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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: ACO1 (CAeditome ID:48) |
Gene summary for ACO1 |
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Gene information | Gene symbol | ACO1 | Gene ID | 48 |
Gene name | aconitase 1 | |
Synonyms | ACONS|HEL60|IREB1|IREBP|IREBP1|IRP1 | |
Cytomap | 9p21.1 | |
Type of gene | protein-coding | |
Description | cytoplasmic aconitate hydrataseaconitase 1, solubleaconitate hydratase, cytoplasmiccitrate hydro-lyasecytoplasmic aconitasecytosplasmic aconitaseepididymis luminal protein 60epididymis secretory sperm binding proteinferritin repressor proteiniron | |
Modification date | 20210518 | |
UniProtAcc | P21399 | |
Context |
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Gene | GO ID | GO term | PubMed ID |
ACO1 | GO:0003723 | Cytoplasmic aconitate hydratase | 1946430 |
ACO1 | GO:0003994 | Cytoplasmic aconitate hydratase | 1946430 |
ACO1 | GO:0003994 | Cytoplasmic aconitate hydratase | 8041788 |
ACO1 | GO:0030350 | Cytoplasmic aconitate hydratase | 8041788 |
ACO1 | GO:0051539 | Cytoplasmic aconitate hydratase | 16407072 |
ACO1 | GO:0006101 | Cytoplasmic aconitate hydratase | 16527810 |
ACO1 | GO:0006101 | Cytoplasmic aconitate hydratase | 8041788 |
ACO1 | GO:0010040 | Cytoplasmic aconitate hydratase | 8041788 |
ACO1 | GO:0005739 | Cytoplasmic aconitate hydratase | 0000052 |
ACO1 | GO:0005783 | Cytoplasmic aconitate hydratase | 16144863 |
ACO1 | GO:0005794 | Cytoplasmic aconitate hydratase | 16144863 |
ACO1 | GO:0005829 | Cytoplasmic aconitate hydratase | 0000052 |
ACO1 | GO:0005829 | Cytoplasmic aconitate hydratase | 16527810 |
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RNA A-to-I events for ACO1 |
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CAediting_680093(32389927, +), CAediting_680094(32409743, +), CAediting_680095(32409747, +), CAediting_680096(32409769, +), CAediting_680097(32411898, +), CAediting_680098(32411902, +), CAediting_680099(32411943, +), CAediting_680100(32411977, +), CAediting_680101(32412003, +), CAediting_680102(32416367, +), CAediting_680103(32451230, +), CAediting_680104(32451259, +), CAediting_680105(32451285, +), CAediting_680106(32451306, +), CAediting_680107(32451805, +), CAediting_680108(32451983, +), CAediting_680109(32452428, +), CAediting_680110(32452429, +), CAediting_680111(32452432, +), CAediting_680112(32452450, +), CAediting_680113(32452453, +), CAediting_680114(32452454, +), CAediting_680115(32452468, +), CAediting_680116(32452700, +), CAediting_680117(32452866, +), CAediting_680118(32452873, +), |
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RNA editing positional annotations for ACO1 using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
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CAeditome ID | Position | Variant type |
CAediting_680093 | chr9_32389927_+ | intronic |
CAediting_680094 | chr9_32409743_+ | intronic |
CAediting_680095 | chr9_32409747_+ | intronic |
CAediting_680096 | chr9_32409769_+ | intronic |
CAediting_680097 | chr9_32411898_+ | intronic |
CAediting_680098 | chr9_32411902_+ | intronic |
CAediting_680099 | chr9_32411943_+ | intronic |
CAediting_680100 | chr9_32411977_+ | intronic |
CAediting_680101 | chr9_32412003_+ | intronic |
CAediting_680102 | chr9_32416367_+ | intronic |
CAediting_680103 | chr9_32451230_+ | UTR3 |
CAediting_680104 | chr9_32451259_+ | UTR3 |
CAediting_680105 | chr9_32451285_+ | UTR3 |
CAediting_680106 | chr9_32451306_+ | UTR3 |
CAediting_680107 | chr9_32451805_+ | UTR3 |
CAediting_680108 | chr9_32451983_+ | UTR3 |
CAediting_680109 | chr9_32452428_+ | UTR3 |
CAediting_680110 | chr9_32452429_+ | UTR3 |
CAediting_680111 | chr9_32452432_+ | UTR3 |
CAediting_680112 | chr9_32452450_+ | UTR3 |
CAediting_680113 | chr9_32452453_+ | UTR3 |
CAediting_680114 | chr9_32452454_+ | UTR3 |
CAediting_680115 | chr9_32452468_+ | UTR3 |
CAediting_680116 | chr9_32452700_+ | UTR3 |
CAediting_680117 | chr9_32452866_+ | UTR3 |
CAediting_680118 | chr9_32452873_+ | UTR3 |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
CAediting_680093 | chr9_32389927_+ | SINE | Alu | AluSx |
CAediting_680094 | chr9_32409743_+ | SINE | Alu | AluJo |
CAediting_680095 | chr9_32409747_+ | SINE | Alu | AluJo |
CAediting_680096 | chr9_32409769_+ | SINE | Alu | AluJo |
CAediting_680097 | chr9_32411898_+ | SINE | Alu | AluJb |
CAediting_680098 | chr9_32411902_+ | SINE | Alu | AluJb |
CAediting_680099 | chr9_32411943_+ | SINE | Alu | AluJb |
CAediting_680100 | chr9_32411977_+ | SINE | Alu | AluJb |
CAediting_680101 | chr9_32412003_+ | SINE | Alu | AluJb |
CAediting_680102 | chr9_32416367_+ | SINE | Alu | AluSg |
CAediting_680103 | chr9_32451230_+ | LTR | ERVL-MaLR | MLT1B |
CAediting_680104 | chr9_32451259_+ | LTR | ERVL-MaLR | MLT1B |
CAediting_680105 | chr9_32451285_+ | LTR | ERVL-MaLR | MLT1B |
CAediting_680106 | chr9_32451306_+ | LTR | ERVL-MaLR | MLT1B |
CAediting_680107 | chr9_32451805_+ | SINE | Alu | AluSq2 |
CAediting_680108 | chr9_32451983_+ | SINE | Alu | AluSq2 |
CAediting_680109 | chr9_32452428_+ | LTR | ERVL-MaLR | MLT1A0 |
CAediting_680110 | chr9_32452429_+ | LTR | ERVL-MaLR | MLT1A0 |
CAediting_680111 | chr9_32452432_+ | LTR | ERVL-MaLR | MLT1A0 |
CAediting_680112 | chr9_32452450_+ | LTR | ERVL-MaLR | MLT1A0 |
CAediting_680113 | chr9_32452453_+ | LTR | ERVL-MaLR | MLT1A0 |
CAediting_680114 | chr9_32452454_+ | LTR | ERVL-MaLR | MLT1A0 |
CAediting_680115 | chr9_32452468_+ | LTR | ERVL-MaLR | MLT1A0 |
CAediting_680116 | chr9_32452700_+ | SINE | Alu | AluJb |
CAediting_680117 | chr9_32452866_+ | SINE | Alu | AluJb |
CAediting_680118 | chr9_32452873_+ | SINE | Alu | AluJb |
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RNA A-to-I editing events in the alternative splicing sites for ACO1 |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ACO1 |
![]() * The grey color means N/A. |
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THCA.CAediting_680106.ENSG00000122729.ACO1.png ![]() |
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Protein coding region RNA A-to-I editings for ACO1 |
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The effects of the RNA editing to the miRNA binding sites for ACO1 |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_680110 | chr9_32452429_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-3074-5p | 32452425 | 32452431 | 7mer-m8 | 32452412 | 32452432 | 150.00 | -18.33 |
CAediting_680110 | chr9_32452429_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-370-3p | 32452423 | 32452430 | 8mer-1a | 32452409 | 32452430 | 144.00 | -24.31 |
CAediting_680110 | chr9_32452429_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-6893-3p | 32452423 | 32452430 | 8mer-1a | 32452409 | 32452430 | 158.00 | -17.53 |
CAediting_680112 | chr9_32452450_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-4664-3p | 32452446 | 32452453 | 8mer-1a | 32452432 | 32452453 | 145.00 | -14.39 |
CAediting_680112 | chr9_32452450_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-671-3p | 32452444 | 32452451 | 8mer-1a | 32452431 | 32452451 | 145.00 | -20.34 |
CAediting_680107 | chr9_32451805_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-10399-5p | 32451802 | 32451808 | 7mer-m8 | 32451788 | 32451809 | 144.00 | -11.77 |
CAediting_680107 | chr9_32451805_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-6504-3p | 32451802 | 32451808 | 7mer-m8 | 32451788 | 32451809 | 160.00 | -16.69 |
CAediting_680107 | chr9_32451805_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-7151-3p | 32451800 | 32451807 | 8mer-1a | 32451791 | 32451807 | 146.00 | -17.62 |
CAediting_680108 | chr9_32451983_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-498-5p | 32451978 | 32451984 | 7mer-m8 | 32451963 | 32451985 | 142.00 | -10.65 |
CAediting_680111 | chr9_32452432_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-6821-3p | 32452428 | 32452435 | 8mer-1a | 32452416 | 32452435 | 143.00 | -16.97 |
CAediting_680113 | chr9_32452453_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-3191-5p | 32452447 | 32452453 | 7mer-m8 | 32452433 | 32452454 | 140.00 | -18.22 |
CAediting_680113 | chr9_32452453_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-4639-3p | 32452450 | 32452456 | 7mer-m8 | 32452438 | 32452457 | 141.00 | -13.32 |
CAediting_680113 | chr9_32452453_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-6764-3p | 32452446 | 32452453 | 8mer-1a | 32452433 | 32452453 | 140.00 | -14.81 |
CAediting_680113 | chr9_32452453_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-6777-3p | 32452451 | 32452457 | 7mer-m8 | 32452440 | 32452458 | 152.00 | -22.02 |
CAediting_680113 | chr9_32452453_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-6817-3p | 32452448 | 32452454 | 7mer-m8 | 32452438 | 32452455 | 151.00 | -19.68 |
CAediting_680113 | chr9_32452453_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-6824-3p | 32452446 | 32452453 | 8mer-1a | 32452434 | 32452453 | 143.00 | -14.48 |
CAediting_680114 | chr9_32452454_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-1224-3p | 32452452 | 32452458 | 7mer-m8 | 32452439 | 32452459 | 148.00 | -15.23 |
CAediting_680114 | chr9_32452454_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-1237-3p | 32452448 | 32452454 | 7mer-m8 | 32452435 | 32452455 | 146.00 | -14.24 |
CAediting_680116 | chr9_32452700_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-3622a-5p | 32452698 | 32452705 | 8mer-1a | 32452686 | 32452705 | 153.00 | -22.34 |
CAediting_680117 | chr9_32452866_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-6849-3p | 32452859 | 32452865 | 7mer-m8 | 32452844 | 32452866 | 149.00 | -17.54 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_680111 | chr9_32452432_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-3164 | 32452430 | 32452436 | 7mer-m8 | 32452416 | 32452437 | 141 | -9.73 |
CAediting_680106 | chr9_32451306_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-3686 | 32451301 | 32451307 | 7mer-m8 | 32451285 | 32451308 | 150 | -12.85 |
CAediting_680115 | chr9_32452468_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-4299 | 32452462 | 32452469 | 8mer-1a | 32452452 | 32452469 | 142 | -13.76 |
CAediting_680108 | chr9_32451983_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-4503 | 32451977 | 32451984 | 8mer-1a | 32451963 | 32451984 | 141 | -10.05 |
CAediting_680103 | chr9_32451230_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-4677-3p | 32451224 | 32451230 | 7mer-m8 | 32451212 | 32451231 | 149 | -12.65 |
CAediting_680118 | chr9_32452873_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-532-3p | 32452867 | 32452873 | 7mer-m8 | 32452855 | 32452874 | 147 | -24.3 |
CAediting_680108 | chr9_32451983_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-629-5p | 32451981 | 32451987 | 7mer-m8 | 32451968 | 32451988 | 143 | -11.24 |
CAediting_680111 | chr9_32452432_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-6505-3p | 32452428 | 32452435 | 8mer-1a | 32452415 | 32452435 | 146 | -13.54 |
CAediting_680105 | chr9_32451285_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-6511a-3p | 32451279 | 32451285 | 7mer-m8 | 32451265 | 32451286 | 140 | -14.76 |
CAediting_680105 | chr9_32451285_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-6511a-3p | 32451279 | 32451285 | 7mer-m8 | 32451265 | 32451286 | 140 | -14.76 |
CAediting_680105 | chr9_32451285_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-6511a-3p | 32451279 | 32451285 | 7mer-m8 | 32451265 | 32451286 | 140 | -14.76 |
CAediting_680105 | chr9_32451285_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-6511a-3p | 32451279 | 32451285 | 7mer-m8 | 32451265 | 32451286 | 140 | -14.76 |
CAediting_680105 | chr9_32451285_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-6511b-3p | 32451279 | 32451285 | 7mer-m8 | 32451264 | 32451286 | 140 | -15.57 |
CAediting_680105 | chr9_32451285_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-6511b-3p | 32451279 | 32451285 | 7mer-m8 | 32451264 | 32451286 | 140 | -15.57 |
CAediting_680118 | chr9_32452873_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-6749-3p | 32452869 | 32452875 | 7mer-m8 | 32452857 | 32452876 | 150 | -23.29 |
CAediting_680111 | chr9_32452432_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-6820-3p | 32452430 | 32452436 | 7mer-m8 | 32452416 | 32452437 | 150 | -17.11 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_393 | chr1_1167164_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-200b-3p | 32454624 | 32454630 | 7mer-m8 | 32454608 | 32454631 | 144 | -9.19 |
CAediting_688080 | chr9_63819626_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-4477b | 32452120 | 32452126 | 7mer-m8 | 32452105 | 32452127 | 150 | -14.1 |
CAediting_1160181 | chr17_7017644_- | ENSG00000122729.17 | ENST00000309951 | hsa-miR-195-3p | 32454304 | 32454311 | 8mer-1a | 32454290 | 32454311 | 140 | -8.55 |
CAediting_1351755 | chr19_40282625_- | ENSG00000122729.17 | ENST00000309951 | hsa-miR-641 | 32451384 | 32451390 | 7mer-m8 | 32451368 | 32451391 | 148 | -18.69 |
CAediting_86358 | chr1_109598906_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-197-5p | 32452179 | 32452185 | 7mer-m8 | 32452166 | 32452186 | 146 | -16.41 |
CAediting_117844 | chr1_162342605_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-556-3p | 32452929 | 32452935 | 7mer-m8 | 32452916 | 32452936 | 141 | -10.77 |
CAediting_396018 | chr5_1062918_- | ENSG00000122729.17 | ENST00000309951 | hsa-miR-4635 | 32452121 | 32452127 | 7mer-m8 | 32452107 | 32452128 | 148 | -15.03 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_1160181 | chr17_7017644_- | ENSG00000122729.17 | ENST00000309951 | hsa-miR-195-3p | 32453629 | 32453635 | 7mer-m8 | 32453616 | 32453636 | 144 | -14.79 |
CAediting_393 | chr1_1167164_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-200b-3p | 32453610 | 32453616 | 7mer-m8 | 32453596 | 32453617 | 148 | -9.59 |
CAediting_1306323 | chr19_13836462_- | ENSG00000122729.17 | ENST00000309951 | hsa-miR-27a-3p | 32452513 | 32452519 | 7mer-m8 | 32452495 | 32452520 | 148 | -18.62 |
CAediting_77128 | chr1_85133844_+ | ENSG00000122729.17 | ENST00000309951 | hsa-miR-4423-3p | 32454704 | 32454710 | 7mer-m8 | 32454691 | 32454711 | 140 | -10.31 |
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The effects of the RNA editing to the stability of the RNA structures for ACO1 |
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ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for ACO1 |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
LIHC | CAediting_680104 | chr9_32451259_+ | 0.00115903003978266 | 0.400078669867342 | . | . | . | . |
THCA | CAediting_680104 | chr9_32451259_+ | 0.0261491038765805 | 0.263924848501504 | . | . | . | . |
LIHC | CAediting_680106 | chr9_32451306_+ | 0.00322925940153056 | 0.342505838225348 | . | . | 0.0451129504103113 | 0.236899770709159 |
STAD | CAediting_680106 | chr9_32451306_+ | . | . | 0.00134626884435841 | 0.370748998076694 | . | . |
THCA | CAediting_680106 | chr9_32451306_+ | 1.32112176196977e-05 | 0.398910739302203 | . | . | . | . |
KIRC | CAediting_680106 | chr9_32451306_+ | 0.0114617661815915 | 0.183558870392523 | . | . | . | . |
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Relation with cancer stages for ACO1 |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
THCA | pathologic_stage | CAediting_680104 | chr9_32451259_+ | 0.000597734147599404 | 0.402935825314305 |
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Relation with survival for ACO1 |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for ACO1 |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ACO1 |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
ACO1 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
ACO1 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
ACO1 | C0086743 | Osteoarthrosis Deformans | 1 | CTD_human |