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Editing gene: STAG3L2 (CAeditome ID:442582)

Gene summary for STAG3L2

Gene summary

Gene information	Gene symbol	STAG3L2
	Gene ID	442582
	Gene name	stromal antigen 3-like 2 (pseudogene)
	Synonyms	STAG3L1\|STAG3L2P\|STAG3L3
	Cytomap	7q11.23
	Type of gene	pseudo
	Description	STAG3-like protein 2
	Modification date	20210518
	UniProtAcc	.
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for STAG3L2

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000277072.3

RNA A-to-I editing events in Cancer.

CAediting_562895(74882514, -), CAediting_562896(74882534, -), CAediting_562897(74882536, -), CAediting_562898(74882539, -), CAediting_562899(74882548, -), CAediting_562900(74882549, -), CAediting_562901(74882550, -), CAediting_562902(74882558, -), CAediting_562903(74882567, -), CAediting_562904(74882571, -), CAediting_562905(74882599, -), CAediting_562906(74882603, -), CAediting_562907(74882611, -), CAediting_562908(74882621, -), CAediting_562909(74882623, -), CAediting_562910(74882625, -), CAediting_562911(74882628, -), CAediting_562912(74882634, -), CAediting_562913(74882644, -), CAediting_562914(74882645, -), CAediting_562915(74882655, -), CAediting_562916(74882658, -), CAediting_562917(74882669, -), CAediting_562918(74882671, -), CAediting_562919(74882674, -), CAediting_562920(74882681, -), CAediting_562921(74882684, -), CAediting_562922(74882693, -), CAediting_562923(74883198, -), CAediting_562924(74883226, -), CAediting_562925(74883266, -), CAediting_562926(74883271, -), CAediting_562927(74883272, -), CAediting_562928(74883280, -), CAediting_562929(74885926, -),

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RNA editing positional annotations for STAG3L2 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_562895	chr7_74882514_-	ncRNA_exonic
CAediting_562896	chr7_74882534_-	ncRNA_exonic
CAediting_562897	chr7_74882536_-	ncRNA_exonic
CAediting_562898	chr7_74882539_-	ncRNA_exonic
CAediting_562899	chr7_74882548_-	ncRNA_exonic
CAediting_562900	chr7_74882549_-	ncRNA_exonic
CAediting_562901	chr7_74882550_-	ncRNA_exonic
CAediting_562902	chr7_74882558_-	ncRNA_exonic
CAediting_562903	chr7_74882567_-	ncRNA_exonic
CAediting_562904	chr7_74882571_-	ncRNA_exonic
CAediting_562905	chr7_74882599_-	ncRNA_exonic
CAediting_562906	chr7_74882603_-	ncRNA_exonic
CAediting_562907	chr7_74882611_-	ncRNA_exonic
CAediting_562908	chr7_74882621_-	ncRNA_exonic
CAediting_562909	chr7_74882623_-	ncRNA_exonic
CAediting_562910	chr7_74882625_-	ncRNA_exonic
CAediting_562911	chr7_74882628_-	ncRNA_exonic
CAediting_562912	chr7_74882634_-	ncRNA_exonic
CAediting_562913	chr7_74882644_-	ncRNA_exonic
CAediting_562914	chr7_74882645_-	ncRNA_exonic
CAediting_562915	chr7_74882655_-	ncRNA_exonic
CAediting_562916	chr7_74882658_-	ncRNA_exonic
CAediting_562917	chr7_74882669_-	ncRNA_exonic
CAediting_562918	chr7_74882671_-	ncRNA_exonic
CAediting_562919	chr7_74882674_-	ncRNA_exonic
CAediting_562920	chr7_74882681_-	ncRNA_exonic
CAediting_562921	chr7_74882684_-	ncRNA_exonic
CAediting_562922	chr7_74882693_-	ncRNA_exonic
CAediting_562923	chr7_74883198_-	ncRNA_exonic
CAediting_562924	chr7_74883226_-	ncRNA_exonic
CAediting_562925	chr7_74883266_-	ncRNA_exonic
CAediting_562926	chr7_74883271_-	ncRNA_exonic
CAediting_562927	chr7_74883272_-	ncRNA_exonic
CAediting_562928	chr7_74883280_-	ncRNA_exonic
CAediting_562929	chr7_74885926_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_562895	chr7_74882514_-	SINE	Alu	AluY
CAediting_562896	chr7_74882534_-	SINE	Alu	AluY
CAediting_562897	chr7_74882536_-	SINE	Alu	AluY
CAediting_562898	chr7_74882539_-	SINE	Alu	AluY
CAediting_562899	chr7_74882548_-	SINE	Alu	AluY
CAediting_562900	chr7_74882549_-	SINE	Alu	AluY
CAediting_562901	chr7_74882550_-	SINE	Alu	AluY
CAediting_562902	chr7_74882558_-	SINE	Alu	AluY
CAediting_562903	chr7_74882567_-	SINE	Alu	AluY
CAediting_562904	chr7_74882571_-	SINE	Alu	AluY
CAediting_562905	chr7_74882599_-	SINE	Alu	AluY
CAediting_562906	chr7_74882603_-	SINE	Alu	AluY
CAediting_562907	chr7_74882611_-	SINE	Alu	AluY
CAediting_562908	chr7_74882621_-	SINE	Alu	AluY
CAediting_562909	chr7_74882623_-	SINE	Alu	AluY
CAediting_562910	chr7_74882625_-	SINE	Alu	AluY
CAediting_562911	chr7_74882628_-	SINE	Alu	AluY
CAediting_562912	chr7_74882634_-	SINE	Alu	AluY
CAediting_562913	chr7_74882644_-	SINE	Alu	AluY
CAediting_562914	chr7_74882645_-	SINE	Alu	AluY
CAediting_562915	chr7_74882655_-	SINE	Alu	AluY
CAediting_562916	chr7_74882658_-	SINE	Alu	AluY
CAediting_562917	chr7_74882669_-	SINE	Alu	AluY
CAediting_562918	chr7_74882671_-	SINE	Alu	AluY
CAediting_562919	chr7_74882674_-	SINE	Alu	AluY
CAediting_562920	chr7_74882681_-	SINE	Alu	AluY
CAediting_562921	chr7_74882684_-	SINE	Alu	AluY
CAediting_562922	chr7_74882693_-	SINE	Alu	AluY
CAediting_562923	chr7_74883198_-	SINE	Alu	FLAM_C
CAediting_562924	chr7_74883226_-	SINE	Alu	FLAM_C
CAediting_562925	chr7_74883266_-	SINE	Alu	FLAM_C
CAediting_562926	chr7_74883271_-	SINE	Alu	FLAM_C
CAediting_562927	chr7_74883272_-	SINE	Alu	FLAM_C
CAediting_562928	chr7_74883280_-	SINE	Alu	FLAM_C
CAediting_562929	chr7_74885926_-	SINE	Alu	AluSc

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RNA A-to-I editing events in the alternative splicing sites for STAG3L2

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000277072.3.STAG3L2.

Correlation between RNA A-to-I editing and PSI for ENSG00000277072.3.STAG3L2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for STAG3L2

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for STAG3L2

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for STAG3L2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for STAG3L2

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000426587.4	processed_transcript

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_562895	ENST00000426587.4	chr7_74882514_-	-829.30	-830.00	-857.10
CAediting_562896	ENST00000426587.4	chr7_74882534_-	-829.30	-830.00	-857.10
CAediting_562897	ENST00000426587.4	chr7_74882536_-	-830.00	-830.00	-857.10
CAediting_562898	ENST00000426587.4	chr7_74882539_-	-832.60	-830.00	-857.10
CAediting_562899	ENST00000426587.4	chr7_74882548_-	-829.70	-830.00	-857.10
CAediting_562900	ENST00000426587.4	chr7_74882549_-	-830.10	-830.00	-857.10
CAediting_562901	ENST00000426587.4	chr7_74882550_-	-829.70	-830.00	-857.10
CAediting_562902	ENST00000426587.4	chr7_74882558_-	-831.20	-830.00	-857.10
CAediting_562903	ENST00000426587.4	chr7_74882567_-	-831.00	-830.00	-857.10
CAediting_562904	ENST00000426587.4	chr7_74882571_-	-829.40	-830.00	-857.10
CAediting_562905	ENST00000426587.4	chr7_74882599_-	-829.20	-830.00	-857.10
CAediting_562906	ENST00000426587.4	chr7_74882603_-	-834.90	-830.00	-857.10
CAediting_562907	ENST00000426587.4	chr7_74882611_-	-829.60	-830.00	-857.10
CAediting_562908	ENST00000426587.4	chr7_74882621_-	-829.40	-830.00	-857.10
CAediting_562909	ENST00000426587.4	chr7_74882623_-	-829.10	-830.00	-857.10
CAediting_562910	ENST00000426587.4	chr7_74882625_-	-829.70	-830.00	-857.10
CAediting_562911	ENST00000426587.4	chr7_74882628_-	-836.60	-830.00	-857.10
CAediting_562912	ENST00000426587.4	chr7_74882634_-	-830.80	-830.00	-857.10
CAediting_562913	ENST00000426587.4	chr7_74882644_-	-831.40	-830.00	-857.10
CAediting_562914	ENST00000426587.4	chr7_74882645_-	-831.40	-830.00	-857.10
CAediting_562915	ENST00000426587.4	chr7_74882655_-	-831.80	-830.00	-857.10
CAediting_562916	ENST00000426587.4	chr7_74882658_-	-830.50	-830.00	-857.10
CAediting_562917	ENST00000426587.4	chr7_74882669_-	-832.00	-830.00	-857.10
CAediting_562918	ENST00000426587.4	chr7_74882671_-	-830.40	-830.00	-857.10
CAediting_562919	ENST00000426587.4	chr7_74882674_-	-831.50	-830.00	-857.10
CAediting_562920	ENST00000426587.4	chr7_74882681_-	-831.40	-830.00	-857.10
CAediting_562921	ENST00000426587.4	chr7_74882684_-	-836.70	-830.00	-857.10
CAediting_562922	ENST00000426587.4	chr7_74882693_-	-831.90	-830.00	-857.10
CAediting_562923	ENST00000426587.4	chr7_74883198_-	-835.90	-830.00	-857.10
CAediting_562924	ENST00000426587.4	chr7_74883226_-	-829.20	-830.00	-857.10
CAediting_562925	ENST00000426587.4	chr7_74883266_-	-829.30	-830.00	-857.10
CAediting_562926	ENST00000426587.4	chr7_74883271_-	-829.70	-830.00	-857.10
CAediting_562927	ENST00000426587.4	chr7_74883272_-	-830.10	-830.00	-857.10
CAediting_562928	ENST00000426587.4	chr7_74883280_-	-829.60	-830.00	-857.10

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Relation with ADAR for STAG3L2

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
STAD	CAediting_562899	chr7_74882548_-	0.0019962490607175	0.31816964408961	.	.	.	.
STAD	CAediting_562906	chr7_74882603_-	5.31803931830251e-05	0.27015067590394	.	.	.	.
ESCA	CAediting_562906	chr7_74882603_-	0.0168962844421875	0.197458057853088	.	.	.	.
STAD	CAediting_562907	chr7_74882611_-	.	.	0.00329496542271172	0.367547466170532	.	.
BRCA	CAediting_562910	chr7_74882625_-	3.13294510880362e-05	0.266941154152314	.	.	.	.
LUAD	CAediting_562910	chr7_74882625_-	0.00324098500576995	0.383403695699803	.	.	.	.
LUSC	CAediting_562910	chr7_74882625_-	0.00369070307749661	0.290662452623579	.	.	.	.
STAD	CAediting_562910	chr7_74882625_-	0.00306096453696387	0.212669645798516	.	.	.	.
THCA	CAediting_562910	chr7_74882625_-	0.00198118901499561	0.2405491632428	.	.	.	.
KIRP	CAediting_562910	chr7_74882625_-	0.00921365531399533	0.273067463966945	.	.	.	.
ESCA	CAediting_562910	chr7_74882625_-	0.00238985286702781	0.280551504834767	.	.	.	.
SKCM	CAediting_562910	chr7_74882625_-	0.0285266180598371	0.196731164823687	.	.	.	.
BLCA	CAediting_562911	chr7_74882628_-	0.000590548951512896	0.444944892457001	.	.	.	.
LGG	CAediting_562911	chr7_74882628_-	.	.	0.0477122710338676	0.226397201528218	0.00158564197700159	0.354006201908406
BRCA	CAediting_562911	chr7_74882628_-	1.55780957833997e-09	0.32505408055819	.	.	.	.
LUAD	CAediting_562911	chr7_74882628_-	0.00796806736722656	0.298380967201402	.	.	.	.
COAD	CAediting_562911	chr7_74882628_-	0.0328772065291972	0.265028189600362	.	.	.	.
LUSC	CAediting_562911	chr7_74882628_-	1.52694903326931e-09	0.436687277015028	.	.	0.0234944033371198	0.171201069030937
GBM	CAediting_562911	chr7_74882628_-	0.00387639191387549	0.263944566627998	.	.	.	.
STAD	CAediting_562911	chr7_74882628_-	1.62089819570907e-06	0.287025825723273	.	.	.	.
THCA	CAediting_562911	chr7_74882628_-	0.00191154135618177	0.218719195649178	.	.	.	.
KIRC	CAediting_562911	chr7_74882628_-	0.00112885987734933	0.219613634708819	.	.	.	.
KIRP	CAediting_562911	chr7_74882628_-	2.93955540497304e-06	0.367644208841053	.	.	.	.
ESCA	CAediting_562911	chr7_74882628_-	2.66231093210031e-06	0.367992597475538	.	.	.	.
LAML	CAediting_562911	chr7_74882628_-	0.0169015737869826	0.207625684871829	.	.	.	.
OV	CAediting_562911	chr7_74882628_-	9.30456639894896e-05	0.219427932884362	.	.	.	.
SKCM	CAediting_562911	chr7_74882628_-	2.28437866475257e-06	0.341188295033186	.	.	.	.
BLCA	CAediting_562918	chr7_74882671_-	0.00049374979805983	0.347188792093404	.	.	.	.
CESC	CAediting_562918	chr7_74882671_-	.	.	0.0272010573770637	0.309309229689499	.	.
COAD	CAediting_562918	chr7_74882671_-	0.0499863573867839	0.233536520794104	.	.	.	.
HNSC	CAediting_562918	chr7_74882671_-	0.0256180965945816	0.239264017370335	.	.	.	.
KIRC	CAediting_562918	chr7_74882671_-	0.0279518376471262	0.152428129358993	.	.	.	.
SKCM	CAediting_562918	chr7_74882671_-	0.00917825735922335	0.179395550128305	.	.	.	.
THYM	CAediting_562918	chr7_74882671_-	.	.	.	.	0.0300911187787461	0.290108565616806
BRCA	CAediting_562922	chr7_74882693_-	0.0403490571998207	0.277364247697834	.	.	.	.

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Relation with cancer stages for STAG3L2

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
BRCA	pathologic_stage	CAediting_562926	chr7_74883271_-	0.0155021395101518	0.306203360496571
ESCA	pathologic_stage	CAediting_562899	chr7_74882548_-	0.0323181962804247	0.244215246875635
KIRC	pathologic_stage	CAediting_562918	chr7_74882671_-	0.030570314405178	0.150367449754337
KIRP	clinical_stage	CAediting_562911	chr7_74882628_-	0.0410078802770697	0.204748977828414
KIRP	pathologic_stage	CAediting_562910	chr7_74882625_-	0.00785338316316509	0.293397218627359
KIRP	pathologic_stage	CAediting_562911	chr7_74882628_-	0.007057839022152	0.229200354598224
STAD	pathologic_stage	CAediting_562906	chr7_74882603_-	0.000673543899257346	0.231169538130875

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Relation with survival for STAG3L2

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
LUAD	CAediting_562911	chr7_74882628_-	0.024475398159202	0.0325823	0.0365065
SKCM	CAediting_562912	chr7_74882634_-	0.0124638808082242	0.00370406	0.00412214

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RelatedDrugs for STAG3L2

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for STAG3L2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene