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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: NOS3 (CAeditome ID:4846)

Gene summary for NOS3

check button Gene summary
Gene informationGene symbol

NOS3

Gene ID

4846

Gene namenitric oxide synthase 3
SynonymsECNOS|eNOS
Cytomap

7q36.1

Type of geneprotein-coding
Descriptionnitric oxide synthase, endothelialEC-NOSNOS type IIINOSIIIcNOSconstitutive NOSendothelial NOSnitric oxide synthase 3 (endothelial cell)nitric oxide synthase 3 transcript variant eNOS-delta20nitric oxide synthase 3 transcript variant eNOS-delta20-
Modification date20210531
UniProtAcc

P29474

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
NOS3

GO:0004517

Nitric oxide synthase, endothelial

1378832

NOS3

GO:0004517

Nitric oxide synthase, endothelial

19666465

NOS3

GO:0004517

Nitric oxide synthase, endothelial

7488039

NOS3

GO:0020037

Nitric oxide synthase, endothelial

7488039

NOS3

GO:0034617

Nitric oxide synthase, endothelial

7488039

NOS3

GO:0034618

Nitric oxide synthase, endothelial

7488039

NOS3

GO:0006527

Nitric oxide synthase, endothelial

1378832

NOS3

GO:0006527

Nitric oxide synthase, endothelial

7488039

NOS3

GO:0006809

Nitric oxide synthase, endothelial

1378832

NOS3

GO:0006809

Nitric oxide synthase, endothelial

7488039

NOS3

GO:0019430

Nitric oxide synthase, endothelial

19666465

NOS3

GO:0043536

Nitric oxide synthase, endothelial

23802567

NOS3

GO:0045766

Nitric oxide synthase, endothelial

23802567

NOS3

GO:0005737

Nitric oxide synthase, endothelial

9794441

NOS3

GO:0005794

Nitric oxide synthase, endothelial

25131610

NOS3

GO:0005886

Nitric oxide synthase, endothelial

25131610

NOS3

GO:0005901

Nitric oxide synthase, endothelial

17502619

NOS3

GO:0005901

Nitric oxide synthase, endothelial

17848177


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RNA A-to-I events for NOS3

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000164867.9

check button RNA A-to-I editing events in Cancer.
CAediting_611531(151003205, +), CAediting_611532(151003238, +), CAediting_611533(151003244, +), CAediting_611534(151003251, +), CAediting_611535(151003267, +), CAediting_611536(151003388, +), CAediting_611537(151004082, +), CAediting_611538(151004957, +), CAediting_611539(151004958, +), CAediting_611540(151004987, +), CAediting_611541(151005790, +), CAediting_611542(151005821, +), CAediting_611543(151005826, +), CAediting_611544(151005827, +), CAediting_611545(151005846, +), CAediting_611546(151005881, +), CAediting_611547(151005941, +), CAediting_611548(151005942, +), CAediting_611549(151005961, +), CAediting_611550(151006009, +), CAediting_611551(151006010, +),

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RNA editing positional annotations for NOS3 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
CAediting_611533chr7_151003244_+nonsynonymous SNVENST00000484524.4c.A1846Gp.T616AD.N
CAediting_611534chr7_151003251_+nonsynonymous SNVENST00000484524.4c.A1853Gp.Q618RD.N

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_611531chr7_151003205_+exonic
CAediting_611532chr7_151003238_+exonic
CAediting_611533chr7_151003244_+exonic
CAediting_611534chr7_151003251_+exonic
CAediting_611535chr7_151003267_+exonic
CAediting_611536chr7_151003388_+exonic
CAediting_611537chr7_151004082_+intronic
CAediting_611538chr7_151004957_+intronic
CAediting_611539chr7_151004958_+intronic
CAediting_611540chr7_151004987_+intronic
CAediting_611541chr7_151005790_+intronic
CAediting_611542chr7_151005821_+intronic
CAediting_611543chr7_151005826_+intronic
CAediting_611544chr7_151005827_+intronic
CAediting_611545chr7_151005846_+intronic
CAediting_611546chr7_151005881_+intronic
CAediting_611547chr7_151005941_+intronic
CAediting_611548chr7_151005942_+intronic
CAediting_611549chr7_151005961_+intronic
CAediting_611550chr7_151006009_+intronic
CAediting_611551chr7_151006010_+intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_611531chr7_151003205_+SINEAluAluJb
CAediting_611532chr7_151003238_+SINEAluAluJb
CAediting_611533chr7_151003244_+SINEAluAluJb
CAediting_611534chr7_151003251_+SINEAluAluJb
CAediting_611535chr7_151003267_+SINEAluAluJb
CAediting_611536chr7_151003388_+SINEAluAluJb
CAediting_611537chr7_151004082_+SINEAluAluSz
CAediting_611538chr7_151004957_+SINEAluAluSx1
CAediting_611539chr7_151004958_+SINEAluAluSx1
CAediting_611540chr7_151004987_+SINEAluAluSx1
CAediting_611541chr7_151005790_+SINEAluAluJr4
CAediting_611542chr7_151005821_+SINEAluAluJr4
CAediting_611543chr7_151005826_+SINEAluAluJr4
CAediting_611544chr7_151005827_+SINEAluAluJr4
CAediting_611545chr7_151005846_+SINEAluAluJr4
CAediting_611546chr7_151005881_+SINEAluAluJr4
CAediting_611547chr7_151005941_+SINEAluAluJr4
CAediting_611548chr7_151005942_+SINEAluAluJr4
CAediting_611549chr7_151005961_+SINEAluAluJr4
CAediting_611550chr7_151006009_+SINEAluAluJr4
CAediting_611551chr7_151006010_+SINEAluAluJr4

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RNA A-to-I editing events in the alternative splicing sites for NOS3

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000164867.9.NOS3.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000164867.9.NOS3.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for NOS3

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for NOS3

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for NOS3

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_611536chr7_151003388_+ENSG00000164867.9ENST00000484524hsa-miR-3189-3p1510033821510033887mer-m8151003366151003389149.00-26.69
CAediting_611536chr7_151003388_+ENSG00000164867.9ENST00000484524hsa-miR-6813-3p1510033831510033897mer-m8151003370151003390140.00-12.15

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393chr1_1167164_+ENSG00000164867.9ENST00000297494hsa-miR-200b-3p1510143001510143078mer-1a151014283151014307146-13.73
CAediting_393chr1_1167164_+ENSG00000164867.9ENST00000461406hsa-miR-200b-3p1510143001510143078mer-1a151014283151014307146-13.73
CAediting_1054808chr15_66496985_-ENSG00000164867.9ENST00000297494hsa-miR-45121510143861510143927mer-m8151014370151014393142-16.3
CAediting_1368054chr19_46709310_-ENSG00000164867.9ENST00000297494hsa-miR-320e1510145801510145878mer-1a151014570151014587152-17.89
CAediting_1054808chr15_66496985_-ENSG00000164867.9ENST00000461406hsa-miR-45121510143861510143927mer-m8151014370151014393142-16.3
CAediting_86358chr1_109598906_+ENSG00000164867.9ENST00000475017hsa-miR-197-5p1510119621510119698mer-1a151011945151011969143-21.22
CAediting_1524209chrX_134546392_-ENSG00000164867.9ENST00000467517hsa-miR-503-5p1510034671510034726mer151003451151003473149-19.67
CAediting_1524209chrX_134546392_-ENSG00000164867.9ENST00000484524hsa-miR-503-5p1510034671510034726mer151003451151003473149-19.67
CAediting_1524209chrX_134546392_-ENSG00000164867.9ENST00000475017hsa-miR-503-5p1510119321510119387mer-1a151011914151011938142-31.63

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1524209chrX_134546392_-ENSG00000164867.9ENST00000467517hsa-miR-503-5p1510038121510038176mer151003796151003818144-18.66
CAediting_1524209chrX_134546392_-ENSG00000164867.9ENST00000484524hsa-miR-503-5p1510038121510038176mer151003796151003818144-18.66

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for NOS3

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000467517.1protein_codingSoverviewSoverview
ENST00000484524.4protein_codingSoverviewSoverview

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
CAediting_611536ENST00000467517.1chr7_151003388_+-962.20-961.10-962.20
CAediting_611531ENST00000484524.4chr7_151003205_+-1016.00-1016.70-1022.90
CAediting_611532ENST00000484524.4chr7_151003238_+-1017.80-1016.70-1022.90
CAediting_611533ENST00000484524.4chr7_151003244_+-1017.90-1016.70-1022.90
CAediting_611534ENST00000484524.4chr7_151003251_+-1016.70-1016.70-1022.90
CAediting_611535ENST00000484524.4chr7_151003267_+-1017.00-1016.70-1022.90
CAediting_611536ENST00000484524.4chr7_151003388_+-1016.40-1016.70-1022.90

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Relation with ADAR for NOS3

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for NOS3

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for NOS3

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for NOS3

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
NOS3P29474DB00360SapropterinNitric oxide synthase, endothelial SmallMoleculeDrugapproved|investigational
NOS3P29474DB09237LevamlodipineNitric oxide synthase, endothelial SmallMoleculeDrugapproved|investigational
NOS3P29474DB01110MiconazoleNitric oxide synthase, endothelial SmallMoleculeDrugapproved|investigational|vet_approved

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RelatedDiseases for NOS3

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
NOS3C0002152Alloxan Diabetes8CTD_human
NOS3C0011853Diabetes Mellitus, Experimental8CTD_human
NOS3C0038433Streptozotocin Diabetes8CTD_human
NOS3C0020538Hypertensive disease5CTD_human
NOS3C0010054Coronary Arteriosclerosis4CTD_human
NOS3C0011570Mental Depression4PSYGENET
NOS3C0011581Depressive disorder4PSYGENET
NOS3C0018800Cardiomegaly4CTD_human
NOS3C0021655Insulin Resistance4CTD_human
NOS3C0920563Insulin Sensitivity4CTD_human
NOS3C1383860Cardiac Hypertrophy4CTD_human
NOS3C1956346Coronary Artery Disease4CTD_human
NOS3C0033578Prostatic Neoplasms3CTD_human
NOS3C0376358Malignant neoplasm of prostate3CTD_human
NOS3C0524620Metabolic Syndrome X3CTD_human
NOS3C0002395Alzheimer's Disease2CTD_human
NOS3C0004153Atherosclerosis2CTD_human
NOS3C0006142Malignant neoplasm of breast2CTD_human
NOS3C0007222Cardiovascular Diseases2CTD_human
NOS3C0010073Coronary Artery Vasospasm2CTD_human
NOS3C0011265Presenile dementia2CTD_human
NOS3C0011860Diabetes Mellitus, Non-Insulin-Dependent2CTD_human
NOS3C0018801Heart failure2CTD_human
NOS3C0018802Congestive heart failure2CTD_human
NOS3C0019284Diaphragmatic Hernia2CTD_human
NOS3C0023212Left-Sided Heart Failure2CTD_human
NOS3C0027051Myocardial Infarction2CTD_human
NOS3C0235527Heart Failure, Right-Sided2CTD_human
NOS3C0242350Erectile dysfunction2CTD_human
NOS3C0276496Familial Alzheimer Disease (FAD)2CTD_human
NOS3C0494463Alzheimer Disease, Late Onset2CTD_human
NOS3C0546126Acute Confusional Senile Dementia2CTD_human
NOS3C0678222Breast Carcinoma2CTD_human
NOS3C0750900Alzheimer's Disease, Focal Onset2CTD_human
NOS3C0750901Alzheimer Disease, Early Onset2CTD_human
NOS3C1257931Mammary Neoplasms, Human2CTD_human
NOS3C1458155Mammary Neoplasms2CTD_human
NOS3C1563937Atherogenesis2CTD_human
NOS3C1959583Myocardial Failure2CTD_human
NOS3C1961112Heart Decompensation2CTD_human
NOS3C4704874Mammary Carcinoma, Human2CTD_human
NOS3C0000832Abruptio Placentae1CTD_human
NOS3C0001418Adenocarcinoma1CTD_human
NOS3C0003129Anoxemia1CTD_human
NOS3C0003130Anoxia1CTD_human
NOS3C0003850Arteriosclerosis1CTD_human
NOS3C0004238Atrial Fibrillation1CTD_human
NOS3C0005398Cholestasis, Extrahepatic1CTD_human
NOS3C0005586Bipolar Disorder1PSYGENET
NOS3C0006826Malignant Neoplasms1CTD_human
NOS3C0008312Primary biliary cirrhosis1CTD_human
NOS3C0008924Cleft upper lip1CTD_human
NOS3C0008925Cleft Palate1CTD_human
NOS3C0010398Cruveilhier-Baumgarten Syndrome1CTD_human
NOS3C0011854Diabetes Mellitus, Insulin-Dependent1CTD_human
NOS3C0011875Diabetic Angiopathies1CTD_human
NOS3C0011881Diabetic Nephropathy1CTD_human
NOS3C0014859Esophageal Neoplasms1CTD_human
NOS3C0015934Fetal Growth Retardation1CTD_human
NOS3C0017667Nodular glomerulosclerosis1CTD_human
NOS3C0018036Hypertension, Goldblatt1CTD_human
NOS3C0019209Hepatomegaly1CTD_human
NOS3C0020456Hyperglycemia1CTD_human
NOS3C0020459Hyperinsulinism1CTD_human
NOS3C0020473Hyperlipidemia1CTD_human
NOS3C0020541Portal Hypertension1CTD_human
NOS3C0020542Pulmonary Hypertension1CTD_human
NOS3C0020545Hypertension, Renovascular1CTD_human
NOS3C0021364Male infertility1CTD_human
NOS3C0021845Intestinal Perforation1CTD_human
NOS3C0022116Ischemia1CTD_human
NOS3C0022660Kidney Failure, Acute1CTD_human
NOS3C0023892Biliary cirrhosis1CTD_human
NOS3C0023893Liver Cirrhosis, Experimental1CTD_human
NOS3C0024117Chronic Obstructive Airway Disease1CTD_human
NOS3C0024623Malignant neoplasm of stomach1CTD_human
NOS3C0025945Microangiopathy, Diabetic1CTD_human
NOS3C0027055Myocardial Reperfusion Injury1CTD_human
NOS3C0027651Neoplasms1CTD_human
NOS3C0028960Oligospermia1CTD_human
NOS3C0034063Pulmonary Edema1CTD_human
NOS3C0034189Pyemia1CTD_human
NOS3C0035126Reperfusion Injury1CTD_human
NOS3C0036690Septicemia1CTD_human
NOS3C0038356Stomach Neoplasms1CTD_human
NOS3C0038358Gastric ulcer1CTD_human
NOS3C0041948Uremia1CTD_human
NOS3C0041956Ureteral obstruction1CTD_human
NOS3C0042514Tachycardia, Ventricular1CTD_human
NOS3C0042594Vestibular Diseases1CTD_human
NOS3C0086692Benign Neoplasm1CTD_human
NOS3C0151636Premature ventricular contractions1CTD_human
NOS3C0151744Myocardial Ischemia1CTD_human
NOS3C0205641Adenocarcinoma, Basal Cell1CTD_human
NOS3C0205642Adenocarcinoma, Oxyphilic1CTD_human
NOS3C0205643Carcinoma, Cribriform1CTD_human
NOS3C0205644Carcinoma, Granular Cell1CTD_human
NOS3C0205645Adenocarcinoma, Tubular1CTD_human
NOS3C0205734Diabetes, Autoimmune1CTD_human
NOS3C0235480Paroxysmal atrial fibrillation1CTD_human
NOS3C0238065Secondary Biliary Cholangitis1CTD_human
NOS3C0242184Hypoxia1CTD_human
NOS3C0243026Sepsis1CTD_human
NOS3C0341934Transient hypertension of pregnancy1CTD_human
NOS3C0342302Brittle diabetes1CTD_human
NOS3C0403824Teratozoospermia1CTD_human
NOS3C0403825Globozoospermia1CTD_human
NOS3C0520459Necrotizing Enterocolitis1CTD_human
NOS3C0546837Malignant neoplasm of esophagus1CTD_human
NOS3C0700292Hypoxemia1CTD_human
NOS3C0848676Subfertility, Male1CTD_human
NOS3C0852036Pregnancy associated hypertension1CTD_human
NOS3C0917731Male sterility1CTD_human
NOS3C1257963Endogenous Hyperinsulinism1CTD_human
NOS3C1257964Exogenous Hyperinsulinism1CTD_human
NOS3C1257965Compensatory Hyperinsulinemia1CTD_human
NOS3C1306571Hepatic Insufficiency1CTD_human
NOS3C1527303Chronic Airflow Obstruction1CTD_human
NOS3C1565662Acute Kidney Insufficiency1CTD_human
NOS3C1706412Lipidemias1CTD_human
NOS3C1708349Hereditary Diffuse Gastric Cancer1CTD_human
NOS3C1719672Severe Sepsis1CTD_human
NOS3C1837218Cleft palate, isolated1CTD_human
NOS3C1855520Hyperglycemia, Postprandial1CTD_human
NOS3C2585653Persistent atrial fibrillation1CTD_human
NOS3C2609414Acute kidney injury1CTD_human
NOS3C3468561familial atrial fibrillation1CTD_human
NOS3C3837958Diabetes Mellitus, Ketosis-Prone1CTD_human
NOS3C4551595Biliary Cirrhosis, Primary, 11CTD_human
NOS3C4554117Diabetes Mellitus, Sudden-Onset1CTD_human