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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: NEK2 (CAeditome ID:4751) |
Gene summary for NEK2 |
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Gene information | Gene symbol | NEK2 | Gene ID | 4751 |
Gene name | NIMA related kinase 2 | |
Synonyms | HsPK21|NEK2A|NLK1|PPP1R111|RP67 | |
Cytomap | 1q32.3 | |
Type of gene | protein-coding | |
Description | serine/threonine-protein kinase Nek2NIMA (never in mitosis gene a)-related kinase 2nimA-like protein kinase 1nimA-related protein kinase 2protein phosphatase 1, regulatory subunit 111 | |
Modification date | 20210519 | |
UniProtAcc | P51955 | |
Context |
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Gene | GO ID | GO term | PubMed ID |
NEK2 | GO:0000776 | Serine/threonine-protein kinase Nek2 | 17621308 |
NEK2 | GO:0004672 | Serine/threonine-protein kinase Nek2 | 10880350 |
NEK2 | GO:0004672 | Serine/threonine-protein kinase Nek2 | 18086858 |
NEK2 | GO:0004672 | Serine/threonine-protein kinase Nek2 | 26220856 |
NEK2 | GO:0006468 | Serine/threonine-protein kinase Nek2 | 21076410 |
NEK2 | GO:0007059 | Serine/threonine-protein kinase Nek2 | 14978040 |
NEK2 | GO:0046777 | Serine/threonine-protein kinase Nek2 | 17626005 |
NEK2 | GO:0051299 | Serine/threonine-protein kinase Nek2 | 18086858 |
NEK2 | GO:0000776 | Serine/threonine-protein kinase Nek2 | 14978040 |
NEK2 | GO:0005654 | Serine/threonine-protein kinase Nek2 | 0000052 |
NEK2 | GO:0005813 | Serine/threonine-protein kinase Nek2 | 0000052 |
NEK2 | GO:0005813 | Serine/threonine-protein kinase Nek2 | 21399614 |
NEK2 | GO:0005813 | Serine/threonine-protein kinase Nek2 | 26220856 |
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RNA A-to-I events for NEK2 |
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CAediting_137150(211664975, -), CAediting_137151(211666687, -), CAediting_137152(211666736, -), CAediting_137153(211666785, -), CAediting_137154(211666807, -), CAediting_137155(211666815, -), |
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RNA editing positional annotations for NEK2 using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
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CAeditome ID | Position | Variant type |
CAediting_137150 | chr1_211664975_- | ncRNA_intronic |
CAediting_137151 | chr1_211666687_- | ncRNA_intronic |
CAediting_137152 | chr1_211666736_- | ncRNA_intronic |
CAediting_137153 | chr1_211666785_- | ncRNA_intronic |
CAediting_137154 | chr1_211666807_- | ncRNA_intronic |
CAediting_137155 | chr1_211666815_- | ncRNA_intronic |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
CAediting_137150 | chr1_211664975_- | SINE | Alu | FAM |
CAediting_137151 | chr1_211666687_- | SINE | Alu | AluY |
CAediting_137152 | chr1_211666736_- | SINE | Alu | AluY |
CAediting_137153 | chr1_211666785_- | SINE | Alu | AluY |
CAediting_137154 | chr1_211666807_- | SINE | Alu | AluY |
CAediting_137155 | chr1_211666815_- | SINE | Alu | AluY |
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RNA A-to-I editing events in the alternative splicing sites for NEK2 |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
IR | CAediting_137154 | chr1_211666807_- | 211666793:211666815 | 3SS | 0+12i | ATTTTTTTATTTTTTTTGAGATG | 3.27 | ATTTTTTTGTTTTTTTTGAGATG | 4.01 |
IR | CAediting_137155 | chr1_211666815_- | 211666793:211666815 | 3SS | 0+20i | ATTTTTTTATTTTTTTTGAGATG | 3.27 | GTTTTTTTATTTTTTTTGAGATG | 3.27 |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for NEK2 |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for NEK2 |
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The effects of the RNA editing to the miRNA binding sites for NEK2 |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_137151 | chr1_211666687_- | ENSG00000117650.11 | ENST00000366998 | hsa-miR-3614-5p | 211666687 | 211666693 | 7mer-m8 | 211666686 | 211666709 | 152.00 | -25.74 |
CAediting_137151 | chr1_211666687_- | ENSG00000117650.11 | ENST00000366998 | hsa-miR-4691-3p | 211666683 | 211666689 | 7mer-m8 | 211666682 | 211666709 | 150.00 | -26.62 |
CAediting_137155 | chr1_211666815_- | ENSG00000117650.11 | ENST00000366998 | hsa-miR-7-1-3p | 211666813 | 211666819 | 7mer-m8 | 211666812 | 211666833 | 142.00 | -3.33 |
CAediting_137155 | chr1_211666815_- | ENSG00000117650.11 | ENST00000366998 | hsa-miR-7-2-3p | 211666813 | 211666819 | 7mer-m8 | 211666812 | 211666833 | 140.00 | -3.33 |
CAediting_137152 | chr1_211666736_- | ENSG00000117650.11 | ENST00000366998 | hsa-miR-17-3p | 211666736 | 211666742 | 7mer-m8 | 211666735 | 211666757 | 153.00 | -18.24 |
CAediting_137152 | chr1_211666736_- | ENSG00000117650.11 | ENST00000366998 | hsa-miR-596 | 211666733 | 211666739 | 7mer-m8 | 211666732 | 211666752 | 140.00 | -18.43 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_137152 | chr1_211666736_- | ENSG00000117650.11 | ENST00000366998 | hsa-miR-4327 | 211666734 | 211666740 | 7mer-m8 | 211666733 | 211666752 | 147 | -17.64 |
CAediting_137152 | chr1_211666736_- | ENSG00000117650.11 | ENST00000366998 | hsa-miR-4538 | 211666733 | 211666738 | 6mer | 211666732 | 211666754 | 143 | -27.8 |
CAediting_137153 | chr1_211666785_- | ENSG00000117650.11 | ENST00000366998 | hsa-miR-5586-3p | 211666781 | 211666787 | 7mer-m8 | 211666780 | 211666801 | 148 | -14.57 |
CAediting_137151 | chr1_211666687_- | ENSG00000117650.11 | ENST00000366998 | hsa-miR-5690 | 211666683 | 211666689 | 7mer-m8 | 211666682 | 211666702 | 145 | -16.74 |
CAediting_137152 | chr1_211666736_- | ENSG00000117650.11 | ENST00000366998 | hsa-miR-6516-5p | 211666736 | 211666742 | 7mer-m8 | 211666735 | 211666760 | 147 | -17.86 |
CAediting_137153 | chr1_211666785_- | ENSG00000117650.11 | ENST00000366998 | hsa-miR-759 | 211666780 | 211666786 | 7mer-m8 | 211666779 | 211666801 | 147 | -13.06 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_524911 | chr7_5495852_- | ENSG00000117650.11 | ENST00000366999 | hsa-miR-589-3p | 211662914 | 211662920 | 7mer-m8 | 211662913 | 211662936 | 146 | -13.09 |
CAediting_77128 | chr1_85133844_+ | ENSG00000117650.11 | ENST00000366998 | hsa-miR-4423-3p | 211666522 | 211666528 | 7mer-m8 | 211666521 | 211666541 | 140 | -12.74 |
CAediting_580943 | chr7_100356700_+ | ENSG00000117650.11 | ENST00000366998 | hsa-miR-6840-3p | 211666721 | 211666727 | 7mer-m8 | 211666720 | 211666741 | 144 | -24.97 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_1229415 | chr17_67471547_+ | ENSG00000117650.11 | ENST00000366999 | hsa-miR-548aa | 211663281 | 211663288 | 8mer-1a | 211663281 | 211663311 | 144 | -8.27 |
CAediting_580943 | chr7_100356700_+ | ENSG00000117650.11 | ENST00000366998 | hsa-miR-6840-3p | 211666920 | 211666926 | 7mer-m8 | 211666919 | 211666940 | 140 | -17.91 |
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The effects of the RNA editing to the stability of the RNA structures for NEK2 |
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ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
ENST00000366998.4 | protein_coding | ![]() | ![]() |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
CAediting_137151 | ENST00000366998.4 | chr1_211666687_- | -540.50 | -536.40 | -547.90 |
CAediting_137152 | ENST00000366998.4 | chr1_211666736_- | -537.90 | -536.40 | -547.90 |
CAediting_137153 | ENST00000366998.4 | chr1_211666785_- | -540.50 | -536.40 | -547.90 |
CAediting_137154 | ENST00000366998.4 | chr1_211666807_- | -537.50 | -536.40 | -547.90 |
CAediting_137155 | ENST00000366998.4 | chr1_211666815_- | -538.50 | -536.40 | -547.90 |
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Relation with ADAR for NEK2 |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for NEK2 |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for NEK2 |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for NEK2 |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
NEK2 | P51955 | DB12010 | Fostamatinib | Serine/threonine-protein kinase Nek2 | SmallMoleculeDrug | approved|investigational |
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RelatedDiseases for NEK2 |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
NEK2 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
NEK2 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
NEK2 | C0035334 | Retinitis Pigmentosa | 1 | ORPHANET |
NEK2 | C2239176 | Liver carcinoma | 1 | CTD_human |