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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: CNOT2 (CAeditome ID:4848)

Gene summary for CNOT2

check button Gene summary
Gene informationGene symbol

CNOT2

Gene ID

4848

Gene nameCCR4-NOT transcription complex subunit 2
SynonymsCDC36|HSPC131|IDNADFS|NOT2|NOT2H
Cytomap

12q15

Type of geneprotein-coding
DescriptionCCR4-NOT transcription complex subunit 2CCR4-associated factor 2negative regulator of transcription 2
Modification date20210518
UniProtAcc

Q9NZN8

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
CNOT2

GO:0001222

CCR4-NOT transcription complex subunit 2

16712523

CNOT2

GO:0000122

CCR4-NOT transcription complex subunit 2

14707134

CNOT2

GO:0000122

CCR4-NOT transcription complex subunit 2

16712523

CNOT2

GO:0005654

CCR4-NOT transcription complex subunit 2

0000052

CNOT2

GO:0005737

CCR4-NOT transcription complex subunit 2

21299754

CNOT2

GO:0005829

CCR4-NOT transcription complex subunit 2

0000052

CNOT2

GO:0005886

CCR4-NOT transcription complex subunit 2

0000052

CNOT2

GO:0030014

CCR4-NOT transcription complex subunit 2

19558367


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RNA A-to-I events for CNOT2

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000111596.10

check button RNA A-to-I editing events in Cancer.
CAediting_909329(70247242, +), CAediting_909330(70247264, +), CAediting_909331(70252207, +), CAediting_909332(70252218, +), CAediting_909333(70252238, +), CAediting_909334(70252290, +), CAediting_909335(70252326, +), CAediting_909336(70252387, +), CAediting_909337(70252439, +), CAediting_909338(70254079, +), CAediting_909339(70254082, +), CAediting_909340(70254087, +), CAediting_909341(70254088, +), CAediting_909342(70254091, +), CAediting_909343(70254117, +), CAediting_909344(70254710, +), CAediting_909345(70254726, +), CAediting_909346(70254727, +), CAediting_909347(70254764, +), CAediting_909348(70254779, +), CAediting_909349(70254780, +), CAediting_909350(70254795, +), CAediting_909351(70254801, +), CAediting_909352(70254804, +), CAediting_909353(70254815, +), CAediting_909354(70254821, +), CAediting_909355(70254822, +), CAediting_909356(70254824, +), CAediting_909357(70254827, +), CAediting_909358(70254828, +), CAediting_909359(70254829, +), CAediting_909360(70254830, +), CAediting_909361(70254831, +), CAediting_909362(70254834, +), CAediting_909363(70254838, +), CAediting_909364(70254860, +), CAediting_909365(70254861, +), CAediting_909366(70254866, +), CAediting_909367(70254892, +), CAediting_909368(70254893, +), CAediting_909369(70254902, +), CAediting_909370(70254936, +), CAediting_909371(70254969, +), CAediting_909372(70257574, +), CAediting_909373(70261394, +), CAediting_909374(70261408, +), CAediting_909375(70283323, +), CAediting_909376(70283339, +), CAediting_909377(70283345, +), CAediting_909378(70283354, +), CAediting_909379(70283374, +), CAediting_909380(70283380, +), CAediting_909381(70283401, +), CAediting_909382(70283447, +), CAediting_909383(70283448, +), CAediting_909384(70284276, +), CAediting_909385(70284284, +), CAediting_909386(70284325, +), CAediting_909387(70284345, +), CAediting_909388(70285423, +), CAediting_909389(70290725, +), CAediting_909390(70290731, +), CAediting_909391(70297876, +), CAediting_909392(70341044, +), CAediting_909393(70344520, +), CAediting_909394(70353202, +), CAediting_909395(70353212, +), CAediting_909396(70353239, +), CAediting_909397(70353247, +), CAediting_909398(70353314, +), CAediting_909399(70353336, +), CAediting_909400(70353337, +),

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RNA editing positional annotations for CNOT2 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_909329chr12_70247242_+ncRNA_intronic
CAediting_909330chr12_70247264_+ncRNA_intronic
CAediting_909331chr12_70252207_+ncRNA_intronic
CAediting_909332chr12_70252218_+ncRNA_intronic
CAediting_909333chr12_70252238_+ncRNA_intronic
CAediting_909334chr12_70252290_+ncRNA_intronic
CAediting_909335chr12_70252326_+ncRNA_intronic
CAediting_909336chr12_70252387_+ncRNA_intronic
CAediting_909337chr12_70252439_+ncRNA_intronic
CAediting_909338chr12_70254079_+ncRNA_intronic
CAediting_909339chr12_70254082_+ncRNA_intronic
CAediting_909340chr12_70254087_+ncRNA_intronic
CAediting_909341chr12_70254088_+ncRNA_intronic
CAediting_909342chr12_70254091_+ncRNA_intronic
CAediting_909343chr12_70254117_+ncRNA_intronic
CAediting_909344chr12_70254710_+ncRNA_intronic
CAediting_909345chr12_70254726_+ncRNA_intronic
CAediting_909346chr12_70254727_+ncRNA_intronic
CAediting_909347chr12_70254764_+ncRNA_intronic
CAediting_909348chr12_70254779_+ncRNA_intronic
CAediting_909349chr12_70254780_+ncRNA_intronic
CAediting_909350chr12_70254795_+ncRNA_intronic
CAediting_909351chr12_70254801_+ncRNA_intronic
CAediting_909352chr12_70254804_+ncRNA_intronic
CAediting_909353chr12_70254815_+ncRNA_intronic
CAediting_909354chr12_70254821_+ncRNA_intronic
CAediting_909355chr12_70254822_+ncRNA_intronic
CAediting_909356chr12_70254824_+ncRNA_intronic
CAediting_909357chr12_70254827_+ncRNA_intronic
CAediting_909358chr12_70254828_+ncRNA_intronic
CAediting_909359chr12_70254829_+ncRNA_intronic
CAediting_909360chr12_70254830_+ncRNA_intronic
CAediting_909361chr12_70254831_+ncRNA_intronic
CAediting_909362chr12_70254834_+ncRNA_intronic
CAediting_909363chr12_70254838_+ncRNA_intronic
CAediting_909364chr12_70254860_+ncRNA_intronic
CAediting_909365chr12_70254861_+ncRNA_intronic
CAediting_909366chr12_70254866_+ncRNA_intronic
CAediting_909367chr12_70254892_+ncRNA_intronic
CAediting_909368chr12_70254893_+ncRNA_intronic
CAediting_909369chr12_70254902_+ncRNA_intronic
CAediting_909370chr12_70254936_+ncRNA_intronic
CAediting_909371chr12_70254969_+ncRNA_intronic
CAediting_909372chr12_70257574_+ncRNA_intronic
CAediting_909373chr12_70261394_+ncRNA_intronic
CAediting_909374chr12_70261408_+ncRNA_intronic
CAediting_909375chr12_70283323_+ncRNA_intronic
CAediting_909376chr12_70283339_+ncRNA_intronic
CAediting_909377chr12_70283345_+ncRNA_intronic
CAediting_909378chr12_70283354_+ncRNA_intronic
CAediting_909379chr12_70283374_+ncRNA_intronic
CAediting_909380chr12_70283380_+ncRNA_intronic
CAediting_909381chr12_70283401_+ncRNA_intronic
CAediting_909382chr12_70283447_+ncRNA_intronic
CAediting_909383chr12_70283448_+ncRNA_intronic
CAediting_909384chr12_70284276_+ncRNA_intronic
CAediting_909385chr12_70284284_+ncRNA_intronic
CAediting_909386chr12_70284325_+ncRNA_intronic
CAediting_909387chr12_70284345_+ncRNA_intronic
CAediting_909388chr12_70285423_+ncRNA_exonic
CAediting_909389chr12_70290725_+splicing
CAediting_909390chr12_70290731_+ncRNA_intronic
CAediting_909391chr12_70297876_+exonic
CAediting_909392chr12_70341044_+ncRNA_intronic
CAediting_909393chr12_70344520_+ncRNA_intronic
CAediting_909394chr12_70353202_+ncRNA_intronic
CAediting_909395chr12_70353212_+ncRNA_intronic
CAediting_909396chr12_70353239_+ncRNA_intronic
CAediting_909397chr12_70353247_+ncRNA_intronic
CAediting_909398chr12_70353314_+ncRNA_intronic
CAediting_909399chr12_70353336_+ncRNA_intronic
CAediting_909400chr12_70353337_+ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_909329chr12_70247242_+SINEAluAluSx
CAediting_909330chr12_70247264_+SINEAluAluSx
CAediting_909331chr12_70252207_+SINEAluAluJb
CAediting_909332chr12_70252218_+SINEAluAluJb
CAediting_909333chr12_70252238_+SINEAluAluJb
CAediting_909334chr12_70252290_+SINEAluAluJb
CAediting_909335chr12_70252326_+SINEAluAluJb
CAediting_909336chr12_70252387_+SINEAluAluJb
CAediting_909337chr12_70252439_+SINEAluAluJb
CAediting_909338chr12_70254079_+SINEAluAluSc8
CAediting_909339chr12_70254082_+SINEAluAluSc8
CAediting_909340chr12_70254087_+SINEAluAluSc8
CAediting_909341chr12_70254088_+SINEAluAluSc8
CAediting_909342chr12_70254091_+SINEAluAluSc8
CAediting_909343chr12_70254117_+SINEAluAluSc8
CAediting_909344chr12_70254710_+SINEAluAluSx3
CAediting_909345chr12_70254726_+SINEAluAluSx3
CAediting_909346chr12_70254727_+SINEAluAluSx3
CAediting_909347chr12_70254764_+SINEAluAluSx3
CAediting_909348chr12_70254779_+SINEAluAluSx3
CAediting_909349chr12_70254780_+SINEAluAluSx3
CAediting_909350chr12_70254795_+SINEAluAluSx3
CAediting_909351chr12_70254801_+SINEAluAluSx3
CAediting_909352chr12_70254804_+SINEAluAluSx3
CAediting_909353chr12_70254815_+SINEAluAluSx3
CAediting_909354chr12_70254821_+SINEAluAluSx3
CAediting_909355chr12_70254822_+SINEAluAluSx3
CAediting_909356chr12_70254824_+SINEAluAluSx3
CAediting_909357chr12_70254827_+SINEAluAluSx3
CAediting_909358chr12_70254828_+SINEAluAluSx3
CAediting_909359chr12_70254829_+SINEAluAluSx3
CAediting_909360chr12_70254830_+SINEAluAluSx3
CAediting_909361chr12_70254831_+SINEAluAluSx3
CAediting_909362chr12_70254834_+SINEAluAluSx3
CAediting_909363chr12_70254838_+SINEAluAluSx3
CAediting_909364chr12_70254860_+SINEAluAluSx3
CAediting_909365chr12_70254861_+SINEAluAluSx3
CAediting_909366chr12_70254866_+SINEAluAluSx3
CAediting_909367chr12_70254892_+SINEAluAluSx3
CAediting_909368chr12_70254893_+SINEAluAluSx3
CAediting_909369chr12_70254902_+SINEAluAluSx3
CAediting_909370chr12_70254936_+SINEAluAluSx3
CAediting_909371chr12_70254969_+SINEAluAluSx3
CAediting_909372chr12_70257574_+SINEAluAluYk3
CAediting_909373chr12_70261394_+SINEAluAluY
CAediting_909374chr12_70261408_+SINEAluAluY
CAediting_909375chr12_70283323_+SINEAluAluJr
CAediting_909376chr12_70283339_+SINEAluAluJr
CAediting_909377chr12_70283345_+SINEAluAluJr
CAediting_909378chr12_70283354_+SINEAluAluJr
CAediting_909379chr12_70283374_+SINEAluAluJr
CAediting_909380chr12_70283380_+SINEAluAluJr
CAediting_909381chr12_70283401_+SINEAluAluJr
CAediting_909382chr12_70283447_+SINEAluAluJr
CAediting_909383chr12_70283448_+SINEAluAluJr
CAediting_909384chr12_70284276_+SINEAluAluSz6
CAediting_909385chr12_70284284_+SINEAluAluSz6
CAediting_909386chr12_70284325_+SINEAluAluSz6
CAediting_909387chr12_70284345_+SINEAluAluSz6
CAediting_909388chr12_70285423_+SINEAluAluY
CAediting_909389chr12_70290725_+SINEAluFLAM_C
CAediting_909390chr12_70290731_+SINEAluFLAM_C
CAediting_909391chr12_70297876_+SINEAluAluSx
CAediting_909392chr12_70341044_+SINEAluAluSz
CAediting_909393chr12_70344520_+SINEAluAluJr4
CAediting_909394chr12_70353202_+SINEAluAluSc
CAediting_909395chr12_70353212_+SINEAluAluSc
CAediting_909396chr12_70353239_+SINEAluAluSc
CAediting_909397chr12_70353247_+SINEAluAluSc
CAediting_909398chr12_70353314_+SINEAluAluSc
CAediting_909399chr12_70353336_+SINEAluAluSc
CAediting_909400chr12_70353337_+SINEAluAluSc

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RNA A-to-I editing events in the alternative splicing sites for CNOT2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESCAediting_909389chr12_70290725_+70290706:702907283SS0+1iTTATTAAAATTTTTTTTATAGAG-9.89TTATTAAAATTTTTTTTATGGAG-1.14
MEX_2CAediting_909389chr12_70290725_+70290706:702907283SS0+1iTTATTAAAATTTTTTTTATAGAG-9.89TTATTAAAATTTTTTTTATGGAG-1.14
MEX_1CAediting_909389chr12_70290725_+70290706:702907283SS0+1iTTATTAAAATTTTTTTTATAGAG-9.89TTATTAAAATTTTTTTTATGGAG-1.14

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000111596.10.CNOT2.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000111596.10.CNOT2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CNOT2

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CNOT2

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for CNOT2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_909393chr12_70344520_+ENSG00000111596.10ENST00000552599hsa-miR-6793-3p70344516703445238mer-1a7034450470344523158.00-24.70

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393chr1_1167164_+ENSG00000111596.10ENST00000548599hsa-miR-200b-3p70335479703354868mer-1a7033546870335486145-13.1
CAediting_393chr1_1167164_+ENSG00000111596.10ENST00000548599hsa-miR-200b-3p70337454703374618mer-1a7033744070337461144-10.14
CAediting_980496chr14_31014685_-ENSG00000111596.10ENST00000552599hsa-miR-624-3p70344716703447227mer-m87034470470344723155-15.7
CAediting_442554chr5_154685830_+ENSG00000111596.10ENST00000552319hsa-miR-130370329559703295657mer-m87032954570329566162-19.91
CAediting_1368054chr19_46709310_-ENSG00000111596.10ENST00000548741hsa-miR-320e70294239702942457mer-m87029422770294246149-20.74
CAediting_1368054chr19_46709310_-ENSG00000111596.10ENST00000548741hsa-miR-320e70301797703018037mer-m87030178770301804140-13.39
CAediting_1368054chr19_46709310_-ENSG00000111596.10ENST00000553020hsa-miR-320e70294239702942457mer-m87029422770294246149-20.74
CAediting_1229415chr17_67471547_+ENSG00000111596.10ENST00000552599hsa-miR-548aa70345251703452577mer-m87034523470345258140-8.2
CAediting_468389chr6_31355314_-ENSG00000111596.10ENST00000552599hsa-miR-6891-5p70345546703455527mer-m87034553670345553144-17.9

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1229415chr17_67471547_+ENSG00000111596.10ENST00000418359hsa-miR-548aa70354504703545107mer-m87035448570354511149-8.43
CAediting_228905chr2_188297554_+ENSG00000111596.10ENST00000552599hsa-miR-561-3p70345905703459117mer-m87034589070345912145-6.22

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CNOT2

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for CNOT2

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for CNOT2

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for CNOT2

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for CNOT2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CNOT2

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource