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Editing gene: EIF2AK4 (CAeditome ID:440275)

Gene summary for EIF2AK4

Gene summary

Gene information	Gene symbol	EIF2AK4
	Gene ID	440275
	Gene name	eukaryotic translation initiation factor 2 alpha kinase 4
	Synonyms	GCN2\|PVOD2
	Cytomap	15q15.1
	Type of gene	protein-coding
	Description	eIF-2-alpha kinase GCN2GCN2 eIF2alpha kinaseGCN2-like proteingeneral control nonderepressible 2
	Modification date	20210518
	UniProtAcc	Q9P2K8
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for EIF2AK4

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000128829.10

RNA A-to-I editing events in Cancer.

CAediting_1027947(39943802, +), CAediting_1027948(39943840, +), CAediting_1027949(39943848, +), CAediting_1027950(39945215, +), CAediting_1027951(39945218, +), CAediting_1027952(39950432, +), CAediting_1027953(39950433, +), CAediting_1027954(39950440, +), CAediting_1027955(39950441, +), CAediting_1027956(39950444, +), CAediting_1027957(39950460, +), CAediting_1027958(39950480, +), CAediting_1027959(39950484, +), CAediting_1027960(39950503, +), CAediting_1027961(39950511, +), CAediting_1027962(39950512, +), CAediting_1027963(39950540, +), CAediting_1027964(39951260, +), CAediting_1027965(39951290, +), CAediting_1027966(39951308, +), CAediting_1027967(39951320, +), CAediting_1027968(39951330, +), CAediting_1027969(39952977, +), CAediting_1027970(39952993, +), CAediting_1027971(39962576, +), CAediting_1027972(39971262, +), CAediting_1027973(39971285, +), CAediting_1027974(39971596, +), CAediting_1027975(39971624, +), CAediting_1027976(39971642, +), CAediting_1027977(40009111, +), CAediting_1027978(40019997, +), CAediting_1027979(40020087, +), CAediting_1027980(40020088, +), CAediting_1027981(40031030, +), CAediting_1027982(40031151, +), CAediting_1027983(40031825, +), CAediting_1027984(40031853, +), CAediting_1027985(40031855, +), CAediting_1027986(40033763, +), CAediting_1027987(40033788, +), CAediting_1027988(40033794, +), CAediting_1027989(40033807, +), CAediting_1027990(40033913, +), CAediting_1027991(40033936, +), CAediting_1027992(40033962, +), CAediting_1027993(40033978, +), CAediting_1027994(40033980, +), CAediting_1027995(40033988, +), CAediting_1027996(40033998, +), CAediting_1027997(40035083, +), CAediting_1027998(40035198, +), CAediting_1027999(40035208, +), CAediting_1028000(40035287, +), CAediting_1028001(40035294, +), CAediting_1028002(40035299, +), CAediting_1028003(40035341, +), CAediting_1028004(40035378, +), CAediting_1028005(40035478, +),

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RNA editing positional annotations for EIF2AK4 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1027947	chr15_39943802_+	intronic
CAediting_1027948	chr15_39943840_+	intronic
CAediting_1027949	chr15_39943848_+	intronic
CAediting_1027950	chr15_39945215_+	intronic
CAediting_1027951	chr15_39945218_+	intronic
CAediting_1027952	chr15_39950432_+	intronic
CAediting_1027953	chr15_39950433_+	intronic
CAediting_1027954	chr15_39950440_+	intronic
CAediting_1027955	chr15_39950441_+	intronic
CAediting_1027956	chr15_39950444_+	intronic
CAediting_1027957	chr15_39950460_+	intronic
CAediting_1027958	chr15_39950480_+	intronic
CAediting_1027959	chr15_39950484_+	intronic
CAediting_1027960	chr15_39950503_+	intronic
CAediting_1027961	chr15_39950511_+	intronic
CAediting_1027962	chr15_39950512_+	intronic
CAediting_1027963	chr15_39950540_+	intronic
CAediting_1027964	chr15_39951260_+	intronic
CAediting_1027965	chr15_39951290_+	intronic
CAediting_1027966	chr15_39951308_+	intronic
CAediting_1027967	chr15_39951320_+	intronic
CAediting_1027968	chr15_39951330_+	intronic
CAediting_1027969	chr15_39952977_+	intronic
CAediting_1027970	chr15_39952993_+	intronic
CAediting_1027971	chr15_39962576_+	intronic
CAediting_1027972	chr15_39971262_+	intronic
CAediting_1027973	chr15_39971285_+	intronic
CAediting_1027974	chr15_39971596_+	intronic
CAediting_1027975	chr15_39971624_+	intronic
CAediting_1027976	chr15_39971642_+	intronic
CAediting_1027977	chr15_40009111_+	ncRNA_intronic
CAediting_1027978	chr15_40019997_+	ncRNA_intronic
CAediting_1027979	chr15_40020087_+	ncRNA_intronic
CAediting_1027980	chr15_40020088_+	ncRNA_intronic
CAediting_1027981	chr15_40031030_+	ncRNA_intronic
CAediting_1027982	chr15_40031151_+	ncRNA_intronic
CAediting_1027983	chr15_40031825_+	ncRNA_intronic
CAediting_1027984	chr15_40031853_+	ncRNA_intronic
CAediting_1027985	chr15_40031855_+	ncRNA_intronic
CAediting_1027986	chr15_40033763_+	ncRNA_intronic
CAediting_1027987	chr15_40033788_+	ncRNA_intronic
CAediting_1027988	chr15_40033794_+	ncRNA_intronic
CAediting_1027989	chr15_40033807_+	ncRNA_intronic
CAediting_1027990	chr15_40033913_+	ncRNA_intronic
CAediting_1027991	chr15_40033936_+	ncRNA_intronic
CAediting_1027992	chr15_40033962_+	ncRNA_intronic
CAediting_1027993	chr15_40033978_+	ncRNA_intronic
CAediting_1027994	chr15_40033980_+	ncRNA_intronic
CAediting_1027995	chr15_40033988_+	ncRNA_intronic
CAediting_1027996	chr15_40033998_+	ncRNA_intronic
CAediting_1027997	chr15_40035083_+	exonic
CAediting_1027998	chr15_40035198_+	ncRNA_exonic
CAediting_1027999	chr15_40035208_+	ncRNA_exonic
CAediting_1028000	chr15_40035287_+	ncRNA_exonic
CAediting_1028001	chr15_40035294_+	ncRNA_exonic
CAediting_1028002	chr15_40035299_+	ncRNA_exonic
CAediting_1028003	chr15_40035341_+	ncRNA_exonic
CAediting_1028004	chr15_40035378_+	ncRNA_exonic
CAediting_1028005	chr15_40035478_+	ncRNA_exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1027947	chr15_39943802_+	SINE	Alu	AluJo
CAediting_1027948	chr15_39943840_+	SINE	Alu	AluJo
CAediting_1027949	chr15_39943848_+	SINE	Alu	AluJo
CAediting_1027950	chr15_39945215_+	SINE	Alu	FLAM_C
CAediting_1027951	chr15_39945218_+	SINE	Alu	FLAM_C
CAediting_1027952	chr15_39950432_+	SINE	Alu	AluSz6
CAediting_1027953	chr15_39950433_+	SINE	Alu	AluSz6
CAediting_1027954	chr15_39950440_+	SINE	Alu	AluSz6
CAediting_1027955	chr15_39950441_+	SINE	Alu	AluSz6
CAediting_1027956	chr15_39950444_+	SINE	Alu	AluSz6
CAediting_1027957	chr15_39950460_+	SINE	Alu	AluSz6
CAediting_1027958	chr15_39950480_+	SINE	Alu	AluSz6
CAediting_1027959	chr15_39950484_+	SINE	Alu	AluSz6
CAediting_1027960	chr15_39950503_+	SINE	Alu	AluSz6
CAediting_1027961	chr15_39950511_+	SINE	Alu	AluSz6
CAediting_1027962	chr15_39950512_+	SINE	Alu	AluSz6
CAediting_1027963	chr15_39950540_+	SINE	Alu	AluSz6
CAediting_1027964	chr15_39951260_+	SINE	Alu	AluSp
CAediting_1027965	chr15_39951290_+	SINE	Alu	AluSp
CAediting_1027966	chr15_39951308_+	SINE	Alu	AluSp
CAediting_1027967	chr15_39951320_+	SINE	Alu	AluSp
CAediting_1027968	chr15_39951330_+	SINE	Alu	AluSp
CAediting_1027969	chr15_39952977_+	SINE	Alu	AluSg4
CAediting_1027970	chr15_39952993_+	SINE	Alu	AluSg4
CAediting_1027971	chr15_39962576_+	SINE	Alu	AluJr4
CAediting_1027972	chr15_39971262_+	SINE	Alu	AluSz
CAediting_1027973	chr15_39971285_+	SINE	Alu	AluSz
CAediting_1027974	chr15_39971596_+	SINE	Alu	AluJo
CAediting_1027975	chr15_39971624_+	SINE	Alu	AluJo
CAediting_1027976	chr15_39971642_+	SINE	Alu	AluJo
CAediting_1027977	chr15_40009111_+	SINE	Alu	AluJb
CAediting_1027978	chr15_40019997_+	SINE	Alu	AluSz6
CAediting_1027979	chr15_40020087_+	SINE	Alu	AluSz6
CAediting_1027980	chr15_40020088_+	SINE	Alu	AluSz6
CAediting_1027981	chr15_40031030_+	SINE	Alu	AluSz
CAediting_1027982	chr15_40031151_+	SINE	Alu	AluSz
CAediting_1027983	chr15_40031825_+	SINE	Alu	AluSx1
CAediting_1027984	chr15_40031853_+	SINE	Alu	AluSx1
CAediting_1027985	chr15_40031855_+	SINE	Alu	AluSx1
CAediting_1027986	chr15_40033763_+	SINE	Alu	AluSq
CAediting_1027987	chr15_40033788_+	SINE	Alu	AluSq
CAediting_1027988	chr15_40033794_+	SINE	Alu	AluSq
CAediting_1027989	chr15_40033807_+	SINE	Alu	AluSq
CAediting_1027990	chr15_40033913_+	SINE	Alu	AluSq
CAediting_1027991	chr15_40033936_+	SINE	Alu	AluSq
CAediting_1027992	chr15_40033962_+	SINE	Alu	AluSq
CAediting_1027993	chr15_40033978_+	SINE	Alu	AluSq
CAediting_1027994	chr15_40033980_+	SINE	Alu	AluSq
CAediting_1027995	chr15_40033988_+	SINE	Alu	AluSq
CAediting_1027996	chr15_40033998_+	SINE	Alu	AluSq
CAediting_1027998	chr15_40035198_+	SINE	Alu	AluJr
CAediting_1027999	chr15_40035208_+	SINE	Alu	AluJr
CAediting_1028000	chr15_40035287_+	SINE	Alu	AluJr
CAediting_1028001	chr15_40035294_+	SINE	Alu	AluJr
CAediting_1028002	chr15_40035299_+	SINE	Alu	AluJr
CAediting_1028003	chr15_40035341_+	SINE	Alu	AluJr
CAediting_1028004	chr15_40035378_+	SINE	Alu	AluJr
CAediting_1028005	chr15_40035478_+	SINE	Alu	AluJr

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RNA A-to-I editing events in the alternative splicing sites for EIF2AK4

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000128829.10.EIF2AK4.

Correlation between RNA A-to-I editing and PSI for ENSG00000128829.10.EIF2AK4.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for EIF2AK4

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for EIF2AK4

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for EIF2AK4

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1027999	chr15_40035208_+	ENSG00000128829.10	ENST00000560855	hsa-miR-4484	40035206	40035213	8mer-1a	40035194	40035213	152.00	-16.56
CAediting_1027999	chr15_40035208_+	ENSG00000128829.10	ENST00000558823	hsa-miR-4484	40035206	40035213	8mer-1a	40035194	40035213	152.00	-16.56
CAediting_1028000	chr15_40035287_+	ENSG00000128829.10	ENST00000560855	hsa-miR-3194-3p	40035284	40035290	7mer-1a	40035267	40035290	145.00	-26.09
CAediting_1028000	chr15_40035287_+	ENSG00000128829.10	ENST00000560855	hsa-miR-367-5p	40035280	40035287	8mer-1a	40035266	40035287	147.00	-15.78
CAediting_1028000	chr15_40035287_+	ENSG00000128829.10	ENST00000560855	hsa-miR-5691	40035284	40035291	8mer-1a	40035269	40035291	150.00	-17.94
CAediting_1028000	chr15_40035287_+	ENSG00000128829.10	ENST00000560855	hsa-miR-6805-3p	40035284	40035291	8mer-1a	40035269	40035291	150.00	-14.12
CAediting_1028000	chr15_40035287_+	ENSG00000128829.10	ENST00000558823	hsa-miR-3194-3p	40035284	40035290	7mer-1a	40035267	40035290	145.00	-26.09
CAediting_1028000	chr15_40035287_+	ENSG00000128829.10	ENST00000558823	hsa-miR-367-5p	40035280	40035287	8mer-1a	40035266	40035287	147.00	-15.78
CAediting_1028000	chr15_40035287_+	ENSG00000128829.10	ENST00000558823	hsa-miR-5691	40035284	40035291	8mer-1a	40035269	40035291	150.00	-17.94
CAediting_1028000	chr15_40035287_+	ENSG00000128829.10	ENST00000558823	hsa-miR-6805-3p	40035284	40035291	8mer-1a	40035269	40035291	150.00	-14.12
CAediting_1028001	chr15_40035294_+	ENSG00000128829.10	ENST00000560855	hsa-miR-1227-5p	40035292	40035298	7mer-m8	40035283	40035299	144.00	-23.07
CAediting_1028001	chr15_40035294_+	ENSG00000128829.10	ENST00000560855	hsa-miR-1915-5p	40035288	40035293	6mer	40035273	40035294	148.00	-25.48
CAediting_1028001	chr15_40035294_+	ENSG00000128829.10	ENST00000558823	hsa-miR-1227-5p	40035292	40035298	7mer-m8	40035283	40035299	144.00	-23.07
CAediting_1028001	chr15_40035294_+	ENSG00000128829.10	ENST00000558823	hsa-miR-1915-5p	40035288	40035293	6mer	40035273	40035294	148.00	-25.48
CAediting_1028002	chr15_40035299_+	ENSG00000128829.10	ENST00000560855	hsa-miR-483-5p	40035295	40035301	7mer-m8	40035281	40035302	140.00	-14.01
CAediting_1028002	chr15_40035299_+	ENSG00000128829.10	ENST00000558823	hsa-miR-483-5p	40035295	40035301	7mer-m8	40035281	40035302	140.00	-14.01
CAediting_1028003	chr15_40035341_+	ENSG00000128829.10	ENST00000560855	hsa-miR-3622a-5p	40035339	40035345	7mer-m8	40035325	40035346	147.00	-21.88
CAediting_1028003	chr15_40035341_+	ENSG00000128829.10	ENST00000560855	hsa-miR-6767-3p	40035336	40035342	7mer-m8	40035322	40035343	155.00	-18.38
CAediting_1028003	chr15_40035341_+	ENSG00000128829.10	ENST00000558823	hsa-miR-3622a-5p	40035339	40035345	7mer-m8	40035325	40035346	147.00	-21.88
CAediting_1028003	chr15_40035341_+	ENSG00000128829.10	ENST00000558823	hsa-miR-6767-3p	40035336	40035342	7mer-m8	40035322	40035343	155.00	-18.38
CAediting_1028004	chr15_40035378_+	ENSG00000128829.10	ENST00000560855	hsa-miR-660-5p	40035373	40035378	6mer	40035356	40035379	146.00	-20.22
CAediting_1028004	chr15_40035378_+	ENSG00000128829.10	ENST00000558823	hsa-miR-660-5p	40035373	40035378	6mer	40035356	40035379	146.00	-20.22

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1028001	chr15_40035294_+	ENSG00000128829.10	ENST00000560855	hsa-miR-193a-5p	40035290	40035296	7mer-m8	40035277	40035297	141	-14.32
CAediting_1027998	chr15_40035198_+	ENSG00000128829.10	ENST00000560855	hsa-miR-3130-3p	40035192	40035198	7mer-m8	40035180	40035199	145	-15.81
CAediting_1027998	chr15_40035198_+	ENSG00000128829.10	ENST00000560855	hsa-miR-3130-3p	40035192	40035198	7mer-m8	40035180	40035199	145	-15.81
CAediting_1027998	chr15_40035198_+	ENSG00000128829.10	ENST00000560855	hsa-miR-4252	40035196	40035202	7mer-m8	40035184	40035203	154	-23.75
CAediting_1028001	chr15_40035294_+	ENSG00000128829.10	ENST00000560855	hsa-miR-431-5p	40035288	40035294	7mer-m8	40035275	40035295	140	-10.41
CAediting_1028003	chr15_40035341_+	ENSG00000128829.10	ENST00000560855	hsa-miR-455-5p	40035335	40035341	7mer-m8	40035320	40035342	144	-14.78
CAediting_1028004	chr15_40035378_+	ENSG00000128829.10	ENST00000560855	hsa-miR-640	40035374	40035380	7mer-m8	40035361	40035381	140	-22.15
CAediting_1028002	chr15_40035299_+	ENSG00000128829.10	ENST00000560855	hsa-miR-6890-5p	40035293	40035299	7mer-m8	40035280	40035300	142	-14.77
CAediting_1028001	chr15_40035294_+	ENSG00000128829.10	ENST00000558823	hsa-miR-193a-5p	40035290	40035296	7mer-m8	40035277	40035297	141	-14.32
CAediting_1027998	chr15_40035198_+	ENSG00000128829.10	ENST00000558823	hsa-miR-3130-3p	40035192	40035198	7mer-m8	40035180	40035199	145	-15.81
CAediting_1027998	chr15_40035198_+	ENSG00000128829.10	ENST00000558823	hsa-miR-3130-3p	40035192	40035198	7mer-m8	40035180	40035199	145	-15.81
CAediting_1027998	chr15_40035198_+	ENSG00000128829.10	ENST00000558823	hsa-miR-4252	40035196	40035202	7mer-m8	40035184	40035203	154	-23.75
CAediting_1028001	chr15_40035294_+	ENSG00000128829.10	ENST00000558823	hsa-miR-431-5p	40035288	40035294	7mer-m8	40035275	40035295	140	-10.41
CAediting_1028003	chr15_40035341_+	ENSG00000128829.10	ENST00000558823	hsa-miR-455-5p	40035335	40035341	7mer-m8	40035320	40035342	144	-14.78
CAediting_1028004	chr15_40035378_+	ENSG00000128829.10	ENST00000558823	hsa-miR-640	40035374	40035380	7mer-m8	40035361	40035381	140	-22.15
CAediting_1028002	chr15_40035299_+	ENSG00000128829.10	ENST00000558823	hsa-miR-6890-5p	40035293	40035299	7mer-m8	40035280	40035300	142	-14.77

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000128829.10	ENST00000559624	hsa-miR-200b-3p	39975261	39975267	7mer-m8	39975247	39975268	140	-8.53
CAediting_393	chr1_1167164_+	ENSG00000128829.10	ENST00000559624	hsa-miR-200b-3p	39974474	39974480	7mer-1a	39974459	39974480	140	-18.69
CAediting_393	chr1_1167164_+	ENSG00000128829.10	ENST00000560648	hsa-miR-200b-3p	39946655	39946661	7mer-m8	39946641	39946662	155	-14.22
CAediting_980496	chr14_31014685_-	ENSG00000128829.10	ENST00000560855	hsa-miR-624-3p	40035457	40035463	7mer-m8	40035444	40035464	156	-14.33
CAediting_980496	chr14_31014685_-	ENSG00000128829.10	ENST00000558823	hsa-miR-624-3p	40035457	40035463	7mer-m8	40035444	40035464	156	-14.33
CAediting_1229415	chr17_67471547_+	ENSG00000128829.10	ENST00000559624	hsa-miR-548aa	39974176	39974182	7mer-m8	39974158	39974183	147	-13.73
CAediting_1160181	chr17_7017644_-	ENSG00000128829.10	ENST00000559624	hsa-miR-195-3p	39974064	39974070	7mer-m8	39974053	39974071	145	-12.96

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_228905	chr2_188297554_+	ENSG00000128829.10	ENST00000559624	hsa-miR-561-3p	39974495	39974501	7mer-m8	39974481	39974502	140	-4.39

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for EIF2AK4

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for EIF2AK4

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for EIF2AK4

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for EIF2AK4

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for EIF2AK4

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
EIF2AK4	Q9P2K8	DB12010	Fostamatinib	eIF-2-alpha kinase GCN2	SmallMoleculeDrug	approved\|investigational

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RelatedDiseases for EIF2AK4

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
EIF2AK4	C0340848	PULMONARY VENOOCCLUSIVE DISEASE 2, AUTOSOMAL RECESSIVE	3	GENOMICS_ENGLAND;UNIPROT
EIF2AK4	C0034091	Pulmonary Veno-Occlusive Disease (disorder)	2	CTD_human;GENOMICS_ENGLAND;ORPHANET
EIF2AK4	C0340543	Familial primary pulmonary hypertension	2	GENOMICS_ENGLAND;ORPHANET
EIF2AK4	C0340548	Pulmonary capillary hemangiomatosis	2	GENOMICS_ENGLAND;ORPHANET
EIF2AK4	C0002514	Amino Acid Metabolism, Inborn Errors	1	CTD_human
EIF2AK4	C0018500	Hair Diseases	1	CTD_human
EIF2AK4	C0020542	Pulmonary Hypertension	1	CTD_human
EIF2AK4	C0021053	Immune System Diseases	1	CTD_human
EIF2AK4	C0026848	Myopathy	1	CTD_human
EIF2AK4	C0152171	Idiopathic pulmonary hypertension	1	GENOMICS_ENGLAND
EIF2AK4	C0750905	Amino Acid Metabolism, Inherited Disorders	1	CTD_human
EIF2AK4	C1150929	2-oxo-hept-3-ene-1,7-dioate hydratase activity	1	GENOMICS_ENGLAND
EIF2AK4	C1701939	Familial pulmonary arterial hypertension	1	ORPHANET
EIF2AK4	C2973725	Pulmonary arterial hypertension	1	GENOMICS_ENGLAND
EIF2AK4	C3203102	Idiopathic pulmonary arterial hypertension	1	GENOMICS_ENGLAND

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene