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Editing gene: NAP1L1 (CAeditome ID:4673)

Gene summary for NAP1L1

Gene summary

Gene information	Gene symbol	NAP1L1
	Gene ID	4673
	Gene name	nucleosome assembly protein 1 like 1
	Synonyms	NAP1\|NAP1L\|NRP
	Cytomap	12q21.2
	Type of gene	protein-coding
	Description	nucleosome assembly protein 1-like 1HSP22-like protein interacting proteinNAP-1-related protein
	Modification date	20210518
	UniProtAcc	P55209
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for NAP1L1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000187109.12

RNA A-to-I editing events in Cancer.

CAediting_910505(76040698, -), CAediting_910506(76051638, -), CAediting_910507(76051794, -), CAediting_910508(76051845, -), CAediting_910509(76056747, -), CAediting_910510(76056756, -), CAediting_910511(76056768, -), CAediting_910512(76056820, -), CAediting_910513(76056829, -), CAediting_910514(76056845, -), CAediting_910515(76056849, -), CAediting_910516(76056864, -), CAediting_910517(76056928, -), CAediting_910518(76056929, -), CAediting_910519(76057284, -), CAediting_910520(76058475, -), CAediting_910521(76058484, -), CAediting_910522(76058498, -), CAediting_910523(76058551, -), CAediting_910524(76058557, -), CAediting_910525(76058558, -), CAediting_910526(76058559, -), CAediting_910527(76058563, -), CAediting_910528(76058564, -), CAediting_910529(76058591, -), CAediting_910530(76058615, -), CAediting_910531(76058658, -), CAediting_910532(76058659, -), CAediting_910533(76058675, -), CAediting_910534(76061031, -), CAediting_910535(76070166, -), CAediting_910536(76070247, -), CAediting_910537(76070290, -), CAediting_910538(76070380, -), CAediting_910539(76070990, -), CAediting_910540(76071004, -), CAediting_910541(76075999, -), CAediting_910542(76076814, -), CAediting_910543(76076818, -), CAediting_910544(76076821, -), CAediting_910545(76076823, -), CAediting_910546(76076828, -), CAediting_910547(76076831, -), CAediting_910548(76076844, -), CAediting_910549(76076887, -), CAediting_910550(76076889, -), CAediting_910551(76076902, -), CAediting_910552(76076915, -), CAediting_910553(76077818, -), CAediting_910554(76077936, -), CAediting_910555(76077945, -), CAediting_910556(76079267, -), CAediting_910557(76079282, -), CAediting_910558(76079308, -), CAediting_910559(76079354, -), CAediting_910560(76079384, -), CAediting_910561(76079400, -), CAediting_910562(76079417, -), CAediting_910563(76079462, -), CAediting_910564(76079712, -), CAediting_910565(76079746, -), CAediting_910566(76079786, -), CAediting_910567(76079822, -), CAediting_910568(76079828, -), CAediting_910569(76079919, -), CAediting_910570(76079921, -), CAediting_910571(76080435, -), CAediting_910572(76080455, -), CAediting_910573(76080458, -), CAediting_910574(76080501, -), CAediting_910575(76080506, -), CAediting_910576(76080513, -), CAediting_910577(76080520, -), CAediting_910578(76080524, -), CAediting_910579(76080538, -), CAediting_910580(76081491, -), CAediting_910581(76081492, -),

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RNA editing positional annotations for NAP1L1 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_910534	chr12_76061031_-	nonsynonymous SNV	ENST00000547479.4	c.A263G	p.Q88R	D	.	N

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_910505	chr12_76040698_-	UTR3
CAediting_910506	chr12_76051638_-	ncRNA_intronic
CAediting_910507	chr12_76051794_-	ncRNA_intronic
CAediting_910508	chr12_76051845_-	ncRNA_intronic
CAediting_910509	chr12_76056747_-	ncRNA_exonic
CAediting_910510	chr12_76056756_-	ncRNA_exonic
CAediting_910511	chr12_76056768_-	ncRNA_exonic
CAediting_910512	chr12_76056820_-	ncRNA_exonic
CAediting_910513	chr12_76056829_-	ncRNA_exonic
CAediting_910514	chr12_76056845_-	ncRNA_exonic
CAediting_910515	chr12_76056849_-	ncRNA_exonic
CAediting_910516	chr12_76056864_-	ncRNA_exonic
CAediting_910517	chr12_76056928_-	ncRNA_exonic
CAediting_910518	chr12_76056929_-	ncRNA_exonic
CAediting_910519	chr12_76057284_-	ncRNA_exonic
CAediting_910520	chr12_76058475_-	intronic
CAediting_910521	chr12_76058484_-	intronic
CAediting_910522	chr12_76058498_-	intronic
CAediting_910523	chr12_76058551_-	intronic
CAediting_910524	chr12_76058557_-	intronic
CAediting_910525	chr12_76058558_-	intronic
CAediting_910526	chr12_76058559_-	intronic
CAediting_910527	chr12_76058563_-	intronic
CAediting_910528	chr12_76058564_-	intronic
CAediting_910529	chr12_76058591_-	intronic
CAediting_910530	chr12_76058615_-	intronic
CAediting_910531	chr12_76058658_-	intronic
CAediting_910532	chr12_76058659_-	intronic
CAediting_910533	chr12_76058675_-	intronic
CAediting_910534	chr12_76061031_-	exonic
CAediting_910535	chr12_76070166_-	ncRNA_intronic
CAediting_910536	chr12_76070247_-	ncRNA_intronic
CAediting_910537	chr12_76070290_-	ncRNA_intronic
CAediting_910538	chr12_76070380_-	ncRNA_intronic
CAediting_910539	chr12_76070990_-	ncRNA_intronic
CAediting_910540	chr12_76071004_-	ncRNA_intronic
CAediting_910541	chr12_76075999_-	ncRNA_intronic
CAediting_910542	chr12_76076814_-	ncRNA_intronic
CAediting_910543	chr12_76076818_-	ncRNA_intronic
CAediting_910544	chr12_76076821_-	ncRNA_intronic
CAediting_910545	chr12_76076823_-	ncRNA_intronic
CAediting_910546	chr12_76076828_-	ncRNA_intronic
CAediting_910547	chr12_76076831_-	ncRNA_intronic
CAediting_910548	chr12_76076844_-	ncRNA_intronic
CAediting_910549	chr12_76076887_-	ncRNA_intronic
CAediting_910550	chr12_76076889_-	ncRNA_intronic
CAediting_910551	chr12_76076902_-	ncRNA_intronic
CAediting_910552	chr12_76076915_-	ncRNA_intronic
CAediting_910553	chr12_76077818_-	ncRNA_intronic
CAediting_910554	chr12_76077936_-	ncRNA_intronic
CAediting_910555	chr12_76077945_-	ncRNA_intronic
CAediting_910556	chr12_76079267_-	ncRNA_intronic
CAediting_910557	chr12_76079282_-	ncRNA_intronic
CAediting_910558	chr12_76079308_-	ncRNA_intronic
CAediting_910559	chr12_76079354_-	ncRNA_intronic
CAediting_910560	chr12_76079384_-	ncRNA_intronic
CAediting_910561	chr12_76079400_-	ncRNA_intronic
CAediting_910562	chr12_76079417_-	ncRNA_intronic
CAediting_910563	chr12_76079462_-	ncRNA_intronic
CAediting_910564	chr12_76079712_-	ncRNA_intronic
CAediting_910565	chr12_76079746_-	ncRNA_intronic
CAediting_910566	chr12_76079786_-	ncRNA_intronic
CAediting_910567	chr12_76079822_-	ncRNA_intronic
CAediting_910568	chr12_76079828_-	ncRNA_intronic
CAediting_910569	chr12_76079919_-	ncRNA_intronic
CAediting_910570	chr12_76079921_-	ncRNA_intronic
CAediting_910571	chr12_76080435_-	ncRNA_intronic
CAediting_910572	chr12_76080455_-	ncRNA_intronic
CAediting_910573	chr12_76080458_-	ncRNA_intronic
CAediting_910574	chr12_76080501_-	ncRNA_intronic
CAediting_910575	chr12_76080506_-	ncRNA_intronic
CAediting_910576	chr12_76080513_-	ncRNA_intronic
CAediting_910577	chr12_76080520_-	ncRNA_intronic
CAediting_910578	chr12_76080524_-	ncRNA_intronic
CAediting_910579	chr12_76080538_-	ncRNA_intronic
CAediting_910580	chr12_76081491_-	ncRNA_intronic
CAediting_910581	chr12_76081492_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_910505	chr12_76040698_-	SINE	Alu	AluSz
CAediting_910506	chr12_76051638_-	SINE	Alu	FLAM_C
CAediting_910507	chr12_76051794_-	SINE	Alu	AluSx
CAediting_910508	chr12_76051845_-	SINE	Alu	AluSx
CAediting_910509	chr12_76056747_-	SINE	Alu	AluSz
CAediting_910510	chr12_76056756_-	SINE	Alu	AluSz
CAediting_910511	chr12_76056768_-	SINE	Alu	AluSz
CAediting_910512	chr12_76056820_-	SINE	Alu	AluSz
CAediting_910513	chr12_76056829_-	SINE	Alu	AluSz
CAediting_910514	chr12_76056845_-	SINE	Alu	AluSz
CAediting_910515	chr12_76056849_-	SINE	Alu	AluSz
CAediting_910516	chr12_76056864_-	SINE	Alu	AluSz
CAediting_910517	chr12_76056928_-	SINE	Alu	AluSz
CAediting_910518	chr12_76056929_-	SINE	Alu	AluSz
CAediting_910519	chr12_76057284_-	SINE	Alu	AluJr
CAediting_910520	chr12_76058475_-	SINE	Alu	AluSx3
CAediting_910521	chr12_76058484_-	SINE	Alu	AluSx3
CAediting_910522	chr12_76058498_-	SINE	Alu	AluSx3
CAediting_910523	chr12_76058551_-	SINE	Alu	AluSx3
CAediting_910524	chr12_76058557_-	SINE	Alu	AluSx3
CAediting_910525	chr12_76058558_-	SINE	Alu	AluSx3
CAediting_910526	chr12_76058559_-	SINE	Alu	AluSx3
CAediting_910527	chr12_76058563_-	SINE	Alu	AluSx3
CAediting_910528	chr12_76058564_-	SINE	Alu	AluSx3
CAediting_910529	chr12_76058591_-	SINE	Alu	AluSx3
CAediting_910530	chr12_76058615_-	SINE	Alu	AluSx3
CAediting_910531	chr12_76058658_-	SINE	Alu	AluSx3
CAediting_910532	chr12_76058659_-	SINE	Alu	AluSx3
CAediting_910533	chr12_76058675_-	SINE	Alu	AluSx3
CAediting_910534	chr12_76061031_-	SINE	Alu	AluJb
CAediting_910535	chr12_76070166_-	SINE	Alu	AluSz6
CAediting_910536	chr12_76070247_-	SINE	Alu	AluSz6
CAediting_910537	chr12_76070290_-	SINE	Alu	AluSz6
CAediting_910538	chr12_76070380_-	SINE	Alu	AluSz6
CAediting_910539	chr12_76070990_-	SINE	Alu	AluSz6
CAediting_910540	chr12_76071004_-	SINE	Alu	AluSz6
CAediting_910541	chr12_76075999_-	SINE	Alu	AluJr
CAediting_910542	chr12_76076814_-	DNA	TcMar-Tigger	Tigger3c
CAediting_910543	chr12_76076818_-	DNA	TcMar-Tigger	Tigger3c
CAediting_910544	chr12_76076821_-	DNA	TcMar-Tigger	Tigger3c
CAediting_910545	chr12_76076823_-	DNA	TcMar-Tigger	Tigger3c
CAediting_910546	chr12_76076828_-	DNA	TcMar-Tigger	Tigger3c
CAediting_910547	chr12_76076831_-	DNA	TcMar-Tigger	Tigger3c
CAediting_910548	chr12_76076844_-	DNA	TcMar-Tigger	Tigger3c
CAediting_910549	chr12_76076887_-	DNA	TcMar-Tigger	Tigger3c
CAediting_910550	chr12_76076889_-	DNA	TcMar-Tigger	Tigger3c
CAediting_910551	chr12_76076902_-	DNA	TcMar-Tigger	Tigger3c
CAediting_910552	chr12_76076915_-	DNA	TcMar-Tigger	Tigger3c
CAediting_910553	chr12_76077818_-	SINE	Alu	AluSx
CAediting_910554	chr12_76077936_-	SINE	Alu	AluSx
CAediting_910555	chr12_76077945_-	SINE	Alu	AluSx
CAediting_910556	chr12_76079267_-	SINE	Alu	AluJr4
CAediting_910557	chr12_76079282_-	SINE	Alu	AluJr4
CAediting_910558	chr12_76079308_-	SINE	Alu	AluJr4
CAediting_910559	chr12_76079354_-	SINE	Alu	AluJr4
CAediting_910560	chr12_76079384_-	SINE	Alu	AluJr4
CAediting_910561	chr12_76079400_-	SINE	Alu	AluJr4
CAediting_910562	chr12_76079417_-	SINE	Alu	AluJr4
CAediting_910563	chr12_76079462_-	SINE	Alu	AluJr4
CAediting_910564	chr12_76079712_-	SINE	Alu	AluJb
CAediting_910565	chr12_76079746_-	SINE	Alu	AluJb
CAediting_910566	chr12_76079786_-	SINE	Alu	AluJb
CAediting_910567	chr12_76079822_-	SINE	Alu	AluJb
CAediting_910568	chr12_76079828_-	SINE	Alu	AluJb
CAediting_910569	chr12_76079919_-	SINE	Alu	AluJb
CAediting_910570	chr12_76079921_-	SINE	Alu	AluJb
CAediting_910571	chr12_76080435_-	DNA	TcMar-Tigger	Tigger3c
CAediting_910572	chr12_76080455_-	DNA	TcMar-Tigger	Tigger3c
CAediting_910573	chr12_76080458_-	DNA	TcMar-Tigger	Tigger3c
CAediting_910574	chr12_76080501_-	DNA	TcMar-Tigger	Tigger3c
CAediting_910575	chr12_76080506_-	DNA	TcMar-Tigger	Tigger3c
CAediting_910576	chr12_76080513_-	DNA	TcMar-Tigger	Tigger3c
CAediting_910577	chr12_76080520_-	DNA	TcMar-Tigger	Tigger3c
CAediting_910578	chr12_76080524_-	DNA	TcMar-Tigger	Tigger3c
CAediting_910579	chr12_76080538_-	DNA	TcMar-Tigger	Tigger3c
CAediting_910580	chr12_76081491_-	SINE	Alu	AluJr
CAediting_910581	chr12_76081492_-	SINE	Alu	AluJr

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RNA A-to-I editing events in the alternative splicing sites for NAP1L1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000187109.12.NAP1L1.

Correlation between RNA A-to-I editing and PSI for ENSG00000187109.12.NAP1L1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for NAP1L1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for NAP1L1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for NAP1L1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1054808	chr15_66496985_-	ENSG00000187109.12	ENST00000552056	hsa-miR-4512	76047334	76047341	8mer-1a	76047334	76047356	154	-17.57
CAediting_1229413	chr17_67471544_+	ENSG00000187109.12	ENST00000552056	hsa-miR-548aa	76047319	76047325	7mer-m8	76047318	76047342	145	-13.5
CAediting_1054808	chr15_66496985_-	ENSG00000187109.12	ENST00000393263	hsa-miR-4512	76047334	76047341	8mer-1a	76047334	76047356	154	-17.57
CAediting_1229413	chr17_67471544_+	ENSG00000187109.12	ENST00000393263	hsa-miR-548aa	76047319	76047325	7mer-m8	76047318	76047342	145	-13.5
CAediting_1160181	chr17_7017644_-	ENSG00000187109.12	ENST00000535020	hsa-miR-195-3p	76049004	76049010	7mer-m8	76049003	76049024	140	-6.08
CAediting_1351755	chr19_40282625_-	ENSG00000187109.12	ENST00000535020	hsa-miR-641	76049431	76049438	8mer-1a	76049431	76049455	150	-17.92
CAediting_1351755	chr19_40282625_-	ENSG00000187109.12	ENST00000549596	hsa-miR-641	76049431	76049438	8mer-1a	76049431	76049455	150	-17.92

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1351755	chr19_40282625_-	ENSG00000187109.12	ENST00000552056	hsa-miR-641	76047569	76047576	8mer-1a	76047569	76047592	140	-9.21
CAediting_1351755	chr19_40282625_-	ENSG00000187109.12	ENST00000393263	hsa-miR-641	76047569	76047576	8mer-1a	76047569	76047592	140	-9.21

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for NAP1L1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for NAP1L1

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for NAP1L1

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for NAP1L1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for NAP1L1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for NAP1L1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene