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Editing gene: NDUFV2 (CAeditome ID:4729)

Gene summary for NDUFV2

Gene summary

Gene information	Gene symbol	NDUFV2
	Gene ID	4729
	Gene name	NADH:ubiquinone oxidoreductase core subunit V2
	Synonyms	CI-24k\|MC1DN7
	Cytomap	18p11.22
	Type of gene	protein-coding
	Description	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialNADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDaNADH dehydrogenase ubiquinone flavoprotein 2, mitochondrialNADH-ubiquinone oxidoreductase 24 kDa subunitNADH-ubiquinone oxidoreductase fl
	Modification date	20210518
	UniProtAcc	P19404
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
NDUFV2	GO:0005654	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	0000052
NDUFV2	GO:0005739	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	0000052
NDUFV2	GO:0005739	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	12754703
NDUFV2	GO:0005829	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	0000052
NDUFV2	GO:0005747	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	12611891

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RNA A-to-I events for NDUFV2

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000178127.11

RNA A-to-I editing events in Cancer.

CAediting_1252186(9108755, +), CAediting_1252187(9110528, +), CAediting_1252188(9110530, +), CAediting_1252189(9110532, +), CAediting_1252190(9110608, +), CAediting_1252191(9110620, +), CAediting_1252192(9110634, +), CAediting_1252193(9110647, +), CAediting_1252194(9110649, +), CAediting_1252195(9110691, +), CAediting_1252196(9110697, +), CAediting_1252197(9110770, +), CAediting_1252198(9111396, +), CAediting_1252199(9111397, +), CAediting_1252200(9111400, +), CAediting_1252201(9111403, +), CAediting_1252202(9111405, +), CAediting_1252203(9111408, +), CAediting_1252204(9111409, +), CAediting_1252205(9111450, +), CAediting_1252206(9111452, +), CAediting_1252207(9111460, +), CAediting_1252208(9111546, +), CAediting_1252209(9111558, +), CAediting_1252210(9111568, +), CAediting_1252211(9111638, +), CAediting_1252212(9111732, +), CAediting_1252213(9111744, +), CAediting_1252214(9111765, +), CAediting_1252215(9111779, +), CAediting_1252216(9111793, +), CAediting_1252217(9111796, +), CAediting_1252218(9111797, +), CAediting_1252219(9111800, +), CAediting_1252220(9111803, +), CAediting_1252221(9111804, +), CAediting_1252222(9111805, +), CAediting_1252223(9111814, +), CAediting_1252224(9111821, +), CAediting_1252225(9111828, +), CAediting_1252226(9111832, +), CAediting_1252227(9111842, +), CAediting_1252228(9111855, +), CAediting_1252229(9111857, +), CAediting_1252230(9111859, +), CAediting_1252231(9111862, +), CAediting_1252232(9111864, +), CAediting_1252233(9111868, +), CAediting_1252234(9111873, +), CAediting_1252235(9111875, +), CAediting_1252236(9111878, +), CAediting_1252237(9111882, +), CAediting_1252238(9111883, +), CAediting_1252239(9111885, +), CAediting_1252240(9111889, +), CAediting_1252241(9111893, +), CAediting_1252242(9111898, +), CAediting_1252243(9117058, +), CAediting_1252244(9117117, +), CAediting_1252245(9117130, +), CAediting_1252246(9117136, +), CAediting_1252247(9117166, +), CAediting_1252248(9117176, +), CAediting_1252249(9117198, +), CAediting_1252250(9117217, +), CAediting_1252251(9117220, +), CAediting_1252252(9117222, +), CAediting_1252253(9117237, +), CAediting_1252254(9117296, +), CAediting_1252255(9117319, +),

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RNA editing positional annotations for NDUFV2 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1252186	chr18_9108755_+	ncRNA_intronic
CAediting_1252187	chr18_9110528_+	ncRNA_intronic
CAediting_1252188	chr18_9110530_+	ncRNA_intronic
CAediting_1252189	chr18_9110532_+	ncRNA_intronic
CAediting_1252190	chr18_9110608_+	ncRNA_intronic
CAediting_1252191	chr18_9110620_+	ncRNA_intronic
CAediting_1252192	chr18_9110634_+	ncRNA_intronic
CAediting_1252193	chr18_9110647_+	ncRNA_intronic
CAediting_1252194	chr18_9110649_+	ncRNA_intronic
CAediting_1252195	chr18_9110691_+	ncRNA_intronic
CAediting_1252196	chr18_9110697_+	ncRNA_intronic
CAediting_1252197	chr18_9110770_+	ncRNA_intronic
CAediting_1252198	chr18_9111396_+	ncRNA_intronic
CAediting_1252199	chr18_9111397_+	ncRNA_intronic
CAediting_1252200	chr18_9111400_+	ncRNA_intronic
CAediting_1252201	chr18_9111403_+	ncRNA_intronic
CAediting_1252202	chr18_9111405_+	ncRNA_intronic
CAediting_1252203	chr18_9111408_+	ncRNA_intronic
CAediting_1252204	chr18_9111409_+	ncRNA_intronic
CAediting_1252205	chr18_9111450_+	ncRNA_intronic
CAediting_1252206	chr18_9111452_+	ncRNA_intronic
CAediting_1252207	chr18_9111460_+	ncRNA_intronic
CAediting_1252208	chr18_9111546_+	ncRNA_intronic
CAediting_1252209	chr18_9111558_+	ncRNA_intronic
CAediting_1252210	chr18_9111568_+	ncRNA_intronic
CAediting_1252211	chr18_9111638_+	ncRNA_intronic
CAediting_1252212	chr18_9111732_+	ncRNA_intronic
CAediting_1252213	chr18_9111744_+	ncRNA_intronic
CAediting_1252214	chr18_9111765_+	ncRNA_intronic
CAediting_1252215	chr18_9111779_+	ncRNA_intronic
CAediting_1252216	chr18_9111793_+	ncRNA_intronic
CAediting_1252217	chr18_9111796_+	ncRNA_intronic
CAediting_1252218	chr18_9111797_+	ncRNA_intronic
CAediting_1252219	chr18_9111800_+	ncRNA_intronic
CAediting_1252220	chr18_9111803_+	ncRNA_intronic
CAediting_1252221	chr18_9111804_+	ncRNA_intronic
CAediting_1252222	chr18_9111805_+	ncRNA_intronic
CAediting_1252223	chr18_9111814_+	ncRNA_intronic
CAediting_1252224	chr18_9111821_+	ncRNA_intronic
CAediting_1252225	chr18_9111828_+	ncRNA_intronic
CAediting_1252226	chr18_9111832_+	ncRNA_intronic
CAediting_1252227	chr18_9111842_+	ncRNA_intronic
CAediting_1252228	chr18_9111855_+	ncRNA_intronic
CAediting_1252229	chr18_9111857_+	ncRNA_intronic
CAediting_1252230	chr18_9111859_+	ncRNA_intronic
CAediting_1252231	chr18_9111862_+	ncRNA_intronic
CAediting_1252232	chr18_9111864_+	ncRNA_intronic
CAediting_1252233	chr18_9111868_+	ncRNA_intronic
CAediting_1252234	chr18_9111873_+	ncRNA_intronic
CAediting_1252235	chr18_9111875_+	ncRNA_intronic
CAediting_1252236	chr18_9111878_+	ncRNA_intronic
CAediting_1252237	chr18_9111882_+	ncRNA_intronic
CAediting_1252238	chr18_9111883_+	ncRNA_intronic
CAediting_1252239	chr18_9111885_+	ncRNA_intronic
CAediting_1252240	chr18_9111889_+	ncRNA_intronic
CAediting_1252241	chr18_9111893_+	ncRNA_intronic
CAediting_1252242	chr18_9111898_+	ncRNA_intronic
CAediting_1252243	chr18_9117058_+	ncRNA_intronic
CAediting_1252244	chr18_9117117_+	ncRNA_intronic
CAediting_1252245	chr18_9117130_+	ncRNA_intronic
CAediting_1252246	chr18_9117136_+	ncRNA_intronic
CAediting_1252247	chr18_9117166_+	ncRNA_intronic
CAediting_1252248	chr18_9117176_+	ncRNA_intronic
CAediting_1252249	chr18_9117198_+	ncRNA_intronic
CAediting_1252250	chr18_9117217_+	ncRNA_intronic
CAediting_1252251	chr18_9117220_+	ncRNA_intronic
CAediting_1252252	chr18_9117222_+	ncRNA_intronic
CAediting_1252253	chr18_9117237_+	ncRNA_intronic
CAediting_1252254	chr18_9117296_+	ncRNA_intronic
CAediting_1252255	chr18_9117319_+	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1252186	chr18_9108755_+	SINE	Alu	AluSz
CAediting_1252187	chr18_9110528_+	SINE	Alu	AluJb
CAediting_1252188	chr18_9110530_+	SINE	Alu	AluJb
CAediting_1252189	chr18_9110532_+	SINE	Alu	AluJb
CAediting_1252190	chr18_9110608_+	SINE	Alu	AluJb
CAediting_1252191	chr18_9110620_+	SINE	Alu	AluJb
CAediting_1252192	chr18_9110634_+	SINE	Alu	AluJb
CAediting_1252193	chr18_9110647_+	SINE	Alu	AluJb
CAediting_1252194	chr18_9110649_+	SINE	Alu	AluJb
CAediting_1252195	chr18_9110691_+	SINE	Alu	AluJb
CAediting_1252196	chr18_9110697_+	SINE	Alu	AluJb
CAediting_1252197	chr18_9110770_+	SINE	Alu	AluJb
CAediting_1252198	chr18_9111396_+	SINE	MIR	MIR
CAediting_1252199	chr18_9111397_+	SINE	MIR	MIR
CAediting_1252200	chr18_9111400_+	SINE	MIR	MIR
CAediting_1252201	chr18_9111403_+	SINE	MIR	MIR
CAediting_1252202	chr18_9111405_+	SINE	MIR	MIR
CAediting_1252203	chr18_9111408_+	SINE	MIR	MIR
CAediting_1252204	chr18_9111409_+	SINE	MIR	MIR
CAediting_1252205	chr18_9111450_+	SINE	Alu	AluSx
CAediting_1252206	chr18_9111452_+	SINE	Alu	AluSx
CAediting_1252207	chr18_9111460_+	SINE	Alu	AluSx
CAediting_1252208	chr18_9111546_+	SINE	Alu	AluSx
CAediting_1252209	chr18_9111558_+	SINE	Alu	AluSx
CAediting_1252210	chr18_9111568_+	SINE	Alu	AluSx
CAediting_1252211	chr18_9111638_+	SINE	Alu	AluSx
CAediting_1252212	chr18_9111732_+	SINE	MIR	MIR
CAediting_1252213	chr18_9111744_+	SINE	MIR	MIR
CAediting_1252214	chr18_9111765_+	SINE	MIR	MIR
CAediting_1252215	chr18_9111779_+	SINE	MIR	MIR
CAediting_1252216	chr18_9111793_+	SINE	MIR	MIR
CAediting_1252217	chr18_9111796_+	SINE	MIR	MIR
CAediting_1252218	chr18_9111797_+	SINE	MIR	MIR
CAediting_1252219	chr18_9111800_+	SINE	MIR	MIR
CAediting_1252220	chr18_9111803_+	SINE	MIR	MIR
CAediting_1252221	chr18_9111804_+	SINE	MIR	MIR
CAediting_1252222	chr18_9111805_+	SINE	MIR	MIR
CAediting_1252223	chr18_9111814_+	SINE	MIR	MIR
CAediting_1252224	chr18_9111821_+	SINE	MIR	MIR
CAediting_1252225	chr18_9111828_+	SINE	MIR	MIR
CAediting_1252226	chr18_9111832_+	SINE	MIR	MIR
CAediting_1252227	chr18_9111842_+	SINE	MIR	MIR
CAediting_1252243	chr18_9117058_+	SINE	Alu	AluSc
CAediting_1252244	chr18_9117117_+	SINE	Alu	AluSc
CAediting_1252245	chr18_9117130_+	SINE	Alu	AluSc
CAediting_1252246	chr18_9117136_+	SINE	Alu	AluSc
CAediting_1252247	chr18_9117166_+	SINE	Alu	AluSc
CAediting_1252248	chr18_9117176_+	SINE	Alu	AluSc
CAediting_1252249	chr18_9117198_+	SINE	Alu	AluSc
CAediting_1252250	chr18_9117217_+	SINE	Alu	AluSc
CAediting_1252251	chr18_9117220_+	SINE	Alu	AluSc
CAediting_1252252	chr18_9117222_+	SINE	Alu	AluSc
CAediting_1252253	chr18_9117237_+	SINE	Alu	AluSc
CAediting_1252254	chr18_9117296_+	SINE	Alu	AluSc
CAediting_1252255	chr18_9117319_+	SINE	Alu	AluSc

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RNA A-to-I editing events in the alternative splicing sites for NDUFV2

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000178127.11.NDUFV2.

Correlation between RNA A-to-I editing and PSI for ENSG00000178127.11.NDUFV2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for NDUFV2

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for NDUFV2

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for NDUFV2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1306323	chr19_13836462_-	ENSG00000178127.11	ENST00000577703	hsa-miR-27a-3p	9102959	9102965	7mer-m8	9102946	9102966	150	-21.98
CAediting_524911	chr7_5495852_-	ENSG00000178127.11	ENST00000577703	hsa-miR-589-3p	9103106	9103112	7mer-m8	9103090	9103113	147	-20.52

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for NDUFV2

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for NDUFV2

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
LAML	CAediting_1252233	chr18_9111868_+	.	.	.	.	0.0377155777491389	0.2544535569372
LAML	CAediting_1252236	chr18_9111878_+	0.0197576199534812	0.297798351420377	.	.	.	.

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Relation with cancer stages for NDUFV2

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for NDUFV2

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for NDUFV2

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
NDUFV2	P19404	DB00157	NADH	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	SmallMoleculeDrug	approved\|nutraceutical

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RelatedDiseases for NDUFV2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
NDUFV2	C0005586	Bipolar Disorder	5	CTD_human;PSYGENET
NDUFV2	C1838979	MITOCHONDRIAL COMPLEX I DEFICIENCY	4	GENOMICS_ENGLAND;ORPHANET
NDUFV2	C0023264	Leigh Disease	2	CLINGEN
NDUFV2	C1838951	LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY	2	CLINGEN
NDUFV2	C1850597	Leigh Syndrome Due To Mitochondrial Complex II Deficiency	2	CLINGEN
NDUFV2	C1850598	Leigh Syndrome due to Mitochondrial Complex III Deficiency	2	CLINGEN
NDUFV2	C1850599	Leigh Syndrome due to Mitochondrial Complex IV Deficiency	2	CLINGEN
NDUFV2	C1850600	Leigh Syndrome due to Mitochondrial Complex V Deficiency	2	CLINGEN
NDUFV2	C2931891	Necrotizing encephalopathy, infantile subacute, of Leigh	2	CLINGEN
NDUFV2	C0005587	Depression, Bipolar	1	CTD_human
NDUFV2	C0024713	Manic Disorder	1	CTD_human
NDUFV2	C0033141	Cardiomyopathies, Primary	1	CTD_human
NDUFV2	C0036341	Schizophrenia	1	CTD_human
NDUFV2	C0036529	Myocardial Diseases, Secondary	1	CTD_human
NDUFV2	C0041696	Unipolar Depression	1	PSYGENET
NDUFV2	C0162666	Mitochondrial Encephalomyopathies	1	CTD_human
NDUFV2	C0338831	Manic	1	CTD_human
NDUFV2	C0878544	Cardiomyopathies	1	CTD_human
NDUFV2	C1269683	Major Depressive Disorder	1	PSYGENET

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene