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Editing gene: NDUFS2 (CAeditome ID:4720)

Gene summary for NDUFS2

Gene summary

Gene information	Gene symbol	NDUFS2
	Gene ID	4720
	Gene name	NADH:ubiquinone oxidoreductase core subunit S2
	Synonyms	CI-49\|MC1DN6
	Cytomap	1q23.3
	Type of gene	protein-coding
	Description	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialCI-49kDNADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)NADH-ubiquinone oxidoreductase 49 kDa subunitNADH-ubiquinone oxidoreductase NDUFS2 subunitcomp
	Modification date	20210518
	UniProtAcc	O75306
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
NDUFS2	GO:0006979	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	12857734
NDUFS2	GO:0005654	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	0000052
NDUFS2	GO:0005739	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	0000052
NDUFS2	GO:0005739	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	9585441
NDUFS2	GO:0005747	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	12611891
NDUFS2	GO:0005747	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	17209039

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RNA A-to-I events for NDUFS2

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000158864.11

RNA A-to-I editing events in Cancer.

CAediting_117068(161203156, +), CAediting_117069(161203695, +), CAediting_117070(161203700, +), CAediting_117071(161207490, +), CAediting_117072(161207598, +), CAediting_117073(161207600, +), CAediting_117074(161207601, +), CAediting_117075(161207603, +), CAediting_117076(161207607, +), CAediting_117077(161207647, +), CAediting_117078(161207659, +), CAediting_117079(161207677, +), CAediting_117080(161207716, +), CAediting_117081(161207916, +), CAediting_117082(161208349, +), CAediting_117083(161210893, +), CAediting_117084(161210930, +), CAediting_117085(161210955, +), CAediting_117086(161210975, +), CAediting_117087(161210992, +), CAediting_117088(161211004, +), CAediting_117089(161211014, +), CAediting_117090(161211016, +), CAediting_117091(161211023, +), CAediting_117092(161211055, +), CAediting_117093(161211058, +), CAediting_117094(161211060, +), CAediting_117095(161211095, +), CAediting_117096(161211096, +), CAediting_117097(161211109, +), CAediting_117098(161211118, +), CAediting_117099(161211135, +), CAediting_117100(161211137, +), CAediting_117101(161211371, +), CAediting_117102(161211385, +), CAediting_117103(161211399, +), CAediting_117104(161211410, +), CAediting_117105(161211415, +), CAediting_117106(161211416, +), CAediting_117107(161211447, +), CAediting_117108(161211472, +), CAediting_117109(161211473, +), CAediting_117110(161211493, +), CAediting_117111(161211496, +), CAediting_117112(161211497, +), CAediting_117113(161211498, +), CAediting_117114(161211500, +), CAediting_117115(161211503, +), CAediting_117116(161211529, +), CAediting_117117(161211530, +), CAediting_117118(161211535, +), CAediting_117119(161211539, +), CAediting_117120(161211546, +), CAediting_117121(161211552, +), CAediting_117122(161211556, +), CAediting_117123(161211570, +), CAediting_117124(161211571, +), CAediting_117125(161211575, +), CAediting_117126(161211578, +), CAediting_117127(161211583, +), CAediting_117128(161211584, +), CAediting_117129(161211595, +), CAediting_117130(161211632, +), CAediting_117131(161211634, +), CAediting_117132(161211951, +), CAediting_117133(161211957, +), CAediting_117134(161211959, +), CAediting_117135(161211960, +), CAediting_117136(161211981, +), CAediting_117137(161211982, +), CAediting_117138(161211983, +), CAediting_117139(161211986, +), CAediting_117140(161212031, +), CAediting_117141(161212032, +), CAediting_117142(161212085, +), CAediting_117143(161212089, +), CAediting_117144(161212094, +), CAediting_117145(161212120, +), CAediting_117146(161212125, +), CAediting_117147(161212131, +), CAediting_117148(161213034, +), CAediting_117149(161213155, +), CAediting_117150(161213180, +),

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RNA editing positional annotations for NDUFS2 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_117068	chr1_161203156_+	ncRNA_intronic
CAediting_117069	chr1_161203695_+	ncRNA_exonic
CAediting_117070	chr1_161203700_+	ncRNA_exonic
CAediting_117071	chr1_161207490_+	ncRNA_intronic
CAediting_117072	chr1_161207598_+	ncRNA_intronic
CAediting_117073	chr1_161207600_+	ncRNA_intronic
CAediting_117074	chr1_161207601_+	ncRNA_intronic
CAediting_117075	chr1_161207603_+	ncRNA_intronic
CAediting_117076	chr1_161207607_+	ncRNA_intronic
CAediting_117077	chr1_161207647_+	ncRNA_intronic
CAediting_117078	chr1_161207659_+	ncRNA_intronic
CAediting_117079	chr1_161207677_+	ncRNA_intronic
CAediting_117080	chr1_161207716_+	ncRNA_intronic
CAediting_117081	chr1_161207916_+	ncRNA_intronic
CAediting_117082	chr1_161208349_+	ncRNA_intronic
CAediting_117083	chr1_161210893_+	ncRNA_intronic
CAediting_117084	chr1_161210930_+	ncRNA_intronic
CAediting_117085	chr1_161210955_+	ncRNA_intronic
CAediting_117086	chr1_161210975_+	ncRNA_intronic
CAediting_117087	chr1_161210992_+	ncRNA_intronic
CAediting_117088	chr1_161211004_+	ncRNA_intronic
CAediting_117089	chr1_161211014_+	ncRNA_intronic
CAediting_117090	chr1_161211016_+	ncRNA_intronic
CAediting_117091	chr1_161211023_+	ncRNA_intronic
CAediting_117092	chr1_161211055_+	ncRNA_intronic
CAediting_117093	chr1_161211058_+	ncRNA_intronic
CAediting_117094	chr1_161211060_+	ncRNA_intronic
CAediting_117095	chr1_161211095_+	ncRNA_intronic
CAediting_117096	chr1_161211096_+	ncRNA_intronic
CAediting_117097	chr1_161211109_+	ncRNA_intronic
CAediting_117098	chr1_161211118_+	ncRNA_intronic
CAediting_117099	chr1_161211135_+	ncRNA_intronic
CAediting_117100	chr1_161211137_+	ncRNA_intronic
CAediting_117101	chr1_161211371_+	ncRNA_intronic
CAediting_117102	chr1_161211385_+	ncRNA_intronic
CAediting_117103	chr1_161211399_+	ncRNA_intronic
CAediting_117104	chr1_161211410_+	ncRNA_intronic
CAediting_117105	chr1_161211415_+	ncRNA_intronic
CAediting_117106	chr1_161211416_+	ncRNA_intronic
CAediting_117107	chr1_161211447_+	ncRNA_intronic
CAediting_117108	chr1_161211472_+	ncRNA_intronic
CAediting_117109	chr1_161211473_+	ncRNA_intronic
CAediting_117110	chr1_161211493_+	ncRNA_intronic
CAediting_117111	chr1_161211496_+	ncRNA_intronic
CAediting_117112	chr1_161211497_+	ncRNA_intronic
CAediting_117113	chr1_161211498_+	ncRNA_intronic
CAediting_117114	chr1_161211500_+	ncRNA_intronic
CAediting_117115	chr1_161211503_+	ncRNA_intronic
CAediting_117116	chr1_161211529_+	ncRNA_intronic
CAediting_117117	chr1_161211530_+	ncRNA_intronic
CAediting_117118	chr1_161211535_+	ncRNA_intronic
CAediting_117119	chr1_161211539_+	ncRNA_intronic
CAediting_117120	chr1_161211546_+	ncRNA_intronic
CAediting_117121	chr1_161211552_+	ncRNA_intronic
CAediting_117122	chr1_161211556_+	ncRNA_intronic
CAediting_117123	chr1_161211570_+	ncRNA_intronic
CAediting_117124	chr1_161211571_+	ncRNA_intronic
CAediting_117125	chr1_161211575_+	ncRNA_intronic
CAediting_117126	chr1_161211578_+	ncRNA_intronic
CAediting_117127	chr1_161211583_+	ncRNA_intronic
CAediting_117128	chr1_161211584_+	ncRNA_intronic
CAediting_117129	chr1_161211595_+	ncRNA_intronic
CAediting_117130	chr1_161211632_+	ncRNA_intronic
CAediting_117131	chr1_161211634_+	ncRNA_intronic
CAediting_117132	chr1_161211951_+	ncRNA_intronic
CAediting_117133	chr1_161211957_+	ncRNA_intronic
CAediting_117134	chr1_161211959_+	ncRNA_intronic
CAediting_117135	chr1_161211960_+	ncRNA_intronic
CAediting_117136	chr1_161211981_+	ncRNA_intronic
CAediting_117137	chr1_161211982_+	ncRNA_intronic
CAediting_117138	chr1_161211983_+	ncRNA_intronic
CAediting_117139	chr1_161211986_+	ncRNA_intronic
CAediting_117140	chr1_161212031_+	ncRNA_intronic
CAediting_117141	chr1_161212032_+	ncRNA_intronic
CAediting_117142	chr1_161212085_+	ncRNA_intronic
CAediting_117143	chr1_161212089_+	ncRNA_intronic
CAediting_117144	chr1_161212094_+	ncRNA_intronic
CAediting_117145	chr1_161212120_+	ncRNA_intronic
CAediting_117146	chr1_161212125_+	ncRNA_intronic
CAediting_117147	chr1_161212131_+	ncRNA_intronic
CAediting_117148	chr1_161213034_+	ncRNA_intronic
CAediting_117149	chr1_161213155_+	ncRNA_exonic
CAediting_117150	chr1_161213180_+	ncRNA_exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_117068	chr1_161203156_+	SINE	Alu	AluSp
CAediting_117069	chr1_161203695_+	SINE	Alu	AluJr4
CAediting_117070	chr1_161203700_+	SINE	Alu	AluJr4
CAediting_117071	chr1_161207490_+	SINE	Alu	AluSz
CAediting_117072	chr1_161207598_+	SINE	Alu	AluSz
CAediting_117073	chr1_161207600_+	SINE	Alu	AluSz
CAediting_117074	chr1_161207601_+	SINE	Alu	AluSz
CAediting_117075	chr1_161207603_+	SINE	Alu	AluSz
CAediting_117076	chr1_161207607_+	SINE	Alu	AluSz
CAediting_117077	chr1_161207647_+	SINE	Alu	AluSz
CAediting_117078	chr1_161207659_+	SINE	Alu	AluSz
CAediting_117079	chr1_161207677_+	SINE	Alu	AluSz
CAediting_117080	chr1_161207716_+	SINE	Alu	AluSz
CAediting_117081	chr1_161207916_+	SINE	Alu	AluSx
CAediting_117082	chr1_161208349_+	SINE	Alu	AluSp
CAediting_117083	chr1_161210893_+	SINE	Alu	AluSp
CAediting_117084	chr1_161210930_+	SINE	Alu	AluSp
CAediting_117085	chr1_161210955_+	SINE	Alu	AluSp
CAediting_117086	chr1_161210975_+	SINE	Alu	AluSp
CAediting_117087	chr1_161210992_+	SINE	Alu	AluSp
CAediting_117088	chr1_161211004_+	SINE	Alu	AluSp
CAediting_117089	chr1_161211014_+	SINE	Alu	AluSp
CAediting_117090	chr1_161211016_+	SINE	Alu	AluSp
CAediting_117091	chr1_161211023_+	SINE	Alu	AluSp
CAediting_117092	chr1_161211055_+	SINE	Alu	AluSp
CAediting_117093	chr1_161211058_+	SINE	Alu	AluSp
CAediting_117094	chr1_161211060_+	SINE	Alu	AluSp
CAediting_117095	chr1_161211095_+	SINE	Alu	AluSp
CAediting_117096	chr1_161211096_+	SINE	Alu	AluSp
CAediting_117097	chr1_161211109_+	SINE	Alu	AluSp
CAediting_117098	chr1_161211118_+	SINE	Alu	AluSp
CAediting_117099	chr1_161211135_+	SINE	Alu	AluSp
CAediting_117100	chr1_161211137_+	SINE	Alu	AluSp
CAediting_117101	chr1_161211371_+	SINE	Alu	AluSz
CAediting_117102	chr1_161211385_+	SINE	Alu	AluSz
CAediting_117103	chr1_161211399_+	SINE	Alu	AluSz
CAediting_117104	chr1_161211410_+	SINE	Alu	AluSz
CAediting_117105	chr1_161211415_+	SINE	Alu	AluSz
CAediting_117106	chr1_161211416_+	SINE	Alu	AluSz
CAediting_117107	chr1_161211447_+	SINE	Alu	AluSz
CAediting_117108	chr1_161211472_+	SINE	Alu	AluSz
CAediting_117109	chr1_161211473_+	SINE	Alu	AluSz
CAediting_117110	chr1_161211493_+	SINE	Alu	AluSz
CAediting_117111	chr1_161211496_+	SINE	Alu	AluSz
CAediting_117112	chr1_161211497_+	SINE	Alu	AluSz
CAediting_117113	chr1_161211498_+	SINE	Alu	AluSz
CAediting_117114	chr1_161211500_+	SINE	Alu	AluSz
CAediting_117115	chr1_161211503_+	SINE	Alu	AluSz
CAediting_117116	chr1_161211529_+	SINE	Alu	AluSz
CAediting_117117	chr1_161211530_+	SINE	Alu	AluSz
CAediting_117118	chr1_161211535_+	SINE	Alu	AluSz
CAediting_117119	chr1_161211539_+	SINE	Alu	AluSz
CAediting_117120	chr1_161211546_+	SINE	Alu	AluSz
CAediting_117121	chr1_161211552_+	SINE	Alu	AluSz
CAediting_117122	chr1_161211556_+	SINE	Alu	AluSz
CAediting_117123	chr1_161211570_+	SINE	Alu	AluSz
CAediting_117124	chr1_161211571_+	SINE	Alu	AluSz
CAediting_117125	chr1_161211575_+	SINE	Alu	AluSz
CAediting_117126	chr1_161211578_+	SINE	Alu	AluSz
CAediting_117127	chr1_161211583_+	SINE	Alu	AluSz
CAediting_117128	chr1_161211584_+	SINE	Alu	AluSz
CAediting_117129	chr1_161211595_+	SINE	Alu	AluSz
CAediting_117130	chr1_161211632_+	SINE	Alu	AluSz
CAediting_117131	chr1_161211634_+	SINE	Alu	AluSz
CAediting_117132	chr1_161211951_+	SINE	Alu	AluJr
CAediting_117133	chr1_161211957_+	SINE	Alu	AluJr
CAediting_117134	chr1_161211959_+	SINE	Alu	AluJr
CAediting_117135	chr1_161211960_+	SINE	Alu	AluJr
CAediting_117136	chr1_161211981_+	SINE	Alu	AluJr
CAediting_117137	chr1_161211982_+	SINE	Alu	AluJr
CAediting_117138	chr1_161211983_+	SINE	Alu	AluJr
CAediting_117139	chr1_161211986_+	SINE	Alu	AluJr
CAediting_117140	chr1_161212031_+	SINE	Alu	AluJr
CAediting_117141	chr1_161212032_+	SINE	Alu	AluJr
CAediting_117142	chr1_161212085_+	SINE	Alu	AluJr
CAediting_117143	chr1_161212089_+	SINE	Alu	AluJr
CAediting_117144	chr1_161212094_+	SINE	Alu	AluJr
CAediting_117145	chr1_161212120_+	SINE	Alu	AluJr
CAediting_117146	chr1_161212125_+	SINE	Alu	AluJr
CAediting_117147	chr1_161212131_+	SINE	Alu	AluJr
CAediting_117148	chr1_161213034_+	SINE	Alu	AluSg
CAediting_117149	chr1_161213155_+	SINE	Alu	AluSg
CAediting_117150	chr1_161213180_+	SINE	Alu	AluSg

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RNA A-to-I editing events in the alternative splicing sites for NDUFS2

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
ES	CAediting_117150	chr1_161213180_+	161213180:161213188	5SS	3+0i	AGCGTGAGT	8.2	GGCGTGAGT	7
MEX_2	CAediting_117150	chr1_161213180_+	161213180:161213188	5SS	3+0i	AGCGTGAGT	8.2	GGCGTGAGT	7

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000158864.11.NDUFS2.

Correlation between RNA A-to-I editing and PSI for ENSG00000158864.11.NDUFS2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for NDUFS2

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

LUAD.CAediting_117101.ENSG00000158864.NDUFS2.png
Soverview

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Protein coding region RNA A-to-I editings for NDUFS2

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for NDUFS2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for NDUFS2

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000475570.1	processed_transcript
ENST00000468828.4	processed_transcript

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_117069	ENST00000475570.1	chr1_161203695_+	-204.50	-202.20	-203.80
CAediting_117070	ENST00000475570.1	chr1_161203700_+	-203.90	-202.20	-203.80
CAediting_117149	ENST00000468828.4	chr1_161213155_+	-296.30	-296.70	-297.80
CAediting_117150	ENST00000468828.4	chr1_161213180_+	-297.30	-296.70	-297.80

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Relation with ADAR for NDUFS2

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for NDUFS2

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for NDUFS2

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for NDUFS2

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
NDUFS2	O75306	DB00157	NADH	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	SmallMoleculeDrug	approved\|nutraceutical

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RelatedDiseases for NDUFS2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
NDUFS2	C1838979	MITOCHONDRIAL COMPLEX I DEFICIENCY	4	GENOMICS_ENGLAND;ORPHANET
NDUFS2	C0023264	Leigh Disease	2	GENOMICS_ENGLAND
NDUFS2	C4748759	MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 6	2	GENOMICS_ENGLAND;UNIPROT
NDUFS2	C0033141	Cardiomyopathies, Primary	1	CTD_human
NDUFS2	C0036529	Myocardial Diseases, Secondary	1	CTD_human
NDUFS2	C0162666	Mitochondrial Encephalomyopathies	1	CTD_human
NDUFS2	C0751651	Mitochondrial Diseases	1	GENOMICS_ENGLAND
NDUFS2	C0878544	Cardiomyopathies	1	CTD_human
NDUFS2	C0917796	Optic Atrophy, Hereditary, Leber	1	ORPHANET

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene