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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: ACO1 (CAeditome ID:48)

Gene summary for ACO1

check button Gene summary
Gene informationGene symbol

ACO1

Gene ID

48

Gene nameaconitase 1
SynonymsACONS|HEL60|IREB1|IREBP|IREBP1|IRP1
Cytomap

9p21.1

Type of geneprotein-coding
Descriptioncytoplasmic aconitate hydrataseaconitase 1, solubleaconitate hydratase, cytoplasmiccitrate hydro-lyasecytoplasmic aconitasecytosplasmic aconitaseepididymis luminal protein 60epididymis secretory sperm binding proteinferritin repressor proteiniron
Modification date20210518
UniProtAcc

P21399

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
ACO1

GO:0003723

Cytoplasmic aconitate hydratase

1946430

ACO1

GO:0003994

Cytoplasmic aconitate hydratase

1946430

ACO1

GO:0003994

Cytoplasmic aconitate hydratase

8041788

ACO1

GO:0030350

Cytoplasmic aconitate hydratase

8041788

ACO1

GO:0051539

Cytoplasmic aconitate hydratase

16407072

ACO1

GO:0006101

Cytoplasmic aconitate hydratase

16527810

ACO1

GO:0006101

Cytoplasmic aconitate hydratase

8041788

ACO1

GO:0010040

Cytoplasmic aconitate hydratase

8041788

ACO1

GO:0005739

Cytoplasmic aconitate hydratase

0000052

ACO1

GO:0005783

Cytoplasmic aconitate hydratase

16144863

ACO1

GO:0005794

Cytoplasmic aconitate hydratase

16144863

ACO1

GO:0005829

Cytoplasmic aconitate hydratase

0000052

ACO1

GO:0005829

Cytoplasmic aconitate hydratase

16527810


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RNA A-to-I events for ACO1

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000122729.17
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_680093(32389927, +), CAediting_680094(32409743, +), CAediting_680095(32409747, +), CAediting_680096(32409769, +), CAediting_680097(32411898, +), CAediting_680098(32411902, +), CAediting_680099(32411943, +), CAediting_680100(32411977, +), CAediting_680101(32412003, +), CAediting_680102(32416367, +), CAediting_680103(32451230, +), CAediting_680104(32451259, +), CAediting_680105(32451285, +), CAediting_680106(32451306, +), CAediting_680107(32451805, +), CAediting_680108(32451983, +), CAediting_680109(32452428, +), CAediting_680110(32452429, +), CAediting_680111(32452432, +), CAediting_680112(32452450, +), CAediting_680113(32452453, +), CAediting_680114(32452454, +), CAediting_680115(32452468, +), CAediting_680116(32452700, +), CAediting_680117(32452866, +), CAediting_680118(32452873, +),

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RNA editing positional annotations for ACO1 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_680093chr9_32389927_+intronic
CAediting_680094chr9_32409743_+intronic
CAediting_680095chr9_32409747_+intronic
CAediting_680096chr9_32409769_+intronic
CAediting_680097chr9_32411898_+intronic
CAediting_680098chr9_32411902_+intronic
CAediting_680099chr9_32411943_+intronic
CAediting_680100chr9_32411977_+intronic
CAediting_680101chr9_32412003_+intronic
CAediting_680102chr9_32416367_+intronic
CAediting_680103chr9_32451230_+UTR3
CAediting_680104chr9_32451259_+UTR3
CAediting_680105chr9_32451285_+UTR3
CAediting_680106chr9_32451306_+UTR3
CAediting_680107chr9_32451805_+UTR3
CAediting_680108chr9_32451983_+UTR3
CAediting_680109chr9_32452428_+UTR3
CAediting_680110chr9_32452429_+UTR3
CAediting_680111chr9_32452432_+UTR3
CAediting_680112chr9_32452450_+UTR3
CAediting_680113chr9_32452453_+UTR3
CAediting_680114chr9_32452454_+UTR3
CAediting_680115chr9_32452468_+UTR3
CAediting_680116chr9_32452700_+UTR3
CAediting_680117chr9_32452866_+UTR3
CAediting_680118chr9_32452873_+UTR3

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_680093chr9_32389927_+SINEAluAluSx
CAediting_680094chr9_32409743_+SINEAluAluJo
CAediting_680095chr9_32409747_+SINEAluAluJo
CAediting_680096chr9_32409769_+SINEAluAluJo
CAediting_680097chr9_32411898_+SINEAluAluJb
CAediting_680098chr9_32411902_+SINEAluAluJb
CAediting_680099chr9_32411943_+SINEAluAluJb
CAediting_680100chr9_32411977_+SINEAluAluJb
CAediting_680101chr9_32412003_+SINEAluAluJb
CAediting_680102chr9_32416367_+SINEAluAluSg
CAediting_680103chr9_32451230_+LTRERVL-MaLRMLT1B
CAediting_680104chr9_32451259_+LTRERVL-MaLRMLT1B
CAediting_680105chr9_32451285_+LTRERVL-MaLRMLT1B
CAediting_680106chr9_32451306_+LTRERVL-MaLRMLT1B
CAediting_680107chr9_32451805_+SINEAluAluSq2
CAediting_680108chr9_32451983_+SINEAluAluSq2
CAediting_680109chr9_32452428_+LTRERVL-MaLRMLT1A0
CAediting_680110chr9_32452429_+LTRERVL-MaLRMLT1A0
CAediting_680111chr9_32452432_+LTRERVL-MaLRMLT1A0
CAediting_680112chr9_32452450_+LTRERVL-MaLRMLT1A0
CAediting_680113chr9_32452453_+LTRERVL-MaLRMLT1A0
CAediting_680114chr9_32452454_+LTRERVL-MaLRMLT1A0
CAediting_680115chr9_32452468_+LTRERVL-MaLRMLT1A0
CAediting_680116chr9_32452700_+SINEAluAluJb
CAediting_680117chr9_32452866_+SINEAluAluJb
CAediting_680118chr9_32452873_+SINEAluAluJb

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RNA A-to-I editing events in the alternative splicing sites for ACO1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000122729.17.ACO1.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000122729.17.ACO1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ACO1

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
THCA.CAediting_680106.ENSG00000122729.ACO1.png
Soverview

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Protein coding region RNA A-to-I editings for ACO1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for ACO1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_680110chr9_32452429_+ENSG00000122729.17ENST00000309951hsa-miR-3074-5p32452425324524317mer-m83245241232452432150.00-18.33
CAediting_680110chr9_32452429_+ENSG00000122729.17ENST00000309951hsa-miR-370-3p32452423324524308mer-1a3245240932452430144.00-24.31
CAediting_680110chr9_32452429_+ENSG00000122729.17ENST00000309951hsa-miR-6893-3p32452423324524308mer-1a3245240932452430158.00-17.53
CAediting_680112chr9_32452450_+ENSG00000122729.17ENST00000309951hsa-miR-4664-3p32452446324524538mer-1a3245243232452453145.00-14.39
CAediting_680112chr9_32452450_+ENSG00000122729.17ENST00000309951hsa-miR-671-3p32452444324524518mer-1a3245243132452451145.00-20.34
CAediting_680107chr9_32451805_+ENSG00000122729.17ENST00000309951hsa-miR-10399-5p32451802324518087mer-m83245178832451809144.00-11.77
CAediting_680107chr9_32451805_+ENSG00000122729.17ENST00000309951hsa-miR-6504-3p32451802324518087mer-m83245178832451809160.00-16.69
CAediting_680107chr9_32451805_+ENSG00000122729.17ENST00000309951hsa-miR-7151-3p32451800324518078mer-1a3245179132451807146.00-17.62
CAediting_680108chr9_32451983_+ENSG00000122729.17ENST00000309951hsa-miR-498-5p32451978324519847mer-m83245196332451985142.00-10.65
CAediting_680111chr9_32452432_+ENSG00000122729.17ENST00000309951hsa-miR-6821-3p32452428324524358mer-1a3245241632452435143.00-16.97
CAediting_680113chr9_32452453_+ENSG00000122729.17ENST00000309951hsa-miR-3191-5p32452447324524537mer-m83245243332452454140.00-18.22
CAediting_680113chr9_32452453_+ENSG00000122729.17ENST00000309951hsa-miR-4639-3p32452450324524567mer-m83245243832452457141.00-13.32
CAediting_680113chr9_32452453_+ENSG00000122729.17ENST00000309951hsa-miR-6764-3p32452446324524538mer-1a3245243332452453140.00-14.81
CAediting_680113chr9_32452453_+ENSG00000122729.17ENST00000309951hsa-miR-6777-3p32452451324524577mer-m83245244032452458152.00-22.02
CAediting_680113chr9_32452453_+ENSG00000122729.17ENST00000309951hsa-miR-6817-3p32452448324524547mer-m83245243832452455151.00-19.68
CAediting_680113chr9_32452453_+ENSG00000122729.17ENST00000309951hsa-miR-6824-3p32452446324524538mer-1a3245243432452453143.00-14.48
CAediting_680114chr9_32452454_+ENSG00000122729.17ENST00000309951hsa-miR-1224-3p32452452324524587mer-m83245243932452459148.00-15.23
CAediting_680114chr9_32452454_+ENSG00000122729.17ENST00000309951hsa-miR-1237-3p32452448324524547mer-m83245243532452455146.00-14.24
CAediting_680116chr9_32452700_+ENSG00000122729.17ENST00000309951hsa-miR-3622a-5p32452698324527058mer-1a3245268632452705153.00-22.34
CAediting_680117chr9_32452866_+ENSG00000122729.17ENST00000309951hsa-miR-6849-3p32452859324528657mer-m83245284432452866149.00-17.54

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_680111chr9_32452432_+ENSG00000122729.17ENST00000309951hsa-miR-316432452430324524367mer-m83245241632452437141-9.73
CAediting_680106chr9_32451306_+ENSG00000122729.17ENST00000309951hsa-miR-368632451301324513077mer-m83245128532451308150-12.85
CAediting_680115chr9_32452468_+ENSG00000122729.17ENST00000309951hsa-miR-429932452462324524698mer-1a3245245232452469142-13.76
CAediting_680108chr9_32451983_+ENSG00000122729.17ENST00000309951hsa-miR-450332451977324519848mer-1a3245196332451984141-10.05
CAediting_680103chr9_32451230_+ENSG00000122729.17ENST00000309951hsa-miR-4677-3p32451224324512307mer-m83245121232451231149-12.65
CAediting_680118chr9_32452873_+ENSG00000122729.17ENST00000309951hsa-miR-532-3p32452867324528737mer-m83245285532452874147-24.3
CAediting_680108chr9_32451983_+ENSG00000122729.17ENST00000309951hsa-miR-629-5p32451981324519877mer-m83245196832451988143-11.24
CAediting_680111chr9_32452432_+ENSG00000122729.17ENST00000309951hsa-miR-6505-3p32452428324524358mer-1a3245241532452435146-13.54
CAediting_680105chr9_32451285_+ENSG00000122729.17ENST00000309951hsa-miR-6511a-3p32451279324512857mer-m83245126532451286140-14.76
CAediting_680105chr9_32451285_+ENSG00000122729.17ENST00000309951hsa-miR-6511a-3p32451279324512857mer-m83245126532451286140-14.76
CAediting_680105chr9_32451285_+ENSG00000122729.17ENST00000309951hsa-miR-6511a-3p32451279324512857mer-m83245126532451286140-14.76
CAediting_680105chr9_32451285_+ENSG00000122729.17ENST00000309951hsa-miR-6511a-3p32451279324512857mer-m83245126532451286140-14.76
CAediting_680105chr9_32451285_+ENSG00000122729.17ENST00000309951hsa-miR-6511b-3p32451279324512857mer-m83245126432451286140-15.57
CAediting_680105chr9_32451285_+ENSG00000122729.17ENST00000309951hsa-miR-6511b-3p32451279324512857mer-m83245126432451286140-15.57
CAediting_680118chr9_32452873_+ENSG00000122729.17ENST00000309951hsa-miR-6749-3p32452869324528757mer-m83245285732452876150-23.29
CAediting_680111chr9_32452432_+ENSG00000122729.17ENST00000309951hsa-miR-6820-3p32452430324524367mer-m83245241632452437150-17.11

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393chr1_1167164_+ENSG00000122729.17ENST00000309951hsa-miR-200b-3p32454624324546307mer-m83245460832454631144-9.19
CAediting_688080chr9_63819626_+ENSG00000122729.17ENST00000309951hsa-miR-4477b32452120324521267mer-m83245210532452127150-14.1
CAediting_1160181chr17_7017644_-ENSG00000122729.17ENST00000309951hsa-miR-195-3p32454304324543118mer-1a3245429032454311140-8.55
CAediting_1351755chr19_40282625_-ENSG00000122729.17ENST00000309951hsa-miR-64132451384324513907mer-m83245136832451391148-18.69
CAediting_86358chr1_109598906_+ENSG00000122729.17ENST00000309951hsa-miR-197-5p32452179324521857mer-m83245216632452186146-16.41
CAediting_117844chr1_162342605_+ENSG00000122729.17ENST00000309951hsa-miR-556-3p32452929324529357mer-m83245291632452936141-10.77
CAediting_396018chr5_1062918_-ENSG00000122729.17ENST00000309951hsa-miR-463532452121324521277mer-m83245210732452128148-15.03

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1160181chr17_7017644_-ENSG00000122729.17ENST00000309951hsa-miR-195-3p32453629324536357mer-m83245361632453636144-14.79
CAediting_393chr1_1167164_+ENSG00000122729.17ENST00000309951hsa-miR-200b-3p32453610324536167mer-m83245359632453617148-9.59
CAediting_1306323chr19_13836462_-ENSG00000122729.17ENST00000309951hsa-miR-27a-3p32452513324525197mer-m83245249532452520148-18.62
CAediting_77128chr1_85133844_+ENSG00000122729.17ENST00000309951hsa-miR-4423-3p32454704324547107mer-m83245469132454711140-10.31

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ACO1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for ACO1

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
LIHCCAediting_680104chr9_32451259_+0.001159030039782660.400078669867342....
THCACAediting_680104chr9_32451259_+0.02614910387658050.263924848501504....
LIHCCAediting_680106chr9_32451306_+0.003229259401530560.342505838225348..0.04511295041031130.236899770709159
STADCAediting_680106chr9_32451306_+..0.001346268844358410.370748998076694..
THCACAediting_680106chr9_32451306_+1.32112176196977e-050.398910739302203....
KIRCCAediting_680106chr9_32451306_+0.01146176618159150.183558870392523....

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Relation with cancer stages for ACO1

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
THCApathologic_stageCAediting_680104chr9_32451259_+0.0005977341475994040.402935825314305

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Relation with survival for ACO1

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for ACO1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ACO1

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
ACO1C0027626Neoplasm Invasiveness1CTD_human
ACO1C0029408Degenerative polyarthritis1CTD_human
ACO1C0086743Osteoarthrosis Deformans1CTD_human