENSG00000204301.6 | ENST00000375023 | hsa-miR-548aa | 32195100 | 32195106 | 7mer-m8 | 32195099 | 32195123 | 146 | -8.5 |
CAediting_468389 | chr6_31355314_- | ENSG00000204301.6 | ENST00000375023 | hsa-miR-6891-5p | 32195212 | 32195218 | 7mer-m8 | 32195211 | 32195229 | 141 | -25.9 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_1229413 | chr17_67471544_+ | ENSG00000204301.6 | ENST00000375023 | hsa-miR-548aa | 32195362 | 32195369 | 8mer-1a | 32195362 | 32195385 | 148 | -12.03 |
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The effects of the RNA editing to the stability of the RNA structures for NOTCH4 |
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ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for NOTCH4 |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for NOTCH4 |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
KIRC | pathologic_stage | CAediting_469388 | chr6_32209239_- | 1.99739736841655e-05 | 0.489175007703979 |
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Relation with survival for NOTCH4 |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
KIRC | CAediting_469388 | chr6_32209239_- | 0.0387861097989957 | 0.00847322 | 81.2962 |
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RelatedDrugs for NOTCH4 |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NOTCH4 |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
NOTCH4 | C0005586 | Bipolar Disorder | 4 | PSYGENET |
NOTCH4 | C0036341 | Schizophrenia | 4 | PSYGENET |
NOTCH4 | C0006142 | Malignant neoplasm of breast | 2 | CTD_human |
NOTCH4 | C0678222 | Breast Carcinoma | 2 | CTD_human |
NOTCH4 | C1257931 | Mammary Neoplasms, Human | 2 | CTD_human |
NOTCH4 | C1458155 | Mammary Neoplasms | 2 | CTD_human |
NOTCH4 | C4704874 | Mammary Carcinoma, Human | 2 | CTD_human |
NOTCH4 | C0007114 | Malignant neoplasm of skin | 1 | CTD_human |
NOTCH4 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
NOTCH4 | C0037286 | Skin Neoplasms | 1 | CTD_human |
NOTCH4 | C0887833 | Carcinoma, Pancreatic Ductal | 1 | CTD_human |
NOTCH4 | C3544321 | Treatment-resistant schizophrenia | 1 | PSYGENET |