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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: MYH6 (CAeditome ID:4624) |
Gene summary for MYH6 |
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Gene information | Gene symbol | MYH6 | Gene ID | 4624 |
Gene name | myosin heavy chain 6 | |
Synonyms | ASD3|CMD1EE|CMH14|MYHC|MYHCA|SSS3|alpha-MHC | |
Cytomap | 14q11.2 | |
Type of gene | protein-coding | |
Description | myosin-6myHC-alphamyosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1) | |
Modification date | 20210518 | |
UniProtAcc | P13533 | |
Context |
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Gene | GO ID | GO term | PubMed ID |
MYH6 | GO:0000146 | Myosin-6 | 15621050 |
MYH6 | GO:0016887 | Myosin-6 | 15621050 |
MYH6 | GO:0002026 | Myosin-6 | 15621050 |
MYH6 | GO:0002027 | Myosin-6 | 15621050 |
MYH6 | GO:0006936 | Myosin-6 | 15621050 |
MYH6 | GO:0046034 | Myosin-6 | 15621050 |
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RNA A-to-I events for MYH6 |
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CAediting_978785(23383306, -), CAediting_978786(23383307, -), CAediting_978787(23383312, -), |
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RNA editing positional annotations for MYH6 using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
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CAeditome ID | Position | Variant type |
CAediting_978785 | chr14_23383306_- | exonic |
CAediting_978786 | chr14_23383307_- | exonic |
CAediting_978787 | chr14_23383312_- | exonic |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
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RNA A-to-I editing events in the alternative splicing sites for MYH6 |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for MYH6 |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for MYH6 |
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The effects of the RNA editing to the miRNA binding sites for MYH6 |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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The effects of the RNA editing to the stability of the RNA structures for MYH6 |
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ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for MYH6 |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for MYH6 |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for MYH6 |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for MYH6 |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MYH6 |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
MYH6 | C0007194 | Hypertrophic Cardiomyopathy | 7 | CLINGEN;CTD_human |
MYH6 | C2750467 | Cardiomyopathy, Familial Hypertrophic, 14 | 4 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
MYH6 | C2750466 | Cardiomyopathy, Dilated, 1EE | 3 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
MYH6 | C3279790 | Atrial Septal Defect 3 | 3 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
MYH6 | C3279791 | SICK SINUS SYNDROME 3, SUSCEPTIBILITY TO | 3 | GENOMICS_ENGLAND;UNIPROT |
MYH6 | C0340427 | Familial dilated cardiomyopathy | 2 | ORPHANET |
MYH6 | C4551472 | Hypertrophic obstructive cardiomyopathy | 2 | CTD_human |
MYH6 | C0004238 | Atrial Fibrillation | 1 | CTD_human |
MYH6 | C0007193 | Cardiomyopathy, Dilated | 1 | CTD_human |
MYH6 | C0018798 | Congenital Heart Defects | 1 | CTD_human |
MYH6 | C0018817 | Atrial Septal Defects | 1 | CTD_human |
MYH6 | C0031192 | Persistent Ostium Primum | 1 | CTD_human |
MYH6 | C0037052 | Sick Sinus Syndrome | 1 | CTD_human;ORPHANET |
MYH6 | C0235480 | Paroxysmal atrial fibrillation | 1 | CTD_human |
MYH6 | C0344724 | Ostium secundum atrial septal defect | 1 | CTD_human;ORPHANET |
MYH6 | C0428908 | Sinus Node Dysfunction (disorder) | 1 | CTD_human |
MYH6 | C0597124 | Obstructive asymmetric septal hypertrophy | 1 | CTD_human |
MYH6 | C0700053 | Idiopathic hypertrophic subaortic stenosis | 1 | CTD_human |
MYH6 | C0949658 | Cardiomyopathy, Hypertrophic, Familial | 1 | CTD_human |
MYH6 | C1135196 | Heart Failure, Diastolic | 1 | CTD_human |
MYH6 | C1449563 | Cardiomyopathy, Familial Idiopathic | 1 | CTD_human |
MYH6 | C1868705 | Shone complex | 1 | GENOMICS_ENGLAND |
MYH6 | C2585653 | Persistent atrial fibrillation | 1 | CTD_human |
MYH6 | C3468561 | familial atrial fibrillation | 1 | CTD_human |