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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: NEFL (CAeditome ID:4747) |
Gene summary for NEFL |
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Gene information | Gene symbol | NEFL | Gene ID | 4747 |
Gene name | neurofilament light chain | |
Synonyms | CMT1F|CMT2E|CMTDIG|NF-L|NF68|NFL|PPP1R110 | |
Cytomap | 8p21.2 | |
Type of gene | protein-coding | |
Description | neurofilament light polypeptidelight molecular weight neurofilament proteinneurofilament protein, light chainneurofilament subunit NF-Lneurofilament triplet L proteinneurofilament, light polypeptide 68kDaprotein phosphatase 1, regulatory subunit 110 | |
Modification date | 20210518 | |
UniProtAcc | P07196 | |
Context |
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Gene | GO ID | GO term | PubMed ID |
NEFL | GO:0005200 | Neurofilament light polypeptide | 12432080 |
NEFL | GO:0033693 | Neurofilament light polypeptide | 12432080 |
NEFL | GO:0005883 | Neurofilament light polypeptide | 15857389 |
NEFL | GO:0030424 | Neurofilament light polypeptide | 14662745 |
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RNA A-to-I events for NEFL |
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CAediting_623498(24956265, -), |
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RNA editing positional annotations for NEFL using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
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CAeditome ID | Position | Variant type |
CAediting_623498 | chr8_24956265_- | exonic |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
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RNA A-to-I editing events in the alternative splicing sites for NEFL |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for NEFL |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for NEFL |
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The effects of the RNA editing to the miRNA binding sites for NEFL |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_1229415 | chr17_67471547_+ | ENSG00000277586.1 | ENST00000610854 | hsa-miR-548aa | 24952602 | 24952608 | 7mer-m8 | 24952601 | 24952625 | 145 | -15.33 |
CAediting_1351755 | chr19_40282625_- | ENSG00000277586.1 | ENST00000610854 | hsa-miR-641 | 24951563 | 24951569 | 7mer-m8 | 24951562 | 24951587 | 159 | -19.44 |
CAediting_396018 | chr5_1062918_- | ENSG00000277586.1 | ENST00000610854 | hsa-miR-4635 | 24951691 | 24951697 | 7mer-m8 | 24951690 | 24951712 | 153 | -22.54 |
CAediting_524911 | chr7_5495852_- | ENSG00000277586.1 | ENST00000610854 | hsa-miR-589-3p | 24951571 | 24951577 | 7mer-m8 | 24951570 | 24951592 | 155 | -15.79 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_117844 | chr1_162342605_+ | ENSG00000277586.1 | ENST00000610854 | hsa-miR-556-3p | 24951600 | 24951606 | 7mer-m8 | 24951599 | 24951619 | 144 | -14.23 |
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The effects of the RNA editing to the stability of the RNA structures for NEFL |
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ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
ENST00000610854.1 | protein_coding | ![]() | ![]() |
ENST00000615973.1 | retained_intron | ![]() | ![]() |
ENST00000619417.1 | protein_coding | ![]() | ![]() |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
CAediting_623498 | ENST00000610854.1 | chr8_24956265_- | -1289.80 | -1283.20 | -1289.80 |
CAediting_623498 | ENST00000615973.1 | chr8_24956265_- | -672.60 | -666.00 | -672.60 |
CAediting_623498 | ENST00000619417.1 | chr8_24956265_- | -641.10 | -634.50 | -641.10 |
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Relation with ADAR for NEFL |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for NEFL |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for NEFL |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for NEFL |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NEFL |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
NEFL | C1843225 | CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2E (disorder) | 8 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
NEFL | C4693509 | CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE G | 6 | GENOMICS_ENGLAND;UNIPROT |
NEFL | C1843164 | Charcot-Marie-Tooth disease, demyelinating, Type 1F | 4 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
NEFL | C0005586 | Bipolar Disorder | 3 | PSYGENET |
NEFL | C0036341 | Schizophrenia | 2 | PSYGENET |
NEFL | C0041696 | Unipolar Depression | 2 | PSYGENET |
NEFL | C1269683 | Major Depressive Disorder | 2 | PSYGENET |
NEFL | C0206157 | Myopathies, Nemaline | 1 | GENOMICS_ENGLAND |
NEFL | C4749824 | Charcot-Marie-Tooth disease type 2B5 | 1 | ORPHANET |