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Editing gene: ATP1A2 (CAeditome ID:477)

Gene summary for ATP1A2

Gene summary

Gene information	Gene symbol	ATP1A2
	Gene ID	477
	Gene name	ATPase Na+/K+ transporting subunit alpha 2
	Synonyms	FHM2\|MHP2
	Cytomap	1q23.2
	Type of gene	protein-coding
	Description	sodium/potassium-transporting ATPase subunit alpha-2ATPase Na+/K+ transporting alpha 2 polypeptideNa(+)/K(+) ATPase alpha-2 subunitNa+/K+ ATPase, alpha-A(+) catalytic polypeptideNa+/K+ ATPase, alpha-B polypeptidesodium pump subunit alpha-2sodium-pot
	Modification date	20210518
	UniProtAcc	P50993
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
ATP1A2	GO:0005391	Sodium/potassium-transporting ATPase subunit alpha-2	10636900
ATP1A2	GO:0019829	Sodium/potassium-transporting ATPase subunit alpha-2	19372756
ATP1A2	GO:1990239	Sodium/potassium-transporting ATPase subunit alpha-2	14742675
ATP1A2	GO:0006883	Sodium/potassium-transporting ATPase subunit alpha-2	10636900
ATP1A2	GO:0030007	Sodium/potassium-transporting ATPase subunit alpha-2	10636900
ATP1A2	GO:0036376	Sodium/potassium-transporting ATPase subunit alpha-2	10636900
ATP1A2	GO:0071383	Sodium/potassium-transporting ATPase subunit alpha-2	14742675
ATP1A2	GO:0098655	Sodium/potassium-transporting ATPase subunit alpha-2	19372756
ATP1A2	GO:1990573	Sodium/potassium-transporting ATPase subunit alpha-2	10636900
ATP1A2	GO:0005737	Sodium/potassium-transporting ATPase subunit alpha-2	12539047
ATP1A2	GO:0005886	Sodium/potassium-transporting ATPase subunit alpha-2	12539047
ATP1A2	GO:0016020	Sodium/potassium-transporting ATPase subunit alpha-2	23954377
ATP1A2	GO:0005890	Sodium/potassium-transporting ATPase subunit alpha-2	10636900
ATP1A2	GO:0005890	Sodium/potassium-transporting ATPase subunit alpha-2	23954377

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RNA A-to-I events for ATP1A2

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000018625.13

RNA A-to-I editing events in Cancer.

CAediting_115338(160130829, +), CAediting_115339(160131116, +), CAediting_115340(160133644, +), CAediting_115341(160140877, +), CAediting_115342(160140918, +), CAediting_115343(160140924, +), CAediting_115344(160140943, +), CAediting_115345(160140962, +), CAediting_115346(160140963, +), CAediting_115347(160140966, +), CAediting_115348(160140967, +), CAediting_115349(160140987, +), CAediting_115350(160140992, +), CAediting_115351(160141010, +), CAediting_115352(160141015, +), CAediting_115353(160141028, +), CAediting_115354(160141029, +), CAediting_115355(160141038, +), CAediting_115356(160141044, +), CAediting_115357(160141047, +), CAediting_115358(160141049, +), CAediting_115359(160141051, +), CAediting_115360(160141053, +), CAediting_115361(160141069, +), CAediting_115362(160141106, +), CAediting_115363(160141120, +), CAediting_115364(160141122, +), CAediting_115365(160142550, +), CAediting_115366(160142551, +), CAediting_115367(160142617, +), CAediting_115368(160142618, +), CAediting_115369(160142628, +), CAediting_115370(160142644, +), CAediting_115371(160142645, +), CAediting_115372(160142651, +), CAediting_115373(160142653, +), CAediting_115374(160142658, +), CAediting_115375(160142676, +), CAediting_115376(160142694, +), CAediting_115377(160142698, +), CAediting_115378(160142733, +), CAediting_115379(160142737, +), CAediting_115380(160142785, +), CAediting_115381(160142787, +), CAediting_115382(160142800, +), CAediting_115383(160142957, +), CAediting_115384(160143055, +),

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RNA editing positional annotations for ATP1A2 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_115338	chr1_160130829_+	ncRNA_intronic
CAediting_115339	chr1_160131116_+	ncRNA_intronic
CAediting_115340	chr1_160133644_+	ncRNA_intronic
CAediting_115341	chr1_160140877_+	ncRNA_intronic
CAediting_115342	chr1_160140918_+	ncRNA_intronic
CAediting_115343	chr1_160140924_+	ncRNA_intronic
CAediting_115344	chr1_160140943_+	ncRNA_intronic
CAediting_115345	chr1_160140962_+	ncRNA_intronic
CAediting_115346	chr1_160140963_+	ncRNA_intronic
CAediting_115347	chr1_160140966_+	ncRNA_intronic
CAediting_115348	chr1_160140967_+	ncRNA_intronic
CAediting_115349	chr1_160140987_+	ncRNA_intronic
CAediting_115350	chr1_160140992_+	ncRNA_intronic
CAediting_115351	chr1_160141010_+	ncRNA_intronic
CAediting_115352	chr1_160141015_+	ncRNA_intronic
CAediting_115353	chr1_160141028_+	ncRNA_intronic
CAediting_115354	chr1_160141029_+	ncRNA_intronic
CAediting_115355	chr1_160141038_+	ncRNA_intronic
CAediting_115356	chr1_160141044_+	ncRNA_intronic
CAediting_115357	chr1_160141047_+	ncRNA_intronic
CAediting_115358	chr1_160141049_+	ncRNA_intronic
CAediting_115359	chr1_160141051_+	ncRNA_intronic
CAediting_115360	chr1_160141053_+	ncRNA_intronic
CAediting_115361	chr1_160141069_+	ncRNA_intronic
CAediting_115362	chr1_160141106_+	ncRNA_intronic
CAediting_115363	chr1_160141120_+	ncRNA_intronic
CAediting_115364	chr1_160141122_+	ncRNA_intronic
CAediting_115365	chr1_160142550_+	UTR3
CAediting_115366	chr1_160142551_+	UTR3
CAediting_115367	chr1_160142617_+	UTR3
CAediting_115368	chr1_160142618_+	UTR3
CAediting_115369	chr1_160142628_+	UTR3
CAediting_115370	chr1_160142644_+	UTR3
CAediting_115371	chr1_160142645_+	UTR3
CAediting_115372	chr1_160142651_+	UTR3
CAediting_115373	chr1_160142653_+	UTR3
CAediting_115374	chr1_160142658_+	UTR3
CAediting_115375	chr1_160142676_+	UTR3
CAediting_115376	chr1_160142694_+	UTR3
CAediting_115377	chr1_160142698_+	UTR3
CAediting_115378	chr1_160142733_+	UTR3
CAediting_115379	chr1_160142737_+	UTR3
CAediting_115380	chr1_160142785_+	UTR3
CAediting_115381	chr1_160142787_+	UTR3
CAediting_115382	chr1_160142800_+	UTR3
CAediting_115383	chr1_160142957_+	UTR3
CAediting_115384	chr1_160143055_+	UTR3

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_115339	chr1_160131116_+	LINE	L2	L2a
CAediting_115341	chr1_160140877_+	SINE	Alu	AluSc8
CAediting_115342	chr1_160140918_+	SINE	Alu	AluSc8
CAediting_115343	chr1_160140924_+	SINE	Alu	AluSc8
CAediting_115344	chr1_160140943_+	SINE	Alu	AluSc8
CAediting_115345	chr1_160140962_+	SINE	Alu	AluSc8
CAediting_115346	chr1_160140963_+	SINE	Alu	AluSc8
CAediting_115347	chr1_160140966_+	SINE	Alu	AluSc8
CAediting_115348	chr1_160140967_+	SINE	Alu	AluSc8
CAediting_115349	chr1_160140987_+	SINE	Alu	AluSc8
CAediting_115350	chr1_160140992_+	SINE	Alu	AluSc8
CAediting_115351	chr1_160141010_+	SINE	Alu	AluSc8
CAediting_115352	chr1_160141015_+	SINE	Alu	AluSc8
CAediting_115353	chr1_160141028_+	SINE	Alu	AluSc8
CAediting_115354	chr1_160141029_+	SINE	Alu	AluSc8
CAediting_115355	chr1_160141038_+	SINE	Alu	AluSc8
CAediting_115356	chr1_160141044_+	SINE	Alu	AluSc8
CAediting_115357	chr1_160141047_+	SINE	Alu	AluSc8
CAediting_115358	chr1_160141049_+	SINE	Alu	AluSc8
CAediting_115359	chr1_160141051_+	SINE	Alu	AluSc8
CAediting_115360	chr1_160141053_+	SINE	Alu	AluSc8
CAediting_115361	chr1_160141069_+	SINE	Alu	AluSc8
CAediting_115362	chr1_160141106_+	SINE	Alu	AluSc8
CAediting_115363	chr1_160141120_+	SINE	Alu	AluSc8
CAediting_115364	chr1_160141122_+	SINE	Alu	AluSc8
CAediting_115365	chr1_160142550_+	SINE	Alu	AluSx3
CAediting_115366	chr1_160142551_+	SINE	Alu	AluSx3
CAediting_115367	chr1_160142617_+	SINE	Alu	AluSx3
CAediting_115368	chr1_160142618_+	SINE	Alu	AluSx3
CAediting_115369	chr1_160142628_+	SINE	Alu	AluSx3
CAediting_115370	chr1_160142644_+	SINE	Alu	AluSx3
CAediting_115371	chr1_160142645_+	SINE	Alu	AluSx3
CAediting_115372	chr1_160142651_+	SINE	Alu	AluSx3
CAediting_115373	chr1_160142653_+	SINE	Alu	AluSx3
CAediting_115374	chr1_160142658_+	SINE	Alu	AluSx3
CAediting_115375	chr1_160142676_+	SINE	Alu	AluSx3
CAediting_115376	chr1_160142694_+	SINE	Alu	AluSx3
CAediting_115377	chr1_160142698_+	SINE	Alu	AluSx3
CAediting_115378	chr1_160142733_+	SINE	Alu	AluSx3
CAediting_115379	chr1_160142737_+	SINE	Alu	AluSx3
CAediting_115380	chr1_160142785_+	SINE	Alu	AluSx3
CAediting_115381	chr1_160142787_+	SINE	Alu	AluSx3
CAediting_115382	chr1_160142800_+	SINE	Alu	AluSx3

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RNA A-to-I editing events in the alternative splicing sites for ATP1A2

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000018625.13.ATP1A2.

Correlation between RNA A-to-I editing and PSI for ENSG00000018625.13.ATP1A2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ATP1A2

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for ATP1A2

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for ATP1A2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_115365	chr1_160142550_+	ENSG00000018625.13	ENST00000361216	hsa-miR-513a-5p	160142544	160142550	7mer-m8	160142534	160142551	152.00	-17.32
CAediting_115365	chr1_160142550_+	ENSG00000018625.13	ENST00000361216	hsa-miR-513a-5p	160142544	160142550	7mer-m8	160142534	160142551	152.00	-17.32
CAediting_115365	chr1_160142550_+	ENSG00000018625.13	ENST00000361216	hsa-miR-638	160142549	160142555	7mer-1a	160142531	160142555	155.00	-34.17
CAediting_115365	chr1_160142550_+	ENSG00000018625.13	ENST00000447527	hsa-miR-513a-5p	160142544	160142550	7mer-m8	160142534	160142551	152.00	-17.32
CAediting_115365	chr1_160142550_+	ENSG00000018625.13	ENST00000447527	hsa-miR-513a-5p	160142544	160142550	7mer-m8	160142534	160142551	152.00	-17.32
CAediting_115365	chr1_160142550_+	ENSG00000018625.13	ENST00000447527	hsa-miR-638	160142549	160142555	7mer-1a	160142531	160142555	155.00	-34.17
CAediting_115366	chr1_160142551_+	ENSG00000018625.13	ENST00000361216	hsa-miR-8052	160142549	160142555	7mer-1a	160142537	160142555	148.00	-29.06
CAediting_115366	chr1_160142551_+	ENSG00000018625.13	ENST00000447527	hsa-miR-8052	160142549	160142555	7mer-1a	160142537	160142555	148.00	-29.06
CAediting_115368	chr1_160142618_+	ENSG00000018625.13	ENST00000361216	hsa-miR-3190-5p	160142611	160142617	7mer-m8	160142599	160142618	158.00	-23.91
CAediting_115368	chr1_160142618_+	ENSG00000018625.13	ENST00000447527	hsa-miR-3190-5p	160142611	160142617	7mer-m8	160142599	160142618	158.00	-23.91
CAediting_115369	chr1_160142628_+	ENSG00000018625.13	ENST00000361216	hsa-miR-3158-3p	160142625	160142631	7mer-m8	160142612	160142632	150.00	-20.06
CAediting_115369	chr1_160142628_+	ENSG00000018625.13	ENST00000361216	hsa-miR-3158-3p	160142625	160142631	7mer-m8	160142612	160142632	150.00	-20.06
CAediting_115369	chr1_160142628_+	ENSG00000018625.13	ENST00000361216	hsa-miR-412-3p	160142621	160142627	7mer-m8	160142601	160142628	154.00	-22.43
CAediting_115369	chr1_160142628_+	ENSG00000018625.13	ENST00000361216	hsa-miR-6754-3p	160142621	160142627	7mer-m8	160142608	160142628	144.00	-15.76
CAediting_115369	chr1_160142628_+	ENSG00000018625.13	ENST00000447527	hsa-miR-3158-3p	160142625	160142631	7mer-m8	160142612	160142632	150.00	-20.06
CAediting_115369	chr1_160142628_+	ENSG00000018625.13	ENST00000447527	hsa-miR-3158-3p	160142625	160142631	7mer-m8	160142612	160142632	150.00	-20.06
CAediting_115369	chr1_160142628_+	ENSG00000018625.13	ENST00000447527	hsa-miR-412-3p	160142621	160142627	7mer-m8	160142601	160142628	154.00	-22.43
CAediting_115369	chr1_160142628_+	ENSG00000018625.13	ENST00000447527	hsa-miR-6754-3p	160142621	160142627	7mer-m8	160142608	160142628	144.00	-15.76
CAediting_115373	chr1_160142653_+	ENSG00000018625.13	ENST00000361216	hsa-miR-6844	160142647	160142654	8mer-1a	160142632	160142654	154.00	-9.40
CAediting_115373	chr1_160142653_+	ENSG00000018625.13	ENST00000447527	hsa-miR-6844	160142647	160142654	8mer-1a	160142632	160142654	154.00	-9.40
CAediting_115374	chr1_160142658_+	ENSG00000018625.13	ENST00000361216	hsa-miR-3190-5p	160142656	160142662	7mer-m8	160142644	160142663	143.00	-15.07
CAediting_115374	chr1_160142658_+	ENSG00000018625.13	ENST00000361216	hsa-miR-548s	160142655	160142661	7mer-m8	160142640	160142662	140.00	-11.40
CAediting_115374	chr1_160142658_+	ENSG00000018625.13	ENST00000447527	hsa-miR-3190-5p	160142656	160142662	7mer-m8	160142644	160142663	143.00	-15.07
CAediting_115374	chr1_160142658_+	ENSG00000018625.13	ENST00000447527	hsa-miR-548s	160142655	160142661	7mer-m8	160142640	160142662	140.00	-11.40
CAediting_115376	chr1_160142694_+	ENSG00000018625.13	ENST00000361216	hsa-miR-646	160142689	160142695	7mer-m8	160142678	160142696	145.00	-15.05
CAediting_115376	chr1_160142694_+	ENSG00000018625.13	ENST00000447527	hsa-miR-646	160142689	160142695	7mer-m8	160142678	160142696	145.00	-15.05
CAediting_115379	chr1_160142737_+	ENSG00000018625.13	ENST00000361216	hsa-miR-5193	160142731	160142738	8mer-1a	160142723	160142741	144.00	-19.92
CAediting_115379	chr1_160142737_+	ENSG00000018625.13	ENST00000361216	hsa-miR-5193	160142734	160142740	7mer-m8	160142723	160142741	144.00	-19.92
CAediting_115379	chr1_160142737_+	ENSG00000018625.13	ENST00000447527	hsa-miR-5193	160142731	160142738	8mer-1a	160142723	160142741	144.00	-19.92
CAediting_115379	chr1_160142737_+	ENSG00000018625.13	ENST00000447527	hsa-miR-5193	160142734	160142740	7mer-m8	160142723	160142741	144.00	-19.92
CAediting_115380	chr1_160142785_+	ENSG00000018625.13	ENST00000361216	hsa-miR-5088-3p	160142784	160142789	6mer	160142770	160142790	148.00	-25.21
CAediting_115380	chr1_160142785_+	ENSG00000018625.13	ENST00000447527	hsa-miR-5088-3p	160142784	160142789	6mer	160142770	160142790	148.00	-25.21
CAediting_115383	chr1_160142957_+	ENSG00000018625.13	ENST00000361216	hsa-miR-6090	160142956	160142961	6mer	160142944	160142962	149.00	-29.24
CAediting_115383	chr1_160142957_+	ENSG00000018625.13	ENST00000447527	hsa-miR-6090	160142956	160142961	6mer	160142944	160142962	149.00	-29.24
CAediting_115381	chr1_160142787_+	ENSG00000018625.13	ENST00000361216	hsa-miR-3127-3p	160142783	160142789	7mer-m8	160142769	160142790	155.00	-27.38
CAediting_115381	chr1_160142787_+	ENSG00000018625.13	ENST00000361216	hsa-miR-6756-3p	160142783	160142789	7mer-m8	160142771	160142790	152.00	-23.59
CAediting_115381	chr1_160142787_+	ENSG00000018625.13	ENST00000447527	hsa-miR-3127-3p	160142783	160142789	7mer-m8	160142769	160142790	155.00	-27.38
CAediting_115381	chr1_160142787_+	ENSG00000018625.13	ENST00000447527	hsa-miR-6756-3p	160142783	160142789	7mer-m8	160142771	160142790	152.00	-23.59

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_115365	chr1_160142550_+	ENSG00000018625.13	ENST00000361216	hsa-miR-10399-5p	160142545	160142551	7mer-m8	160142531	160142552	144	-11.88
CAediting_115366	chr1_160142551_+	ENSG00000018625.13	ENST00000361216	hsa-miR-10399-5p	160142545	160142551	7mer-m8	160142531	160142552	144	-11.88
CAediting_115377	chr1_160142698_+	ENSG00000018625.13	ENST00000361216	hsa-miR-1200	160142694	160142700	7mer-m8	160142682	160142701	146	-23.05
CAediting_115379	chr1_160142737_+	ENSG00000018625.13	ENST00000361216	hsa-miR-1236-3p	160142733	160142739	7mer-m8	160142719	160142740	142	-18.33
CAediting_115384	chr1_160143055_+	ENSG00000018625.13	ENST00000361216	hsa-miR-192-5p	160143053	160143059	7mer-m8	160143040	160143060	145	-10.21
CAediting_115384	chr1_160143055_+	ENSG00000018625.13	ENST00000361216	hsa-miR-215-5p	160143053	160143059	7mer-m8	160143040	160143060	145	-12.45
CAediting_115374	chr1_160142658_+	ENSG00000018625.13	ENST00000361216	hsa-miR-3064-5p	160142657	160142662	6mer	160142643	160142663	143	-19.04
CAediting_115375	chr1_160142676_+	ENSG00000018625.13	ENST00000361216	hsa-miR-3186-5p	160142675	160142680	6mer	160142660	160142681	140	-29.98
CAediting_115382	chr1_160142800_+	ENSG00000018625.13	ENST00000361216	hsa-miR-3198	160142793	160142799	7mer-m8	160142779	160142800	140	-13.17
CAediting_115382	chr1_160142800_+	ENSG00000018625.13	ENST00000361216	hsa-miR-3198	160142793	160142799	7mer-m8	160142779	160142800	140	-13.17
CAediting_115382	chr1_160142800_+	ENSG00000018625.13	ENST00000361216	hsa-miR-4309	160142793	160142799	7mer-m8	160142783	160142800	145	-16.36
CAediting_115367	chr1_160142617_+	ENSG00000018625.13	ENST00000361216	hsa-miR-4435	160142610	160142617	8mer-1a	160142597	160142617	154	-24.06
CAediting_115367	chr1_160142617_+	ENSG00000018625.13	ENST00000361216	hsa-miR-4435	160142610	160142617	8mer-1a	160142597	160142617	154	-24.06
CAediting_115382	chr1_160142800_+	ENSG00000018625.13	ENST00000361216	hsa-miR-4534	160142795	160142801	7mer-m8	160142786	160142802	140	-14.24
CAediting_115368	chr1_160142618_+	ENSG00000018625.13	ENST00000361216	hsa-miR-4716-5p	160142616	160142622	7mer-m8	160142602	160142623	140	-14.76
CAediting_115374	chr1_160142658_+	ENSG00000018625.13	ENST00000361216	hsa-miR-4735-5p	160142652	160142658	7mer-m8	160142638	160142659	140	-5.64
CAediting_115367	chr1_160142617_+	ENSG00000018625.13	ENST00000361216	hsa-miR-4781-3p	160142614	160142620	7mer-m8	160142599	160142621	153	-19.29
CAediting_115368	chr1_160142618_+	ENSG00000018625.13	ENST00000361216	hsa-miR-4781-3p	160142614	160142620	7mer-m8	160142599	160142621	153	-19.29
CAediting_115374	chr1_160142658_+	ENSG00000018625.13	ENST00000361216	hsa-miR-4794	160142656	160142662	7mer-m8	160142642	160142663	140	-13.84
CAediting_115366	chr1_160142551_+	ENSG00000018625.13	ENST00000361216	hsa-miR-5089-5p	160142549	160142555	7mer-m8	160142537	160142556	146	-13.24
CAediting_115378	chr1_160142733_+	ENSG00000018625.13	ENST00000361216	hsa-miR-513a-5p	160142726	160142732	7mer-m8	160142716	160142733	140	-15
CAediting_115378	chr1_160142733_+	ENSG00000018625.13	ENST00000361216	hsa-miR-513a-5p	160142726	160142732	7mer-m8	160142716	160142733	140	-15
CAediting_115382	chr1_160142800_+	ENSG00000018625.13	ENST00000361216	hsa-miR-6514-5p	160142794	160142800	7mer-m8	160142777	160142801	145	-17.37
CAediting_115374	chr1_160142658_+	ENSG00000018625.13	ENST00000361216	hsa-miR-664a-5p	160142656	160142662	7mer-m8	160142640	160142663	141	-14.92
CAediting_115369	chr1_160142628_+	ENSG00000018625.13	ENST00000361216	hsa-miR-6823-5p	160142626	160142632	7mer-m8	160142613	160142633	143	-17.07
CAediting_115376	chr1_160142694_+	ENSG00000018625.13	ENST00000361216	hsa-miR-6869-5p	160142691	160142697	7mer-m8	160142674	160142698	146	-20.88
CAediting_115377	chr1_160142698_+	ENSG00000018625.13	ENST00000361216	hsa-miR-6869-5p	160142691	160142697	7mer-m8	160142674	160142698	146	-20.88
CAediting_115383	chr1_160142957_+	ENSG00000018625.13	ENST00000361216	hsa-miR-6892-5p	160142950	160142956	7mer-m8	160142938	160142957	151	-19.69
CAediting_115365	chr1_160142550_+	ENSG00000018625.13	ENST00000361216	hsa-miR-7151-3p	160142543	160142550	8mer-1a	160142534	160142550	146	-17.62
CAediting_115382	chr1_160142800_+	ENSG00000018625.13	ENST00000361216	hsa-miR-8082	160142795	160142801	7mer-m8	160142780	160142802	141	-17.49
CAediting_115379	chr1_160142737_+	ENSG00000018625.13	ENST00000361216	hsa-miR-877-3p	160142734	160142740	7mer-m8	160142721	160142741	143	-17.74
CAediting_115365	chr1_160142550_+	ENSG00000018625.13	ENST00000447527	hsa-miR-10399-5p	160142545	160142551	7mer-m8	160142531	160142552	144	-11.88
CAediting_115366	chr1_160142551_+	ENSG00000018625.13	ENST00000447527	hsa-miR-10399-5p	160142545	160142551	7mer-m8	160142531	160142552	144	-11.88
CAediting_115377	chr1_160142698_+	ENSG00000018625.13	ENST00000447527	hsa-miR-1200	160142694	160142700	7mer-m8	160142682	160142701	146	-23.05
CAediting_115379	chr1_160142737_+	ENSG00000018625.13	ENST00000447527	hsa-miR-1236-3p	160142733	160142739	7mer-m8	160142719	160142740	142	-18.33
CAediting_115384	chr1_160143055_+	ENSG00000018625.13	ENST00000447527	hsa-miR-192-5p	160143053	160143059	7mer-m8	160143040	160143060	145	-10.21
CAediting_115384	chr1_160143055_+	ENSG00000018625.13	ENST00000447527	hsa-miR-215-5p	160143053	160143059	7mer-m8	160143040	160143060	145	-12.45
CAediting_115374	chr1_160142658_+	ENSG00000018625.13	ENST00000447527	hsa-miR-3064-5p	160142657	160142662	6mer	160142643	160142663	143	-19.04
CAediting_115375	chr1_160142676_+	ENSG00000018625.13	ENST00000447527	hsa-miR-3186-5p	160142675	160142680	6mer	160142660	160142681	140	-29.98
CAediting_115382	chr1_160142800_+	ENSG00000018625.13	ENST00000447527	hsa-miR-3198	160142793	160142799	7mer-m8	160142779	160142800	140	-13.17
CAediting_115382	chr1_160142800_+	ENSG00000018625.13	ENST00000447527	hsa-miR-3198	160142793	160142799	7mer-m8	160142779	160142800	140	-13.17
CAediting_115382	chr1_160142800_+	ENSG00000018625.13	ENST00000447527	hsa-miR-4309	160142793	160142799	7mer-m8	160142783	160142800	145	-16.36
CAediting_115367	chr1_160142617_+	ENSG00000018625.13	ENST00000447527	hsa-miR-4435	160142610	160142617	8mer-1a	160142597	160142617	154	-24.06
CAediting_115367	chr1_160142617_+	ENSG00000018625.13	ENST00000447527	hsa-miR-4435	160142610	160142617	8mer-1a	160142597	160142617	154	-24.06
CAediting_115382	chr1_160142800_+	ENSG00000018625.13	ENST00000447527	hsa-miR-4534	160142795	160142801	7mer-m8	160142786	160142802	140	-14.24
CAediting_115368	chr1_160142618_+	ENSG00000018625.13	ENST00000447527	hsa-miR-4716-5p	160142616	160142622	7mer-m8	160142602	160142623	140	-14.76
CAediting_115374	chr1_160142658_+	ENSG00000018625.13	ENST00000447527	hsa-miR-4735-5p	160142652	160142658	7mer-m8	160142638	160142659	140	-5.64
CAediting_115367	chr1_160142617_+	ENSG00000018625.13	ENST00000447527	hsa-miR-4781-3p	160142614	160142620	7mer-m8	160142599	160142621	153	-19.29
CAediting_115368	chr1_160142618_+	ENSG00000018625.13	ENST00000447527	hsa-miR-4781-3p	160142614	160142620	7mer-m8	160142599	160142621	153	-19.29
CAediting_115374	chr1_160142658_+	ENSG00000018625.13	ENST00000447527	hsa-miR-4794	160142656	160142662	7mer-m8	160142642	160142663	140	-13.84
CAediting_115366	chr1_160142551_+	ENSG00000018625.13	ENST00000447527	hsa-miR-5089-5p	160142549	160142555	7mer-m8	160142537	160142556	146	-13.24
CAediting_115378	chr1_160142733_+	ENSG00000018625.13	ENST00000447527	hsa-miR-513a-5p	160142726	160142732	7mer-m8	160142716	160142733	140	-15
CAediting_115378	chr1_160142733_+	ENSG00000018625.13	ENST00000447527	hsa-miR-513a-5p	160142726	160142732	7mer-m8	160142716	160142733	140	-15
CAediting_115382	chr1_160142800_+	ENSG00000018625.13	ENST00000447527	hsa-miR-6514-5p	160142794	160142800	7mer-m8	160142777	160142801	145	-17.37
CAediting_115374	chr1_160142658_+	ENSG00000018625.13	ENST00000447527	hsa-miR-664a-5p	160142656	160142662	7mer-m8	160142640	160142663	141	-14.92
CAediting_115369	chr1_160142628_+	ENSG00000018625.13	ENST00000447527	hsa-miR-6823-5p	160142626	160142632	7mer-m8	160142613	160142633	143	-17.07
CAediting_115376	chr1_160142694_+	ENSG00000018625.13	ENST00000447527	hsa-miR-6869-5p	160142691	160142697	7mer-m8	160142674	160142698	146	-20.88
CAediting_115377	chr1_160142698_+	ENSG00000018625.13	ENST00000447527	hsa-miR-6869-5p	160142691	160142697	7mer-m8	160142674	160142698	146	-20.88
CAediting_115383	chr1_160142957_+	ENSG00000018625.13	ENST00000447527	hsa-miR-6892-5p	160142950	160142956	7mer-m8	160142938	160142957	151	-19.69
CAediting_115365	chr1_160142550_+	ENSG00000018625.13	ENST00000447527	hsa-miR-7151-3p	160142543	160142550	8mer-1a	160142534	160142550	146	-17.62
CAediting_115382	chr1_160142800_+	ENSG00000018625.13	ENST00000447527	hsa-miR-8082	160142795	160142801	7mer-m8	160142780	160142802	141	-17.49
CAediting_115379	chr1_160142737_+	ENSG00000018625.13	ENST00000447527	hsa-miR-877-3p	160142734	160142740	7mer-m8	160142721	160142741	143	-17.74

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_846604	chr11_93733708_-	ENSG00000018625.13	ENST00000361216	hsa-miR-1304-3p	160143437	160143443	7mer-m8	160143424	160143444	144	-14.32
CAediting_980496	chr14_31014685_-	ENSG00000018625.13	ENST00000361216	hsa-miR-624-3p	160142627	160142633	7mer-m8	160142614	160142634	152	-13.11
CAediting_846604	chr11_93733708_-	ENSG00000018625.13	ENST00000447527	hsa-miR-1304-3p	160143437	160143443	7mer-m8	160143424	160143444	144	-14.32
CAediting_980496	chr14_31014685_-	ENSG00000018625.13	ENST00000447527	hsa-miR-624-3p	160142627	160142633	7mer-m8	160142614	160142634	152	-13.11
CAediting_1229413	chr17_67471544_+	ENSG00000018625.13	ENST00000361216	hsa-miR-548aa	160142917	160142924	8mer-1a	160142903	160142924	150	-15.91
CAediting_1368054	chr19_46709310_-	ENSG00000018625.13	ENST00000361216	hsa-miR-320e	160142014	160142020	7mer-m8	160142002	160142021	145	-18.11
CAediting_86358	chr1_109598906_+	ENSG00000018625.13	ENST00000361216	hsa-miR-197-5p	160141742	160141748	7mer-m8	160141726	160141749	167	-28.69
CAediting_77128	chr1_85133844_+	ENSG00000018625.13	ENST00000361216	hsa-miR-4423-3p	160142890	160142896	7mer-m8	160142877	160142897	142	-11.75
CAediting_524911	chr7_5495852_-	ENSG00000018625.13	ENST00000361216	hsa-miR-589-3p	160142975	160142981	7mer-m8	160142959	160142982	152	-14.7
CAediting_1229413	chr17_67471544_+	ENSG00000018625.13	ENST00000447527	hsa-miR-548aa	160142917	160142924	8mer-1a	160142903	160142924	150	-15.91
CAediting_1368054	chr19_46709310_-	ENSG00000018625.13	ENST00000447527	hsa-miR-320e	160142014	160142020	7mer-m8	160142002	160142021	145	-18.11
CAediting_86358	chr1_109598906_+	ENSG00000018625.13	ENST00000447527	hsa-miR-197-5p	160141742	160141748	7mer-m8	160141726	160141749	167	-28.69
CAediting_77128	chr1_85133844_+	ENSG00000018625.13	ENST00000447527	hsa-miR-4423-3p	160142890	160142896	7mer-m8	160142877	160142897	142	-11.75
CAediting_524911	chr7_5495852_-	ENSG00000018625.13	ENST00000447527	hsa-miR-589-3p	160142975	160142981	7mer-m8	160142959	160142982	152	-14.7

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_524911	chr7_5495852_-	ENSG00000018625.13	ENST00000361216	hsa-miR-589-3p	160142256	160142263	8mer-1a	160142240	160142263	148	-17.87
CAediting_524911	chr7_5495852_-	ENSG00000018625.13	ENST00000447527	hsa-miR-589-3p	160142256	160142263	8mer-1a	160142240	160142263	148	-17.87

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ATP1A2

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000361216.6	protein_coding
ENST00000447527.1	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_115365	ENST00000361216.6	chr1_160142550_+	-1998.30	-1998.30	-2023.00
CAediting_115366	ENST00000361216.6	chr1_160142551_+	-1998.30	-1998.30	-2023.00
CAediting_115367	ENST00000361216.6	chr1_160142617_+	-1999.60	-1998.30	-2023.00
CAediting_115368	ENST00000361216.6	chr1_160142618_+	-1998.70	-1998.30	-2023.00
CAediting_115369	ENST00000361216.6	chr1_160142628_+	-1998.30	-1998.30	-2023.00
CAediting_115370	ENST00000361216.6	chr1_160142644_+	-1998.30	-1998.30	-2023.00
CAediting_115371	ENST00000361216.6	chr1_160142645_+	-1998.30	-1998.30	-2023.00
CAediting_115372	ENST00000361216.6	chr1_160142651_+	-1998.30	-1998.30	-2023.00
CAediting_115373	ENST00000361216.6	chr1_160142653_+	-1999.80	-1998.30	-2023.00
CAediting_115374	ENST00000361216.6	chr1_160142658_+	-1999.70	-1998.30	-2023.00
CAediting_115375	ENST00000361216.6	chr1_160142676_+	-2000.10	-1998.30	-2023.00
CAediting_115376	ENST00000361216.6	chr1_160142694_+	-1999.20	-1998.30	-2023.00
CAediting_115377	ENST00000361216.6	chr1_160142698_+	-1997.60	-1998.30	-2023.00
CAediting_115378	ENST00000361216.6	chr1_160142733_+	-2000.00	-1998.30	-2023.00
CAediting_115379	ENST00000361216.6	chr1_160142737_+	-1999.10	-1998.30	-2023.00
CAediting_115380	ENST00000361216.6	chr1_160142785_+	-1998.90	-1998.30	-2023.00
CAediting_115381	ENST00000361216.6	chr1_160142787_+	-2001.00	-1998.30	-2023.00
CAediting_115382	ENST00000361216.6	chr1_160142800_+	-2000.70	-1998.30	-2023.00
CAediting_115383	ENST00000361216.6	chr1_160142957_+	-2004.60	-1998.30	-2023.00
CAediting_115384	ENST00000361216.6	chr1_160143055_+	-1998.00	-1998.30	-2023.00
CAediting_115365	ENST00000447527.1	chr1_160142550_+	-1581.70	-1579.80	-1605.80
CAediting_115366	ENST00000447527.1	chr1_160142551_+	-1582.50	-1579.80	-1605.80
CAediting_115367	ENST00000447527.1	chr1_160142617_+	-1581.10	-1579.80	-1605.80
CAediting_115368	ENST00000447527.1	chr1_160142618_+	-1580.20	-1579.80	-1605.80
CAediting_115369	ENST00000447527.1	chr1_160142628_+	-1579.80	-1579.80	-1605.80
CAediting_115370	ENST00000447527.1	chr1_160142644_+	-1580.00	-1579.80	-1605.80
CAediting_115371	ENST00000447527.1	chr1_160142645_+	-1580.30	-1579.80	-1605.80
CAediting_115372	ENST00000447527.1	chr1_160142651_+	-1579.80	-1579.80	-1605.80
CAediting_115373	ENST00000447527.1	chr1_160142653_+	-1581.00	-1579.80	-1605.80
CAediting_115374	ENST00000447527.1	chr1_160142658_+	-1583.60	-1579.80	-1605.80
CAediting_115375	ENST00000447527.1	chr1_160142676_+	-1582.80	-1579.80	-1605.80
CAediting_115376	ENST00000447527.1	chr1_160142694_+	-1578.80	-1579.80	-1605.80
CAediting_115377	ENST00000447527.1	chr1_160142698_+	-1579.10	-1579.80	-1605.80
CAediting_115378	ENST00000447527.1	chr1_160142733_+	-1585.90	-1579.80	-1605.80
CAediting_115379	ENST00000447527.1	chr1_160142737_+	-1583.40	-1579.80	-1605.80
CAediting_115380	ENST00000447527.1	chr1_160142785_+	-1584.20	-1579.80	-1605.80
CAediting_115381	ENST00000447527.1	chr1_160142787_+	-1580.70	-1579.80	-1605.80
CAediting_115382	ENST00000447527.1	chr1_160142800_+	-1580.60	-1579.80	-1605.80
CAediting_115383	ENST00000447527.1	chr1_160142957_+	-1583.90	-1579.80	-1605.80
CAediting_115384	ENST00000447527.1	chr1_160143055_+	-1579.50	-1579.80	-1605.80

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Relation with ADAR for ATP1A2

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for ATP1A2

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for ATP1A2

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for ATP1A2

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
ATP1A2	P50993	DB01092	Ouabain	Sodium/potassium-transporting ATPase subunit alpha-2	SmallMoleculeDrug	approved

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RelatedDiseases for ATP1A2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
ATP1A2	C1865322	MIGRAINE, FAMILIAL HEMIPLEGIC, 2	9	CTD_human;GENOMICS_ENGLAND;UNIPROT
ATP1A2	C3549447	ALTERNATING HEMIPLEGIA OF CHILDHOOD 1	4	GENOMICS_ENGLAND;UNIPROT
ATP1A2	C0013421	Dystonia	2	GENOMICS_ENGLAND
ATP1A2	C0020538	Hypertensive disease	2	CTD_human
ATP1A2	C0149931	Migraine Disorders	2	GENOMICS_ENGLAND
ATP1A2	C0003886	Arthrogryposis	1	GENOMICS_ENGLAND
ATP1A2	C0005586	Bipolar Disorder	1	PSYGENET
ATP1A2	C0009421	Comatose	1	GENOMICS_ENGLAND
ATP1A2	C0020305	Hydrops Fetalis	1	GENOMICS_ENGLAND
ATP1A2	C0025958	Microcephaly	1	GENOMICS_ENGLAND
ATP1A2	C0085584	Encephalopathies	1	GENOMICS_ENGLAND
ATP1A2	C0220669	Familial benign neonatal epilepsy	1	GENOMICS_ENGLAND
ATP1A2	C0238358	Hypokalemic periodic paralysis	1	GENOMICS_ENGLAND
ATP1A2	C0270816	epilepsy and migraine	1	GENOMICS_ENGLAND
ATP1A2	C0338488	Alternating hemiplegia of childhood	1	CTD_human;ORPHANET
ATP1A2	C2733158	Cerebral Small Vessel Diseases	1	GENOMICS_ENGLAND

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene